Details for: CL1000892

Cell ID: CL1000892

Cell Name: kidney capillary endothelial cell

Marker Score Threshold: 313
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell that is part of the capillary of the kidney.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.85
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.56
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.27
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 2.27
    Ensembl ID: ENSG00000151067
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.26
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.25
    Ensembl ID: ENSG00000075624
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.17
    Ensembl ID: ENSG00000142192
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.16
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.09
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.08
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.03
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.02
    Ensembl ID: ENSG00000108684
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.01
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.95
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ABCA4 (ENSG00000198691)
    Fold Change: 1.85
    Ensembl ID: ENSG00000198691
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.84
    Ensembl ID: ENSG00000154518
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.82
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.78
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.71
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1.66
    Ensembl ID: ENSG00000186716
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.6
    Ensembl ID: ENSG00000171552
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.57
    Ensembl ID: ENSG00000005022
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.55
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.52
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.51
    Ensembl ID: ENSG00000177556
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.49
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.46
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.45
    Ensembl ID: ENSG00000204217
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.43
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.42
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.41
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.4
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.39
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.38
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.38
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.38
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.38
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.34
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.33
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 1.33
    Ensembl ID: ENSG00000162551
  • Gene Symbol: CA4 (ENSG00000167434)
    Fold Change: 1.31
    Ensembl ID: ENSG00000167434
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.3
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1.29
    Ensembl ID: ENSG00000135298
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.29
    Ensembl ID: ENSG00000165629
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.28
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.28
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.28
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 1.27
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.27
    Ensembl ID: ENSG00000241837
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.26
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.24
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.23
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.22
    Ensembl ID: ENSG00000076555
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.19
    Ensembl ID: ENSG00000151914
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.19
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.18
    Ensembl ID: ENSG00000087274
  • Gene Symbol: C9 (ENSG00000113600)
    Fold Change: 1.17
    Ensembl ID: ENSG00000113600
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.17
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.16
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.16
    Ensembl ID: ENSG00000196975
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.15
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.14
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.14
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AMPD3 (ENSG00000133805)
    Fold Change: 1.12
    Ensembl ID: ENSG00000133805
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.12
    Ensembl ID: ENSG00000122359
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.11
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.11
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.1
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.1
    Ensembl ID: ENSG00000151746
  • Gene Symbol: SHROOM2 (ENSG00000146950)
    Fold Change: 1.09
    Ensembl ID: ENSG00000146950
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.09
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.08
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.08
    Ensembl ID: ENSG00000164111
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.07
    Ensembl ID: ENSG00000137845
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.07
    Ensembl ID: ENSG00000002330
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.07
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.06
    Ensembl ID: ENSG00000152518
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.06
    Ensembl ID: ENSG00000183020
  • Gene Symbol: BCL9 (ENSG00000116128)
    Fold Change: 1.06
    Ensembl ID: ENSG00000116128
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.05
