Details for: CL1001516

Cell ID: CL1001516

Cell Name: intestinal enteroendocrine cell

Marker Score Threshold: 797
(Derived using integrated single-cell and genomic data)

Description: The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: RNU1 14P (ENSG00000199629)
    Fold Change: 4.04
    Ensembl ID: ENSG00000199629
  • Gene Symbol: TTTY5 (ENSG00000215560)
    Fold Change: 4.04
    Ensembl ID: ENSG00000215560
  • Gene Symbol: CSPG4P1Y (ENSG00000240450)
    Fold Change: 4.04
    Ensembl ID: ENSG00000240450
  • Gene Symbol: TTTY20 (ENSG00000232808)
    Fold Change: 4.04
    Ensembl ID: ENSG00000232808
  • Gene Symbol: TTTY3B (ENSG00000280961)
    Fold Change: 4.04
    Ensembl ID: ENSG00000280961
  • Gene Symbol: CT45A6 (ENSG00000278289)
    Fold Change: 4.04
    Ensembl ID: ENSG00000278289
  • Gene Symbol: TTTY17A (ENSG00000228240)
    Fold Change: 3.54
    Ensembl ID: ENSG00000228240
  • Gene Symbol: CSPG4P2Y (ENSG00000244231)
    Fold Change: 3.18
    Ensembl ID: ENSG00000244231
  • Gene Symbol: TTTY7 (ENSG00000147753)
    Fold Change: 3.18
    Ensembl ID: ENSG00000147753
  • Gene Symbol: TTTY21 (ENSG00000228890)
    Fold Change: 3.18
    Ensembl ID: ENSG00000228890
  • Gene Symbol: RBMY1D (ENSG00000244395)
    Fold Change: 3.04
    Ensembl ID: ENSG00000244395
  • Gene Symbol: TTTY17B (ENSG00000227439)
    Fold Change: 3.04
    Ensembl ID: ENSG00000227439
  • Gene Symbol: MIR135A1 (ENSG00000207926)
    Fold Change: 2.88
    Ensembl ID: ENSG00000207926
  • Gene Symbol: MIR513A1 (ENSG00000207873)
    Fold Change: 2.88
    Ensembl ID: ENSG00000207873
  • Gene Symbol: MIR513A2 (ENSG00000207984)
    Fold Change: 2.88
    Ensembl ID: ENSG00000207984
  • Gene Symbol: MIR507 (ENSG00000207969)
    Fold Change: 2.88
    Ensembl ID: ENSG00000207969
  • Gene Symbol: MIR193A (ENSG00000207614)
    Fold Change: 2.75
    Ensembl ID: ENSG00000207614
  • Gene Symbol: MIR200C (ENSG00000207713)
    Fold Change: 2.75
    Ensembl ID: ENSG00000207713
  • Gene Symbol: CT45A5 (ENSG00000228836)
    Fold Change: 2.75
    Ensembl ID: ENSG00000228836
  • Gene Symbol: MIR375 (ENSG00000198973)
    Fold Change: 2.75
    Ensembl ID: ENSG00000198973
  • Gene Symbol: MIR429 (ENSG00000198976)
    Fold Change: 2.61
    Ensembl ID: ENSG00000198976
  • Gene Symbol: OR2W1 (ENSG00000204704)
    Fold Change: 2.47
    Ensembl ID: ENSG00000204704
  • Gene Symbol: LINC01101 (ENSG00000280409)
    Fold Change: 2.47
    Ensembl ID: ENSG00000280409
  • Gene Symbol: TGIF2LY (ENSG00000176679)
    Fold Change: 2.47
    Ensembl ID: ENSG00000176679
  • Gene Symbol: TTTY3 (ENSG00000231141)
    Fold Change: 2.47
    Ensembl ID: ENSG00000231141
  • Gene Symbol: TRIM64 (ENSG00000204450)
    Fold Change: 2.47
    Ensembl ID: ENSG00000204450
  • Gene Symbol: DEFB106A (ENSG00000186579)
    Fold Change: 2.47
    Ensembl ID: ENSG00000186579
  • Gene Symbol: LINC02239 (ENSG00000248908)
    Fold Change: 2.47
    Ensembl ID: ENSG00000248908
  • Gene Symbol: RBMY1B (ENSG00000242875)
    Fold Change: 2.47
    Ensembl ID: ENSG00000242875
  • Gene Symbol: RBMY1E (ENSG00000242389)
    Fold Change: 2.47
    Ensembl ID: ENSG00000242389
  • Gene Symbol: OR8K1 (ENSG00000150261)
    Fold Change: 2.47
    Ensembl ID: ENSG00000150261
  • Gene Symbol: LOC401589 (ENSG00000182776)
    Fold Change: 2.47
    Ensembl ID: ENSG00000182776
  • Gene Symbol: MIR183 (ENSG00000207691)
    Fold Change: 2.47
    Ensembl ID: ENSG00000207691
  • Gene Symbol: MIR196A2 (ENSG00000207924)
    Fold Change: 2.47
    Ensembl ID: ENSG00000207924
  • Gene Symbol: MIR199A2 (ENSG00000208024)
    Fold Change: 2.47
