Details for: CL1000348

Cell ID: CL1000348

Cell Name: basal cell of epithelium of trachea

Marker Score Threshold: 7444
(Derived using integrated single-cell and genomic data)

Description: A basal cell that is part of the epithelium of trachea.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.18
    Ensembl ID: ENSG00000166710
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 4.08
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.98
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.93
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.9
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 3.74
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.61
    Ensembl ID: ENSG00000124172
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.61
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.5
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.42
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 3.31
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 3.26
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 3.25
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 3.24
    Ensembl ID: ENSG00000165092
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 3.16
    Ensembl ID: ENSG00000161798
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 3.12
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ALDH3A1 (ENSG00000108602)
    Fold Change: 3.11
    Ensembl ID: ENSG00000108602
  • Gene Symbol: ALOX15 (ENSG00000161905)
    Fold Change: 3.03
    Ensembl ID: ENSG00000161905
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.93
    Ensembl ID: ENSG00000104964
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.91
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.91
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.9
    Ensembl ID: ENSG00000169020
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.9
    Ensembl ID: ENSG00000084234
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.85
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.84
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.79
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.76
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.75
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 2.65
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.63
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.59
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.55
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ADH1C (ENSG00000248144)
    Fold Change: 2.54
    Ensembl ID: ENSG00000248144
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 2.52
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.5
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.46
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.46
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.43
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.39
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 2.38
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.31
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.28
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 2.21
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.21
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.19
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.18
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ADH7 (ENSG00000196344)
    Fold Change: 2.17
    Ensembl ID: ENSG00000196344
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2.14
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.13
    Ensembl ID: ENSG00000143761
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.11
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 2.07
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.92
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.91
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.9
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.89
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.86
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.84
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: 1.75
    Ensembl ID: ENSG00000175906
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.74
    Ensembl ID: ENSG00000151150
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.66
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.6
    Ensembl ID: ENSG00000138279
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.59
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.59
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.59
    Ensembl ID: ENSG00000168374
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.58
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.56
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.54
    Ensembl ID: ENSG00000071553
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.51
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.49
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.46
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.45
    Ensembl ID: ENSG00000100852
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.43
    Ensembl ID: ENSG00000113916
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.43
    Ensembl ID: ENSG00000143727
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.42
    Ensembl ID: ENSG00000101384
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.41
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.4
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.39
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.39
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.38
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.36
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.36
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.35
    Ensembl ID: ENSG00000058668
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.31
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.29
    Ensembl ID: ENSG00000138175
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.19
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.16
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.16
    Ensembl ID: ENSG00000128272
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.14
    Ensembl ID: ENSG00000198356
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.12
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.1
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.08
    Ensembl ID: ENSG00000241837
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.08
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.05
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.04
    Ensembl ID: ENSG00000170634
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.02
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ASCL2 (ENSG00000183734)
    Fold Change: 1.01
    Ensembl ID: ENSG00000183734
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.01
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1
    Ensembl ID: ENSG00000164062
Hovered Details

