Details for: CL0019029

Cell ID: CL0019029

Cell Name: centrilobular region hepatocyte

Marker Score Threshold: 6,429
(Derived using integrated single-cell and genomic data)

Description: Any hepatocyte that is part of the liver lobule centrilobular region. These cells are the primary location for the biotransformation of drugs.

Synonyms: centrilobular hepatocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 2.45
    Ensembl ID: ENSG00000163631
  • Gene Symbol: HP (ENSG00000257017)
    Fold Change: 2.42
    Ensembl ID: ENSG00000257017
  • Gene Symbol: FGB (ENSG00000171564)
    Fold Change: 2.4
    Ensembl ID: ENSG00000171564
  • Gene Symbol: SERPINA1 (ENSG00000197249)
    Fold Change: 2.39
    Ensembl ID: ENSG00000197249
  • Gene Symbol: FGA (ENSG00000171560)
    Fold Change: 2.37
    Ensembl ID: ENSG00000171560
  • Gene Symbol: FGG (ENSG00000171557)
    Fold Change: 2.36
    Ensembl ID: ENSG00000171557
  • Gene Symbol: AGXT (ENSG00000172482)
    Fold Change: 2.33
    Ensembl ID: ENSG00000172482
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 2.32
    Ensembl ID: ENSG00000110245
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 2.31
    Ensembl ID: ENSG00000125730
  • Gene Symbol: FGL1 (ENSG00000104760)
    Fold Change: 2.3
    Ensembl ID: ENSG00000104760
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 2.3
    Ensembl ID: ENSG00000198938
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 2.28
    Ensembl ID: ENSG00000198899
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 2.27
    Ensembl ID: ENSG00000198712
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 2.26
    Ensembl ID: ENSG00000198804
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 2.26
    Ensembl ID: ENSG00000118137
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 2.25
    Ensembl ID: ENSG00000198840
  • Gene Symbol: APOB (ENSG00000084674)
    Fold Change: 2.24
    Ensembl ID: ENSG00000084674
  • Gene Symbol: HPX (ENSG00000110169)
    Fold Change: 2.24
    Ensembl ID: ENSG00000110169
  • Gene Symbol: MGST1 (ENSG00000008394)
    Fold Change: 2.22
    Ensembl ID: ENSG00000008394
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 2.21
    Ensembl ID: ENSG00000198886
  • Gene Symbol: NNMT (ENSG00000166741)
    Fold Change: 2.2
    Ensembl ID: ENSG00000166741
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 2.2
    Ensembl ID: ENSG00000196616
  • Gene Symbol: MAT1A (ENSG00000151224)
    Fold Change: 2.19
    Ensembl ID: ENSG00000151224
  • Gene Symbol: CYB5A (ENSG00000166347)
    Fold Change: 2.18
    Ensembl ID: ENSG00000166347
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 2.17
    Ensembl ID: ENSG00000136872
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 2.17
    Ensembl ID: ENSG00000141505
  • Gene Symbol: CYP2E1 (ENSG00000130649)
    Fold Change: 2.16
    Ensembl ID: ENSG00000130649
  • Gene Symbol: APOH (ENSG00000091583)
    Fold Change: 2.16
    Ensembl ID: ENSG00000091583
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 2.14
    Ensembl ID: ENSG00000198888
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 2.13
    Ensembl ID: ENSG00000130208
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 2.12
    Ensembl ID: ENSG00000198727
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 2.12
    Ensembl ID: ENSG00000182326
  • Gene Symbol: CYP3A5 (ENSG00000106258)
    Fold Change: 2.11
    Ensembl ID: ENSG00000106258
  • Gene Symbol: CYP2C8 (ENSG00000138115)
    Fold Change: 2.11
    Ensembl ID: ENSG00000138115
  • Gene Symbol: C9 (ENSG00000113600)
    Fold Change: 2.1
    Ensembl ID: ENSG00000113600
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 2.1
    Ensembl ID: ENSG00000198763
  • Gene Symbol: CFH (ENSG00000000971)
    Fold Change: 2.1
    Ensembl ID: ENSG00000000971
  • Gene Symbol: PLG (ENSG00000122194)
    Fold Change: 2.1
    Ensembl ID: ENSG00000122194
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 2.1
    Ensembl ID: ENSG00000160862
  • Gene Symbol: AMBP (ENSG00000106927)
    Fold Change: 2.09
    Ensembl ID: ENSG00000106927
  • Gene Symbol: CYP2C9 (ENSG00000138109)
    Fold Change: 2.09
    Ensembl ID: ENSG00000138109
  • Gene Symbol: CP (ENSG00000047457)
    Fold Change: 2.08
    Ensembl ID: ENSG00000047457
  • Gene Symbol: KNG1 (ENSG00000113889)
    Fold Change: 2.07
    Ensembl ID: ENSG00000113889
  • Gene Symbol: PCK1 (ENSG00000124253)
    Fold Change: 2.07
    Ensembl ID: ENSG00000124253
  • Gene Symbol: ACSL1 (ENSG00000151726)
    Fold Change: 2.07
    Ensembl ID: ENSG00000151726
  • Gene Symbol: CPS1 (ENSG00000021826)
    Fold Change: 2.05
    Ensembl ID: ENSG00000021826
  • Gene Symbol: SERPINF2 (ENSG00000167711)
    Fold Change: 2.02
    Ensembl ID: ENSG00000167711
  • Gene Symbol: PAH (ENSG00000171759)
    Fold Change: 2.01
    Ensembl ID: ENSG00000171759
