Details for: CL0019031

Cell ID: CL0019031

Cell Name: intestine goblet cell

Marker Score Threshold: 958
(Derived using integrated single-cell and genomic data)

Description: Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3.

Synonyms: intestinal goblet cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.72
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.57
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.41
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.25
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.2
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.12
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.87
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.84
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.83
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.8
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.77
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.76
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.75
    Ensembl ID: ENSG00000099624
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.71
    Ensembl ID: ENSG00000134825
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.69
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.59
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.54
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.48
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.44
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.43
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.38
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.37
    Ensembl ID: ENSG00000159199
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 2.32
    Ensembl ID: ENSG00000102554
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.32
    Ensembl ID: ENSG00000067560
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.27
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.25
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.24
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 2.23
    Ensembl ID: ENSG00000162772
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.18
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.18
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.12
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.11
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.09
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.08
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.06
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.05
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.04
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.04
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.03
    Ensembl ID: ENSG00000143153
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATOH1 (ENSG00000172238)
    Fold Change: 1.98
    Ensembl ID: ENSG00000172238
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.96
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.9
    Ensembl ID: ENSG00000196975
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.88
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.88
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.87
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.84
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ANG (ENSG00000214274)
    Fold Change: 1.84
    Ensembl ID: ENSG00000214274
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.83
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.81
    Ensembl ID: ENSG00000127022
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.8
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.8
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.78
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.75
    Ensembl ID: ENSG00000165092
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.73
    Ensembl ID: ENSG00000090013
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.69
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.66
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: 1.64
    Ensembl ID: ENSG00000002726
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.64
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.58
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.57
    Ensembl ID: ENSG00000074370
  • Gene Symbol: ANXA13 (ENSG00000104537)
    Fold Change: 1.54
    Ensembl ID: ENSG00000104537
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.53
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.53
    Ensembl ID: ENSG00000130707
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.47
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CAPN5 (ENSG00000149260)
    Fold Change: 1.43
    Ensembl ID: ENSG00000149260
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 1.42
    Ensembl ID: ENSG00000118137
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.42
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.41
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.37
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.36
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.36
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.32
    Ensembl ID: ENSG00000120805
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.27
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.27
    Ensembl ID: ENSG00000004059
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.27
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.27
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.27
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 1.24
    Ensembl ID: ENSG00000136872
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.23
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.22
    Ensembl ID: ENSG00000197894
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.2
    Ensembl ID: ENSG00000183255
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.19
    Ensembl ID: ENSG00000165272
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.17
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.15
    Ensembl ID: ENSG00000095139
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.13
    Ensembl ID: ENSG00000149823
  • Gene Symbol: DDR1 (ENSG00000204580)
    Fold Change: 1.12
    Ensembl ID: ENSG00000204580
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100412
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.1
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.08
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.08
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACADS (ENSG00000122971)
    Fold Change: 1.07
    Ensembl ID: ENSG00000122971
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.07
    Ensembl ID: ENSG00000173020
  • Gene Symbol: CA12 (ENSG00000074410)
    Fold Change: 1.06
    Ensembl ID: ENSG00000074410
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.05
    Ensembl ID: ENSG00000166825
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.04
    Ensembl ID: ENSG00000004455
  • Gene Symbol: CAPN1 (ENSG00000014216)
    Fold Change: 1.04
    Ensembl ID: ENSG00000014216
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.03
    Ensembl ID: ENSG00000134287
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.01
    Ensembl ID: ENSG00000101966
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1
    Ensembl ID: ENSG00000123505
Hovered Details

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Hovered Details

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**Key Characteristics** Intestinal goblet cells possess several distinct characteristics that enable them to perform their specialized functions: 1. **Mucin secretion**: Intestinal goblet cells are responsible for synthesizing and secreting mucins, which are high-molecular-weight glycoproteins that provide protective and lubricating properties to the intestinal lumen. 2. **Cellular polarity**: Intestinal goblet cells exhibit strong cellular polarity, with distinct apical and basolateral domains that enable them to maintain the integrity of the intestinal epithelium. 3. **Expression of specific mucus components**: Human intestinal goblet cells express a range of specific mucus components, including MUC2, CLCA1, FCGBP, AGR2, ZG16, and TFF3, which contribute to the protective and lubricating properties of the mucus blanket. 4. **Adhesion to the extracellular matrix**: Intestinal goblet cells adhere to the extracellular matrix via specific adhesion molecules, such as integrins and cadherins, which enable them to maintain their position within the intestinal epithelium. **Clinical Significance** Intestinal goblet cells play a critical role in maintaining the health and function of the intestinal epithelium, and alterations in their function or number can contribute to a range of gastrointestinal disorders. Some of the key clinical implications of intestinal goblet cells include: 1. **Inflammatory bowel disease (IBD)**: Intestinal goblet cells are often reduced or absent in patients with IBD, leading to impaired mucin secretion and increased susceptibility to inflammation. 2. **Celiac disease**: Intestinal goblet cells are also reduced in celiac disease, leading to impaired mucin secretion and increased risk of malabsorption. 3. **Gastrointestinal cancer**: Intestinal goblet cells have been implicated in the development of gastrointestinal cancer, particularly in the context of chronic inflammation and epithelial damage. 4. **Gastrointestinal motility disorders**: Intestinal goblet cells play a role in regulating gastrointestinal motility, and alterations in their function can contribute to disorders such as irritable bowel syndrome (IBS). In summary, intestinal goblet cells are specialized epithelial cells that play a critical role in maintaining the health and function of the intestinal epithelium. Alterations in their function or number can contribute to a range of gastrointestinal disorders, highlighting the importance of understanding the biology and clinical significance of these cells.