Details for: CL1000320

Cell ID: CL1000320

Cell Name: large intestine goblet cell

Marker Score Threshold: 265
(Derived using integrated single-cell and genomic data)

Description: A goblet cell that is part of the epithelium of large intestine.

Synonyms: goblet cell of epithelium of large intestine

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.26
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.13
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.62
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.59
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.56
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.53
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.51
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.48
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.48
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.4
    Ensembl ID: ENSG00000070831
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.32
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.2
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.07
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.99
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.97
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.93
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.86
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.83
    Ensembl ID: ENSG00000110955
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.83
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.81
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.78
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.77
    Ensembl ID: ENSG00000135404
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.77
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.73
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.73
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.71
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.71
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.7
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.69
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.68
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.65
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.64
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.63
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.61
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.61
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.6
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.6
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.57
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.57
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.57
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.57
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.54
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.5
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.49
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.48
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.48
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.47
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.45
    Ensembl ID: ENSG00000099624
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.45
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.43
    Ensembl ID: ENSG00000070961
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.43
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.43
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.41
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.41
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.4
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.4
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.39
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.39
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.37
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.37
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.37
    Ensembl ID: ENSG00000104763
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100823
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.34
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.32
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.32
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.32
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.31
    Ensembl ID: ENSG00000153922
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.3
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.3
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.3
    Ensembl ID: ENSG00000109861
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.28
    Ensembl ID: ENSG00000130402
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.26
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.26
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.24
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.23
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 1.23
    Ensembl ID: ENSG00000166165
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.22
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.2
    Ensembl ID: ENSG00000159199
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.17
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.17
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.16
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.16
    Ensembl ID: ENSG00000149311
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.16
    Ensembl ID: ENSG00000100300
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.14
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.14
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.14
    Ensembl ID: ENSG00000111642
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.14
    Ensembl ID: ENSG00000197043
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.14
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.13
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.12
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.1
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.07
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.05
    Ensembl ID: ENSG00000162772
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.03
    Ensembl ID: ENSG00000111276
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.03
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.02
    Ensembl ID: ENSG00000196954
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1
    Ensembl ID: ENSG00000197894
Hovered Details

