Details for: CL0017000

Cell ID: CL0017000

Cell Name: pulmonary ionocyte

Marker Score Threshold: 614
(Derived using integrated single-cell and genomic data)

Description: An ionocyte that is part of the lung epithelium. The cells from this type are major sources of the CFTR protein in human and mice.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.97
    Ensembl ID: ENSG00000185883
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.93
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.91
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.65
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.51
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.47
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.45
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.43
    Ensembl ID: ENSG00000124172
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.33
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.32
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.32
    Ensembl ID: ENSG00000143933
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.31
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.31
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.3
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.29
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.22
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.13
    Ensembl ID: ENSG00000099624
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.12
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.11
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.11
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.05
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.01
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.01
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.93
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.91
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.89
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.89
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.88
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.87
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.86
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.86
    Ensembl ID: ENSG00000162909
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.82
    Ensembl ID: ENSG00000134825
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.82
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.81
    Ensembl ID: ENSG00000143153
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.81
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.8
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.8
    Ensembl ID: ENSG00000133639
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.78
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.73
    Ensembl ID: ENSG00000077549
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.72
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.71
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP6V1B1 (ENSG00000116039)
    Fold Change: 1.67
    Ensembl ID: ENSG00000116039
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.67
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.66
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.62
    Ensembl ID: ENSG00000004059
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.6
    Ensembl ID: ENSG00000198931
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.59
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.58
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.57
    Ensembl ID: ENSG00000114573
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.57
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.54
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.52
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CBR1 (ENSG00000159228)
    Fold Change: 1.47
    Ensembl ID: ENSG00000159228
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.47
    Ensembl ID: ENSG00000177556
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.44
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.43
    Ensembl ID: ENSG00000085224
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.41
    Ensembl ID: ENSG00000138760
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.4
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.4
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.38
    Ensembl ID: ENSG00000196975
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.37
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.34
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.34
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.32
    Ensembl ID: ENSG00000177697
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.31
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.31
    Ensembl ID: ENSG00000165272
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.31
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.31
    Ensembl ID: ENSG00000071553
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.3
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.3
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.3
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.27
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 1.26
    Ensembl ID: ENSG00000221869
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.26
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.25
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.25
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.23
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.23
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.2
    Ensembl ID: ENSG00000174437
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.18
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.17
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.16
    Ensembl ID: ENSG00000072110
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.15
    Ensembl ID: ENSG00000126247
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.15
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.14
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.12
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.07
    Ensembl ID: ENSG00000128272
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.07
    Ensembl ID: ENSG00000151729
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.07
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.06
    Ensembl ID: ENSG00000138175
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.06
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100412
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.06
    Ensembl ID: ENSG00000198589
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.05
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.04
    Ensembl ID: ENSG00000131100
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.03
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.02
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.02
    Ensembl ID: ENSG00000121691
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.01
    Ensembl ID: ENSG00000074370
Hovered Details

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Hovered Details

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**Key Characteristics** Pulmonary ionocytes are characterized by their ability to regulate ion transport across the cell membrane. They express the CFTR protein, which is a chloride channel that allows chloride ions to flow into the cell. This process helps to regulate the movement of water and other ions across the epithelial layer, maintaining proper fluid balance and pH levels in the lungs. Key characteristics of pulmonary ionocytes include: * Expression of the CFTR protein * Ability to regulate ion transport across the cell membrane * Role in maintaining proper fluid balance and pH levels in the lungs * Major source of CFTR protein in humans and mice * Encoded by the ATP6V0C gene **Clinical Significance** Pulmonary ionocytes play a critical role in the maintenance of proper ion balance and fluid homeostasis in the lungs. Dysregulation of ion transport in these cells can lead to various respiratory disorders, including cystic fibrosis. Cystic fibrosis is a genetic disorder that affects the lungs and other organs, causing chronic respiratory problems and other complications. Clinical significance of pulmonary ionocytes includes: * Regulation of ion transport and fluid balance in the lungs * Maintenance of proper pH levels in the lungs * Role in the pathogenesis of cystic fibrosis * Potential therapeutic targets for the treatment of cystic fibrosis and other respiratory disorders * Importance of CFTR protein in regulating ion transport across the cell membrane In conclusion, pulmonary ionocytes are a critical component of the lung epithelium, playing a vital role in regulating ion transport and maintaining proper fluid balance and pH levels in the lungs. Dysregulation of ion transport in these cells can lead to various respiratory disorders, including cystic fibrosis. Further research on pulmonary ionocytes and their role in regulating ion transport may lead to the development of novel therapeutic strategies for the treatment of cystic fibrosis and other respiratory disorders.