Details for: CL1001568

Cell ID: CL1001568

Cell Name: pulmonary artery endothelial cell

Marker Score Threshold: 861
(Derived using integrated single-cell and genomic data)

Description: Any endothelial cell of vascular tree that is part of some pulmonary artery.

Synonyms: PAEC cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 5.68
    Ensembl ID: ENSG00000124172
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.15
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.07
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 3.88
    Ensembl ID: ENSG00000105974
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 3.6
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.59
    Ensembl ID: ENSG00000184009
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 3.51
    Ensembl ID: ENSG00000175899
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 3.5
    Ensembl ID: ENSG00000085063
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 3.26
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.23
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.14
    Ensembl ID: ENSG00000145741
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 3.08
    Ensembl ID: ENSG00000240583
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.01
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.88
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.84
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 2.76
    Ensembl ID: ENSG00000198898
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.75
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.69
    Ensembl ID: ENSG00000010278
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.68
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.59
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 2.55
    Ensembl ID: ENSG00000105971
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.49
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.49
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.48
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.43
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.42
    Ensembl ID: ENSG00000179218
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.36
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.35
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.26
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: 2.25
    Ensembl ID: ENSG00000139567
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.24
    Ensembl ID: ENSG00000143761
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 2.23
    Ensembl ID: ENSG00000183255
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.16
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.16
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.15
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.13
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.09
    Ensembl ID: ENSG00000149925
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.07
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.04
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.04
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.03
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.03
    Ensembl ID: ENSG00000111348
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 2.03
    Ensembl ID: ENSG00000149131
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.93
    Ensembl ID: ENSG00000119138
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.9
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.87
    Ensembl ID: ENSG00000110955
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.85
    Ensembl ID: ENSG00000084234
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.83
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.7
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.68
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.66
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.62
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.62
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.61
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.61
    Ensembl ID: ENSG00000153113
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.59
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.55
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.51
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.51
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.5
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.48
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.47
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.43
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.43
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.42
    Ensembl ID: ENSG00000213465
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.41
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CD34 (ENSG00000174059)
    Fold Change: 1.35
    Ensembl ID: ENSG00000174059
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.34
    Ensembl ID: ENSG00000149257
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.33
    Ensembl ID: ENSG00000117410
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.33
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.32
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.3
    Ensembl ID: ENSG00000140299
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.29
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.29
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.26
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.23
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD58 (ENSG00000116815)
    Fold Change: 1.2
    Ensembl ID: ENSG00000116815
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.2
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.19
    Ensembl ID: ENSG00000196776
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.19
    Ensembl ID: ENSG00000085662
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.15
    Ensembl ID: ENSG00000106546
  • Gene Symbol: BMX (ENSG00000102010)
    Fold Change: 1.13
    Ensembl ID: ENSG00000102010
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.13
    Ensembl ID: ENSG00000130208
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.12
    Ensembl ID: ENSG00000138760
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.1
    Ensembl ID: ENSG00000075239
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.1
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ENTPD1 (ENSG00000138185)
    Fold Change: 1.1
    Ensembl ID: ENSG00000138185
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.1
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.1
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.09
    Ensembl ID: ENSG00000122359
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.09
    Ensembl ID: ENSG00000142188
  • Gene Symbol: BCL3 (ENSG00000069399)
    Fold Change: 1.08
    Ensembl ID: ENSG00000069399
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.06
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.06
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.05
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.05
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.04
    Ensembl ID: ENSG00000146731
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.04
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.01
    Ensembl ID: ENSG00000196954
Hovered Details

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Hovered Details

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**Key Characteristics** * Pulmonary artery endothelial cell (PAEC) * Lines the pulmonary arteries * Involved in regulating blood flow and pressure in the lungs * Gene symbol: ATP5F1E * Involvement in cristae formation and mitochondrial biogenesis * Involvement in metabolism, specifically in the formation of ATP by chemiosmotic coupling * Involved in the adaptive immune system, specifically in antigen presentation and processing via MHC class I and II molecules **Clinical Significance** Pulmonary artery endothelial cells play a critical role in maintaining the integrity of the pulmonary vasculature and regulating blood flow and pressure in the lungs. Dysfunction of these cells can lead to various clinical conditions, including: * Pulmonary hypertension: a condition characterized by high blood pressure in the pulmonary arteries, which can lead to right ventricular failure and death. * Pulmonary embolism: a condition characterized by the blockage of a pulmonary artery by a blood clot, which can lead to acute respiratory distress syndrome (ARDS) and death. * Chronic obstructive pulmonary disease (COPD): a condition characterized by chronic inflammation and damage to the airways, which can lead to airflow limitation and respiratory failure. Understanding the function and dysfunction of pulmonary artery endothelial cells is crucial for the development of novel therapeutic strategies for these conditions. Additionally, the study of these cells can provide insights into the mechanisms of immune response and the development of new immunotherapies. **Pathways and Ontology** The cell's pathways and ontology include: * Cristae formation * Mitochondrial biogenesis * Metabolism * Adaptive immune system * Antigen presentation and processing via MHC class I and II molecules These pathways are involved in various cellular processes, including energy production, immune response, and cell signaling. **Proteins and Gene Products** The cell's gene products include: * ATP5F1E: a protein involved in the formation of cristae in mitochondria * B2M: a protein involved in antigen presentation and processing via MHC class I and II molecules * ACTB: a protein involved in actin cytoskeleton dynamics and cell signaling These proteins play critical roles in various cellular processes, including energy production, immune response, and cell signaling. **Infectious Disease and Immune Response** The cell's involvement in the adaptive immune system makes it a critical component in the response to infectious diseases. The cell's ability to present antigens via MHC class I and II molecules allows for the activation of T cells and the initiation of an immune response. **Diseases and Disorders** The cell's dysfunction can lead to various clinical conditions, including: * Pulmonary hypertension * Pulmonary embolism * Chronic obstructive pulmonary disease (COPD) Understanding the function and dysfunction of pulmonary artery endothelial cells is crucial for the development of novel therapeutic strategies for these conditions. **References** * [Insert references here] Note: This is a summary article, and the references section should be updated with actual references.