Details for: CL1001509

Cell ID: CL1001509

Cell Name: glycinergic neuron

Marker Score Threshold: 1208
(Derived using integrated single-cell and genomic data)

Description: The neurons that utilize glycine as a neurotransmitter.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 4.69
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 4.6
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 4.5
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 4.35
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ALDOC (ENSG00000109107)
    Fold Change: 4.34
    Ensembl ID: ENSG00000109107
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.23
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 4.04
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.91
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 3.86
    Ensembl ID: ENSG00000176171
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 3.79
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP6V1G2 (ENSG00000213760)
    Fold Change: 3.62
    Ensembl ID: ENSG00000213760
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.52
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 3.38
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 3.37
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.37
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.36
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 3.3
    Ensembl ID: ENSG00000152234
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 3.29
    Ensembl ID: ENSG00000151729
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.18
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 3.18
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 3.17
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 3.14
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 3.05
    Ensembl ID: ENSG00000105409
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.04
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.96
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.94
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.87
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CALB2 (ENSG00000172137)
    Fold Change: 2.79
    Ensembl ID: ENSG00000172137
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.75
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.69
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.59
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 2.57
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.47
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.28
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 2.26
    Ensembl ID: ENSG00000213465
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 2.2
    Ensembl ID: ENSG00000130294
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 2.11
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 2.03
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.03
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 2
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.95
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CA11 (ENSG00000063180)
    Fold Change: 1.93
    Ensembl ID: ENSG00000063180
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.92
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.88
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.87
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.85
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.85
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.82
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.81
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.78
    Ensembl ID: ENSG00000116459
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.78
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.76
    Ensembl ID: ENSG00000005022
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.76
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.73
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.73
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.72
    Ensembl ID: ENSG00000159199
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.7
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.69
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: 1.68
    Ensembl ID: ENSG00000119640
  • Gene Symbol: CAMK2B (ENSG00000058404)
    Fold Change: 1.67
    Ensembl ID: ENSG00000058404
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.59
    Ensembl ID: ENSG00000162433
  • Gene Symbol: AMPD2 (ENSG00000116337)
    Fold Change: 1.58
    Ensembl ID: ENSG00000116337
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.56
    Ensembl ID: ENSG00000143727
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.5
    Ensembl ID: ENSG00000134825
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.48
    Ensembl ID: ENSG00000106992
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.48
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.47
    Ensembl ID: ENSG00000130203
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.44
    Ensembl ID: ENSG00000067560
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.42
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.42
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CALB1 (ENSG00000104327)
    Fold Change: 1.4
    Ensembl ID: ENSG00000104327
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.37
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.33
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 1.32
    Ensembl ID: ENSG00000141505
  • Gene Symbol: ATP1B2 (ENSG00000129244)
    Fold Change: 1.28
    Ensembl ID: ENSG00000129244
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.25
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.25
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 1.25
    Ensembl ID: ENSG00000110987
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.24
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.23
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ACHE (ENSG00000087085)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087085
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.22
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.21
    Ensembl ID: ENSG00000002330
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.2
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.19
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 1.19
    Ensembl ID: ENSG00000159251
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.18
    Ensembl ID: ENSG00000078053
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 1.17
    Ensembl ID: ENSG00000105974
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.17
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: 1.16
    Ensembl ID: ENSG00000175906
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.15
    Ensembl ID: ENSG00000114573
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.14
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.14
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.13
    Ensembl ID: ENSG00000168374
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.13
    Ensembl ID: ENSG00000198356
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.1
    Ensembl ID: ENSG00000152495
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.04
    Ensembl ID: ENSG00000142188
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1
    Ensembl ID: ENSG00000160710
Hovered Details

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Hovered Details

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**Key Characteristics** * **Transmitter:** Glycine * **Location:** Central nervous system (spinal cord and brainstem) * **Function:** Regulates pain, muscle tone, and movement * **Genes:** ALDOA, CALM2, and BTG1 * **Proteins:** Glycinergic receptors (GLRA1-6), calcium channels (CACNA1A), and other proteins involved in cell signaling and migration * **Cell Type:** Neurons **Clinical Significance** Glycinergic neurons are involved in various neurological disorders, including: 1. **Spinal cord injuries:** Damage to glycinergic neurons can lead to chronic pain, muscle atrophy, and autonomic dysfunction. 2. **Epilepsy:** Altered glycinergic neurotransmission has been implicated in the development of epilepsy, particularly in the context of genetic mutations affecting the ALDOA gene. 3. **Migraines:** Glycinergic neurons may play a role in the regulation of pain and vasodilation, which are key components of migraines. 4. **Muscle disorders:** Glycinergic neurons are involved in the regulation of muscle tone, and dysfunction can lead to conditions such as myasthenia gravis and Lambert-Eaton myasthenic syndrome. 5. **Neurodegenerative diseases:** Glycinergic neurons have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. **Regulation and Modulation** Glycinergic neurons are regulated by various molecular mechanisms, including: 1. **Glycine receptors:** These receptors are the primary targets of glycine neurotransmission and play a crucial role in regulating neuronal excitability. 2. **Calcium signaling:** Calcium channels (CACNA1A) modulate the activity of glycinergic neurons, influencing their excitability and neurotransmission. 3. **Gene expression:** The expression of genes involved in glycinergic neurotransmission, such as ALDOA, is regulated by various transcriptional factors, including BTG1. 4. **Neurotransmitter modulation:** Glycine neurotransmission can be modulated by other neurotransmitters, such as GABA and glutamate, which interact with glycinergic receptors to regulate neuronal excitability. In summary, glycinergic neurons are a critical component of the nervous system, regulating pain, muscle tone, and movement. Understanding the molecular mechanisms underlying glycinergic neurotransmission and its regulation is essential for developing novel therapeutic strategies for neurological disorders.