Details for: CL1000347

Cell ID: CL1000347

Cell Name: enterocyte of colon

Marker Score Threshold: 1,541
(Derived using integrated single-cell and genomic data)

Description: A columnar cell of the colon that is part of the colonic epithelium.

Synonyms: colonocyte, enterocyte of colon, vacuolar absorptive cell of epithelium of colon

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: MTTP (ENSG00000138823)
    Fold Change: 12.74
    Ensembl ID: ENSG00000138823
  • Gene Symbol: HPN (ENSG00000105707)
    Fold Change: 9.67
    Ensembl ID: ENSG00000105707
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 9.03
    Ensembl ID: ENSG00000130203
  • Gene Symbol: CPS1 (ENSG00000021826)
    Fold Change: 8.33
    Ensembl ID: ENSG00000021826
  • Gene Symbol: FGB (ENSG00000171564)
    Fold Change: 8.22
    Ensembl ID: ENSG00000171564
  • Gene Symbol: AADAC (ENSG00000114771)
    Fold Change: 7.67
    Ensembl ID: ENSG00000114771
  • Gene Symbol: MME (ENSG00000196549)
    Fold Change: 7.48
    Ensembl ID: ENSG00000196549
  • Gene Symbol: MFAP2 (ENSG00000117122)
    Fold Change: 7.25
    Ensembl ID: ENSG00000117122
  • Gene Symbol: FOLH1 (ENSG00000086205)
    Fold Change: 7.02
    Ensembl ID: ENSG00000086205
  • Gene Symbol: GSTA2 (ENSG00000244067)
    Fold Change: 6.11
    Ensembl ID: ENSG00000244067
  • Gene Symbol: AFP (ENSG00000081051)
    Fold Change: 6.04
    Ensembl ID: ENSG00000081051
  • Gene Symbol: FGG (ENSG00000171557)
    Fold Change: 5.21
    Ensembl ID: ENSG00000171557
  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 4.93
    Ensembl ID: ENSG00000173406
  • Gene Symbol: F10 (ENSG00000126218)
    Fold Change: 4.67
    Ensembl ID: ENSG00000126218
  • Gene Symbol: AGT (ENSG00000135744)
    Fold Change: 4.34
    Ensembl ID: ENSG00000135744
  • Gene Symbol: GAMT (ENSG00000130005)
    Fold Change: 4.3
    Ensembl ID: ENSG00000130005
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 3.85
    Ensembl ID: ENSG00000104267
  • Gene Symbol: KEL (ENSG00000197993)
    Fold Change: 3.85
    Ensembl ID: ENSG00000197993
  • Gene Symbol: MYH10 (ENSG00000133026)
    Fold Change: 3.72
    Ensembl ID: ENSG00000133026
  • Gene Symbol: FBLN1 (ENSG00000077942)
    Fold Change: 3.61
    Ensembl ID: ENSG00000077942
  • Gene Symbol: FN1 (ENSG00000115414)
    Fold Change: 3.57
    Ensembl ID: ENSG00000115414
  • Gene Symbol: AMHR2 (ENSG00000135409)
    Fold Change: 3.47
    Ensembl ID: ENSG00000135409
  • Gene Symbol: LCT (ENSG00000115850)
    Fold Change: 3.45
    Ensembl ID: ENSG00000115850
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 3.38
    Ensembl ID: ENSG00000158874
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 3.32
    Ensembl ID: ENSG00000141505
  • Gene Symbol: APOC2 (ENSG00000234906)
    Fold Change: 3.21
    Ensembl ID: ENSG00000234906
  • Gene Symbol: GJA1 (ENSG00000152661)
    Fold Change: 3.19
    Ensembl ID: ENSG00000152661
  • Gene Symbol: EDNRB (ENSG00000136160)
    Fold Change: 3.16
    Ensembl ID: ENSG00000136160
  • Gene Symbol: MFGE8 (ENSG00000140545)
    Fold Change: 2.99
    Ensembl ID: ENSG00000140545
  • Gene Symbol: GATA4 (ENSG00000136574)
    Fold Change: 2.84
    Ensembl ID: ENSG00000136574
  • Gene Symbol: GSDME (ENSG00000105928)
    Fold Change: 2.79
    Ensembl ID: ENSG00000105928
  • Gene Symbol: KIFC3 (ENSG00000140859)
    Fold Change: 2.76
    Ensembl ID: ENSG00000140859
  • Gene Symbol: FABP6 (ENSG00000170231)
    Fold Change: 2.75
    Ensembl ID: ENSG00000170231
  • Gene Symbol: DPEP1 (ENSG00000015413)
    Fold Change: 2.74
    Ensembl ID: ENSG00000015413
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 2.74
    Ensembl ID: ENSG00000136872
  • Gene Symbol: FABP1 (ENSG00000163586)
    Fold Change: 2.73
    Ensembl ID: ENSG00000163586
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.73
    Ensembl ID: ENSG00000087086
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 2.73
    Ensembl ID: ENSG00000166825
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.73
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.73
    Ensembl ID: ENSG00000167996
  • Gene Symbol: LGALS2 (ENSG00000100079)
    Fold Change: 2.72
    Ensembl ID: ENSG00000100079
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.72
    Ensembl ID: ENSG00000166710
  • Gene Symbol: FABP2 (ENSG00000145384)
    Fold Change: 2.72
    Ensembl ID: ENSG00000145384
  • Gene Symbol: LGALS4 (ENSG00000171747)
    Fold Change: 2.72
    Ensembl ID: ENSG00000171747
  • Gene Symbol: KRT8 (ENSG00000170421)
    Fold Change: 2.72
    Ensembl ID: ENSG00000170421
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.72
    Ensembl ID: ENSG00000111640
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.72
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CLDN3 (ENSG00000165215)
