Details for: CL0019028

Cell ID: CL0019028

Cell Name: midzonal region hepatocyte

Marker Score Threshold: 4,315
(Derived using integrated single-cell and genomic data)

Description: Any hepatocyte that is part of the liver lobule midzonal region. These cells have mixed functionality in comparison with those in the other two regions of the liver lobule.

Synonyms: midzonal hepatocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 2.55
    Ensembl ID: ENSG00000163631
  • Gene Symbol: HP (ENSG00000257017)
    Fold Change: 2.51
    Ensembl ID: ENSG00000257017
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 2.48
    Ensembl ID: ENSG00000110245
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 2.45
    Ensembl ID: ENSG00000118137
  • Gene Symbol: FGB (ENSG00000171564)
    Fold Change: 2.4
    Ensembl ID: ENSG00000171564
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 2.39
    Ensembl ID: ENSG00000198938
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 2.38
    Ensembl ID: ENSG00000198899
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 2.37
    Ensembl ID: ENSG00000198712
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 2.36
    Ensembl ID: ENSG00000198840
  • Gene Symbol: FGG (ENSG00000171557)
    Fold Change: 2.36
    Ensembl ID: ENSG00000171557
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 2.36
    Ensembl ID: ENSG00000198804
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 2.36
    Ensembl ID: ENSG00000130208
  • Gene Symbol: FGA (ENSG00000171560)
    Fold Change: 2.35
    Ensembl ID: ENSG00000171560
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 2.33
    Ensembl ID: ENSG00000198886
  • Gene Symbol: AGXT (ENSG00000172482)
    Fold Change: 2.33
    Ensembl ID: ENSG00000172482
  • Gene Symbol: NNMT (ENSG00000166741)
    Fold Change: 2.32
    Ensembl ID: ENSG00000166741
  • Gene Symbol: FGL1 (ENSG00000104760)
    Fold Change: 2.3
    Ensembl ID: ENSG00000104760
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 2.3
    Ensembl ID: ENSG00000198888
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 2.28
    Ensembl ID: ENSG00000198763
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 2.28
    Ensembl ID: ENSG00000136872
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 2.28
    Ensembl ID: ENSG00000198727
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 2.27
    Ensembl ID: ENSG00000158874
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 2.25
    Ensembl ID: ENSG00000125730
  • Gene Symbol: APOH (ENSG00000091583)
    Fold Change: 2.22
    Ensembl ID: ENSG00000091583
  • Gene Symbol: HPX (ENSG00000110169)
    Fold Change: 2.2
    Ensembl ID: ENSG00000110169
  • Gene Symbol: ORM1 (ENSG00000229314)
    Fold Change: 2.2
    Ensembl ID: ENSG00000229314
  • Gene Symbol: APOB (ENSG00000084674)
    Fold Change: 2.19
    Ensembl ID: ENSG00000084674
  • Gene Symbol: MAT1A (ENSG00000151224)
    Fold Change: 2.19
    Ensembl ID: ENSG00000151224
  • Gene Symbol: MGST1 (ENSG00000008394)
    Fold Change: 2.19
    Ensembl ID: ENSG00000008394
  • Gene Symbol: CYB5A (ENSG00000166347)
    Fold Change: 2.18
    Ensembl ID: ENSG00000166347
  • Gene Symbol: AMBP (ENSG00000106927)
    Fold Change: 2.18
    Ensembl ID: ENSG00000106927
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.15
    Ensembl ID: ENSG00000087086
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 2.13
    Ensembl ID: ENSG00000160862
  • Gene Symbol: FABP1 (ENSG00000163586)
    Fold Change: 2.11
    Ensembl ID: ENSG00000163586
  • Gene Symbol: PCK1 (ENSG00000124253)
    Fold Change: 2.09
    Ensembl ID: ENSG00000124253
  • Gene Symbol: MT2A (ENSG00000125148)
    Fold Change: 2.09
    Ensembl ID: ENSG00000125148
  • Gene Symbol: C9 (ENSG00000113600)
    Fold Change: 2.08
    Ensembl ID: ENSG00000113600
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 2.07
    Ensembl ID: ENSG00000141505
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 2.07
    Ensembl ID: ENSG00000196616
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2.06
    Ensembl ID: ENSG00000130203
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 2.05
    Ensembl ID: ENSG00000182326
  • Gene Symbol: ITIH3 (ENSG00000162267)
    Fold Change: 2.04
    Ensembl ID: ENSG00000162267
  • Gene Symbol: CP (ENSG00000047457)
    Fold Change: 2.03
    Ensembl ID: ENSG00000047457
  • Gene Symbol: CFH (ENSG00000000971)
    Fold Change: 2.03
    Ensembl ID: ENSG00000000971
  • Gene Symbol: CYP2C8 (ENSG00000138115)
    Fold Change: 2.03
    Ensembl ID: ENSG00000138115
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 2.03
    Ensembl ID: ENSG00000149131
  • Gene Symbol: KNG1 (ENSG00000113889)
    Fold Change: 2.01
    Ensembl ID: ENSG00000113889
  • Gene Symbol: CYP3A5 (ENSG00000106258)
    Fold Change: 2
    Ensembl ID: ENSG00000106258
