Details for: CL1000494

Cell ID: CL1000494

Cell Name: nephron tubule epithelial cell

Marker Score Threshold: 235
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell that is part of a nephron tubule.

Synonyms: kidney tubule epithelial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.94
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.9
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.09
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.07
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.05
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.04
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.99
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.98
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.96
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.96
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.93
    Ensembl ID: ENSG00000149925
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.93
    Ensembl ID: ENSG00000067560
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 1.93
    Ensembl ID: ENSG00000137731
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.91
    Ensembl ID: ENSG00000152234
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.9
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.9
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.89
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.87
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.86
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.83
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.8
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.79
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.78
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.78
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.78
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.74
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.74
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.71
    Ensembl ID: ENSG00000122359
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.68
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.67
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.67
    Ensembl ID: ENSG00000135046
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.64
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.64
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.61
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.61
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.6
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.58
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.57
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.56
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.55
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.55
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.55
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.54
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.49
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.48
    Ensembl ID: ENSG00000071553
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.46
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.46
    Ensembl ID: ENSG00000004059
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.44
    Ensembl ID: ENSG00000127837
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.43
    Ensembl ID: ENSG00000151729
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.42
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.4
    Ensembl ID: ENSG00000151150
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.39
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.32
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.3
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.3
    Ensembl ID: ENSG00000120805
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.3
    Ensembl ID: ENSG00000104964
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.3
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.3
    Ensembl ID: ENSG00000100852
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.3
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.29
    Ensembl ID: ENSG00000100412
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.28
    Ensembl ID: ENSG00000123505
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.28
    Ensembl ID: ENSG00000198356
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.27
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.27
    Ensembl ID: ENSG00000165092
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.26
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.25
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.24
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.22
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.22
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.21
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.21
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.21
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.19
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.19
    Ensembl ID: ENSG00000101444
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.17
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.16
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.16
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.15
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.14
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.13
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.13
    Ensembl ID: ENSG00000060971
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.09
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.09
    Ensembl ID: ENSG00000140836
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.05
    Ensembl ID: ENSG00000106992
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.04
    Ensembl ID: ENSG00000204574
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.04
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ATP6V1B1 (ENSG00000116039)
    Fold Change: 1.04
    Ensembl ID: ENSG00000116039
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.04
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.03
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.03
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: 1.02
    Ensembl ID: ENSG00000136518
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.02
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.02
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138279
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.01
    Ensembl ID: ENSG00000101384
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.01
    Ensembl ID: ENSG00000162772
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.01
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: N/A
    Ensembl ID: ENSG00000175906
Hovered Details