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Hovered Details

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**Key Characteristics** The basal cell of epithelium of trachea is characterized by its gene expression profile, which includes: * Genes involved in adaptive immune responses, such as adaptive immune system, antigen presentation: folding, assembly and peptide loading of class I MHC, and antigen processing and presentation of endogenous peptide antigen via MHC class I. * Genes involved in antigen processing and presentation, such as antigen processing and presentation of exogenous peptide antigen via MHC class II, and peptide antigen binding. * Genes involved in regulation of cellular proliferation, such as negative regulation of epithelial cell proliferation and negative regulation of forebrain neuron differentiation. * Genes involved in response to pathogens, such as bacterial infection pathways, and response to molecule of bacterial origin. **Clinical Significance** The basal cell of epithelium of trachea plays a crucial role in the maintenance of the tracheal epithelium and is involved in various physiological and pathological processes, including: * Respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, where the basal cell of epithelium of trachea is involved in the pathogenesis of inflammation and airway remodeling. * Cancer, where the basal cell of epithelium of trachea is involved in the development and progression of lung cancer. * Infection, where the basal cell of epithelium of trachea is involved in the response to pathogens, such as bacteria and viruses. * Allergic diseases, such as allergic rhinitis and allergic asthma, where the basal cell of epithelium of trachea is involved in the pathogenesis of inflammation and airway remodeling. Overall, the basal cell of epithelium of trachea is an important cell type that plays a crucial role in the maintenance of the tracheal epithelium and is involved in various physiological and pathological processes. Further research is needed to fully understand the function and regulation of this cell type. **Gene Symbol and Ensembl ID** The gene symbol for the basal cell of epithelium of trachea is B2M, and its Ensembl ID is ENSG00000166710. **Pathways and Ontology** The basal cell of epithelium of trachea is involved in various pathways and ontologies, including: * Adaptive immune system * Amyloid fiber formation * Amyloid fibril formation * Antigen presentation: folding, assembly and peptide loading of class I MHC * Antigen processing-cross presentation * Antigen processing and presentation of endogenous peptide antigen via MHC class I * Antigen processing and presentation of exogenous peptide antigen via MHC class II * Antigen processing and presentation of exogenous protein antigen via MHC class Ib * Bacterial infection pathways * Cellular response to iron(III) ion * Cellular response to iron ion * Cellular response to nicotine * Class I MHC mediated antigen processing & presentation * Cytokine signaling in immune system * Cytosol * Dap12 interactions * Dap12 signaling * Disease * Early endosome lumen * Early endosome membrane * Endoplasmic reticulum * Endoplasmic reticulum lumen * Endosomal/vacuolar pathway * Er-phagosome pathway * Er to Golgi transport vesicle membrane * External side of plasma membrane * Extracellular exosome * Extracellular region * Extracellular space * Focal adhesion * Golgi apparatus * Golgi membrane * Hfe-transferrin receptor complex * Hiv infection * Host interactions of hiv factors * Identical protein binding * Immune system * Immunoregulatory interactions between a lymphoid and a non-lymphoid cell * Infection with mycobacterium tuberculosis * Infectious disease * Innate immune system * Interferon gamma signaling * Interferon signaling * Intracellular iron ion homeostasis * Iron ion transport * Late endosome membrane * Learning or memory * Lysosomal membrane * Membrane * Metabolism of proteins * MHC class II protein complex * MHC class II protein complex binding * MHC class I peptide loading complex * MHC class I protein complex * Modulation by mtb of host immune system * Multicellular organismal-level iron ion homeostasis * Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters * Nef mediated downregulation of MHC class I complex cell surface expression * Negative regulation of epithelial cell proliferation * Negative regulation of forebrain neuron differentiation * Negative regulation of neurogenesis * Negative regulation of neuron projection development * Negative regulation of receptor binding * Neutrophil degranulation * Peptide antigen assembly with MHC class II protein complex * Peptide antigen assembly with MHC class I protein complex * Peptide antigen binding * Phagocytic vesicle membrane * Plasma membrane * Positive regulation of cellular senescence * Positive regulation of ferrous iron binding * Positive regulation of immune response * Positive regulation of protein binding * Positive regulation of receptor-mediated endocytosis * Positive regulation of receptor binding * Positive regulation of T cell activation * Positive regulation of T cell cytokine production * Positive regulation of T cell mediated cytotoxicity * Positive regulation of transferrin receptor binding * Protein binding * Protein homodimerization activity * Protein homotetramerization * Protein refolding * Recycling endosome membrane * Regulation of erythrocyte differentiation * Regulation of iron ion transport * Response to molecule of bacterial origin * SARS-CoV-2 activates/modulates innate and adaptive immune responses * SARS-CoV-2 infection * SARS-CoV infections * Sensory perception of smell * Specific granule lumen * Structural molecule activity * T cell differentiation in thymus * T cell mediated cytotoxicity * Tertiary granule lumen * The role of Nef in HIV-1 replication and disease pathogenesis * Viral infection pathways