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Hovered Details

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**Key Characteristics** * **Cell Type**: Large intestine goblet cell * **Location**: Epithelium of large intestine * **Gene Symbol**: ACTB * **Ensembl ID**: ENSG00000075624 * **Pathways/Ontology**: + Actin cytoskeleton + Actin filament + Adherens junction + Adherens junction assembly + Adherens junctions interactions + Apical junction complex + Apical protein localization + Atp binding + Axon + Axon guidance + Axonogenesis + B-wich complex positively regulates rrna expression + Bbaf complex + Blood microparticle + Brahma complex + Brush border + Calyx of held + Cell-cell communication + Cell-cell junction + Cell-cell junction organization + Cell-extracellular matrix interactions + Cell junction organization + Cell motility + Cellular response to cytochalasin b + Chaperonin-mediated protein folding + Chromatin + Chromatin modifying enzymes + Chromatin organization + Chromatin remodeling + Clathrin-mediated endocytosis + Cooperation of prefoldin and tric/cct in actin and tubulin folding + Cortical cytoskeleton + Cytoplasm + Cytoplasmic ribonucleoprotein granule + Cytoskeleton + Cytosol + Dense body + Deubiquitination + Developmental biology + Disease + Diseases of signal transduction by growth factor receptors and second messengers + Dna damage recognition in gg-ner + Dna repair + Eph-ephrin mediated repulsion of cells + Eph-ephrin signaling + Ephb-mediated forward signaling + Epigenetic regulation of gene expression + Establishment or maintenance of cell polarity + Extracellular exosome + Extracellular space + Factors involved in megakaryocyte development and platelet production + Fcgamma receptor (fcgr) dependent phagocytosis + Fcgr3a-mediated phagocytosis + Focal adhesion + Folding of actin by cct/tric + Formation of annular gap junctions + Gap junction degradation + Gap junction trafficking + Gap junction trafficking and regulation + Gbaf complex + Gene expression (transcription) + Global genome nucleotide excision repair (gg-ner) + Glutamatergic synapse + Hats acetylate histones + Hemostasis + Hydrolase activity + Identical protein binding + Immune system + Infectious disease + Innate immune system + Interaction between l1 and ankyrins + Kinesin binding + Kinetochore + L1cam interactions + Lamellipodium + Leishmania infection + Leishmania phagocytosis + Maintenance of blood-brain barrier + Map2k and mapk activation + Mapk1/mapk3 signaling + Mapk family signaling cascades + Membrane + Membrane trafficking + Metabolism of proteins + Morphogenesis of a polarized epithelium + Nbaf complex + Negative regulation of cell differentiation + Negative regulation of protein binding + Nervous system development + Nitric-oxide synthase binding + Npbaf complex + Nua4 histone acetyltransferase complex + Nuclear matrix + Nucleoplasm + Nucleosomal dna binding + Nucleosome + Nucleotide excision repair + Nucleus + Oncogenic mapk signaling + Paradoxical activation of raf signaling by kinase inactive braf + Parasite infection + Parasitic infection pathways + Plasma membrane + Platelet aggregation + Positive epigenetic regulation of rrna expression + Positive regulation of cell differentiation + Positive regulation of cell population proliferation + Positive regulation of dna-templated transcription + Positive regulation of double-strand break repair + Positive regulation of double-strand break repair via homologous recombination + Positive regulation of myoblast differentiation + Positive regulation of norepinephrine uptake + Positive regulation of stem cell population maintenance + Positive regulation of t cell differentiation + Post-translational protein modification + Postsynaptic actin cytoskeleton + Postsynaptic actin cytoskeleton organization + Prefoldin mediated transfer of substrate to cct/tric + Presynapse + Protein-containing complex + Protein binding + Protein folding + Protein kinase binding + Protein localization to adherens junction + Raf/map kinase cascade + Recycling pathway of l1 + Regulation of actin dynamics for phagocytic cup formation + Regulation of apoptotic process + Regulation of cell cycle + Regulation of cyclin-dependent protein serine/threonine kinase activity + Regulation of double-strand break repair + Regulation of g0 to g1 transition + Regulation of g1/s transition of mitotic cell cycle + Regulation of mitotic metaphase/anaphase transition + Regulation of norepinephrine uptake + Regulation of nucleotide-excision repair + Regulation of protein localization to plasma membrane + Regulation of synaptic vesicle endocytosis + Regulation of transcription by rna polymerase ii + Regulation of transepithelial transport + Regulation of transmembrane transporter activity + Rhof gtpase cycle + Rho gtpase cycle + Rho gtpase effectors + Rho gtpases activate formins + Rho gtpases activate iqgaps + Rho gtpases activate wasps and waves + Ribonucleoprotein complex + Rsc-type complex + Schaffer collateral - ca1 synapse + Sensory perception + Sensory processing of sound + Sensory processing of sound by inner hair cells of the cochlea + Sensory processing of sound by outer hair cells of the cochlea + Signaling by braf and raf1 fusions + Signaling by high-kinase activity braf mutants + Signaling by moderate kinase activity braf mutants + Signaling by raf1 mutants + Signaling by ras mutants + Signaling by receptor tyrosine kinases + Signaling by rho gtpases + Signaling by rho gtpases, miro gtpases and rhobtb3 + Signaling by vegf + Signaling downstream of ras mutants + Signal transduction + Structural constituent of cytoskeleton + Structural constituent of postsynaptic actin cytoskeleton + Substantia nigra development + Swi/snf complex + Synapse + Tat protein binding + Tau protein binding + Tight junction + Translocation of slc2a4 (glut4) to the plasma membrane + Uch proteinases + Vegfa-vegfr2 pathway + Vesicle + Vesicle-mediated transport **Clinical Significance** As a large intestine goblet cell, this cell plays a crucial role in maintaining the integrity of the digestive tract. Goblet cells produce mucins, which form the mucus that lines the digestive tract and protects it from damage caused by digestive enzymes and other external factors. Alterations in goblet cell function or number have been linked to various gastrointestinal disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and colorectal cancer. In addition, the cell's involvement in signaling pathways and its role in maintaining cell polarity and adhesion to the epithelial layer make it an important component of the immune system. Abnormalities in goblet cell function or number may contribute to the development of immune-related disorders, such as autoimmune enteropathy. Furthermore, the cell's involvement in actin cytoskeleton organization and cell-cell communication makes it an important component of the epithelial barrier function. Alterations in these processes may contribute to the development of gastrointestinal disorders, such as leaky gut syndrome. Overall, the large intestine goblet cell is an important component of the digestive tract, and its dysfunction or abnormalities in number or function may contribute to various gastrointestinal disorders.