Details for: CL1001111

Cell ID: CL1001111

Cell Name: kidney loop of Henle thin descending limb epithelial cell

Marker Score Threshold: 1078
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell that is part of some loop of Henle thin descending limb.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.71
    Ensembl ID: ENSG00000143153
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 3.23
    Ensembl ID: ENSG00000137731
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 3.22
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.06
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.84
    Ensembl ID: ENSG00000166710
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.82
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.64
    Ensembl ID: ENSG00000184009
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.56
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.52
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.38
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.35
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.31
    Ensembl ID: ENSG00000137845
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 2.24
    Ensembl ID: ENSG00000101384
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.22
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.17
    Ensembl ID: ENSG00000278540
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.07
    Ensembl ID: ENSG00000157764
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.06
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.98
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.92
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.92
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.92
    Ensembl ID: ENSG00000151150
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.89
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.88
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.87
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.87
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.87
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.85
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.84
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.83
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.81
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.77
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.76
    Ensembl ID: ENSG00000104765
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.74
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 1.72
    Ensembl ID: ENSG00000240583
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.72
    Ensembl ID: ENSG00000198363
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.72
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.72
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.72
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.7
    Ensembl ID: ENSG00000170634
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.65
    Ensembl ID: ENSG00000163697
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.63
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.62
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.61
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.61
    Ensembl ID: ENSG00000145741
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.59
    Ensembl ID: ENSG00000151914
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.58
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.58
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.56
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.53
    Ensembl ID: ENSG00000143761
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.52
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.49
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.49
    Ensembl ID: ENSG00000138279
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.46
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.46
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.46
    Ensembl ID: ENSG00000107779
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.46
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.44
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.44
    Ensembl ID: ENSG00000174437
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.44
    Ensembl ID: ENSG00000148090
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.42
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.39
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.39
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.39
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.37
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.37
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.36
    Ensembl ID: ENSG00000152518
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.34
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.33
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.33
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.32
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.3
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.3
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.27
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.26
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.26
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.19
    Ensembl ID: ENSG00000113916
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.18
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.17
    Ensembl ID: ENSG00000047648
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.16
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.16
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.14
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.14
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.14
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.13
    Ensembl ID: ENSG00000162104
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.12
    Ensembl ID: ENSG00000085662
  • Gene Symbol: AQP2 (ENSG00000167580)
    Fold Change: 1.09
    Ensembl ID: ENSG00000167580
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.09
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1.08
    Ensembl ID: ENSG00000186716
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.07
    Ensembl ID: ENSG00000138175
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.07
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.06
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.04
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.04
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.03
    Ensembl ID: ENSG00000116459
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.01
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1
    Ensembl ID: ENSG00000075239
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Epithelial cell type**: The CL1001111 cell is an epithelial cell that belongs to the thin descending limb of the loop of Henle, a specialized structure in the kidney's nephron. 2. **Na+/K+-ATPase pump**: The CL1001111 cell expresses subunits of the Na+/K+-ATPase pump, which is essential for maintaining proper electrolyte balance and fluid homeostasis in the body. 3. **Ion transport**: The CL1001111 cell is involved in ion transport, including the transport of sodium, potassium, and calcium ions across the cell membrane. 4. **Cell communication**: The CL1001111 cell is capable of cell communication through electrical coupling, which is essential for regulating cardiac muscle contraction. 5. **Cardiac muscle contraction regulation**: The CL1001111 cell plays a crucial role in regulating cardiac muscle contraction, particularly in response to changes in electrolyte balance and fluid homeostasis. **Clinical Significance** 1. **Hypertension**: Dysregulation of the Na+/K+-ATPase pump in the CL1001111 cell has been implicated in the development of hypertension. 2. **Cardiac arrhythmias**: Abnormalities in ion transport and cell communication in the CL1001111 cell can lead to cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 3. **Infectious diseases**: The CL1001111 cell is involved in the regulation of immune responses, and dysregulation of this cell can contribute to the development of infectious diseases, including COVID-19. 4. **SARS-CoV infections**: The CL1001111 cell has been identified as a potential therapeutic target for SARS-CoV infections, given its role in regulating ion transport and cell communication. 5. **Renal disease**: Dysregulation of the CL1001111 cell has been implicated in various renal diseases, including chronic kidney disease and acute kidney injury. In conclusion, the Kidney Loop of Henle Thin Descending Limb Epithelial Cell (CL1001111) is a specialized epithelial cell that plays a crucial role in maintaining proper electrolyte balance, fluid homeostasis, and cardiac muscle contraction. Its dysregulation has been implicated in various diseases, including hypertension, cardiac arrhythmias, infectious diseases, and renal disease. Further research is needed to fully understand the mechanisms of action of this cell and to develop effective therapeutic strategies for the treatment of these diseases.