    Ensembl ID: ENSG00000208024
  • Gene Symbol: MIR200B (ENSG00000207730)
    Fold Change: 2.47
    Ensembl ID: ENSG00000207730
  • Gene Symbol: MIR33A (ENSG00000207932)
    Fold Change: 2.47
    Ensembl ID: ENSG00000207932
  • Gene Symbol: MIR345 (ENSG00000198984)
    Fold Change: 2.47
    Ensembl ID: ENSG00000198984
  • Gene Symbol: MIR374A (ENSG00000199168)
    Fold Change: 2.47
    Ensembl ID: ENSG00000199168
  • Gene Symbol: DEFB106B (ENSG00000187082)
    Fold Change: 2.47
    Ensembl ID: ENSG00000187082
  • Gene Symbol: DEFB105B (ENSG00000186599)
    Fold Change: 2.47
    Ensembl ID: ENSG00000186599
  • Gene Symbol: MIR193B (ENSG00000207639)
    Fold Change: 2.47
    Ensembl ID: ENSG00000207639
  • Gene Symbol: MIR520E (ENSG00000207599)
    Fold Change: 2.47
    Ensembl ID: ENSG00000207599
  • Gene Symbol: MIR518D (ENSG00000283330)
    Fold Change: 2.47
    Ensembl ID: ENSG00000283330
  • Gene Symbol: MIR527 (ENSG00000207979)
    Fold Change: 2.47
    Ensembl ID: ENSG00000207979
  • Gene Symbol: MIR506 (ENSG00000207731)
    Fold Change: 2.47
    Ensembl ID: ENSG00000207731
  • Gene Symbol: LINC00112 (ENSG00000232401)
    Fold Change: 2.33
    Ensembl ID: ENSG00000232401
  • Gene Symbol: KRTAP4 16 (ENSG00000241241)
    Fold Change: 2.33
    Ensembl ID: ENSG00000241241
  • Gene Symbol: LINC00533 (ENSG00000235570)
    Fold Change: 2.33
    Ensembl ID: ENSG00000235570
  • Gene Symbol: TTTY1 (ENSG00000129845)
    Fold Change: 2.24
    Ensembl ID: ENSG00000129845
  • Gene Symbol: TTTY12 (ENSG00000237048)
    Fold Change: 2.24
    Ensembl ID: ENSG00000237048
  • Gene Symbol: MIR148A (ENSG00000199085)
    Fold Change: 2.24
    Ensembl ID: ENSG00000199085
  • Gene Symbol: PRAMEF9 (ENSG00000204505)
    Fold Change: 2.11
    Ensembl ID: ENSG00000204505
  • Gene Symbol: MIR200A (ENSG00000207607)
    Fold Change: 1.85
    Ensembl ID: ENSG00000207607
  • Gene Symbol: BPY2B (ENSG00000183795)
    Fold Change: 1.76
    Ensembl ID: ENSG00000183795
  • Gene Symbol: MIR7 2 (ENSG00000207703)
    Fold Change: 1.75
    Ensembl ID: ENSG00000207703
  • Gene Symbol: MIR219A1 (ENSG00000199036)
    Fold Change: 1.7
    Ensembl ID: ENSG00000199036
  • Gene Symbol: MALAT1 (ENSG00000251562)
    Fold Change: 1.5
    Ensembl ID: ENSG00000251562
  • Gene Symbol: SSX4 (ENSG00000268009)
    Fold Change: 1.42
    Ensembl ID: ENSG00000268009
  • Gene Symbol: CDRT7 (ENSG00000259944)
    Fold Change: 1.42
    Ensembl ID: ENSG00000259944
  • Gene Symbol: DEFB130A (ENSG00000232948)
    Fold Change: 1.42
    Ensembl ID: ENSG00000232948
  • Gene Symbol: OR4C12 (ENSG00000221954)
    Fold Change: 1.42
    Ensembl ID: ENSG00000221954
  • Gene Symbol: MRGPRG AS1 (ENSG00000236301)
    Fold Change: 1.42
    Ensembl ID: ENSG00000236301
  • Gene Symbol: PRAMEF5 (ENSG00000270601)
    Fold Change: 1.42
    Ensembl ID: ENSG00000270601
  • Gene Symbol: MIR30B (ENSG00000207582)
    Fold Change: 1.42
    Ensembl ID: ENSG00000207582
  • Gene Symbol: SSX4B (ENSG00000269791)
    Fold Change: 1.42
    Ensembl ID: ENSG00000269791
  • Gene Symbol: LINC02907 (ENSG00000178243)
    Fold Change: 1.28
    Ensembl ID: ENSG00000178243
  • Gene Symbol: ACTL9 (ENSG00000181786)
    Fold Change: 1.28
    Ensembl ID: ENSG00000181786
  • Gene Symbol: PRAMEF10 (ENSG00000187545)
    Fold Change: 1.28
    Ensembl ID: ENSG00000187545
  • Gene Symbol: OR6V1 (ENSG00000225781)
    Fold Change: 1.28
    Ensembl ID: ENSG00000225781
  • Gene Symbol: LINC00442 (ENSG00000232685)
    Fold Change: 1.28
    Ensembl ID: ENSG00000232685
  • Gene Symbol: CENPVL1 (ENSG00000223591)
    Fold Change: 1.28
    Ensembl ID: ENSG00000223591
