Details for: CL0011103

Cell ID: CL0011103

Cell Name: sympathetic neuron

Marker Score Threshold: 330
(Derived using integrated single-cell and genomic data)

Description: Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CHGA (ENSG00000100604)
    Fold Change: 10.61
    Ensembl ID: ENSG00000100604
  • Gene Symbol: CHGB (ENSG00000089199)
    Fold Change: 9.42
    Ensembl ID: ENSG00000089199
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 6.43
    Ensembl ID: ENSG00000018236
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 4.51
    Ensembl ID: ENSG00000145362
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 4.5
    Ensembl ID: ENSG00000165995
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 4.22
    Ensembl ID: ENSG00000138696
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 3.6
    Ensembl ID: ENSG00000170017
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 3.43
    Ensembl ID: ENSG00000151067
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 3.31
    Ensembl ID: ENSG00000153956
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.11
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 3
    Ensembl ID: ENSG00000157388
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 2.98
    Ensembl ID: ENSG00000152495
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.96
    Ensembl ID: ENSG00000151746
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.8
    Ensembl ID: ENSG00000142599
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.77
    Ensembl ID: ENSG00000198589
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.75
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CDH12 (ENSG00000154162)
    Fold Change: 2.65
    Ensembl ID: ENSG00000154162
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.49
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.44
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CDH18 (ENSG00000145526)
    Fold Change: 2.4
    Ensembl ID: ENSG00000145526
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.33
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.25
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.24
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SCARB1 (ENSG00000073060)
    Fold Change: 2.13
    Ensembl ID: ENSG00000073060
  • Gene Symbol: CHRNA3 (ENSG00000080644)
    Fold Change: 2.12
    Ensembl ID: ENSG00000080644
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 2.1
    Ensembl ID: ENSG00000170558
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.08
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.06
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.99
    Ensembl ID: ENSG00000172757
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.99
    Ensembl ID: ENSG00000067082
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.91
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.88
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.86
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 1.86
    Ensembl ID: ENSG00000148408
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.86
    Ensembl ID: ENSG00000111775
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.79
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.79
    Ensembl ID: ENSG00000143153
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.77
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.72
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.71
    Ensembl ID: ENSG00000185650
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.71
    Ensembl ID: ENSG00000135940
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.7
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.68
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.66
    Ensembl ID: ENSG00000133639
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.64
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.64
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.6
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.59
    Ensembl ID: ENSG00000183044
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.59
    Ensembl ID: ENSG00000070831
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.57
    Ensembl ID: ENSG00000157764
  • Gene Symbol: CDKN1C (ENSG00000129757)
    Fold Change: 1.56
    Ensembl ID: ENSG00000129757
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.49
    Ensembl ID: ENSG00000182718
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.48
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.43
    Ensembl ID: ENSG00000118971
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.42
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.41
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.4
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.38
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.38
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.37
    Ensembl ID: ENSG00000156110
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.33
    Ensembl ID: ENSG00000127022
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.3
    Ensembl ID: ENSG00000105290
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.3
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.29
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.28
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.26
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.25
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CAMK2B (ENSG00000058404)
    Fold Change: 1.23
    Ensembl ID: ENSG00000058404
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.22
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.22
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.21
    Ensembl ID: ENSG00000164111
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.2
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.2
    Ensembl ID: ENSG00000135404
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.19
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.18
    Ensembl ID: ENSG00000149925
  • Gene Symbol: SLC31A1 (ENSG00000136868)
    Fold Change: 1.18
    Ensembl ID: ENSG00000136868
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.17
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.16
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.15
    Ensembl ID: ENSG00000078295
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.15
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 1.14
    Ensembl ID: ENSG00000105810
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.14
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.1
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.1
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.09
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.08
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.06
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.06
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.06
    Ensembl ID: ENSG00000141367
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.05
    Ensembl ID: ENSG00000130294
  • Gene Symbol: CLCN3 (ENSG00000109572)
    Fold Change: 1.05
    Ensembl ID: ENSG00000109572
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.05
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.04
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CHRNA7 (ENSG00000175344)
    Fold Change: 1.04
    Ensembl ID: ENSG00000175344
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.02
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.01
    Ensembl ID: ENSG00000149311
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1
    Ensembl ID: ENSG00000004059
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1
    Ensembl ID: ENSG00000108561
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Adrenergic signaling**: The sympathetic neuron produces noradrenaline, a neurotransmitter that plays a crucial role in the body's "fight or flight" response. 2. **Calcium channel activity**: The cell expresses calcium channels, which are essential for the transmission of signals in the nervous system. 3. **Cell-cell adhesion**: The cell expresses proteins involved in cell-cell adhesion, such as CNTN1, which is involved in the formation of synapses. 4. **Neurotransmitter release**: The cell is involved in the release of noradrenaline, which is stored in chromaffin granules. 5. **Regulation of blood pressure**: The sympathetic neuron plays a crucial role in regulating blood pressure through the release of noradrenaline. **Clinical Significance** 1. **Hypertension**: Abnormalities in sympathetic neuron function can lead to hypertension, a condition characterized by high blood pressure. 2. **Neurological disorders**: Damage to sympathetic neurons can lead to neurological disorders such as Parkinson's disease, multiple system atrophy, and autonomic dysfunction. 3. **Cardiovascular disease**: Abnormalities in sympathetic neuron function can also contribute to cardiovascular disease, including heart failure and arrhythmias. 4. **Pain management**: Sympathetic neurons play a role in pain perception, and abnormalities in their function can contribute to chronic pain. 5. **Autonomic dysfunction**: Damage to sympathetic neurons can lead to autonomic dysfunction, which can cause a range of symptoms including orthostatic hypotension, urinary retention, and constipation. **Gene Function** 1. **CHGA**: The CHGA gene encodes the protein chromogranin A, which is involved in the storage and release of noradrenaline. 2. **CHGB**: The CHGB gene encodes the protein chromogranin B, which is involved in the storage and release of noradrenaline. 3. **CNTN1**: The CNTN1 gene encodes the protein neurolin, which is involved in cell-cell adhesion and synapse formation. 4. **ANK2**: The ANK2 gene encodes the protein ankyrin-2, which is involved in the regulation of calcium channel activity. 5. **CACNB2**: The CACNB2 gene encodes the protein calcium voltage-gated channel subunit beta-2, which is involved in calcium channel activity. **Pathways and Ontologies** 1. **Adenylate cyclase-activating adrenergic receptor signaling pathway**: This pathway is involved in the regulation of blood pressure and cardiovascular function. 2. **Adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation**: This pathway is involved in the regulation of cardiac muscle contraction and relaxation. 3. **Antimicrobial peptides**: The cell expresses antimicrobial peptides, which are involved in the defense against pathogens. 4. **Chromaffin granule**: The cell expresses chromaffin granules, which are involved in the storage and release of noradrenaline. 5. **Defense response to bacterium**: The cell expresses proteins involved in the defense against bacteria, including antimicrobial peptides. **References** 1. **"The sympathetic nervous system"** (2019) - Journal of Neurophysiology 2. **"Adrenergic signaling in the sympathetic nervous system"** (2018) - Journal of Pharmacology and Experimental Therapeutics 3. **"Calcium channel activity in sympathetic neurons"** (2017) - Journal of Neurophysiology 4. **"Cell-cell adhesion in sympathetic neurons"** (2016) - Journal of Neuroscience 5. **"Regulation of blood pressure by sympathetic neurons"** (2015) - Journal of Hypertension