Details for: CL0019028

Cell ID: CL0019028

Cell Name: midzonal region hepatocyte

Marker Score Threshold: 4315
(Derived using integrated single-cell and genomic data)

Description: Any hepatocyte that is part of the liver lobule midzonal region. These cells have mixed functionality in comparison with those in the other two regions of the liver lobule.

Synonyms: midzonal hepatocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 2.55
    Ensembl ID: ENSG00000163631
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 2.48
    Ensembl ID: ENSG00000110245
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 2.45
    Ensembl ID: ENSG00000118137
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 2.36
    Ensembl ID: ENSG00000130208
  • Gene Symbol: AGXT (ENSG00000172482)
    Fold Change: 2.33
    Ensembl ID: ENSG00000172482
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 2.28
    Ensembl ID: ENSG00000136872
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 2.27
    Ensembl ID: ENSG00000158874
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 2.25
    Ensembl ID: ENSG00000125730
  • Gene Symbol: APOH (ENSG00000091583)
    Fold Change: 2.22
    Ensembl ID: ENSG00000091583
  • Gene Symbol: APOB (ENSG00000084674)
    Fold Change: 2.19
    Ensembl ID: ENSG00000084674
  • Gene Symbol: AMBP (ENSG00000106927)
    Fold Change: 2.18
    Ensembl ID: ENSG00000106927
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 2.13
    Ensembl ID: ENSG00000160862
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 2.07
    Ensembl ID: ENSG00000141505
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 2.07
    Ensembl ID: ENSG00000196616
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2.06
    Ensembl ID: ENSG00000130203
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 2.05
    Ensembl ID: ENSG00000182326
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 2.03
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ARG1 (ENSG00000118520)
    Fold Change: 1.95
    Ensembl ID: ENSG00000118520
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.93
    Ensembl ID: ENSG00000159403
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.92
    Ensembl ID: ENSG00000121410
  • Gene Symbol: AOX1 (ENSG00000138356)
    Fold Change: 1.88
    Ensembl ID: ENSG00000138356
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.86
    Ensembl ID: ENSG00000130707
  • Gene Symbol: C4BPA (ENSG00000123838)
    Fold Change: 1.85
    Ensembl ID: ENSG00000123838
  • Gene Symbol: APCS (ENSG00000132703)
    Fold Change: 1.82
    Ensembl ID: ENSG00000132703
  • Gene Symbol: ASGR2 (ENSG00000161944)
    Fold Change: 1.81
    Ensembl ID: ENSG00000161944
  • Gene Symbol: AGT (ENSG00000135744)
    Fold Change: 1.79
    Ensembl ID: ENSG00000135744
  • Gene Symbol: BAAT (ENSG00000136881)
    Fold Change: 1.79
    Ensembl ID: ENSG00000136881
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 1.75
    Ensembl ID: ENSG00000117601
  • Gene Symbol: AFM (ENSG00000079557)
    Fold Change: 1.75
    Ensembl ID: ENSG00000079557
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.74
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.72
    Ensembl ID: ENSG00000165029
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 1.72
    Ensembl ID: ENSG00000145692
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.71
    Ensembl ID: ENSG00000175899
  • Gene Symbol: AHSG (ENSG00000145192)
    Fold Change: 1.7
    Ensembl ID: ENSG00000145192
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.69
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.69
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.67
    Ensembl ID: ENSG00000156110
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: AR (ENSG00000169083)
    Fold Change: 1.64
    Ensembl ID: ENSG00000169083
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.62
    Ensembl ID: ENSG00000161533
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.61
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.59
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ADH4 (ENSG00000198099)
    Fold Change: 1.59
    Ensembl ID: ENSG00000198099
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.59
    Ensembl ID: ENSG00000126522
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.58
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.57
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.55
    Ensembl ID: ENSG00000111275
  • Gene Symbol: BDH1 (ENSG00000161267)
    Fold Change: 1.55
    Ensembl ID: ENSG00000161267
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.53
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 1.51
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.47
    Ensembl ID: ENSG00000196177
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.46
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ABCC6 (ENSG00000091262)
    Fold Change: 1.45
    Ensembl ID: ENSG00000091262
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.43
    Ensembl ID: ENSG00000170017
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.37
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AADAC (ENSG00000114771)
    Fold Change: 1.37
    Ensembl ID: ENSG00000114771
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.37
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.37
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.34
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.33
    Ensembl ID: ENSG00000166825
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.33
    Ensembl ID: ENSG00000170634