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 2
    Ensembl ID: ENSG00000149131
  • Gene Symbol: CYP4F3 (ENSG00000186529)
    Fold Change: 2
    Ensembl ID: ENSG00000186529
  • Gene Symbol: HPN (ENSG00000105707)
    Fold Change: 1.99
    Ensembl ID: ENSG00000105707
  • Gene Symbol: ARG1 (ENSG00000118520)
    Fold Change: 1.98
    Ensembl ID: ENSG00000118520
  • Gene Symbol: HGD (ENSG00000113924)
    Fold Change: 1.98
    Ensembl ID: ENSG00000113924
  • Gene Symbol: ITIH3 (ENSG00000162267)
    Fold Change: 1.97
    Ensembl ID: ENSG00000162267
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 1.97
    Ensembl ID: ENSG00000158874
  • Gene Symbol: AOX1 (ENSG00000138356)
    Fold Change: 1.96
    Ensembl ID: ENSG00000138356
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 1.96
    Ensembl ID: ENSG00000087086
  • Gene Symbol: CPB2 (ENSG00000080618)
    Fold Change: 1.95
    Ensembl ID: ENSG00000080618
  • Gene Symbol: FN1 (ENSG00000115414)
    Fold Change: 1.95
    Ensembl ID: ENSG00000115414
  • Gene Symbol: C5 (ENSG00000106804)
    Fold Change: 1.94
    Ensembl ID: ENSG00000106804
  • Gene Symbol: CYP3A4 (ENSG00000160868)
    Fold Change: 1.94
    Ensembl ID: ENSG00000160868
  • Gene Symbol: ORM1 (ENSG00000229314)
    Fold Change: 1.92
    Ensembl ID: ENSG00000229314
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.91
    Ensembl ID: ENSG00000159403
  • Gene Symbol: F12 (ENSG00000131187)
    Fold Change: 1.91
    Ensembl ID: ENSG00000131187
  • Gene Symbol: HPD (ENSG00000158104)
    Fold Change: 1.89
    Ensembl ID: ENSG00000158104
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 1.88
    Ensembl ID: ENSG00000145692
  • Gene Symbol: FABP1 (ENSG00000163586)
    Fold Change: 1.87
    Ensembl ID: ENSG00000163586
  • Gene Symbol: ADH4 (ENSG00000198099)
    Fold Change: 1.87
    Ensembl ID: ENSG00000198099
  • Gene Symbol: ABCB4 (ENSG00000005471)
    Fold Change: 1.87
    Ensembl ID: ENSG00000005471
  • Gene Symbol: MYO1B (ENSG00000128641)
    Fold Change: 1.86
    Ensembl ID: ENSG00000128641
  • Gene Symbol: MT2A (ENSG00000125148)
    Fold Change: 1.85
    Ensembl ID: ENSG00000125148
  • Gene Symbol: C4BPB (ENSG00000123843)
    Fold Change: 1.85
    Ensembl ID: ENSG00000123843
  • Gene Symbol: C4BPA (ENSG00000123838)
    Fold Change: 1.85
    Ensembl ID: ENSG00000123838
  • Gene Symbol: DPYS (ENSG00000147647)
    Fold Change: 1.84
    Ensembl ID: ENSG00000147647
  • Gene Symbol: C6 (ENSG00000039537)
    Fold Change: 1.84
    Ensembl ID: ENSG00000039537
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.84
    Ensembl ID: ENSG00000130203
  • Gene Symbol: F2 (ENSG00000180210)
    Fold Change: 1.83
    Ensembl ID: ENSG00000180210
  • Gene Symbol: BAAT (ENSG00000136881)
    Fold Change: 1.83
    Ensembl ID: ENSG00000136881
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.83
    Ensembl ID: ENSG00000122786
  • Gene Symbol: NFIA (ENSG00000162599)
    Fold Change: 1.83
    Ensembl ID: ENSG00000162599
  • Gene Symbol: CES1 (ENSG00000198848)
    Fold Change: 1.82
    Ensembl ID: ENSG00000198848
  • Gene Symbol: EHHADH (ENSG00000113790)
    Fold Change: 1.82
    Ensembl ID: ENSG00000113790
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.81
    Ensembl ID: ENSG00000076555
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.81
    Ensembl ID: ENSG00000121410
  • Gene Symbol: GC (ENSG00000145321)
    Fold Change: 1.8
    Ensembl ID: ENSG00000145321
  • Gene Symbol: C8A (ENSG00000157131)
    Fold Change: 1.79
    Ensembl ID: ENSG00000157131
  • Gene Symbol: MST1 (ENSG00000173531)
    Fold Change: 1.78
    Ensembl ID: ENSG00000173531
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.78
    Ensembl ID: ENSG00000151914
  • Gene Symbol: PCSK6 (ENSG00000140479)
    Fold Change: 1.77
    Ensembl ID: ENSG00000140479
  • Gene Symbol: IL1RAP (ENSG00000196083)
    Fold Change: 1.76
    Ensembl ID: ENSG00000196083
  • Gene Symbol: INSR (ENSG00000171105)
    Fold Change: 1.76
    Ensembl ID: ENSG00000171105
  • Gene Symbol: AFM (ENSG00000079557)
    Fold Change: 1.76
    Ensembl ID: ENSG00000079557
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 1.76
    Ensembl ID: ENSG00000144674
  • Gene Symbol: ITPR2 (ENSG00000123104)
    Fold Change: 1.76
    Ensembl ID: ENSG00000123104
  • Gene Symbol: FKBP5 (ENSG00000096060)
    Fold Change: 1.76
    Ensembl ID: ENSG00000096060
  • Gene Symbol: HMGCS2 (ENSG00000134240)
    Fold Change: 1.76
    Ensembl ID: ENSG00000134240
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.75
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.75
    Ensembl ID: ENSG00000156110
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 1.74
    Ensembl ID: ENSG00000122566
  • Gene Symbol: MGMT (ENSG00000170430)
    Fold Change: 1.74
    Ensembl ID: ENSG00000170430

