Details for: CL1000347

Cell ID: CL1000347

Cell Name: enterocyte of colon

Marker Score Threshold: 1541
(Derived using integrated single-cell and genomic data)

Description: A columnar cell of the colon that is part of the colonic epithelium.

Synonyms: colonocyte, enterocyte of colon, vacuolar absorptive cell of epithelium of colon

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 9.03
    Ensembl ID: ENSG00000130203
  • Gene Symbol: AADAC (ENSG00000114771)
    Fold Change: 7.67
    Ensembl ID: ENSG00000114771
  • Gene Symbol: AFP (ENSG00000081051)
    Fold Change: 6.04
    Ensembl ID: ENSG00000081051
  • Gene Symbol: AGT (ENSG00000135744)
    Fold Change: 4.34
    Ensembl ID: ENSG00000135744
  • Gene Symbol: AMHR2 (ENSG00000135409)
    Fold Change: 3.47
    Ensembl ID: ENSG00000135409
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 3.38
    Ensembl ID: ENSG00000158874
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 3.32
    Ensembl ID: ENSG00000141505
  • Gene Symbol: APOC2 (ENSG00000234906)
    Fold Change: 3.21
    Ensembl ID: ENSG00000234906
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 2.74
    Ensembl ID: ENSG00000136872
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 2.73
    Ensembl ID: ENSG00000166825
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.72
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.72
    Ensembl ID: ENSG00000075624
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 2.7
    Ensembl ID: ENSG00000110245
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 2.68
    Ensembl ID: ENSG00000118137
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.67
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.67
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.66
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.65
    Ensembl ID: ENSG00000163399
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.63
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.62
    Ensembl ID: ENSG00000149925
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.61
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.59
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.57
    Ensembl ID: ENSG00000154518
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: 2.56
    Ensembl ID: ENSG00000002726
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.55
    Ensembl ID: ENSG00000154723
  • Gene Symbol: APOA4 (ENSG00000110244)
    Fold Change: 2.53
    Ensembl ID: ENSG00000110244
  • Gene Symbol: APOB (ENSG00000084674)
    Fold Change: 2.52
    Ensembl ID: ENSG00000084674
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.5
    Ensembl ID: ENSG00000145741
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.5
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.48
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 2.45
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.44
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.39
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 2.31
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.29
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.28
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 2.23
    Ensembl ID: ENSG00000196975
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.21
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.16
    Ensembl ID: ENSG00000143153
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 2.16
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2.14
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.07
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.07
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.06
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 2.05
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ACADS (ENSG00000122971)
    Fold Change: 2.04
    Ensembl ID: ENSG00000122971
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.04
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.02
    Ensembl ID: ENSG00000159199
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.99
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.96
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.89
    Ensembl ID: ENSG00000122359
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.89
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.87
    Ensembl ID: ENSG00000100412
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.86
    Ensembl ID: ENSG00000165272
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.84
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.84
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.83
    Ensembl ID: ENSG00000111275
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.83
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.78
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.77
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ALPI (ENSG00000163295)
    Fold Change: 1.76
    Ensembl ID: ENSG00000163295
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.76
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.75
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.69
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.68
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.62
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.62
    Ensembl ID: ENSG00000116459
  • Gene Symbol: C5 (ENSG00000106804)
    Fold Change: 1.61
    Ensembl ID: ENSG00000106804
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.58
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.55
    Ensembl ID: ENSG00000161533
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.53
    Ensembl ID: ENSG00000107262
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.53
    Ensembl ID: ENSG00000102554
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.53
    Ensembl ID: ENSG00000185883
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.5
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.48
    Ensembl ID: ENSG00000165092
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.47
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AMBP (ENSG00000106927)
    Fold Change: 1.41
    Ensembl ID: ENSG00000106927
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: 1.37
    Ensembl ID: ENSG00000175164
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.36
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.36
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.34
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ADH4 (ENSG00000198099)
    Fold Change: 1.29
    Ensembl ID: ENSG00000198099
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.29
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.28
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.25
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.23
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.22
    Ensembl ID: ENSG00000085224
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 1.21
    Ensembl ID: ENSG00000137731
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.2
    Ensembl ID: ENSG00000213465
  • Gene Symbol: AQP7 (ENSG00000165269)
    Fold Change: 1.19
    Ensembl ID: ENSG00000165269
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.16
    Ensembl ID: ENSG00000149823
  • Gene Symbol: APOBEC1 (ENSG00000111701)
    Fold Change: 1.16
    Ensembl ID: ENSG00000111701
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ACY1 (ENSG00000243989)
    Fold Change: 1.1
    Ensembl ID: ENSG00000243989
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.09
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.09
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.08
    Ensembl ID: ENSG00000002330
  • Gene Symbol: AFM (ENSG00000079557)
    Fold Change: 1.07
    Ensembl ID: ENSG00000079557
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 1.07
    Ensembl ID: ENSG00000189058
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.04
    Ensembl ID: ENSG00000177105
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Columnar shape**: The enterocyte is a columnar cell, which allows for efficient absorption of nutrients from the lumen of the colon. 2. **Vacuolar structure**: The enterocyte has a distinct vacuolar structure, which is involved in the storage and transport of lipids and cholesterol. 3. **Lipid transport**: The enterocyte is involved in the transport of lipids, including fatty acids and cholesterol, from the lumen of the colon to the bloodstream. 4. **Cholesterol efflux**: The enterocyte plays a key role in the efflux of cholesterol from the bloodstream to the liver, where it can be excreted. 5. **Amyloid-beta clearance**: The enterocyte is involved in the clearance of amyloid-beta, a protein associated with Alzheimer's disease, from the bloodstream. 6. **Gap junctions**: The enterocyte is interconnected with other cells through gap junctions, allowing for the exchange of signaling molecules and nutrients. 7. **Specialized gene expression**: The enterocyte has a unique gene expression profile, which includes genes involved in lipid transport, cholesterol efflux, and amyloid-beta clearance. **Clinical Significance** 1. **Lipid metabolism disorders**: Dysregulation of lipid metabolism in the enterocyte can lead to lipid metabolism disorders, such as hyperlipidemia and atherosclerosis. 2. **Cholesterol homeostasis**: The enterocyte plays a crucial role in maintaining cholesterol homeostasis, and dysregulation of this process can lead to cardiovascular disease. 3. **Alzheimer's disease**: The enterocyte's role in amyloid-beta clearance has implications for the development of Alzheimer's disease, as impaired clearance of amyloid-beta can contribute to disease progression. 4. **Inflammatory bowel disease**: The enterocyte's role in maintaining the integrity of the blood-brain barrier is critical in inflammatory bowel disease, where inflammation can disrupt this barrier and lead to neurological symptoms. 5. **Nutrient absorption**: The enterocyte's ability to absorb nutrients from the lumen of the colon is essential for maintaining energy homeostasis and overall health. In conclusion, the enterocyte of colon is a specialized cell type that plays a critical role in lipid metabolism, cholesterol homeostasis, and amyloid-beta clearance. Its dysregulation can contribute to various diseases, including lipid metabolism disorders, cardiovascular disease, Alzheimer's disease, and inflammatory bowel disease. Further research is needed to fully understand the enterocyte's role in human health and disease.