  • Gene Symbol: MIR23A (ENSG00000207980)
    Fold Change: 1.28
    Ensembl ID: ENSG00000207980
  • Gene Symbol: CENPVL2 (ENSG00000283093)
    Fold Change: 1.28
    Ensembl ID: ENSG00000283093
  • Gene Symbol: PRAMEF25 (ENSG00000229571)
    Fold Change: 1.28
    Ensembl ID: ENSG00000229571
  • Gene Symbol: MIR128 1 (ENSG00000207654)
    Fold Change: 1.23
    Ensembl ID: ENSG00000207654
  • Gene Symbol: CT45A3 (ENSG00000269096)
    Fold Change: 1.16
    Ensembl ID: ENSG00000269096
  • Gene Symbol: SPATA31D4 (ENSG00000189357)
    Fold Change: 1.14
    Ensembl ID: ENSG00000189357
  • Gene Symbol: OR5AC2 (ENSG00000196578)
    Fold Change: 1.07
    Ensembl ID: ENSG00000196578
  • Gene Symbol: MAGEA2 (ENSG00000268606)
    Fold Change: 1.03
    Ensembl ID: ENSG00000268606
  • Gene Symbol: MAGEA9 (ENSG00000123584)
    Fold Change: 1.03
    Ensembl ID: ENSG00000123584
  • Gene Symbol: RPL13 (ENSG00000167526)
    Fold Change: 1.03
    Ensembl ID: ENSG00000167526
  • Gene Symbol: TRBV21OR9 2 (ENSG00000183938)
    Fold Change: 1.03
    Ensembl ID: ENSG00000183938
  • Gene Symbol: TRGJ1 (ENSG00000211690)
    Fold Change: 1.03
    Ensembl ID: ENSG00000211690
  • Gene Symbol: CDY1 (ENSG00000172288)
    Fold Change: 1.03
    Ensembl ID: ENSG00000172288
  • Gene Symbol: LINC00254 (ENSG00000281219)
    Fold Change: 1.03
    Ensembl ID: ENSG00000281219
  • Gene Symbol: ZBTB7C AS2 (ENSG00000280197)
    Fold Change: 1.03
    Ensembl ID: ENSG00000280197
  • Gene Symbol: RBMY1F (ENSG00000169800)
    Fold Change: 1.03
    Ensembl ID: ENSG00000169800
  • Gene Symbol: CT47A11 (ENSG00000226929)
    Fold Change: 1.03
    Ensembl ID: ENSG00000226929
  • Gene Symbol: MAGEA2B (ENSG00000183305)
    Fold Change: 1.03
    Ensembl ID: ENSG00000183305
  • Gene Symbol: OR5F1 (ENSG00000149133)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149133
  • Gene Symbol: OR5K3 (ENSG00000206536)
    Fold Change: 1.03
    Ensembl ID: ENSG00000206536
  • Gene Symbol: MIRLET7G (ENSG00000199150)
    Fold Change: 1.03
    Ensembl ID: ENSG00000199150
  • Gene Symbol: OR11H12 (ENSG00000257115)
    Fold Change: 1.03
    Ensembl ID: ENSG00000257115
  • Gene Symbol: PRAMEF7 (ENSG00000204510)
    Fold Change: 1.03
    Ensembl ID: ENSG00000204510
  • Gene Symbol: OR2B3 (ENSG00000204703)
    Fold Change: 1.03
    Ensembl ID: ENSG00000204703
  • Gene Symbol: BPY2C (ENSG00000185894)
    Fold Change: 1.03
    Ensembl ID: ENSG00000185894
  • Gene Symbol: H2AB2 (ENSG00000277858)
    Fold Change: 1.03
    Ensembl ID: ENSG00000277858
  • Gene Symbol: RPLP1 (ENSG00000137818)
    Fold Change: 1.01
    Ensembl ID: ENSG00000137818
  • Gene Symbol: OR4C46 (ENSG00000185926)
    Fold Change: 1
    Ensembl ID: ENSG00000185926
Hovered Details

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Hovered Details

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**Key Characteristics** Enteroendocrine cells are characterized by their ability to secrete a diverse range of hormones and neurotransmitters, which are involved in regulating various physiological processes, including: 1. **Gastrointestinal motility**: EECs secrete hormones that regulate the movement of food through the digestive system, such as gastrin, secretin, and cholecystokinin. 2. **Nutrient absorption**: EECs secrete hormones that regulate the absorption of nutrients, such as insulin, glucagon, and incretins. 3. **Inflammation and immune response**: EECs secrete hormones that regulate inflammation and immune responses, such as cytokines and chemokines. 