Details for: CL1000849

Cell ID: CL1000849

Cell Name: kidney distal convoluted tubule epithelial cell

Marker Score Threshold: 1,061
(Derived using integrated single-cell and genomic data)

Description: Any epithelial cell of distal tubule that is part of some distal convoluted tubule.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: DACH1 (ENSG00000276644)
    Fold Change: 5.99
    Ensembl ID: ENSG00000276644
  • Gene Symbol: GTF2I (ENSG00000263001)
    Fold Change: 4.46
    Ensembl ID: ENSG00000263001
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 4.28
    Ensembl ID: ENSG00000143153
  • Gene Symbol: DEFB1 (ENSG00000164825)
    Fold Change: 4.25
    Ensembl ID: ENSG00000164825
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 4.21
    Ensembl ID: ENSG00000137731
  • Gene Symbol: IGFBP7 (ENSG00000163453)
    Fold Change: 4.15
    Ensembl ID: ENSG00000163453
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 4.07
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CA12 (ENSG00000074410)
    Fold Change: 3.89
    Ensembl ID: ENSG00000074410
  • Gene Symbol: KNG1 (ENSG00000113889)
    Fold Change: 3.89
    Ensembl ID: ENSG00000113889
  • Gene Symbol: CDH16 (ENSG00000166589)
    Fold Change: 3.71
    Ensembl ID: ENSG00000166589
  • Gene Symbol: KCNJ16 (ENSG00000153822)
    Fold Change: 3.67
    Ensembl ID: ENSG00000153822
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 3.64
    Ensembl ID: ENSG00000156508
  • Gene Symbol: HSD11B2 (ENSG00000176387)
    Fold Change: 3.58
    Ensembl ID: ENSG00000176387
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 3.52
    Ensembl ID: ENSG00000087086
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 3.48
    Ensembl ID: ENSG00000167996
  • Gene Symbol: CLCNKB (ENSG00000184908)
    Fold Change: 3.47
    Ensembl ID: ENSG00000184908
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.46
    Ensembl ID: ENSG00000075624
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 3.41
    Ensembl ID: ENSG00000122566
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.34
    Ensembl ID: ENSG00000166710
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.32
    Ensembl ID: ENSG00000142192
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 3.28
    Ensembl ID: ENSG00000127184
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 3.25
    Ensembl ID: ENSG00000135940
  • Gene Symbol: KCNJ1 (ENSG00000151704)
    Fold Change: 3.24
    Ensembl ID: ENSG00000151704
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 3.24
    Ensembl ID: ENSG00000099622
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 3.22
    Ensembl ID: ENSG00000111640
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 3.13
    Ensembl ID: ENSG00000149806
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.11
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 3.1
    Ensembl ID: ENSG00000164919
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 3.1
    Ensembl ID: ENSG00000131143
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 3.08
    Ensembl ID: ENSG00000126267
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 3.07
    Ensembl ID: ENSG00000080824
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.06
    Ensembl ID: ENSG00000108654
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 3.03
    Ensembl ID: ENSG00000087460
  • Gene Symbol: EMX1 (ENSG00000135638)
    Fold Change: 3.02
    Ensembl ID: ENSG00000135638
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.01
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.01
    Ensembl ID: ENSG00000135390
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.97
    Ensembl ID: ENSG00000189403
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 2.97
    Ensembl ID: ENSG00000084207
  • Gene Symbol: HNRNPH1 (ENSG00000169045)
    Fold Change: 2.97
    Ensembl ID: ENSG00000169045
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.95
    Ensembl ID: ENSG00000084234
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 2.95
    Ensembl ID: ENSG00000131174
  • Gene Symbol: ACSL4 (ENSG00000068366)
    Fold Change: 2.94
    Ensembl ID: ENSG00000068366
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.92
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.92
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.9
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.89
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.89
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.88
    Ensembl ID: ENSG00000117410
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.86
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 2.85
    Ensembl ID: ENSG00000104267
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 2.85
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.83
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.82
    Ensembl ID: ENSG00000165629
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 2.82
    Ensembl ID: ENSG00000130226
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.81
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 2.8
    Ensembl ID: ENSG00000101439
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 2.8
    Ensembl ID: ENSG00000163041
  • Gene Symbol: IDH2 (ENSG00000182054)
    Fold Change: 2.8
    Ensembl ID: ENSG00000182054
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 2.8
    Ensembl ID: ENSG00000169567
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 2.8
    Ensembl ID: ENSG00000167468
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.8
    Ensembl ID: ENSG00000132475
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 2.77
    Ensembl ID: ENSG00000166165
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 2.76
    Ensembl ID: ENSG00000074800
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 2.75
    Ensembl ID: ENSG00000117984
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.75
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.72
    Ensembl ID: ENSG00000122359
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.69
    Ensembl ID: ENSG00000169100
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 2.66
    Ensembl ID: ENSG00000096384
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.65
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.63
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CYB5A (ENSG00000166347)
    Fold Change: 2.63
    Ensembl ID: ENSG00000166347
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.62
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.58
    Ensembl ID: ENSG00000159199
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.58
    Ensembl ID: ENSG00000092199
  • Gene Symbol: GSTM3 (ENSG00000134202)
    Fold Change: 2.58
    Ensembl ID: ENSG00000134202
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.56
    Ensembl ID: ENSG00000104529
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 2.56
    Ensembl ID: ENSG00000206503
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 2.54
    Ensembl ID: ENSG00000110651
  • Gene Symbol: EGF (ENSG00000138798)
    Fold Change: 2.54
    Ensembl ID: ENSG00000138798
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.53
    Ensembl ID: ENSG00000010278
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.51
    Ensembl ID: ENSG00000167658
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 2.51
    Ensembl ID: ENSG00000165119
  • Gene Symbol: CLCNKA (ENSG00000186510)
    Fold Change: 2.5
    Ensembl ID: ENSG00000186510
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 2.5
    Ensembl ID: ENSG00000153187
  • Gene Symbol: HSPB1 (ENSG00000106211)
    Fold Change: 2.5
    Ensembl ID: ENSG00000106211
  • Gene Symbol: GLS (ENSG00000115419)
    Fold Change: 2.5
    Ensembl ID: ENSG00000115419
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 2.49
    Ensembl ID: ENSG00000127022
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 2.49
    Ensembl ID: ENSG00000168028
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 2.48
    Ensembl ID: ENSG00000156976
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 2.48
    Ensembl ID: ENSG00000135486
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.48
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.42
    Ensembl ID: ENSG00000198668
  • Gene Symbol: FKBP2 (ENSG00000173486)
    Fold Change: 2.41
    Ensembl ID: ENSG00000173486
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.39
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.39
    Ensembl ID: ENSG00000278540
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 2.38
    Ensembl ID: ENSG00000155368
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 2.37
    Ensembl ID: ENSG00000129562
  • Gene Symbol: HSPE1 (ENSG00000115541)
    Fold Change: 2.36
    Ensembl ID: ENSG00000115541
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 2.36
    Ensembl ID: ENSG00000110321
  • Gene Symbol: MECOM (ENSG00000085276)
    Fold Change: 2.35
    Ensembl ID: ENSG00000085276

