Details for: CL1000398

Cell ID: CL1000398

Cell Name: endothelial cell of hepatic sinusoid

Marker Score Threshold: 219
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates.

Synonyms: LSEC, endotheliocyte of hepatic sinusoid, liver sinusoidal endothelial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.58
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.26
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.86
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.69
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.61
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 2.59
    Ensembl ID: ENSG00000163631
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.59
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.54
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.5
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.47
    Ensembl ID: ENSG00000143933
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.4
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.31
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.23
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.19
    Ensembl ID: ENSG00000143761
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 2.18
    Ensembl ID: ENSG00000110245
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.16
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.11
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.06
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.03
    Ensembl ID: ENSG00000172270
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.98
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.96
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.96
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.87
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.87
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.86
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.83
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.83
    Ensembl ID: ENSG00000165629
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.82
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.78
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.78
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.75
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.74
    Ensembl ID: ENSG00000168374
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 1.73
    Ensembl ID: ENSG00000158874
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.73
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.68
    Ensembl ID: ENSG00000182718
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.66
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 1.65
    Ensembl ID: ENSG00000120907
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.65
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.63
    Ensembl ID: ENSG00000072778
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.63
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.63
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.62
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.58
    Ensembl ID: ENSG00000149925
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.58
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.58
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.58
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.55
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.54
    Ensembl ID: ENSG00000122359
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.54
    Ensembl ID: ENSG00000143878
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.52
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.51
    Ensembl ID: ENSG00000241837
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.51
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.5
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.5
    Ensembl ID: ENSG00000130402
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.49
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.46
    Ensembl ID: ENSG00000069849
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 1.46
    Ensembl ID: ENSG00000118137
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.45
    Ensembl ID: ENSG00000177556
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.44
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.43
    Ensembl ID: ENSG00000164111
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.43
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.43
    Ensembl ID: ENSG00000102575
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.41
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.41
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.39
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.38
    Ensembl ID: ENSG00000087088
  • Gene Symbol: C7 (ENSG00000112936)
    Fold Change: 1.38
    Ensembl ID: ENSG00000112936
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.35
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.35
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.33
    Ensembl ID: ENSG00000165527
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.3
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.29
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.29
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.27
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.26
    Ensembl ID: ENSG00000104765
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.21
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.2
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.2
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.19
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.19
    Ensembl ID: ENSG00000122786
  • Gene Symbol: AMBP (ENSG00000106927)
    Fold Change: 1.17
    Ensembl ID: ENSG00000106927
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.17
    Ensembl ID: ENSG00000130203
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.15
    Ensembl ID: ENSG00000004455
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.15
    Ensembl ID: ENSG00000142599
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.15
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.11
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.11
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.11
    Ensembl ID: ENSG00000131100
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.11
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.08
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.06
    Ensembl ID: ENSG00000197043
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.06
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.05
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.04
    Ensembl ID: ENSG00000204574
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.03
    Ensembl ID: ENSG00000023445
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.03
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.02
    Ensembl ID: ENSG00000111275
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.02
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: N/A
    Ensembl ID: ENSG00000196975
Hovered Details

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Hovered Details

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**Key Characteristics** The CL1000398 cell has several distinctive features, including: 1. **Fenestrae**: The cell contains flattened areas with small pores, known as fenestrae, which allow for the exchange of molecules between the bloodstream and the liver cells. 2. **Sieve plates**: The fenestrae are arranged in groups known as sieve plates, which are critical for the exchange of molecules. 3. **Actin cytoskeleton**: The cell has a dynamic actin cytoskeleton, which is involved in cell motility and shape changes. 4. **Apical junction complex**: The cell has an apical junction complex, which is involved in cell-cell communication and adhesion. 5. **Adherens junctions**: The cell has adherens junctions, which are involved in cell-cell adhesion and signaling. **Clinical Significance** The CL1000398 cell plays a critical role in liver function, and its dysfunction can lead to various liver diseases. Some of the clinical significance of this cell includes: 1. **Liver disease**: The CL1000398 cell is involved in liver disease, including conditions such as liver cirrhosis, liver fibrosis, and liver cancer. 2. **Hepatic sinusoid dysfunction**: The cell's dysfunction can lead to impaired exchange of molecules between the bloodstream and liver cells, resulting in liver dysfunction. 3. **Cancer**: The CL1000398 cell is involved in cancer, including liver cancer, where its dysfunction can contribute to tumor growth and metastasis. 4. **Infectious diseases**: The cell's role in immune system function makes it relevant to infectious diseases, such as hepatitis and malaria, where it can be involved in the pathogenesis of these diseases. In conclusion, the CL1000398 cell is a specialized cell type that plays a critical role in liver function, and its dysfunction can lead to various liver diseases. Further research is needed to understand the mechanisms underlying its function and to develop therapeutic strategies to treat liver diseases.