Details for: CL0019022

Cell ID: CL0019022

Cell Name: endothelial cell of pericentral hepatic sinusoid

Marker Score Threshold: 1,071
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid.

Synonyms: central venous hepatic sinusoidal endothelial cell, pericentral LSEC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 3.77
    Ensembl ID: ENSG00000163631
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 2.9
    Ensembl ID: ENSG00000110245
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 2.74
    Ensembl ID: ENSG00000118137
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.5
    Ensembl ID: ENSG00000142192
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.37
    Ensembl ID: ENSG00000163697
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.28
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 2.23
    Ensembl ID: ENSG00000135218
  • Gene Symbol: APOB (ENSG00000084674)
    Fold Change: 2.22
    Ensembl ID: ENSG00000084674
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 2.16
    Ensembl ID: ENSG00000130208
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 2.07
    Ensembl ID: ENSG00000158874
  • Gene Symbol: AMBP (ENSG00000106927)
    Fold Change: 2.01
    Ensembl ID: ENSG00000106927
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.01
    Ensembl ID: ENSG00000204217
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 2.01
    Ensembl ID: ENSG00000125730
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2
    Ensembl ID: ENSG00000130203
  • Gene Symbol: APOH (ENSG00000091583)
    Fold Change: 1.87
    Ensembl ID: ENSG00000091583
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 1.87
    Ensembl ID: ENSG00000136872
  • Gene Symbol: AGXT (ENSG00000172482)
    Fold Change: 1.84
    Ensembl ID: ENSG00000172482
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.8
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.75
    Ensembl ID: ENSG00000114423
  • Gene Symbol: C9 (ENSG00000113600)
    Fold Change: 1.73
    Ensembl ID: ENSG00000113600
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.73
    Ensembl ID: ENSG00000076555
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.73
    Ensembl ID: ENSG00000168675
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.7
    Ensembl ID: ENSG00000183020
  • Gene Symbol: CES1 (ENSG00000198848)
    Fold Change: 1.69
    Ensembl ID: ENSG00000198848
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.69
    Ensembl ID: ENSG00000175899
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.68
    Ensembl ID: ENSG00000198589
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.68
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.64
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.62
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.62
    Ensembl ID: ENSG00000149131
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.61
    Ensembl ID: ENSG00000141367
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 1.6
    Ensembl ID: ENSG00000160862
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 1.6
    Ensembl ID: ENSG00000120885
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.59
    Ensembl ID: ENSG00000122786
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 1.59
    Ensembl ID: ENSG00000134871
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.57
    Ensembl ID: ENSG00000097007
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.55
    Ensembl ID: ENSG00000157764
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.55
    Ensembl ID: ENSG00000099622
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 1.55
    Ensembl ID: ENSG00000182326
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 1.52
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.51
    Ensembl ID: ENSG00000185650
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.5
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.49
    Ensembl ID: ENSG00000148700
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.47
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ART4 (ENSG00000111339)
    Fold Change: 1.38
    Ensembl ID: ENSG00000111339
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.37
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.37
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.36
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.36
    Ensembl ID: ENSG00000153113
  • Gene Symbol: COL4A1 (ENSG00000187498)
    Fold Change: 1.36
    Ensembl ID: ENSG00000187498
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.34
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.34
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.33
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.33
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.28
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.27
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.26
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.25
    Ensembl ID: ENSG00000166825
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.21
    Ensembl ID: ENSG00000004897
  • Gene Symbol: AGT (ENSG00000135744)
    Fold Change: 1.21
    Ensembl ID: ENSG00000135744
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.2
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 1.19
    Ensembl ID: ENSG00000117601
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.19
    Ensembl ID: ENSG00000121410
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.18
    Ensembl ID: ENSG00000159403
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.16
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 1.15
    Ensembl ID: ENSG00000141505
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 1.15
    Ensembl ID: ENSG00000140743
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.14
    Ensembl ID: ENSG00000140836
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.13
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.13
    Ensembl ID: ENSG00000165029
  • Gene Symbol: CHKA (ENSG00000110721)
    Fold Change: 1.13
    Ensembl ID: ENSG00000110721
  • Gene Symbol: CEACAM1 (ENSG00000079385)
    Fold Change: 1.12
    Ensembl ID: ENSG00000079385
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.12
    Ensembl ID: ENSG00000119138
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.11
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.1
    Ensembl ID: ENSG00000278540
  • Gene Symbol: CNN3 (ENSG00000117519)
    Fold Change: 1.1
    Ensembl ID: ENSG00000117519
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.09
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.09
    Ensembl ID: ENSG00000130707
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 1.09
    Ensembl ID: ENSG00000145692
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.07
    Ensembl ID: ENSG00000070831
  • Gene Symbol: C5 (ENSG00000106804)
    Fold Change: 1.07
    Ensembl ID: ENSG00000106804
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.05
    Ensembl ID: ENSG00000179218
  • Gene Symbol: AOX1 (ENSG00000138356)
    Fold Change: 1.05
    Ensembl ID: ENSG00000138356
  • Gene Symbol: APCS (ENSG00000132703)
    Fold Change: 1.05
    Ensembl ID: ENSG00000132703
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.04
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.03
    Ensembl ID: ENSG00000127022
  • Gene Symbol: KRIT1 (ENSG00000001631)
    Fold Change: 1.03
    Ensembl ID: ENSG00000001631
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.03
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.03
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 1.03
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.02
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.02
    Ensembl ID: ENSG00000058668
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.02
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.02
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.01
    Ensembl ID: ENSG00000134480
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.01
    Ensembl ID: ENSG00000122218
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.01
    Ensembl ID: ENSG00000151746
  • Gene Symbol: AHSG (ENSG00000145192)
    Fold Change: 1
    Ensembl ID: ENSG00000145192
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1
    Ensembl ID: ENSG00000116489

