Details for: CL0019001

Cell ID: CL0019001

Cell Name: tracheobronchial serous cell

Marker Score Threshold: 365
(Derived using integrated single-cell and genomic data)

Description: Any serous secreting cell that is part of the tracheobronchial epithelium.

Synonyms: serous cell of tracheobronchial tree

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.25
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.92
    Ensembl ID: ENSG00000124172
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.81
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.81
    Ensembl ID: ENSG00000127184
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.64
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 2.63
    Ensembl ID: ENSG00000101439
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.59
    Ensembl ID: ENSG00000131143
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.56
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.54
    Ensembl ID: ENSG00000169020
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 2.53
    Ensembl ID: ENSG00000160862
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.52
    Ensembl ID: ENSG00000135390
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.46
    Ensembl ID: ENSG00000112695
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.41
    Ensembl ID: ENSG00000145741
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.41
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.28
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.22
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.2
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.19
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.13
    Ensembl ID: ENSG00000135404
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.07
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 2.06
    Ensembl ID: ENSG00000176340
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.05
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.03
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.02
    Ensembl ID: ENSG00000154723
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.97
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.97
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.94
    Ensembl ID: ENSG00000099624
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.88
    Ensembl ID: ENSG00000198931
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.87
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.85
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.84
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.8
    Ensembl ID: ENSG00000070831
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 1.78
    Ensembl ID: ENSG00000161798
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.75
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.75
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.72
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 1.71
    Ensembl ID: ENSG00000104267
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.68
    Ensembl ID: ENSG00000159199
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.68
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.66
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.66
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.65
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.63
    Ensembl ID: ENSG00000128272
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.63
    Ensembl ID: ENSG00000131174
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.58
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.55
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.42
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.4
    Ensembl ID: ENSG00000160213
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.39
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.39
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.39
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.39
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.37
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.35
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.32
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.32
    Ensembl ID: ENSG00000185650
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.31
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CCNC (ENSG00000112237)
    Fold Change: 1.31
    Ensembl ID: ENSG00000112237
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.3
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.29
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.27
    Ensembl ID: ENSG00000116489
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.25
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.24
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CPD (ENSG00000108582)
    Fold Change: 1.23
    Ensembl ID: ENSG00000108582
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.22
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.22
    Ensembl ID: ENSG00000113328
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.19
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.19
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.19
    Ensembl ID: ENSG00000168036
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.19
    Ensembl ID: ENSG00000173575
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.18
    Ensembl ID: ENSG00000177879
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.15
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.14
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.13
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.13
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.12
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160014
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.08
    Ensembl ID: ENSG00000106992
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.08
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.08
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.08
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.08
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.06
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.06
