Details for: CL1001033

Cell ID: CL1001033

Cell Name: peritubular capillary endothelial cell

Marker Score Threshold: 233
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell that is part of the peritubular capillary of the kidney. This cell is highly fenestrated and plays a vital role in the kidney's filtration process, enabling the exchange of materials between the blood and the renal tubules.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.52
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.22
    Ensembl ID: ENSG00000075624
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 3
    Ensembl ID: ENSG00000175899
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.99
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.77
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.68
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 2.68
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.67
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.65
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.53
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.48
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.46
    Ensembl ID: ENSG00000145741
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.43
    Ensembl ID: ENSG00000143878
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.41
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.35
    Ensembl ID: ENSG00000130303
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.24
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.18
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.17
    Ensembl ID: ENSG00000169020
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 2.15
    Ensembl ID: ENSG00000119138
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.14
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.09
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD34 (ENSG00000174059)
    Fold Change: 2.07
    Ensembl ID: ENSG00000174059
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.96
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.88
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.86
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.85
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.85
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.82
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.82
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CEACAM1 (ENSG00000079385)
    Fold Change: 1.82
    Ensembl ID: ENSG00000079385
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.75
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.75
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.74
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.74
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.72
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CA4 (ENSG00000167434)
    Fold Change: 1.7
    Ensembl ID: ENSG00000167434
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.7
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.68
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.63
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.63
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 1.63
    Ensembl ID: ENSG00000136872
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.62
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.61
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.59
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.59
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.58
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.54
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.52
    Ensembl ID: ENSG00000152518
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.51
    Ensembl ID: ENSG00000130203
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.5
    Ensembl ID: ENSG00000100300
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.5
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.48
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.46
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.45
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.42
    Ensembl ID: ENSG00000172270
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 1.42
    Ensembl ID: ENSG00000137731
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.39
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.38
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.38
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.38
    Ensembl ID: ENSG00000165629
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.35
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.35
    Ensembl ID: ENSG00000213465
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.34
    Ensembl ID: ENSG00000160014
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.31
    Ensembl ID: ENSG00000149131
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.27
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.26
    Ensembl ID: ENSG00000130707
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.26
    Ensembl ID: ENSG00000204217
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.26
    Ensembl ID: ENSG00000100823
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.26
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.25
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.24
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.24
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087274
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.22
    Ensembl ID: ENSG00000115963
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.2
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.2
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.19
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: 1.17
    Ensembl ID: ENSG00000139567
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.16
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.13
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.1
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.1
    Ensembl ID: ENSG00000146731
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.09
    Ensembl ID: ENSG00000149257
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.08
    Ensembl ID: ENSG00000141522
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.08
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.07
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.07
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.07
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.07
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.06
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.06
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.06
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.04
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.03
    Ensembl ID: ENSG00000140299
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.02
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104763
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Highly Fenestrated**: The PTEC is characterized by its high number of fenestrae, which are small pores that allow for the exchange of materials between the blood and the renal tubules. 2. **Specialized Gene Expression**: The PTEC has a unique gene expression profile that includes genes involved in immune response, antigen presentation, and iron ion homeostasis. 3. **Antigen Presentation**: The PTEC is involved in antigen presentation, which is the process by which the immune system recognizes and responds to pathogens. 4. **Iron Ion Homeostasis**: The PTEC plays a crucial role in regulating iron ion homeostasis, which is essential for maintaining normal cellular function. 5. **Cell Migration and Adhesion**: The PTEC is involved in cell migration and adhesion, which are important processes for maintaining the integrity of the blood-renal barrier. 6. **Signaling**: The PTEC is involved in various signaling pathways, including those involved in immune response, antigen presentation, and iron ion homeostasis. **Clinical Significance** 1. **Kidney Disease**: The PTEC plays a crucial role in maintaining the integrity of the blood-renal barrier, and dysfunction of the PTEC can lead to kidney disease. 2. **HIV-1 Infection**: The PTEC is involved in HIV-1 infection, and the virus can infect and replicate within the PTEC, leading to immune dysfunction and disease progression. 3. **Mycobacterium Tuberculosis Infection**: The PTEC is also involved in Mycobacterium tuberculosis infection, and the virus can infect and replicate within the PTEC, leading to immune dysfunction and disease progression. 4. **Iron Ion Homeostasis**: Dysregulation of iron ion homeostasis can lead to anemia, iron deficiency, and other diseases. 5. **Immune Response**: The PTEC plays a crucial role in the immune response, and dysfunction of the PTEC can lead to immune dysfunction and disease progression. In conclusion, the peritubular capillary endothelial cell is a specialized endothelial cell that plays a crucial role in maintaining the integrity of the blood-renal barrier and regulating the exchange of nutrients, waste products, and hormones between the blood and the kidney. Dysfunction of the PTEC can lead to kidney disease, HIV-1 infection, Mycobacterium tuberculosis infection, iron ion homeostasis disorders, and immune dysfunction. Further research is needed to fully understand the role of the PTEC in maintaining normal cellular function and to develop effective treatments for diseases associated with PTEC dysfunction.