Details for: CL1000488

Cell ID: CL1000488

Cell Name: cholangiocyte

Marker Score Threshold: 374
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.

Synonyms: epithelial cell of bile duct

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.68
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.47
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.3
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.27
    Ensembl ID: ENSG00000185650
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.16
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.05
    Ensembl ID: ENSG00000135390
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 2.04
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.03
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.03
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.98
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.94
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.89
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.89
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.85
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.85
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.83
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.83
    Ensembl ID: ENSG00000145349
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.83
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.81
    Ensembl ID: ENSG00000152518
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.79
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.72
    Ensembl ID: ENSG00000072778
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.69
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.66
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.62
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.6
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.58
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.58
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.58
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.55
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.54
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.54
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.53
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.52
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.5
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.5
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.48
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.47
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.46
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.45
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.45
    Ensembl ID: ENSG00000100852
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.43
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.43
    Ensembl ID: ENSG00000152234
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.42
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.41
    Ensembl ID: ENSG00000170634
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.4
    Ensembl ID: ENSG00000005022
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.39
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.39
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.39
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.37
    Ensembl ID: ENSG00000156273
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.35
    Ensembl ID: ENSG00000116489
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.35
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.34
    Ensembl ID: ENSG00000087274
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.33
    Ensembl ID: ENSG00000130203
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.33
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.32
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.32
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.31
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.31
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.31
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.3
    Ensembl ID: ENSG00000198363
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.3
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.26
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.24
    Ensembl ID: ENSG00000116459
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.21
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.2
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.2
    Ensembl ID: ENSG00000111275
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.19
    Ensembl ID: ENSG00000160014
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.18
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.17
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.16
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.14
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.13
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.13
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.13
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.12
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.12
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.11
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.11
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.1
    Ensembl ID: ENSG00000117054
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.1
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.1
    Ensembl ID: ENSG00000060971
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.08
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.08
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.07
    Ensembl ID: ENSG00000165092
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.07
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149925
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.06
    Ensembl ID: ENSG00000119138
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.05
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.04
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.03
    Ensembl ID: ENSG00000072110
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.03
    Ensembl ID: ENSG00000130208
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.03
    Ensembl ID: ENSG00000101966
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.01
    Ensembl ID: ENSG00000147872
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.01
    Ensembl ID: ENSG00000100300
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.01
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.01
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.01
    Ensembl ID: ENSG00000160710
Hovered Details

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Hovered Details

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**Key Characteristics** * **Location**: Cholangiocytes are found in the small interlobular bile ducts, but become columnar and mucus-secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. * **Function**: Cholangiocytes are responsible for the secretion of bile, which is composed of bile salts, cholesterol, and bilirubin. * **Bicarbonate and water secretion**: Cholangiocytes secrete bicarbonate and water into the bile, which helps to neutralize the acidity of the bile and facilitate its flow into the intestine. * **Immune response**: Cholangiocytes are involved in the immune response, particularly in the context of viral infections such as HIV and SARS-CoV-2. * **Gene expression**: Cholangiocytes express a range of genes involved in immune response, including those involved in antigen presentation, cytokine signaling, and the response to viral infections. **Clinical Significance** * **Bile duct disease**: Cholangiocytes are involved in the pathogenesis of bile duct disease, including cholestasis, which is characterized by the accumulation of bile in the liver and gallbladder. * **Cholangiocarcinoma**: Cholangiocytes can give rise to cholangiocarcinoma, a type of cancer that occurs in the bile ducts. * **Viral infections**: Cholangiocytes are involved in the immune response to viral infections such as HIV and SARS-CoV-2, which can lead to chronic liver disease and cirrhosis. * **Liver transplantation**: Cholangiocytes play a crucial role in the liver's ability to regenerate after transplantation, and their dysfunction can lead to graft failure. In conclusion, cholangiocytes are a crucial component of the liver's biliary system, and their dysfunction can lead to a range of clinical disorders. Further research is needed to understand the mechanisms underlying cholangiocyte function and dysfunction, and to develop effective treatments for bile duct disease and cholangiocarcinoma.