Details for: CL0019022

Cell ID: CL0019022

Cell Name: endothelial cell of pericentral hepatic sinusoid

Marker Score Threshold: 1071
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid.

Synonyms: central venous hepatic sinusoidal endothelial cell, pericentral LSEC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 3.77
    Ensembl ID: ENSG00000163631
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 2.9
    Ensembl ID: ENSG00000110245
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 2.74
    Ensembl ID: ENSG00000118137
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.5
    Ensembl ID: ENSG00000142192
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.37
    Ensembl ID: ENSG00000163697
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.28
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 2.23
    Ensembl ID: ENSG00000135218
  • Gene Symbol: APOB (ENSG00000084674)
    Fold Change: 2.22
    Ensembl ID: ENSG00000084674
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 2.16
    Ensembl ID: ENSG00000130208
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 2.07
    Ensembl ID: ENSG00000158874
  • Gene Symbol: AMBP (ENSG00000106927)
    Fold Change: 2.01
    Ensembl ID: ENSG00000106927
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.01
    Ensembl ID: ENSG00000204217
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 2.01
    Ensembl ID: ENSG00000125730
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2
    Ensembl ID: ENSG00000130203
  • Gene Symbol: APOH (ENSG00000091583)
    Fold Change: 1.87
    Ensembl ID: ENSG00000091583
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 1.87
    Ensembl ID: ENSG00000136872
  • Gene Symbol: AGXT (ENSG00000172482)
    Fold Change: 1.84
    Ensembl ID: ENSG00000172482
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.8
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.75
    Ensembl ID: ENSG00000114423
  • Gene Symbol: C9 (ENSG00000113600)
    Fold Change: 1.73
    Ensembl ID: ENSG00000113600
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.73
    Ensembl ID: ENSG00000076555
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.73
    Ensembl ID: ENSG00000168675
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.7
    Ensembl ID: ENSG00000183020
  • Gene Symbol: CES1 (ENSG00000198848)
    Fold Change: 1.69
    Ensembl ID: ENSG00000198848
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.69
    Ensembl ID: ENSG00000175899
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.68
    Ensembl ID: ENSG00000198589
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.68
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.64
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.62
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.62
    Ensembl ID: ENSG00000149131
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.61
    Ensembl ID: ENSG00000141367
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 1.6
    Ensembl ID: ENSG00000160862
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 1.6
    Ensembl ID: ENSG00000120885
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.59
    Ensembl ID: ENSG00000122786
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 1.59
    Ensembl ID: ENSG00000134871
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.57
    Ensembl ID: ENSG00000097007
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.55
    Ensembl ID: ENSG00000157764
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.55
    Ensembl ID: ENSG00000099622
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 1.55
    Ensembl ID: ENSG00000182326
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 1.52
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.51
    Ensembl ID: ENSG00000185650
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.5
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.49
    Ensembl ID: ENSG00000148700
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.47
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ART4 (ENSG00000111339)
    Fold Change: 1.38
    Ensembl ID: ENSG00000111339
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.37
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.37
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.36
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.36
    Ensembl ID: ENSG00000153113
  • Gene Symbol: COL4A1 (ENSG00000187498)
    Fold Change: 1.36
    Ensembl ID: ENSG00000187498
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.34
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.34
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.33
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.33
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.28
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.27
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.26
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.25
    Ensembl ID: ENSG00000166825
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.21
    Ensembl ID: ENSG00000004897
  • Gene Symbol: AGT (ENSG00000135744)
    Fold Change: 1.21
    Ensembl ID: ENSG00000135744
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.2
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 1.19
    Ensembl ID: ENSG00000117601
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.19