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in centrilobular region hepatocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in centrilobular region hepatocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * Located in the centrilobular region of the liver lobule * Specialized for biotransformation of drugs * Involved in antioxidant activity * Plays a crucial role in bile acid and bile salt metabolism * Scavenges heme from plasma * Involved in the regulation of various cellular processes, including metabolism, transport, and signaling pathways * Characterized by its unique expression of genes, including ALB, HP, and SERPINA1 **Clinical Significance** The centrilobular region hepatocyte plays a critical role in the metabolism and biotransformation of various substances, including drugs, toxins, and endogenous compounds. Dysfunction or damage to these cells can lead to impaired biotransformation, resulting in altered levels of these substances in the body. This can have significant clinical implications, including: * Impaired drug metabolism: Altered levels of drugs and their metabolites can lead to reduced efficacy or increased toxicity. * Increased risk of toxicity: Impaired biotransformation can lead to the accumulation of toxic substances, increasing the risk of liver damage and other adverse effects. * Impaired antioxidant activity: Reduced antioxidant activity can lead to increased oxidative stress, contributing to the development of various diseases, including liver disease, cardiovascular disease, and cancer. Understanding the characteristics and clinical significance of the centrilobular region hepatocyte is essential for the diagnosis and treatment of liver-related disorders. This includes the development of targeted therapies aimed at restoring the function of these cells and improving the biotransformation of various substances. **Pathways and Ontologies** The centrilobular region hepatocyte is involved in various cellular processes, including: * Antioxidant activity * Bile acid and bile salt metabolism * Scavenging of heme from plasma * Metabolism * Transport * Signaling pathways These processes are mediated by various genes, including ALB, HP, and SERPINA1, which are involved in the regulation of antioxidant activity, biotransformation, and other cellular processes. **Gene Symbol and Ensembl ID** The gene symbol for the centrilobular region hepatocyte is ALB, with an Ensembl ID of ENSG00000163631. The gene symbol for the hepatocyte antigen HP is HP, with an Ensembl ID of ENSG00000257017. The gene symbol for the serine protease inhibitor SERPINA1 is SERPINA1, with an Ensembl ID of ENSG00000197249. **Gene Expression and Regulation** The expression of genes involved in the centrilobular region hepatocyte is regulated by various transcription factors and signaling pathways. These include: * Antioxidant activity * Bile acid and bile salt metabolism * Scavenging of heme from plasma * Metabolism * Transport * Signaling pathways These regulatory mechanisms are critical for maintaining the function and integrity of the centrilobular region hepatocyte. **Clinical Implications** Understanding the clinical implications of the centrilobular region hepatocyte is essential for the diagnosis and treatment of liver-related disorders. This includes: * Impaired drug metabolism * Increased risk of toxicity * Impaired antioxidant activity * Increased oxidative stress Targeted therapies aimed at restoring the function of these cells and improving the biotransformation of various substances can help to mitigate these clinical implications. **Conclusion** The centrilobular region hepatocyte is a specialized type of hepatocyte found in the liver lobule. Its unique location and specialized functions in biotransformation and antioxidant activity make it an essential component of the liver's metabolic and detoxification processes. Understanding the characteristics and clinical significance of this cell type is critical for the diagnosis and treatment of liver-related disorders.