Cell ID: CL1000223

Cell Name: lung neuroendocrine cell

CSI Thresholds:

Select	Context	Threshold
	Overall	9.9185
	Lung parenchyma + Healthy	406.0491
	Lung parenchyma	399.5623
	Lung adenocarcinoma	49.9684
	Respiratory airway + Healthy	35.2921
	Respiratory airway	35.1366
	Lung + COVID-19	10.2515
	Chronic obstructive pulmonary disease	10.0495
	Healthy	7.7954
	Lung	6.6157
	Lung + Cystic fibrosis	4.8020
	Cystic fibrosis	4.7874
	Lung + Healthy	3.2395
	Interstitial lung disease	3.2045
	Lung + Interstitial lung disease	3.2028
	Lung + Chronic obstructive pulmonary disease	3.1942
	COVID-19	2.0819
	Lung + Pulmonary fibrosis	1.5596
	Pulmonary fibrosis	1.5556
	Lung + Hypersensitivity pneumonitis	1.4020
	Hypersensitivity pneumonitis	1.3945
	Lung + Lung adenocarcinoma	0.4297

Select

(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury.

Synonyms: lung neuroendocrine cell, PNEC