  • Gene Symbol: ACSL1 (ENSG00000151726)
    Fold Change: 2
    Ensembl ID: ENSG00000151726
  • Gene Symbol: CPS1 (ENSG00000021826)
    Fold Change: 1.99
    Ensembl ID: ENSG00000021826
  • Gene Symbol: CYP2C9 (ENSG00000138109)
    Fold Change: 1.98
    Ensembl ID: ENSG00000138109
  • Gene Symbol: ND5 (ENSG00000198786)
    Fold Change: 1.95
    Ensembl ID: ENSG00000198786
  • Gene Symbol: PAH (ENSG00000171759)
    Fold Change: 1.95
    Ensembl ID: ENSG00000171759
  • Gene Symbol: ARG1 (ENSG00000118520)
    Fold Change: 1.95
    Ensembl ID: ENSG00000118520
  • Gene Symbol: FN1 (ENSG00000115414)
    Fold Change: 1.94
    Ensembl ID: ENSG00000115414
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.93
    Ensembl ID: ENSG00000159403
  • Gene Symbol: F12 (ENSG00000131187)
    Fold Change: 1.93
    Ensembl ID: ENSG00000131187
  • Gene Symbol: HPN (ENSG00000105707)
    Fold Change: 1.93
    Ensembl ID: ENSG00000105707
  • Gene Symbol: CPB2 (ENSG00000080618)
    Fold Change: 1.92
    Ensembl ID: ENSG00000080618
  • Gene Symbol: CYP2E1 (ENSG00000130649)
    Fold Change: 1.92
    Ensembl ID: ENSG00000130649
  • Gene Symbol: GC (ENSG00000145321)
    Fold Change: 1.92
    Ensembl ID: ENSG00000145321
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.92
    Ensembl ID: ENSG00000121410
  • Gene Symbol: F2 (ENSG00000180210)
    Fold Change: 1.91
    Ensembl ID: ENSG00000180210
  • Gene Symbol: HGD (ENSG00000113924)
    Fold Change: 1.9
    Ensembl ID: ENSG00000113924
  • Gene Symbol: CYP4F3 (ENSG00000186529)
    Fold Change: 1.89
    Ensembl ID: ENSG00000186529
  • Gene Symbol: C5 (ENSG00000106804)
    Fold Change: 1.88
    Ensembl ID: ENSG00000106804
  • Gene Symbol: AOX1 (ENSG00000138356)
    Fold Change: 1.88
    Ensembl ID: ENSG00000138356
  • Gene Symbol: HPD (ENSG00000158104)
    Fold Change: 1.87
    Ensembl ID: ENSG00000158104
  • Gene Symbol: CES1 (ENSG00000198848)
    Fold Change: 1.87
    Ensembl ID: ENSG00000198848
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.86
    Ensembl ID: ENSG00000130707
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.86
    Ensembl ID: ENSG00000122786
  • Gene Symbol: C4BPA (ENSG00000123838)
    Fold Change: 1.85
    Ensembl ID: ENSG00000123838
  • Gene Symbol: MST1 (ENSG00000173531)
    Fold Change: 1.84
    Ensembl ID: ENSG00000173531
  • Gene Symbol: C4BPB (ENSG00000123843)
    Fold Change: 1.84
    Ensembl ID: ENSG00000123843
  • Gene Symbol: ITIH1 (ENSG00000055957)
    Fold Change: 1.82
    Ensembl ID: ENSG00000055957
  • Gene Symbol: CRP (ENSG00000132693)
    Fold Change: 1.82
    Ensembl ID: ENSG00000132693
  • Gene Symbol: PEBP1 (ENSG00000089220)
    Fold Change: 1.82
    Ensembl ID: ENSG00000089220
  • Gene Symbol: HMGCS2 (ENSG00000134240)
    Fold Change: 1.82
    Ensembl ID: ENSG00000134240
  • Gene Symbol: APCS (ENSG00000132703)
    Fold Change: 1.82
    Ensembl ID: ENSG00000132703
  • Gene Symbol: ASGR2 (ENSG00000161944)
    Fold Change: 1.81
    Ensembl ID: ENSG00000161944
  • Gene Symbol: DPYS (ENSG00000147647)
    Fold Change: 1.8
    Ensembl ID: ENSG00000147647
  • Gene Symbol: AGT (ENSG00000135744)
    Fold Change: 1.79
    Ensembl ID: ENSG00000135744
  • Gene Symbol: FBP1 (ENSG00000165140)
    Fold Change: 1.79
    Ensembl ID: ENSG00000165140
  • Gene Symbol: BAAT (ENSG00000136881)
    Fold Change: 1.79
    Ensembl ID: ENSG00000136881
  • Gene Symbol: MYO1B (ENSG00000128641)
    Fold Change: 1.79
    Ensembl ID: ENSG00000128641
  • Gene Symbol: DHCR24 (ENSG00000116133)
    Fold Change: 1.78
    Ensembl ID: ENSG00000116133
  • Gene Symbol: C6 (ENSG00000039537)
    Fold Change: 1.77
    Ensembl ID: ENSG00000039537
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 1.77
    Ensembl ID: ENSG00000120885
  • Gene Symbol: C8A (ENSG00000157131)
    Fold Change: 1.76
    Ensembl ID: ENSG00000157131
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 1.75
    Ensembl ID: ENSG00000117601
  • Gene Symbol: ND4L (ENSG00000212907)
    Fold Change: 1.75
    Ensembl ID: ENSG00000212907
  • Gene Symbol: AFM (ENSG00000079557)
    Fold Change: 1.75
    Ensembl ID: ENSG00000079557
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.74
    Ensembl ID: ENSG00000076555
  • Gene Symbol: NFIA (ENSG00000162599)
    Fold Change: 1.74
    Ensembl ID: ENSG00000162599
  • Gene Symbol: INSIG1 (ENSG00000186480)
    Fold Change: 1.73
    Ensembl ID: ENSG00000186480
  • Gene Symbol: LBP (ENSG00000129988)
    Fold Change: 1.73
    Ensembl ID: ENSG00000129988
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.72
    Ensembl ID: ENSG00000165029
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 1.72
    Ensembl ID: ENSG00000145692
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.71
    Ensembl ID: ENSG00000175899
  • Gene Symbol: MGMT (ENSG00000170430)
    Fold Change: 1.71
    Ensembl ID: ENSG00000170430

