Details for: CL1000488

Cell ID: CL1000488

Cell Name: cholangiocyte

Marker Score Threshold: 374
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.

Synonyms: epithelial cell of bile duct

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 3.85
    Ensembl ID: ENSG00000198938
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 3.78
    Ensembl ID: ENSG00000198712
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 3.72
    Ensembl ID: ENSG00000198804
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 3.67
    Ensembl ID: ENSG00000198899
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 3.61
    Ensembl ID: ENSG00000198840
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 3.5
    Ensembl ID: ENSG00000198886
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 3.41
    Ensembl ID: ENSG00000198888
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 3.39
    Ensembl ID: ENSG00000198727
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 3.33
    Ensembl ID: ENSG00000198763
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 3.18
    Ensembl ID: ENSG00000087086
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.83
    Ensembl ID: ENSG00000122566
  • Gene Symbol: ND5 (ENSG00000198786)
    Fold Change: 2.73
    Ensembl ID: ENSG00000198786
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.68
    Ensembl ID: ENSG00000166710
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.58
    Ensembl ID: ENSG00000092199
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 2.55
    Ensembl ID: ENSG00000152601
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.47
    Ensembl ID: ENSG00000075624
  • Gene Symbol: HNRNPH1 (ENSG00000169045)
    Fold Change: 2.47
    Ensembl ID: ENSG00000169045
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.44
    Ensembl ID: ENSG00000149806
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.43
    Ensembl ID: ENSG00000108654
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.38
    Ensembl ID: ENSG00000167996
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.33
    Ensembl ID: ENSG00000132475
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.3
    Ensembl ID: ENSG00000169100
  • Gene Symbol: RPL10A (ENSG00000198755)
    Fold Change: 2.27
    Ensembl ID: ENSG00000198755
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.27
    Ensembl ID: ENSG00000185650
  • Gene Symbol: LPP (ENSG00000145012)
    Fold Change: 2.27
    Ensembl ID: ENSG00000145012
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 2.23
    Ensembl ID: ENSG00000144674
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.23
    Ensembl ID: ENSG00000111640
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.21
    Ensembl ID: ENSG00000156508
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.2
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ND4L (ENSG00000212907)
    Fold Change: 2.2
    Ensembl ID: ENSG00000212907
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.16
    Ensembl ID: ENSG00000142599
  • Gene Symbol: OAZ1 (ENSG00000104904)
    Fold Change: 2.16
    Ensembl ID: ENSG00000104904
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 2.12
    Ensembl ID: ENSG00000080824
  • Gene Symbol: MYL6 (ENSG00000092841)
    Fold Change: 2.12
    Ensembl ID: ENSG00000092841
  • Gene Symbol: PFDN5 (ENSG00000123349)
    Fold Change: 2.1
    Ensembl ID: ENSG00000123349
  • Gene Symbol: NFIB (ENSG00000147862)
    Fold Change: 2.09
    Ensembl ID: ENSG00000147862
  • Gene Symbol: NACA (ENSG00000196531)
    Fold Change: 2.08
    Ensembl ID: ENSG00000196531
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 2.06
    Ensembl ID: ENSG00000168028
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 2.06
    Ensembl ID: ENSG00000113712
  • Gene Symbol: NKTR (ENSG00000114857)
    Fold Change: 2.06
    Ensembl ID: ENSG00000114857
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.05
    Ensembl ID: ENSG00000135390
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.05
    Ensembl ID: ENSG00000099622
  • Gene Symbol: FKBP5 (ENSG00000096060)
    Fold Change: 2.05
    Ensembl ID: ENSG00000096060
  • Gene Symbol: KTN1 (ENSG00000126777)
    Fold Change: 2.05
    Ensembl ID: ENSG00000126777
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.04
    Ensembl ID: ENSG00000131143
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 2.04
    Ensembl ID: ENSG00000196975
  • Gene Symbol: PEBP1 (ENSG00000089220)
    Fold Change: 2.04
    Ensembl ID: ENSG00000089220
  • Gene Symbol: ELF1 (ENSG00000120690)
    Fold Change: 2.03
    Ensembl ID: ENSG00000120690
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.03
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.03
    Ensembl ID: ENSG00000145741
  • Gene Symbol: GTF2I (ENSG00000263001)
    Fold Change: 2.02
    Ensembl ID: ENSG00000263001
  • Gene Symbol: PCBP2 (ENSG00000197111)
    Fold Change: 2.02
    Ensembl ID: ENSG00000197111
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 1.99
    Ensembl ID: ENSG00000171634
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 1.99
    Ensembl ID: ENSG00000096384
  • Gene Symbol: PFN1 (ENSG00000108518)
    Fold Change: 1.99
    Ensembl ID: ENSG00000108518
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.98
    Ensembl ID: ENSG00000085224
  • Gene Symbol: NFIA (ENSG00000162599)
    Fold Change: 1.98
    Ensembl ID: ENSG00000162599
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.97
    Ensembl ID: ENSG00000127184
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 1.97
    Ensembl ID: ENSG00000189403
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.94
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.94
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.91
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.89
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.89
    Ensembl ID: ENSG00000198668
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 1.88
    Ensembl ID: ENSG00000104529
  • Gene Symbol: PCM1 (ENSG00000078674)
    Fold Change: 1.88
    Ensembl ID: ENSG00000078674
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.88
    Ensembl ID: ENSG00000198589
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 1.87
    Ensembl ID: ENSG00000089280
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.87
    Ensembl ID: ENSG00000114942
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 1.86
    Ensembl ID: ENSG00000167658
  • Gene Symbol: P4HB (ENSG00000185624)
    Fold Change: 1.86
    Ensembl ID: ENSG00000185624
  • Gene Symbol: MAP4 (ENSG00000047849)
    Fold Change: 1.85
    Ensembl ID: ENSG00000047849
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.85
    Ensembl ID: ENSG00000130402
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 1.85
    Ensembl ID: ENSG00000153187
  • Gene Symbol: IL6ST (ENSG00000134352)
    Fold Change: 1.85
    Ensembl ID: ENSG00000134352
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.85
    Ensembl ID: ENSG00000156110
  • Gene Symbol: NR3C1 (ENSG00000113580)
    Fold Change: 1.84
    Ensembl ID: ENSG00000113580
  • Gene Symbol: MKLN1 (ENSG00000128585)
    Fold Change: 1.84
    Ensembl ID: ENSG00000128585
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.83
    Ensembl ID: ENSG00000163399
  • Gene Symbol: HSPA8 (ENSG00000109971)
    Fold Change: 1.83
    Ensembl ID: ENSG00000109971
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.83
    Ensembl ID: ENSG00000145349
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.83
    Ensembl ID: ENSG00000133639
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.83
    Ensembl ID: ENSG00000067082
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.82
    Ensembl ID: ENSG00000156976
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.81
    Ensembl ID: ENSG00000152518
  • Gene Symbol: FOXO3 (ENSG00000118689)
    Fold Change: 1.8
    Ensembl ID: ENSG00000118689
  • Gene Symbol: NFE2L2 (ENSG00000116044)
    Fold Change: 1.79
    Ensembl ID: ENSG00000116044
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.79
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ABLIM1 (ENSG00000099204)
    Fold Change: 1.79
    Ensembl ID: ENSG00000099204
  • Gene Symbol: NPM1 (ENSG00000181163)
    Fold Change: 1.79
    Ensembl ID: ENSG00000181163
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 1.79
    Ensembl ID: ENSG00000204525
  • Gene Symbol: EIF3E (ENSG00000104408)
    Fold Change: 1.79
    Ensembl ID: ENSG00000104408
  • Gene Symbol: YBX1 (ENSG00000065978)
    Fold Change: 1.78
    Ensembl ID: ENSG00000065978
  • Gene Symbol: PAFAH1B1 (ENSG00000007168)
    Fold Change: 1.78
    Ensembl ID: ENSG00000007168
  • Gene Symbol: GNAQ (ENSG00000156052)
    Fold Change: 1.78
    Ensembl ID: ENSG00000156052
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 1.78
    Ensembl ID: ENSG00000120885
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.76
    Ensembl ID: ENSG00000173575
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 1.76
    Ensembl ID: ENSG00000206503
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.76
    Ensembl ID: ENSG00000164919

