Details for: CL2000001

Cell ID: CL2000001

Cell Name: peripheral blood mononuclear cell

Marker Score Threshold: 361
(Derived using integrated single-cell and genomic data)

Description: A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.91
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.76
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.38
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.35
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.31
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.3
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.28
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.26
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.18
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.14
    Ensembl ID: ENSG00000145741
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.03
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.01
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.96
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.94
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.87
    Ensembl ID: ENSG00000135404
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.83
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.81
    Ensembl ID: ENSG00000112695
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.81
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.79
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.78
    Ensembl ID: ENSG00000179218
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.77
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.74
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.69
    Ensembl ID: ENSG00000077549
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.69
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.67
    Ensembl ID: ENSG00000143761
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.66
    Ensembl ID: ENSG00000111775
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.65
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.62
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.61
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.59
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.58
    Ensembl ID: ENSG00000185650
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.57
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.57
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.54
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.53
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.5
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.49
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.49
    Ensembl ID: ENSG00000085224
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.47
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.46
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.46
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.44
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.43
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.42
    Ensembl ID: ENSG00000153113
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.41
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.38
    Ensembl ID: ENSG00000051523
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.38
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.36
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.36
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.35
    Ensembl ID: ENSG00000160213
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.32
    Ensembl ID: ENSG00000013441
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.31
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.3
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.3
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.3
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.29
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.28
    Ensembl ID: ENSG00000168374
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.27
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.26
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.21
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.21
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.21
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.2
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.2
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.2
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.2
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.19
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.19
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.18
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.18
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.17
    Ensembl ID: ENSG00000168036
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.16
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.16
    Ensembl ID: ENSG00000122359
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.15
    Ensembl ID: ENSG00000053254
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.14
    Ensembl ID: ENSG00000104765
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.14
    Ensembl ID: ENSG00000108561
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.14
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.12
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.11
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.11
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.11
    Ensembl ID: ENSG00000117984
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.11
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.09
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.08
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.06
    Ensembl ID: ENSG00000101439
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.06
    Ensembl ID: ENSG00000141367
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100823
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.04
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.03
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 1.03
    Ensembl ID: ENSG00000164733
  • Gene Symbol: CREM (ENSG00000095794)
    Fold Change: 1.03
    Ensembl ID: ENSG00000095794
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.03
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.02
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.01
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.01
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.01
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1
    Ensembl ID: ENSG00000164615
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1
    Ensembl ID: ENSG00000122218
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Morphology**: PBMCs have a single non-segmented nucleus in their mature form. 2. **Gene Symbol**: ACTB (Actin beta) 3. **Ensembl ID**: ENSG00000075624 4. **Pathways/Ontology**: Actin cytoskeleton, adherens junction, cell-cell communication, adaptive immune system, amyloid fiber formation, and antigen presentation. 5. **Function**: Involved in various cellular processes, including actin dynamics, cell-cell communication, and immune system regulation. **Clinical Significance** 1. **Infectious Diseases**: PBMCs play a crucial role in the immune system's response to infections, making them a target for therapeutic interventions in diseases such as HIV and tuberculosis. 2. **Immune System Disorders**: PBMCs are involved in various immune system disorders, including autoimmune diseases and immunodeficiency disorders. 3. **Cancer**: PBMCs have been implicated in cancer development and progression, particularly in hematological malignancies such as leukemia and lymphoma. 4. **Transplantation**: PBMCs are used in bone marrow transplantation to reconstitute the immune system in recipients. 5. **Immunotherapy**: PBMCs are being explored as a target for immunotherapy in various cancers, including melanoma and lung cancer. **Gene Symbol and Ensembl ID** The gene symbol ACTB (Actin beta) is associated with the Ensembl ID ENSG00000075624. ACTB is a gene that codes for a protein involved in the regulation of the actin cytoskeleton, which is essential for cell movement, division, and signaling. The Ensembl ID provides a unique identifier for the gene, allowing for the tracking of its expression and regulation across different tissues and developmental stages. **Pathways/Ontology** The pathways/ontology associated with PBMCs include: 1. **Actin cytoskeleton**: The actin cytoskeleton plays a crucial role in cell movement, division, and signaling. 2. **Adherens junction**: Adherens junctions are involved in cell-cell communication and the regulation of cell adhesion. 3. **Cell-cell communication**: Cell-cell communication involves the exchange of signals between cells, which is essential for the coordination of immune responses. 4. **Adaptive immune system**: The adaptive immune system is a complex network of cells and molecules that work together to recognize and eliminate pathogens. 5. **Amyloid fiber formation**: Amyloid fibers are involved in the formation of amyloid plaques, which are characteristic of Alzheimer's disease. 6. **Antigen presentation**: Antigen presentation involves the processing and presentation of antigens to the immune system, which is essential for the activation of immune responses. In conclusion, PBMCs are a crucial component of the immune system, and their dysregulation has been implicated in various diseases, including infectious diseases, immune system disorders, and cancer. Understanding the key characteristics, clinical significance, and gene symbol and Ensembl ID of PBMCs is essential for the development of effective therapeutic interventions.