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in midzonal region hepatocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in midzonal region hepatocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The midzonal hepatocyte (CL0019028) shares the following characteristics: 1. **Mixed functionality**: Unlike the sinusoidal and centrilobular regions, the midzonal hepatocyte exhibits mixed functionality, making it a unique cell type in the liver lobule. 2. **Antioxidant activity**: Midzonal hepatocytes are involved in antioxidant activity, which is essential for protecting the liver from oxidative damage. 3. **Bile acid and bile salt metabolism**: These cells play a crucial role in the metabolism of bile acids and bile salts, which are essential for fat digestion and absorption. 4. **Cholesterol homeostasis**: Midzonal hepatocytes are involved in maintaining cholesterol homeostasis, which is critical for maintaining normal lipid levels in the body. 5. **Scavenger receptor activity**: These cells bind and uptake ligands by scavenger receptors, which is essential for removing excess cholesterol and other lipids from the body. 6. **Cellular responses to stimuli and stress**: Midzonal hepatocytes respond to various stimuli and stressors, including oxidative stress, calcium ion starvation, and chemical stress. 7. **Regulation of IGF transport and uptake**: These cells regulate the transport and uptake of IGF by IGFBPs, which is essential for maintaining normal growth and development. 8. **Negative regulation of hydrogen peroxide catabolic process**: Midzonal hepatocytes negatively regulate the catabolic process of hydrogen peroxide, which is essential for preventing oxidative damage to the liver. **Clinical Significance** The midzonal hepatocyte (CL0019028) has significant clinical implications, including: 1. **Liver disease**: Abnormalities in midzonal hepatocytes have been implicated in various liver diseases, including fatty liver disease, alcoholic liver disease, and non-alcoholic steatohepatitis (NASH). 2. **Cholesterol metabolism disorders**: Dysregulation of cholesterol homeostasis in midzonal hepatocytes can lead to cholesterol metabolism disorders, such as hypercholesterolemia and dyslipidemia. 3. **Cancer**: Alterations in the function and expression of midzonal hepatocytes have been linked to various types of cancer, including hepatocellular carcinoma (HCC) and colorectal cancer. 4. **Metabolic disorders**: Midzonal hepatocytes play a critical role in maintaining normal glucose and lipid metabolism, and dysregulation of these cells can contribute to metabolic disorders, such as type 2 diabetes and insulin resistance. In conclusion, the midzonal hepatocyte (CL0019028) is a unique and specialized cell type that plays a crucial role in various metabolic processes. Understanding the characteristics and clinical significance of this cell type is essential for developing new therapeutic strategies for liver disease and metabolic disorders.