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in cholangiocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in cholangiocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Location**: Cholangiocytes are found in the bile ducts of the liver, specifically in the small interlobular bile ducts and larger bile ducts approaching the porta hepatis and the extrahepatic ducts. 2. **Shape**: Cholangiocytes are cuboidal in shape in small interlobular bile ducts and columnar in shape in larger bile ducts. 3. **Function**: Cholangiocytes are responsible for the secretion of bile, which is essential for the digestion and absorption of fats and fat-soluble vitamins. 4. **Gene Symbol**: The gene symbol for cholangiocytes is COX3. 5. **Homologues**: Cholangiocytes have several homologues, including COX2, COX1, ATP6, ND3, ND4, ND1, and CYTB, which are involved in different aspects of mitochondrial function and cellular metabolism. **Clinical Significance** 1. **Bile Duct Disorders**: Cholangiocytes play a crucial role in the functioning of the bile ducts, and disorders affecting these cells can lead to bile duct diseases, such as cholangitis, cholangiocarcinoma, and primary sclerosing cholangitis. 2. **Liver Disease**: Cholangiocytes are also involved in liver disease, such as primary biliary cholangitis and primary sclerosing cholangitis, which can lead to liver cirrhosis and liver failure. 3. **Cancer**: Cholangiocytes can give rise to cholangiocarcinoma, a type of cancer that affects the bile ducts. 4. **Metabolic Disorders**: Cholangiocytes are involved in the metabolism of bile acids, and disorders affecting these cells can lead to metabolic disorders, such as bile acid diarrhea and cholestasis. 5. **Infectious Diseases**: Cholangiocytes can be affected by infectious diseases, such as cholangitis, which can lead to sepsis and liver failure. In summary, cholangiocytes play a critical role in the functioning of the bile ducts and the liver, and disorders affecting these cells can lead to a range of clinical conditions, including bile duct diseases, liver disease, cancer, and metabolic disorders.