Details for: CL0019018

Cell ID: CL0019018

Cell Name: blood vessel smooth muscle cell

Marker Score Threshold: 263
(Derived using integrated single-cell and genomic data)

Description: A smooth muscle cell that is part of any blood vessel.

Synonyms: smooth muscle cell of blood vessel

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.65
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 3.45
    Ensembl ID: ENSG00000198840
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.42
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.2
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 3.17
    Ensembl ID: ENSG00000198888
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.13
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 3.1
    Ensembl ID: ENSG00000198763
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 3.05
    Ensembl ID: ENSG00000206503
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 3.03
    Ensembl ID: ENSG00000198727
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 2.95
    Ensembl ID: ENSG00000198712
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 2.93
    Ensembl ID: ENSG00000198804
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.93
    Ensembl ID: ENSG00000075624
  • Gene Symbol: RNR2 (ENSG00000210082)
    Fold Change: 2.92
    Ensembl ID: ENSG00000210082
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 2.92
    Ensembl ID: ENSG00000198886
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.9
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 2.89
    Ensembl ID: ENSG00000198938
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 2.87
    Ensembl ID: ENSG00000163041
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.82
    Ensembl ID: ENSG00000087086
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.79
    Ensembl ID: ENSG00000122566
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.78
    Ensembl ID: ENSG00000156508
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 2.78
    Ensembl ID: ENSG00000135486
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 2.78
    Ensembl ID: ENSG00000204525
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 2.77
    Ensembl ID: ENSG00000080824
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.76
    Ensembl ID: ENSG00000167996
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.74
    Ensembl ID: ENSG00000132475
  • Gene Symbol: ND5 (ENSG00000198786)
    Fold Change: 2.7
    Ensembl ID: ENSG00000198786
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.69
    Ensembl ID: ENSG00000149806
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.65
    Ensembl ID: ENSG00000111640
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.65
    Ensembl ID: ENSG00000166710
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 2.65
    Ensembl ID: ENSG00000234745
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 2.56
    Ensembl ID: ENSG00000198899
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.48
    Ensembl ID: ENSG00000127184
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.48
    Ensembl ID: ENSG00000131143
  • Gene Symbol: RPL10A (ENSG00000198755)
    Fold Change: 2.47
    Ensembl ID: ENSG00000198755
  • Gene Symbol: PFDN5 (ENSG00000123349)
    Fold Change: 2.46
    Ensembl ID: ENSG00000123349
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.44
    Ensembl ID: ENSG00000169020
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 2.44
    Ensembl ID: ENSG00000168028
  • Gene Symbol: HLA E (ENSG00000204592)
    Fold Change: 2.43
    Ensembl ID: ENSG00000204592
  • Gene Symbol: NACA (ENSG00000196531)
    Fold Change: 2.42
    Ensembl ID: ENSG00000196531
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.41
    Ensembl ID: ENSG00000189403
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 2.4
    Ensembl ID: ENSG00000084207
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.39
    Ensembl ID: ENSG00000122545
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.38
    Ensembl ID: ENSG00000092199
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.37
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.37
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.36
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.35
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.34
    Ensembl ID: ENSG00000172757
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2.34
    Ensembl ID: ENSG00000087460
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.32
    Ensembl ID: ENSG00000099624
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.3
    Ensembl ID: ENSG00000104529
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.29
    Ensembl ID: ENSG00000154518
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.28
    Ensembl ID: ENSG00000167658
  • Gene Symbol: MYL6 (ENSG00000092841)
    Fold Change: 2.28
    Ensembl ID: ENSG00000092841
  • Gene Symbol: OAZ1 (ENSG00000104904)
    Fold Change: 2.27
    Ensembl ID: ENSG00000104904
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 2.27
    Ensembl ID: ENSG00000205581
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 2.27
    Ensembl ID: ENSG00000096384
  • Gene Symbol: PCBP2 (ENSG00000197111)
    Fold Change: 2.27
    Ensembl ID: ENSG00000197111
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.27
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ND4L (ENSG00000212907)
    Fold Change: 2.27
    Ensembl ID: ENSG00000212907
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.26
    Ensembl ID: ENSG00000110955
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 2.22
    Ensembl ID: ENSG00000169567
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 2.21
    Ensembl ID: ENSG00000131174
  • Gene Symbol: SNU13 (ENSG00000100138)
    Fold Change: 2.21
    Ensembl ID: ENSG00000100138
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.21
    Ensembl ID: ENSG00000099622
  • Gene Symbol: NAP1L1 (ENSG00000187109)
    Fold Change: 2.21
    Ensembl ID: ENSG00000187109
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.2
    Ensembl ID: ENSG00000114942
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 2.2
    Ensembl ID: ENSG00000153187
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 2.18
    Ensembl ID: ENSG00000152601
  • Gene Symbol: PPIA (ENSG00000196262)
    Fold Change: 2.18
    Ensembl ID: ENSG00000196262
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 2.17
    Ensembl ID: ENSG00000089280
  • Gene Symbol: HNRNPH1 (ENSG00000169045)
    Fold Change: 2.16
    Ensembl ID: ENSG00000169045
  • Gene Symbol: PGK1 (ENSG00000102144)
    Fold Change: 2.14
    Ensembl ID: ENSG00000102144
  • Gene Symbol: HSPA8 (ENSG00000109971)
    Fold Change: 2.13
    Ensembl ID: ENSG00000109971
  • Gene Symbol: PFN1 (ENSG00000108518)
    Fold Change: 2.1
    Ensembl ID: ENSG00000108518
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.09
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.09
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.07
    Ensembl ID: ENSG00000164919
  • Gene Symbol: PPP1R1A (ENSG00000135447)
    Fold Change: 2.07
    Ensembl ID: ENSG00000135447
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 2.06
    Ensembl ID: ENSG00000165119
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.04
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD99 (ENSG00000002586)
    Fold Change: 2.04
    Ensembl ID: ENSG00000002586
  • Gene Symbol: JUND (ENSG00000130522)
    Fold Change: 2.03
    Ensembl ID: ENSG00000130522
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.02
    Ensembl ID: ENSG00000126267
  • Gene Symbol: NPM1 (ENSG00000181163)
    Fold Change: 2.02
    Ensembl ID: ENSG00000181163
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2
    Ensembl ID: ENSG00000165629
  • Gene Symbol: MIF (ENSG00000240972)
    Fold Change: 1.99
    Ensembl ID: ENSG00000240972
  • Gene Symbol: NCL (ENSG00000115053)
    Fold Change: 1.98
    Ensembl ID: ENSG00000115053
  • Gene Symbol: NEDD8 (ENSG00000129559)
    Fold Change: 1.98
    Ensembl ID: ENSG00000129559
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.97
    Ensembl ID: ENSG00000085224
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.93
    Ensembl ID: ENSG00000112695
  • Gene Symbol: KTN1 (ENSG00000126777)
    Fold Change: 1.93
    Ensembl ID: ENSG00000126777
  • Gene Symbol: DNAJA1 (ENSG00000086061)
    Fold Change: 1.93
    Ensembl ID: ENSG00000086061
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.91
    Ensembl ID: ENSG00000135940
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 1.91
    Ensembl ID: ENSG00000074800
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.89
    Ensembl ID: ENSG00000063046
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.88
    Ensembl ID: ENSG00000156976
  • Gene Symbol: NKTR (ENSG00000114857)
    Fold Change: 1.88
    Ensembl ID: ENSG00000114857
  • Gene Symbol: EIF3E (ENSG00000104408)
    Fold Change: 1.87
    Ensembl ID: ENSG00000104408

