Details for: CL0019021

Cell ID: CL0019021

Cell Name: endothelial cell of periportal hepatic sinusoid

Marker Score Threshold: 275
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid.

Synonyms: periportal LSEC, periportal hepatic sinusoidal endothelial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.11
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.93
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.59
    Ensembl ID: ENSG00000184009
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.5
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.45
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.42
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.42
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.3
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 2.27
    Ensembl ID: ENSG00000163631
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.2
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.2
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.99
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.98
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.94
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.94
    Ensembl ID: ENSG00000110955
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.93
    Ensembl ID: ENSG00000142192
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.92
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.88
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.88
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.84
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.8
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.8
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.79
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.78
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 1.75
    Ensembl ID: ENSG00000110245
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.73
    Ensembl ID: ENSG00000204217
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.73
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.7
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.68
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.66
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.64
    Ensembl ID: ENSG00000198931
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 1.6
    Ensembl ID: ENSG00000118137
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.57
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.56
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.56
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.55
    Ensembl ID: ENSG00000127022
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.52
    Ensembl ID: ENSG00000175899
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.52
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.5
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.46
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.44
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.44
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.42
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.41
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.41
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.39
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.38
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 1.38
    Ensembl ID: ENSG00000135218
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.37
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.36
    Ensembl ID: ENSG00000159199
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.34
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.34
    Ensembl ID: ENSG00000104763
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.33
    Ensembl ID: ENSG00000100823
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.31
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.3
    Ensembl ID: ENSG00000146731
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.3
    Ensembl ID: ENSG00000130203
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.3
    Ensembl ID: ENSG00000010278
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 1.3
    Ensembl ID: ENSG00000158874
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.29
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.26
    Ensembl ID: ENSG00000135046
  • Gene Symbol: APOB (ENSG00000084674)
    Fold Change: 1.26
    Ensembl ID: ENSG00000084674
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.26
    Ensembl ID: ENSG00000130208
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.25
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.25
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.24
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.24
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.24
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.23
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.23
    Ensembl ID: ENSG00000198898
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.22
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.21
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.2
    Ensembl ID: ENSG00000138279
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.2
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.2
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.19
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.18
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.17
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.17
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.15
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.12
    Ensembl ID: ENSG00000070961
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 1.12
    Ensembl ID: ENSG00000125730
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.11
    Ensembl ID: ENSG00000168675
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.11
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164615
  • Gene Symbol: AMBP (ENSG00000106927)
    Fold Change: 1.1
    Ensembl ID: ENSG00000106927
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.09
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.07
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.07
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.07
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.06
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.06
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.05
    Ensembl ID: ENSG00000087274
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143878
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.04
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.03
    Ensembl ID: ENSG00000076555
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.03
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.01
    Ensembl ID: ENSG00000134480
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: N/A
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: N/A
    Ensembl ID: ENSG00000149311
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: The cell is located in the periportal region of the hepatic sinusoid, near the portal triad. 2. **Fenestrae**: The endothelial cells in this region have larger but fewer fenestrae compared to those in the centrilobular region. 3. **Gene Symbol**: The gene symbol of this cell is ACTB. 4. **Pathways/Ontology**: The cell is involved in various cellular processes, including actin cytoskeleton organization, adherens junction assembly, and cell-cell communication. 5. **Synonyms**: The cell is also known as a Periportal LSEC (Liver Sinusoidal Endothelial Cell) or Periportal hepatic sinusoidal endothelial cell. **Clinical Significance** The endothelial cells of the periportal hepatic sinusoid play a crucial role in the hepatic sinusoidal microcirculation, which is essential for the exchange of nutrients, waste products, and signaling molecules between hepatocytes and the bloodstream. Abnormalities in these cells have been implicated in various liver diseases, including cirrhosis, liver fibrosis, and liver cancer. Some potential clinical implications of this cell type include: 1. **Liver Disease**: Abnormalities in the endothelial cells of the periportal hepatic sinusoid may contribute to the development of liver disease, including cirrhosis and liver cancer. 2. **Hepatic Sinusoidal Obliteration**: Damage to the endothelial cells of the periportal hepatic sinusoid can lead to hepatic sinusoidal obliteration, which is a hallmark of cirrhosis. 3. **Liver Regeneration**: The endothelial cells of the periportal hepatic sinusoid may play a role in liver regeneration, as they are involved in the exchange of signaling molecules between hepatocytes and the bloodstream. 4. **Hepatic Vascularization**: The endothelial cells of the periportal hepatic sinusoid may also play a role in hepatic vascularization, as they are involved in the formation of new blood vessels in the liver. Overall, the endothelial cells of the periportal hepatic sinusoid are an important component of the hepatic sinusoidal microcirculation, and abnormalities in these cells may contribute to various liver diseases.