    Ensembl ID: ENSG00000121410
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.18
    Ensembl ID: ENSG00000159403
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.16
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 1.15
    Ensembl ID: ENSG00000141505
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 1.15
    Ensembl ID: ENSG00000140743
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.14
    Ensembl ID: ENSG00000140836
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.13
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.13
    Ensembl ID: ENSG00000165029
  • Gene Symbol: CHKA (ENSG00000110721)
    Fold Change: 1.13
    Ensembl ID: ENSG00000110721
  • Gene Symbol: CEACAM1 (ENSG00000079385)
    Fold Change: 1.12
    Ensembl ID: ENSG00000079385
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.12
    Ensembl ID: ENSG00000119138
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.11
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.1
    Ensembl ID: ENSG00000278540
  • Gene Symbol: CNN3 (ENSG00000117519)
    Fold Change: 1.1
    Ensembl ID: ENSG00000117519
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.09
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.09
    Ensembl ID: ENSG00000130707
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 1.09
    Ensembl ID: ENSG00000145692
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.07
    Ensembl ID: ENSG00000070831
  • Gene Symbol: C5 (ENSG00000106804)
    Fold Change: 1.07
    Ensembl ID: ENSG00000106804
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.05
    Ensembl ID: ENSG00000179218
  • Gene Symbol: AOX1 (ENSG00000138356)
    Fold Change: 1.05
    Ensembl ID: ENSG00000138356
  • Gene Symbol: APCS (ENSG00000132703)
    Fold Change: 1.05
    Ensembl ID: ENSG00000132703
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.04
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.03
    Ensembl ID: ENSG00000127022
  • Gene Symbol: KRIT1 (ENSG00000001631)
    Fold Change: 1.03
    Ensembl ID: ENSG00000001631
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.03
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.03
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 1.03
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.02
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.02
    Ensembl ID: ENSG00000058668
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.02
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.02
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.01
    Ensembl ID: ENSG00000134480
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.01
    Ensembl ID: ENSG00000122218
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.01
    Ensembl ID: ENSG00000151746
  • Gene Symbol: AHSG (ENSG00000145192)
    Fold Change: 1
    Ensembl ID: ENSG00000145192
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1
    Ensembl ID: ENSG00000116489
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: The cell is located in the centrilobular region of the hepatic sinusoid, near the central vein. 2. **Fenestrae**: The cell has smaller but more numerous fenestrae compared to endothelial cells in the periportal region. 3. **Function**: The cell plays a crucial role in maintaining liver homeostasis and is involved in various biological processes, including lipid metabolism, cholesterol homeostasis, and antioxidant activity. 4. **Gene Expression**: The cell expresses genes related to lipid metabolism, cholesterol homeostasis, and antioxidant activity, including APOC3, APOA1, and ALB. 5. **Pathways/Ontology**: The cell is involved in various biological pathways, including antioxidant activity, aspirin adme, bile acid and bile salt metabolism, binding and uptake of ligands by scavenger receptors, and cellular responses to stimuli. **Clinical Significance** 1. **Liver Disease**: The LSEC plays a crucial role in maintaining liver homeostasis, and dysfunction of this cell type has been implicated in various liver diseases, including fatty liver disease, non-alcoholic steatohepatitis (NASH), and liver fibrosis. 2. **Lipid Metabolism**: The LSEC is involved in lipid metabolism, and alterations in lipid metabolism have been implicated in various diseases, including atherosclerosis and metabolic syndrome. 3. **Cholesterol Homeostasis**: The LSEC is involved in cholesterol homeostasis, and alterations in cholesterol metabolism have been implicated in various diseases, including atherosclerosis and hyperlipidemia. 4. **Antioxidant Activity**: The LSEC has antioxidant activity, and alterations in antioxidant activity have been implicated in various diseases, including oxidative stress and inflammation. 5. **Therapeutic Target**: The LSEC has been identified as a potential therapeutic target for various diseases, including liver disease, lipid metabolism disorders, and cholesterol homeostasis disorders. In conclusion, the endothelial cell described in this article plays a crucial role in maintaining liver homeostasis and is involved in various biological processes, including lipid metabolism, cholesterol homeostasis, and antioxidant activity. Dysfunction of this cell type has been implicated in various liver diseases, and the cell has been identified as a potential therapeutic target for various diseases.