Cell ID: CL0019031

Cell Name: intestine goblet cell

CSI Thresholds:

Select	Context	Threshold
	Overall	8.6154
	Cardia of stomach	240.5102
	Cardia of stomach + Gastric intestinal metaplasia	240.5102
	Gastric intestinal metaplasia	114.8422
	MONDO0004298	113.7223
	Lower esophagus	83.9760
	Body of stomach	78.9273
	Cardia of stomach	73.4331
	Body of stomach + Gastric intestinal metaplasia	57.8750
	Body of stomach	57.8438
	Barrett esophagus	50.5868
	Lower esophagus + Barrett esophagus	50.5868
	Body of stomach + Healthy	39.5939
	Caecum + Healthy	32.5555
	Rectum	29.2640
	Large intestine	20.3607
	Colon	16.9696
	Sigmoid colon	16.0528
	Ileum	15.8243
	Lung	13.4438
	Colon + Healthy	12.4562
	Ileum + Crohn disease	12.3384
	Cardia of stomach + Healthy	11.8473
	Small intestine + Healthy	11.3067
	Small intestine	10.8216
	Sigmoid colon + Healthy	10.7720
	Crohn disease	9.5124
	Caecum	8.7143
	Duodeno-jejunal junction	7.8086
	Duodeno-jejunal junction + Healthy	7.8086
	Duodenum	7.2223
	Healthy	7.1091
	Duodenum + Healthy	7.0552
	Large intestine + Healthy	5.9685
	Rectum + Healthy	5.1379
	Pyloric antrum	2.8780
	Pyloric antrum + Healthy	2.8780
	Lung + Healthy	2.0272
	Gastritis	1.7367
	Body of stomach + Gastritis	1.7367
	Ileum + Healthy	-15.3345
	Transverse colon + Healthy	-22.3554
	Transverse colon	-29.6187
	Jejunum + Healthy	-67.3703
	Jejunum	-67.7171
	Ascending colon + Healthy	-206.3133
	Ascending colon	-213.5939

Select

(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3.

Synonyms: intestinal goblet cell