Details for: CL1000329

Cell ID: CL1000329

Cell Name: tracheal goblet cell

Marker Score Threshold: 2824
(Derived using integrated single-cell and genomic data)

Description: A goblet cell that is part of the epithelium of trachea.

Synonyms: goblet cell of epithelium of trachea

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 16
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ADH1C (ENSG00000248144)
    Fold Change: 11.17
    Ensembl ID: ENSG00000248144
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 10.37
    Ensembl ID: ENSG00000166825
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 8.37
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CFB (ENSG00000243649)
    Fold Change: 7.53
    Ensembl ID: ENSG00000243649
  • Gene Symbol: ASCL2 (ENSG00000183734)
    Fold Change: 3.31
    Ensembl ID: ENSG00000183734
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.08
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.88
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.77
    Ensembl ID: ENSG00000278540
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.56
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: 2.53
    Ensembl ID: ENSG00000175164
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.47
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.47
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.38
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.31
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.21
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.19
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.14
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CCK (ENSG00000187094)
    Fold Change: 2.14
    Ensembl ID: ENSG00000187094
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.03
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 2.02
    Ensembl ID: ENSG00000102575
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.01
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.95
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.93
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.92
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.88
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.87
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.87
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.87
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BCKDHA (ENSG00000248098)
    Fold Change: 1.85
    Ensembl ID: ENSG00000248098
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.84
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.84
    Ensembl ID: ENSG00000005022
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.8
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.79
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.78
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.72
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.7
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.69
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.68
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.61
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.6
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.59
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP6V1B1 (ENSG00000116039)
    Fold Change: 1.59
    Ensembl ID: ENSG00000116039
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.59
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.57
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.55
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.53
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.52
    Ensembl ID: ENSG00000130402
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.52
    Ensembl ID: ENSG00000104964
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.47
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.47
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.46
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.46
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.45
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.42
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.4
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.39
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.37
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.37
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.37
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.37
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.36
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.36
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.36
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.34
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.29
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.29
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.29
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.28
    Ensembl ID: ENSG00000146731
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.27
    Ensembl ID: ENSG00000111348
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.23
    Ensembl ID: ENSG00000123505
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.23
    Ensembl ID: ENSG00000142599
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.22
    Ensembl ID: ENSG00000108561
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.21
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.2
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.19
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.17
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.17
    Ensembl ID: ENSG00000004059
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.15
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.14
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.13
    Ensembl ID: ENSG00000112576
  • Gene Symbol: C4B (ENSG00000224389)
    Fold Change: 1.13
    Ensembl ID: ENSG00000224389
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.12
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.1
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.09
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.08
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.08
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.07
    Ensembl ID: ENSG00000087088
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.05
    Ensembl ID: ENSG00000010278
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.04
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.04
    Ensembl ID: ENSG00000137845
  • Gene Symbol: C4A (ENSG00000244731)
    Fold Change: 1.03
    Ensembl ID: ENSG00000244731
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.02
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.02
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.01
    Ensembl ID: ENSG00000131100
Hovered Details

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Hovered Details

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**Key Characteristics** * Tracheal goblet cell (SLC25A6) + Produces and secretes mucus + Involved in apoptosis and mitochondrial function + Involvement in protein metabolism and transport * ADH1C (alcohol dehydrogenase) + Involved in alcohol metabolism + Has zinc-dependent activity + Involvement in biological oxidations and ethanol oxidation * ANPEP (aminopeptidase) + Involved in protein degradation and catabolism + Has metalloaminopeptidase activity + Involvement in immune system and neutrophil degranulation * ATP6V0C (proton-transporting ATPase) + Involved in ion transport and proton motive force-driven ATP synthesis + Has V-type ATPase activity + Involvement in cellular responses to stimuli, stress, and starvation **Clinical Significance** The tracheal goblet cell plays a crucial role in the respiratory system, and its dysfunction can lead to respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma. The ADH1C, ANPEP, and ATP6V0C cells are also involved in various physiological processes, and their dysfunction can lead to metabolic disorders, such as alcoholism and protein-related diseases. Understanding the functions and dysregulation of these cells can provide insights into the development of novel therapeutic strategies for various diseases. Additionally, the study of these cells can help to identify potential biomarkers for disease diagnosis and monitoring. **Disease Association** The tracheal goblet cell has been implicated in various respiratory diseases, including: * Chronic obstructive pulmonary disease (COPD) * Asthma * Cystic fibrosis * Pneumonia * Bronchiectasis The ADH1C, ANPEP, and ATP6V0C cells have been implicated in various metabolic disorders, including: * Alcoholism * Protein-related diseases (e.g., kidney disease, cancer) * Ion transport disorders (e.g., hypokalemic periodic paralysis) * Metabolic syndrome **References** * [Insert references] **Note**: The information provided is a summary of the cell characteristics, key characteristics, and clinical significance of the cell ID CL1000329. The references section is not provided as it is not included in the original text.