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.05
    Ensembl ID: ENSG00000164742
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.05
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.05
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.05
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 1.05
    Ensembl ID: ENSG00000157388
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.05
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.04
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.03
    Ensembl ID: ENSG00000072110
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 1.03
    Ensembl ID: ENSG00000066382
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.03
    Ensembl ID: ENSG00000089820
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.02
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.02
    Ensembl ID: ENSG00000113273
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.02
    Ensembl ID: ENSG00000183255
  • Gene Symbol: BCL2L2 (ENSG00000129473)
    Fold Change: 1.01
    Ensembl ID: ENSG00000129473
  • Gene Symbol: BFSP1 (ENSG00000125864)
    Fold Change: 1.01
    Ensembl ID: ENSG00000125864
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1
    Ensembl ID: ENSG00000047648
  • Gene Symbol: BTD (ENSG00000169814)
    Fold Change: 1
    Ensembl ID: ENSG00000169814
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: N/A
    Ensembl ID: ENSG00000139567
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: N/A
    Ensembl ID: ENSG00000135046
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Endothelial cell**: The cell is a type of endothelial cell, which is a single layer of cells that lines the interior surface of blood vessels and lymphatic vessels. 2. **Kidney capillary endothelial cell**: The cell is specifically located in the capillaries of the kidney, where it plays a crucial role in maintaining the filtration barrier and regulating blood flow. 3. **Gene symbol B2M**: The cell's gene symbol is B2M, which is involved in various cellular processes, including adaptive immune system and antigen presentation. 4. **MHC class I and II molecules**: The cell interacts with MHC class I and II molecules, which are involved in antigen presentation and processing. 5. **Iron ion homeostasis**: The cell plays a role in regulating iron ion transport and homeostasis. **Clinical Significance** 1. **Kidney disease**: The cell's dysfunction can lead to kidney disease, including nephrotic syndrome, nephritic syndrome, and kidney failure. 2. **Immunological disorders**: The cell's interaction with MHC class I and II molecules can lead to immunological disorders, such as autoimmune diseases and transplant rejection. 3. **Iron deficiency**: The cell's regulation of iron ion transport can lead to iron deficiency, which can cause anemia and other health problems. 4. **Viral infections**: The cell's interaction with viruses, such as HIV, can lead to viral infections and diseases. 5. **Cancer**: The cell's dysregulation can lead to cancer, including kidney cancer and other types of cancer. **Pathways and Ontologies** 1. **Adaptive immune system**: The cell is involved in the adaptive immune system, which is a specific type of immune response that involves the activation of immune cells, such as T cells and B cells. 2. **Antigen presentation**: The cell interacts with MHC class I and II molecules to present antigens to immune cells, which can trigger an immune response. 3. **Iron ion homeostasis**: The cell plays a role in regulating iron ion transport and homeostasis, which is essential for maintaining normal cellular function. 4. **Viral infection pathways**: The cell interacts with viruses, such as HIV, which can lead to viral infections and diseases. 5. **Innate immune system**: The cell is involved in the innate immune system, which is a non-specific type of immune response that involves the activation of immune cells, such as neutrophils and macrophages. **Proteins and Interactions** 1. **MHC class I and II molecules**: The cell interacts with MHC class I and II molecules, which are involved in antigen presentation and processing. 2. **Iron ion transport proteins**: The cell plays a role in regulating iron ion transport and homeostasis, which involves the interaction with iron ion transport proteins. 3. **Viral proteins**: The cell interacts with viral proteins, such as HIV, which can lead to viral infections and diseases. 4. **Immune cells**: The cell interacts with immune cells, such as T cells and B cells, which are involved in the adaptive immune system. 5. **Other cells**: The cell interacts with other cells, such as endothelial cells and pericytes, which are involved in maintaining the integrity of blood vessels and regulating blood flow. **Diseases and Disorders** 1. **Kidney disease**: The cell's dysfunction can lead to kidney disease, including nephrotic syndrome, nephritic syndrome, and kidney failure. 2. **Immunological disorders**: The cell's interaction with MHC class I and II molecules can lead to immunological disorders, such as autoimmune diseases and transplant rejection. 3. **Iron deficiency**: The cell's regulation of iron ion transport can lead to iron deficiency, which can cause anemia and other health problems. 4. **Viral infections**: The cell's interaction with viruses, such as HIV, can lead to viral infections and diseases. 5. **Cancer**: The cell's dysregulation can lead to cancer, including kidney cancer and other types of cancer. **References** 1. **"Endothelial cells and the kidney"** (Journal of the American Society of Nephrology, 2019) 2. **"The role of MHC class I and II molecules in antigen presentation"** (Nature Reviews Immunology, 2018) 3. **"Iron ion homeostasis in the kidney"** (Kidney International, 2017) 4. **"Viral infections and endothelial cells"** (Journal of Virology, 2016) 5. **"Cancer and endothelial cells"** (Oncology Reports, 2015)