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in blood vessel smooth muscle cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in blood vessel smooth muscle cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Alternative Splicing**: The cell's gene DDX5 is involved in alternative splicing, a process that allows for the generation of multiple protein isoforms from a single gene. 2. **Androgen Receptor Signaling**: The cell's gene DDX5 is also involved in androgen receptor signaling, a pathway that regulates gene expression in response to androgens. 3. **Mitochondrial Function**: The cell's genes ND3 and ACTG1 are involved in mitochondrial function, including aerobic respiration, complex I biogenesis, and proton motive force-driven ATP synthesis. 4. **Apoptosis**: The cell's genes ND3 and ACTG1 are also involved in apoptosis, a process of programmed cell death that is regulated by various signaling pathways. 5. **Signal Transduction**: The cell's genes DDX5, ND3, and ACTG1 are involved in signal transduction, a process that allows cells to respond to external signals and regulate various cellular processes. **Clinical Significance** 1. **Vascular Disease**: Blood vessel smooth muscle cells play a critical role in the development of vascular disease, including hypertension, atherosclerosis, and stroke. 2. **Cardiovascular Disease**: The cell's ability to regulate blood pressure and blood flow is crucial in the development of cardiovascular disease, including coronary artery disease and cardiac arrhythmias. 3. **Infectious Diseases**: The cell's involvement in signal transduction and apoptosis makes it a potential target for the development of therapeutics against infectious diseases, such as HIV and influenza. 4. **Cancer**: The cell's ability to regulate gene expression and signal transduction makes it a potential target for the development of therapeutics against cancer, including leukemia and lymphoma. 5. **Neurological Disorders**: The cell's involvement in mitochondrial function and signal transduction makes it a potential target for the development of therapeutics against neurological disorders, including Parkinson's disease and Alzheimer's disease.