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.32
    Ensembl ID: ENSG00000162688
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.32
    Ensembl ID: ENSG00000143878
  • Gene Symbol: AQP9 (ENSG00000103569)
    Fold Change: 1.3
    Ensembl ID: ENSG00000103569
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.29
    Ensembl ID: ENSG00000164742
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.28
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.28
    Ensembl ID: ENSG00000117054
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.26
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.26
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.26
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.25
    Ensembl ID: ENSG00000278540
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.23
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.23
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.23
    Ensembl ID: ENSG00000198363
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.22
    Ensembl ID: ENSG00000107282
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.21
    Ensembl ID: ENSG00000119138
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.21
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADH6 (ENSG00000172955)
    Fold Change: 1.16
    Ensembl ID: ENSG00000172955
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.14
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AGTR1 (ENSG00000144891)
    Fold Change: 1.13
    Ensembl ID: ENSG00000144891
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.12
    Ensembl ID: ENSG00000148090
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.11
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 1.11
    Ensembl ID: ENSG00000115170
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 1.1
    Ensembl ID: ENSG00000157087
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.1
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ART4 (ENSG00000111339)
    Fold Change: 1.1
    Ensembl ID: ENSG00000111339
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.08
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143153
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.08
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ALAS1 (ENSG00000023330)
    Fold Change: 1.07
    Ensembl ID: ENSG00000023330
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.06
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.05
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.05
    Ensembl ID: ENSG00000097007
  • Gene Symbol: BCHE (ENSG00000114200)
    Fold Change: 1.03
    Ensembl ID: ENSG00000114200
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.03
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.03
    Ensembl ID: ENSG00000196975
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.01
    Ensembl ID: ENSG00000101966
  • Gene Symbol: BPHL (ENSG00000137274)
    Fold Change: 1
    Ensembl ID: ENSG00000137274
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1
    Ensembl ID: ENSG00000204217
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: Midzonal region hepatocytes are located in the midzonal region of the liver lobule, which is distinct from the centrilobular and pericentral regions. 2. **Mixed functionality**: Midzonal region hepatocytes exhibit characteristics of both centrilobular and pericentral hepatocytes, with a mix of metabolic and transport functions. 3. **Lipid metabolism**: These cells play a crucial role in lipid metabolism, including the clearance of bile acids and salts. 4. **Cholesterol efflux**: Midzonal region hepatocytes are involved in the efflux of cholesterol from the cell membrane. 5. **Antioxidant activity**: These cells exhibit antioxidant activity, which helps protect the cell from oxidative stress. 6. **Cellular responses to stress**: Midzonal region hepatocytes respond to cellular stress by activating various signaling pathways and regulating gene expression. 7. **Regulation of lipid metabolism**: These cells regulate lipid metabolism by controlling the expression of genes involved in lipid synthesis and degradation. **Clinical Significance** 1. **Liver disease**: Understanding the characteristics and functions of midzonal region hepatocytes is essential for comprehending the mechanisms of liver disease, including fatty liver disease, non-alcoholic steatohepatitis (NASH), and cirrhosis. 2. **Cholesterol metabolism**: The role of midzonal region hepatocytes in cholesterol efflux and lipid metabolism has implications for the treatment of hypercholesterolemia and atherosclerosis. 3. **Bile acid metabolism**: The clearance of bile acids and salts by midzonal region hepatocytes has implications for the treatment of cholestasis and liver disease. 4. **Antioxidant therapy**: The antioxidant activity of midzonal region hepatocytes has implications for the treatment of oxidative stress-related diseases, such as cancer and neurodegenerative disorders. 5. **Regulation of lipid metabolism**: The regulation of lipid metabolism by midzonal region hepatocytes has implications for the treatment of metabolic disorders, such as obesity and insulin resistance. In conclusion, the midzonal region hepatocyte is a specialized type of hepatocyte that plays a crucial role in lipid metabolism, cholesterol efflux, and the clearance of bile acids and salts. Understanding the characteristics and functions of this cell type is essential for comprehending the mechanisms of liver function and the pathogenesis of liver disease.