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in endothelial cell of pericentral hepatic sinusoid cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in endothelial cell of pericentral hepatic sinusoid cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * **Location**: Pericentral region of the hepatic sinusoid, near the central vein of the liver * **Fenestrae**: Smaller but more numerous fenestrae compared to endothelial cells in the periportal region * **Gene Symbols**: ALB, APOC3, APOA1, B2M * **Pathways/Ontology**: Antioxidant activity, Aspirin adme, Bile acid and bile salt metabolism, Binding and uptake of ligands by scavenger receptors, Blood microparticle, Cellular oxidant detoxification, Cellular responses to stimuli, Cellular responses to stress, Cellular response to calcium ion starvation, Cellular response to chemical stress, Cellular response to starvation, Ciprofloxacin adme, Copper ion binding, Cytoplasm, Cytoprotection by hmox1, Dna binding, Drug adme, Endoplasmic reticulum, Endoplasmic reticulum lumen, Enterobactin binding, Exogenous protein binding, Extracellular exosome, Extracellular region, Extracellular space, Fatty acid binding, Golgi apparatus, Hdl remodeling, Heme biosynthesis, Heme degradation, Hemostasis, Identical protein binding, Metabolism, Metabolism of lipids, Metabolism of porphyrins, Metabolism of proteins, Metabolism of steroids, Negative regulation of mitochondrial depolarization, Nucleus, Oxygen binding, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Platelet activation, signaling and aggregation, Platelet alpha granule lumen, Platelet degranulation, Post-translational protein modification, Post-translational protein phosphorylation, Prednisone adme, Protein-containing complex, Protein-folding chaperone binding, Protein binding, Pyridoxal phosphate binding, Recycling of bile acids and salts, Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps), Response to elevated platelet cytosolic ca2+, Scavenging of heme from plasma, Small molecule binding, Toxic substance binding, Transport, Transport of small molecules, Vesicle-mediated transport **Clinical Significance** The endothelial cell of the pericentral hepatic sinusoid plays a crucial role in the regulation of lipid metabolism, including the transport of lipids, cholesterol, and other small molecules. Abnormalities in this cell type have been implicated in various diseases, including atherosclerosis, fatty liver disease, and metabolic syndrome. The cell's ability to regulate the transport of lipids and cholesterol also makes it an important target for the treatment of hyperlipidemia and cardiovascular disease. In addition, the cell's involvement in the regulation of insulin-like growth factor (IGF) transport and uptake makes it an important player in the development of diabetes and metabolic disorders. The cell's ability to scavange heme from plasma also makes it an important target for the treatment of anemia and other diseases related to heme metabolism. Overall, the endothelial cell of the pericentral hepatic sinusoid is an important cell type that plays a critical role in the regulation of lipid metabolism and other biological processes. Further research is needed to fully understand the functions of this cell type and to develop effective treatments for diseases related to its dysfunction.