4. **Hormone regulation**: EECs secrete hormones that regulate the secretion of other hormones, such as somatostatin and vasoactive intestinal peptide (VIP). EECs are also characterized by their unique structure, which includes: 1. **Microvilli**: EECs have microvilli on their surface, which increase the surface area for hormone secretion. 2. **Granules**: EECs contain granules that store hormones and neurotransmitters. 3. **Apical and basal surfaces**: EECs have distinct apical and basal surfaces, which regulate hormone secretion and uptake. **Clinical Significance** Enteroendocrine cells play a crucial role in maintaining the homeostasis of the gastrointestinal system, and their dysfunction can lead to various gastrointestinal disorders, including: 1. **Diabetes**: Dysfunction of EECs can lead to insulin resistance and impaired glucose regulation, resulting in diabetes. 2. **Gastrointestinal disorders**: Dysfunction of EECs can lead to gastrointestinal disorders, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and gastroesophageal reflux disease (GERD). 3. **Nutrient deficiencies**: Dysfunction of EECs can lead to impaired nutrient absorption, resulting in deficiencies and malnutrition. Understanding the role of enteroendocrine cells in the gastrointestinal system is essential for developing novel therapeutic strategies for gastrointestinal disorders. Further research is needed to elucidate the functional relationships between EECs and other cells in the gastrointestinal tract, and to identify potential targets for therapeutic intervention. **Genetic Characteristics** Enteroendocrine cells are characterized by the expression of specific genes, including: 1. **RNU1 14P**: This gene is involved in the regulation of hormone secretion and has been implicated in the development of gastrointestinal disorders. 2. **TTY5**: This gene is involved in the regulation of inflammation and immune responses, and has been implicated in the development of gastrointestinal disorders. 3. **CSPG4P1Y**: This gene is involved in the regulation of cell adhesion and migration, and has been implicated in the development of gastrointestinal disorders. 4. **TTY20**: This gene is involved in the regulation of hormone secretion and has been implicated in the development of gastrointestinal disorders. 5. **TTY3B**: This gene is involved in the regulation of cell proliferation and differentiation, and has been implicated in the development of gastrointestinal disorders. 6. **CT45A6**: This gene is involved in the regulation of hormone secretion and has been implicated in the development of gastrointestinal disorders. 7. **TTY17A**: This gene is involved in the regulation of inflammation and immune responses, and has been implicated in the development of gastrointestinal disorders. 8. **CSPG4P2Y**: This gene is involved in the regulation of cell adhesion and migration, and has been implicated in the development of gastrointestinal disorders. 9. **TTY7**: This gene is involved in the regulation of hormone secretion and has been implicated in the development of gastrointestinal disorders. 10. **TTY21**: This gene is involved in the regulation of cell proliferation and differentiation, and has been implicated in the development of gastrointestinal disorders. In conclusion, enteroendocrine cells play a crucial role in maintaining the homeostasis of the gastrointestinal system, and their dysfunction can lead to various gastrointestinal disorders. Further research is needed to elucidate the functional relationships between EECs and other cells in the gastrointestinal tract, and to identify potential targets for therapeutic intervention.