Details for: CL1000353

Cell ID: CL1000353

Cell Name: microfold cell of epithelium of small intestine

Marker Score Threshold: 239
(Derived using integrated single-cell and genomic data)

Description: A M cell that is part of the epithelium of small intestine.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.86
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.63
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 4.63
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 4.6
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 4.6
    Ensembl ID: ENSG00000087086
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 4.53
    Ensembl ID: ENSG00000132475
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 4.44
    Ensembl ID: ENSG00000149806
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 4.42
    Ensembl ID: ENSG00000198804
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 4.36
    Ensembl ID: ENSG00000111640
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 4.32
    Ensembl ID: ENSG00000198938
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 4.31
    Ensembl ID: ENSG00000198712
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 4.3
    Ensembl ID: ENSG00000122566
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 4.24
    Ensembl ID: ENSG00000080824
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 4.17
    Ensembl ID: ENSG00000198899
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 4.1
    Ensembl ID: ENSG00000198886
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 4.1
    Ensembl ID: ENSG00000108654
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 4.09
    Ensembl ID: ENSG00000198727
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.04
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 3.99
    Ensembl ID: ENSG00000131143
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 3.98
    Ensembl ID: ENSG00000189403
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.95
    Ensembl ID: ENSG00000169100
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 3.93
    Ensembl ID: ENSG00000168028
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 3.93
    Ensembl ID: ENSG00000198840
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.93
    Ensembl ID: ENSG00000172757
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 3.93
    Ensembl ID: ENSG00000167658
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 3.89
    Ensembl ID: ENSG00000127184
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 3.89
    Ensembl ID: ENSG00000198888
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 3.84
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 3.78
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 3.78
    Ensembl ID: ENSG00000198763
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 3.71
    Ensembl ID: ENSG00000096384
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.65
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.64
    Ensembl ID: ENSG00000145741
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 3.52
    Ensembl ID: ENSG00000206503
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.47
    Ensembl ID: ENSG00000135390
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 3.45
    Ensembl ID: ENSG00000169567
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 3.4
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.39
    Ensembl ID: ENSG00000124172
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 3.39
    Ensembl ID: ENSG00000156976
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 3.37
    Ensembl ID: ENSG00000114942
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.36
    Ensembl ID: ENSG00000133639
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 3.34
    Ensembl ID: ENSG00000092199
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 3.34
    Ensembl ID: ENSG00000165119
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 3.32
    Ensembl ID: ENSG00000087460
  • Gene Symbol: ND5 (ENSG00000198786)
    Fold Change: 3.32
    Ensembl ID: ENSG00000198786
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 3.29
    Ensembl ID: ENSG00000234745
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 3.26
    Ensembl ID: ENSG00000204525
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 3.19
    Ensembl ID: ENSG00000126267
  • Gene Symbol: HSPA8 (ENSG00000109971)
    Fold Change: 3.18
    Ensembl ID: ENSG00000109971
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 3.17
    Ensembl ID: ENSG00000163041
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.15
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 3.14
    Ensembl ID: ENSG00000070831
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 3.13
    Ensembl ID: ENSG00000135486
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 3.13
    Ensembl ID: ENSG00000112695
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 3.12
    Ensembl ID: ENSG00000153187
  • Gene Symbol: EIF3E (ENSG00000104408)
    Fold Change: 3.1
    Ensembl ID: ENSG00000104408
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.07
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 3.06
    Ensembl ID: ENSG00000135940
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 3.06
    Ensembl ID: ENSG00000205581
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.03
    Ensembl ID: ENSG00000135404
  • Gene Symbol: JUNB (ENSG00000171223)
    Fold Change: 3.02
    Ensembl ID: ENSG00000171223
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 2.98
    Ensembl ID: ENSG00000089280
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 2.94
    Ensembl ID: ENSG00000074800
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.93
    Ensembl ID: ENSG00000067082
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 2.93
    Ensembl ID: ENSG00000167468
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 2.92
    Ensembl ID: ENSG00000110321
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.91
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.89
    Ensembl ID: ENSG00000077549
  • Gene Symbol: HNRNPH1 (ENSG00000169045)
    Fold Change: 2.89
    Ensembl ID: ENSG00000169045
  • Gene Symbol: JUN (ENSG00000177606)
    Fold Change: 2.89
    Ensembl ID: ENSG00000177606
  • Gene Symbol: KTN1 (ENSG00000126777)
    Fold Change: 2.89
    Ensembl ID: ENSG00000126777
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.88
    Ensembl ID: ENSG00000179218
  • Gene Symbol: GUK1 (ENSG00000143774)
    Fold Change: 2.87
    Ensembl ID: ENSG00000143774
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 2.87
    Ensembl ID: ENSG00000120129
  • Gene Symbol: HLA E (ENSG00000204592)
    Fold Change: 2.85
    Ensembl ID: ENSG00000204592
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 2.84
    Ensembl ID: ENSG00000084207
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 2.83
    Ensembl ID: ENSG00000170345
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.79
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.78
    Ensembl ID: ENSG00000122545
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 2.78
    Ensembl ID: ENSG00000176340
  • Gene Symbol: H2AZ1 (ENSG00000164032)
    Fold Change: 2.77
    Ensembl ID: ENSG00000164032
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.76
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ND4L (ENSG00000212907)
    Fold Change: 2.75
    Ensembl ID: ENSG00000212907
  • Gene Symbol: PDIA3 (ENSG00000167004)
    Fold Change: 2.71
    Ensembl ID: ENSG00000167004
  • Gene Symbol: HSPA5 (ENSG00000044574)
    Fold Change: 2.7
    Ensembl ID: ENSG00000044574
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.69
    Ensembl ID: ENSG00000152518
  • Gene Symbol: JUND (ENSG00000130522)
    Fold Change: 2.67
    Ensembl ID: ENSG00000130522
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 2.67
    Ensembl ID: ENSG00000063046
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.66
    Ensembl ID: ENSG00000154723
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 2.64
    Ensembl ID: ENSG00000152601
  • Gene Symbol: HMGN2 (ENSG00000198830)
    Fold Change: 2.63
    Ensembl ID: ENSG00000198830
  • Gene Symbol: LDHA (ENSG00000134333)
    Fold Change: 2.62
    Ensembl ID: ENSG00000134333
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.61
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.61
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.58
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.58
    Ensembl ID: ENSG00000213719
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.56
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.56
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.56
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 2.55
    Ensembl ID: ENSG00000051523