    Ensembl ID: ENSG00000117984
  • Gene Symbol: CSTA (ENSG00000121552)
    Fold Change: 1.06
    Ensembl ID: ENSG00000121552
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.05
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.05
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.03
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.02
    Ensembl ID: ENSG00000160710
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.02
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.02
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.01
    Ensembl ID: ENSG00000196776
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.01
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.01
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138772
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.01
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1
    Ensembl ID: ENSG00000153922
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: TBS cells are found in the tracheobronchial epithelium, which lines the airways of the lungs. 2. **Function**: TBS cells produce and secrete various proteins, including antimicrobial peptides and cytokines, which help to protect the airways from infection and inflammation. 3. **Antigen processing and presentation**: TBS cells are involved in the processing and presentation of antigens to T-cells, which is essential for the adaptive immune response. 4. **Serous secretion**: TBS cells are serous secreting cells, meaning they produce and secrete fluids that help to protect the airways. 5. **Immune system regulation**: TBS cells play a crucial role in regulating the immune system, particularly in the defense against pathogens and the regulation of inflammation. **Clinical Significance** 1. **Respiratory diseases**: TBS cells are involved in the pathogenesis of various respiratory diseases, including chronic obstructive pulmonary disease (COPD) and asthma. 2. **Infectious diseases**: TBS cells are essential for the defense against infectious diseases, such as tuberculosis and influenza. 3. **Cancer**: TBS cells have been implicated in the pathogenesis of certain types of cancer, including lung cancer. 4. **Allergic reactions**: TBS cells play a role in the regulation of allergic reactions, particularly in the context of asthma and atopic diseases. 5. **Immunotherapy**: TBS cells have been explored as a target for immunotherapy in the treatment of various diseases, including cancer and infectious diseases. **Gene Symbol and Ensembl ID** * Gene Symbol: B2M * Ensembl ID: ENSG00000166710 **Pathways and Ontologies** * Adaptive immune system * Amyloid fiber formation * Amyloid fibril formation * Antigen presentation: folding, assembly and peptide loading of class I MHC * Antigen processing-cross presentation * Antigen processing and presentation of endogenous peptide antigen via MHC class I * Antigen processing and presentation of exogenous peptide antigen via MHC class II * Antigen processing and presentation of exogenous protein antigen via MHC class IB * Bacterial infection pathways * Cellular response to iron(III) ion * Cellular response to iron ion * Cellular response to nicotine * Class I MHC mediated antigen processing & presentation * Cytokine signaling in immune system * Cytosol * Dap12 interactions * Dap12 signaling * Disease * Early endosome lumen * Early endosome membrane * Endoplasmic reticulum * Endoplasmic reticulum lumen * Endosomal/vacuolar pathway * Er-phagosome pathway * Er to Golgi transport vesicle membrane * External side of plasma membrane * Extracellular exosome * Extracellular region * Extracellular space * Focal adhesion * Golgi apparatus * Golgi membrane * Hfe-transferrin receptor complex * Hiv infection * Host interactions of Hiv factors * Identical protein binding * Immune system * Immunoregulatory interactions between a lymphoid and a non-lymphoid cell * Infection with Mycobacterium tuberculosis * Infectious disease * Innate immune system * Interferon gamma signaling * Interferon signaling * Intracellular iron ion homeostasis * Iron ion transport * Late endosome membrane * Learning or memory * Lysosomal membrane * Membrane * Metabolism of proteins * MHC class II protein complex * MHC class II protein complex binding * MHC class I peptide loading complex * MHC class I protein complex * Modulation by Mtb of host immune system * Multicellular organismal-level iron ion homeostasis * Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters * Nef mediated downregulation of MHC class I complex cell surface expression * Negative regulation of epithelial cell proliferation * Negative regulation of forebrain neuron differentiation * Negative regulation of neurogenesis * Negative regulation of neuron projection development * Negative regulation of receptor binding * Neutrophil degranulation * Peptide antigen assembly with MHC class II protein complex * Peptide antigen assembly with MHC class I protein complex * Peptide antigen binding * Phagocytic vesicle membrane * Plasma membrane * Positive regulation of cellular senescence * Positive regulation of ferrous iron binding * Positive regulation of immune response * Positive regulation of protein binding * Positive regulation of receptor-mediated endocytosis * Positive regulation of receptor binding * Positive regulation of T cell activation * Positive regulation of T cell cytokine production * Positive regulation of T cell mediated cytotoxicity * Positive regulation of transferrin receptor binding * Protein binding * Protein homodimerization activity * Protein homotetramerization * Protein refolding * Recycling endosome membrane * Regulation of erythrocyte differentiation * Regulation of iron ion transport * Response to molecule of bacterial origin * SARS-CoV-2 activates/modulates innate and adaptive immune responses * SARS-CoV-2 infection * SARS-CoV infections * Sensory perception of smell * Specific granule lumen * Structural molecule activity * T cell differentiation in thymus * T cell mediated cytotoxicity * Tertiary granule lumen * The role of Nef in HIV-1 replication and disease pathogenesis * Viral infection pathways