Details for: CL1000353

Cell ID: CL1000353

Cell Name: microfold cell of epithelium of small intestine

Marker Score Threshold: 239
(Derived using integrated single-cell and genomic data)

Description: A M cell that is part of the epithelium of small intestine.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.86
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.63
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.04
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.95
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.65
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.64
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.47
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.39
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.36
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.15
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.07
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.79
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.76
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.69
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.66
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.61
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.61
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.58
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.56
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.56
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.56
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.48
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.37
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.34
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.26
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.26
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.24
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.23
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.09
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.06
    Ensembl ID: ENSG00000164111
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.05
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.04
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.04
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.03
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.03
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.02
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.92
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.9
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.89
    Ensembl ID: ENSG00000069849
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.88
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.84
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.84
    Ensembl ID: ENSG00000104765
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.82
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.8
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.8
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.79
    Ensembl ID: ENSG00000072778
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.78
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.75
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.7
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.69
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.68
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.67
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.66
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.64
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.63
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.61
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.59
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.58
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.57
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.57
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.54
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.52
    Ensembl ID: ENSG00000087274
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.51
    Ensembl ID: ENSG00000142599
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.49
    Ensembl ID: ENSG00000143799
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.48
    Ensembl ID: ENSG00000107262
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.48
    Ensembl ID: ENSG00000183255
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.47
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.44
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.39
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.38
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.38
    Ensembl ID: ENSG00000130303
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.35
    Ensembl ID: ENSG00000006125
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.35
    Ensembl ID: ENSG00000149823
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.34
    Ensembl ID: ENSG00000140299
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.29
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.29
    Ensembl ID: ENSG00000137845
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.28
    Ensembl ID: ENSG00000177105
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.26
    Ensembl ID: ENSG00000004455
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.23
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.23
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.2
    Ensembl ID: ENSG00000197043
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.19
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.18
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.15
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.14
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.13
    Ensembl ID: ENSG00000213465
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.13
    Ensembl ID: ENSG00000147872
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.12
    Ensembl ID: ENSG00000142188
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.11
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.11
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.1
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.1
    Ensembl ID: ENSG00000071553
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.1
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100852
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.08
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.07
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.04
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.02
    Ensembl ID: ENSG00000120805
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.01
    Ensembl ID: ENSG00000002330
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Morphology**: M cells have a unique morphology, characterized by finger-like projections and a high expression of MHC class II molecules. 2. **Antigen Uptake**: M cells are specialized for the uptake of antigens from the gut lumen, facilitating the initiation of immune responses. 3. **MHC Class II Expression**: M cells express high levels of MHC class II molecules, which are essential for the presentation of antigens to T cells. 4. **T Cell Activation**: M cells interact with T cells, activating the immune response against pathogens. 5. **Disease Implication**: Dysregulation of M cells has been implicated in various diseases, including inflammatory bowel disease and autoimmune disorders. **Clinical Significance** 1. **Inflammatory Bowel Disease**: M cells have been implicated in the pathogenesis of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. 2. **Autoimmune Disorders**: Dysregulation of M cells has been linked to the development of autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. 3. **Vaccine Development**: M cells have been explored as a target for vaccine development, as they can be used to deliver antigens to the immune system. 4. **Cancer Immunotherapy**: M cells have been investigated as a potential target for cancer immunotherapy, as they can be used to deliver antigens to the immune system. 5. **Gut Microbiome Research**: M cells have been implicated in the regulation of the gut microbiome, and dysregulation of M cells has been linked to changes in the composition of the gut microbiome. In conclusion, the microfold cell is a specialized epithelial cell that plays a crucial role in the immune system by facilitating the uptake of antigens from the gut lumen. Its dysregulation has been implicated in various diseases, including inflammatory bowel disease and autoimmune disorders, and has potential applications in vaccine development and cancer immunotherapy.