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Hovered Details

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**Key Characteristics** * The cell is an epithelial cell, which means it forms the lining of various organs and tissues in the body. * It is a nephron tubule epithelial cell, which means it is specifically found in the kidneys and is involved in the filtration of waste and excess substances from the blood. * The cell expresses a range of proteins and receptors, including MHC class I and II molecules, which are involved in antigen presentation and immune response. * The cell is involved in the presentation of antigens to T-cells, which is an important process in the adaptive immune response. * The cell's functions are regulated by a complex network of signaling pathways, including those involved in protein folding, antigen presentation, and immune response. * The cell is responsive to a range of stimuli, including bacterial infection, iron ion transport, and nicotine exposure. **Clinical Significance** * The nephron tubule epithelial cell plays a crucial role in the regulation of electrolyte and water balance in the body, and dysfunction of these cells can lead to a range of clinical problems, including kidney disease and electrolyte imbalances. * The cell's involvement in antigen presentation and immune response makes it an important target for the development of new immunotherapies for the treatment of infectious diseases and cancer. * The cell's response to bacterial infection and iron ion transport makes it an important model for the study of immune responses to infection and the regulation of iron homeostasis. * The cell's involvement in the presentation of antigens to T-cells makes it an important target for the development of new vaccines and immunotherapies for the treatment of infectious diseases and cancer. * The cell's complex network of signaling pathways makes it an important model for the study of cellular signaling and the regulation of cellular processes. **Disease Associations** * Kidney disease: dysfunction of the nephron tubule epithelial cell has been implicated in a range of kidney diseases, including diabetic nephropathy and chronic kidney disease. * Electrolyte imbalances: dysfunction of the nephron tubule epithelial cell can lead to electrolyte imbalances, including hypokalemia and hyperphosphatemia. * Infections: the cell's response to bacterial infection makes it an important model for the study of immune responses to infection. * Cancer: the cell's involvement in antigen presentation and immune response makes it an important target for the development of new immunotherapies for the treatment of cancer. **Gene Expression** * The cell expresses a range of genes involved in protein folding, antigen presentation, and immune response, including B2M, ACTB, and MHC class I and II molecules. * The cell's gene expression is regulated by a complex network of transcription factors and signaling pathways, including those involved in protein folding, antigen presentation, and immune response. * The cell's gene expression is responsive to a range of stimuli, including bacterial infection, iron ion transport, and nicotine exposure. **Pathways/Ontology** * The cell is involved in a range of signaling pathways, including those involved in protein folding, antigen presentation, and immune response. * The cell's pathways and ontology include adaptive immune system, amyloid fiber formation, amyloid fibril formation, antigen presentation: folding, assembly and peptide loading of class I MHC, antigen processing-cross presentation, antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of exogenous protein antigen via MHC class IB, tap-dependent, bacterial infection pathways, cellular response to iron(III) ion, cellular response to iron ion, cellular response to nicotine, class I MHC mediated antigen processing & presentation, cytokine signaling in immune system, cytosol, dap12 interactions, dap12 signaling, disease, early endosome lumen, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum lumen, endosomal/vacuolar pathway, er-phagosome pathway, er to golgi transport vesicle membrane, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, focal adhesion, golgi apparatus, golgi membrane, hfe-transferrin receptor complex, hiv infection, host interactions of hiv factors, identical protein binding, immune system, immunoregulatory interactions between a lymphoid and a non-lymphoid cell, infection with mycobacterium tuberculosis, infectious disease, innate immune system, interferon gamma signaling, interferon signaling, intracellular iron ion homeostasis, iron ion transport, late endosome membrane, learning or memory, lysosomal membrane, membrane, metabolism of proteins, MHC class II protein complex, MHC class II protein complex binding, MHC class I peptide loading complex, MHC class I protein complex, modulation by mtb of host immune system, multicellular organismal-level iron ion homeostasis, nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, nef mediated downregulation of MHC class I complex cell surface expression, negative regulation of epithelial cell proliferation, negative regulation of forebrain neuron differentiation, negative regulation of neurogenesis, negative regulation of neuron projection development, negative regulation of receptor binding, neutrophil degranulation, peptide antigen assembly with MHC class II protein complex, peptide antigen assembly with MHC class I protein complex, peptide antigen binding, phagocytic vesicle membrane, plasma membrane, positive regulation of cellular senescence, positive regulation of ferrous iron binding, positive regulation of immune response, positive regulation of protein binding, positive regulation of receptor-mediated endocytosis, positive regulation of receptor binding, positive regulation of T cell activation, positive regulation of T cell cytokine production, positive regulation of T cell mediated cytotoxicity, positive regulation of transferrin receptor binding, protein binding, protein homodimerization activity, protein homotetramerization, protein refolding, recycling endosome membrane, regulation of erythrocyte differentiation, regulation of iron ion transport, response to molecule of bacterial origin, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2 infection, SARS-CoV-2-host interactions, SARS-CoV infections, sensory perception of smell, specific granule lumen, structural molecule activity, T cell differentiation in thymus, T cell mediated cytotoxicity, tertiary granule lumen, the role of nef in HIV-1 replication and disease pathogenesis, viral infection pathways