    Fold Change: 2.72
    Ensembl ID: ENSG00000165215
  • Gene Symbol: GUCA2A (ENSG00000197273)
    Fold Change: 2.72
    Ensembl ID: ENSG00000197273
  • Gene Symbol: KRT19 (ENSG00000171345)
    Fold Change: 2.71
    Ensembl ID: ENSG00000171345
  • Gene Symbol: MYL6 (ENSG00000092841)
    Fold Change: 2.71
    Ensembl ID: ENSG00000092841
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 2.71
    Ensembl ID: ENSG00000198804
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 2.71
    Ensembl ID: ENSG00000198938
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.71
    Ensembl ID: ENSG00000149806
  • Gene Symbol: EPCAM (ENSG00000119888)
    Fold Change: 2.71
    Ensembl ID: ENSG00000119888
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 2.71
    Ensembl ID: ENSG00000198712
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.71
    Ensembl ID: ENSG00000131143
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 2.71
    Ensembl ID: ENSG00000198840
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.7
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 2.7
    Ensembl ID: ENSG00000198727
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 2.7
    Ensembl ID: ENSG00000198886
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 2.7
    Ensembl ID: ENSG00000198888
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 2.7
    Ensembl ID: ENSG00000198899
  • Gene Symbol: IGF2 (ENSG00000167244)
    Fold Change: 2.7
    Ensembl ID: ENSG00000167244
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 2.7
    Ensembl ID: ENSG00000198763
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.7
    Ensembl ID: ENSG00000019582
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.7
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 2.7
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ND5 (ENSG00000198786)
    Fold Change: 2.7
    Ensembl ID: ENSG00000198786
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 2.7
    Ensembl ID: ENSG00000110245
  • Gene Symbol: ABCC2 (ENSG00000023839)
    Fold Change: 2.7
    Ensembl ID: ENSG00000023839
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.7
    Ensembl ID: ENSG00000172757
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 2.69
    Ensembl ID: ENSG00000206503
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.69
    Ensembl ID: ENSG00000126267
  • Gene Symbol: MT2A (ENSG00000125148)
    Fold Change: 2.69
    Ensembl ID: ENSG00000125148
  • Gene Symbol: LGALS3 (ENSG00000131981)
    Fold Change: 2.69
    Ensembl ID: ENSG00000131981
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 2.68
    Ensembl ID: ENSG00000204525
  • Gene Symbol: HLA DRA (ENSG00000204287)
    Fold Change: 2.68
    Ensembl ID: ENSG00000204287
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 2.68
    Ensembl ID: ENSG00000118137
  • Gene Symbol: KHK (ENSG00000138030)
    Fold Change: 2.68
    Ensembl ID: ENSG00000138030
  • Gene Symbol: MT1E (ENSG00000169715)
    Fold Change: 2.68
    Ensembl ID: ENSG00000169715
  • Gene Symbol: MT1G (ENSG00000125144)
    Fold Change: 2.68
    Ensembl ID: ENSG00000125144
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 2.68
    Ensembl ID: ENSG00000234745
  • Gene Symbol: IFI27 (ENSG00000165949)
    Fold Change: 2.68
    Ensembl ID: ENSG00000165949
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.67
    Ensembl ID: ENSG00000164919
  • Gene Symbol: CLDN4 (ENSG00000189143)
    Fold Change: 2.67
    Ensembl ID: ENSG00000189143
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.67
    Ensembl ID: ENSG00000114942
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.67
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.67
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CLDN7 (ENSG00000181885)
    Fold Change: 2.67
    Ensembl ID: ENSG00000181885
  • Gene Symbol: FGA (ENSG00000171560)
    Fold Change: 2.67
    Ensembl ID: ENSG00000171560
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.66
    Ensembl ID: ENSG00000124172
  • Gene Symbol: KRT18 (ENSG00000111057)
    Fold Change: 2.66
    Ensembl ID: ENSG00000111057
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 2.66
    Ensembl ID: ENSG00000117984
  • Gene Symbol: MLN (ENSG00000096395)
    Fold Change: 2.65
    Ensembl ID: ENSG00000096395
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.65
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CYB5A (ENSG00000166347)
    Fold Change: 2.65
    Ensembl ID: ENSG00000166347
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.64
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.64
    Ensembl ID: ENSG00000111775
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.64
    Ensembl ID: ENSG00000167658