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in microfold cell of epithelium of small intestine cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in microfold cell of epithelium of small intestine cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * **Location**: Microfold cells are found in the epithelium of the small intestine. * **Function**: M cells are involved in the uptake and processing of antigens from the gut lumen, which are then presented to immune cells via MHC class II molecules. * **Gene Expression**: M cells express a unique set of genes involved in actin cytoskeleton dynamics, adherens junctions, and antigen processing and presentation. * **MHC Class II Expression**: M cells express MHC class II molecules, which are involved in the presentation of antigens to immune cells. * **Antigen Presentation**: M cells are responsible for the uptake and processing of antigens from the gut lumen, which are then presented to immune cells via MHC class II molecules. * **Immune Regulation**: M cells are involved in the regulation of immune responses, including the activation of T cells and the production of cytokines. **Clinical Significance** * **Inflammatory Bowel Disease**: Abnormalities in M cell function have been implicated in the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. * **Vaccine Development**: M cells are an important target for vaccine development, as they are involved in the uptake and processing of antigens from the gut lumen. * **Immunotherapy**: M cells are also a target for immunotherapy, as they are involved in the regulation of immune responses. * **Cancer**: Abnormalities in M cell function have been implicated in the development of certain types of cancer, including colorectal cancer. * **Gastrointestinal Disorders**: M cells are involved in the regulation of immune responses in the gut, and abnormalities in M cell function have been implicated in a range of gastrointestinal disorders, including celiac disease and irritable bowel syndrome (IBS).