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in kidney distal convoluted tubule epithelial cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in kidney distal convoluted tubule epithelial cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Cell Type**: The cell ID CL1000849 refers to a distal convoluted tubule epithelial cell, which is a type of epithelial cell found in the kidney. 2. **Genes**: The cell is characterized by the presence of three distinct genes: DACH1, GTF2I, and ATP1B1. 3. **DACH1**: The DACH1 gene is involved in the development of primary female sexual characteristics. 4. **GTF2I**: The GTF2I gene plays a role in transcription regulation and is involved in the regulation of gene expression. 5. **ATP1B1**: The ATP1B1 gene is responsible for maintaining the transmembrane electrochemical gradient. 6. **Cellular Processes**: The cell is involved in various cellular processes, including cell adhesion, immune response, and regulation of ion homeostasis. **Clinical Significance** 1. **Kidney Function**: The distal convoluted tubule epithelial cell plays a crucial role in maintaining kidney function, particularly in the regulation of ion homeostasis. 2. **Immunological Response**: The cell's involvement in immune response is significant, as it helps to protect the body against pathogens and other foreign substances. 3. **Developmental Disorders**: The DACH1 gene's role in development suggests that abnormalities in this gene may be associated with developmental disorders, such as sex-related developmental disorders. 4. **Cardiac Function**: The ATP1B1 gene's involvement in cardiac conduction suggests that abnormalities in this gene may be associated with cardiac dysfunction. 5. **Sars-Cov Infections**: The cell's involvement in viral infection pathways, particularly with Sars-Cov infections, highlights the importance of this cell type in understanding the mechanisms of viral infections. In conclusion, the cell ID CL1000849 refers to a specific type of epithelial cell found in the distal convoluted tubule of the kidney, characterized by the presence of three distinct genes: DACH1, GTF2I, and ATP1B1. The cell's involvement in various cellular processes, including cell adhesion, immune response, and regulation of ion homeostasis, makes it a significant component of kidney function and overall health.