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in enterocyte of colon cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in enterocyte of colon cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The Enterocyte of Colon has several key characteristics that distinguish it from other cell types: 1. **Gene Expression Profile**: The Enterocyte of Colon has a unique gene expression profile that includes genes involved in lipid metabolism, cholesterol homeostasis, and protein secretion. The cell expresses genes such as MTTP, HPN, and APOE, which are involved in the transport of lipids and proteins across the epithelial barrier. 2. **Lipid Metabolism**: The Enterocyte of Colon is involved in the metabolism of lipids, including the transport of cholesterol and phospholipids across the epithelial barrier. 3. **Cholesterol Homeostasis**: The cell plays a crucial role in maintaining cholesterol homeostasis, including the efflux of cholesterol from the cell and its transport to the bloodstream. 4. **Protein Secretion**: The Enterocyte of Colon is involved in the secretion of proteins, including enzymes and receptors, that play a role in maintaining the epithelial barrier and regulating the transport of nutrients. 5. **Epithelial Barrier Function**: The cell plays a crucial role in maintaining the epithelial barrier, including the transport of small molecules across the barrier and the regulation of the immune response. **Clinical Significance** The Enterocyte of Colon has significant clinical implications, including: 1. **Atherosclerosis**: The cell's role in lipid metabolism and cholesterol homeostasis has been implicated in the development of atherosclerosis, a condition characterized by the buildup of plaque in the arteries. 2. **Alzheimer's Disease**: The cell's expression of APOE has been linked to Alzheimer's disease, a condition characterized by the buildup of amyloid-beta plaques in the brain. 3. **Gastrointestinal Disorders**: The cell's role in maintaining the epithelial barrier has been implicated in gastrointestinal disorders, including inflammatory bowel disease and irritable bowel syndrome. 4. **Nutrition and Metabolism**: The cell's role in nutrient absorption and metabolism has significant implications for human health, including the regulation of glucose and lipid metabolism. 5. **Cancer**: The cell's expression of genes involved in lipid metabolism and cholesterol homeostasis has been implicated in the development of certain types of cancer, including colorectal cancer. In summary, the Enterocyte of Colon is a unique cell type that plays a crucial role in maintaining the epithelial barrier and regulating the transport of nutrients across the gut. Its gene expression profile and functional characteristics have significant clinical implications, including the development of atherosclerosis, Alzheimer's disease, and gastrointestinal disorders.