Details for: CL2000002

Cell ID: CL2000002

Cell Name: decidual cell

Marker Score Threshold: 4312
(Derived using integrated single-cell and genomic data)

Description: A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization.

Synonyms: decidua cell, decidual stromal cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 2.97
    Ensembl ID: ENSG00000189058
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.85
    Ensembl ID: ENSG00000184009
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2.85
    Ensembl ID: ENSG00000130203
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.84
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.84
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.84
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 2.82
    Ensembl ID: ENSG00000107796
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.81
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.79
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.78
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.77
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.73
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.71
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.65
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.63
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.62
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.61
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.59
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.59
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.57
    Ensembl ID: ENSG00000154518
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.56
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.56
    Ensembl ID: ENSG00000169020
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.53
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.51
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.48
    Ensembl ID: ENSG00000152234
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.48
    Ensembl ID: ENSG00000067560
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.44
    Ensembl ID: ENSG00000142192
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.39
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.39
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.37
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 2.37
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.36
    Ensembl ID: ENSG00000116459
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 2.36
    Ensembl ID: ENSG00000101444
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 2.33
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.3
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.26
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 2.22
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 2.22
    Ensembl ID: ENSG00000162772
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.22
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.19
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.19
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 2.18
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.18
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.15
    Ensembl ID: ENSG00000004059
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.12
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 2.11
    Ensembl ID: ENSG00000106624
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 2.09
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.03
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.93
    Ensembl ID: ENSG00000002330
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.9
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.9
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.89
    Ensembl ID: ENSG00000128272
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.89
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.89
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.88
    Ensembl ID: ENSG00000138175
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.88
    Ensembl ID: ENSG00000198356
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.82
    Ensembl ID: ENSG00000130208
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.81
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.78
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.73
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.71
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.68
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.67
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.66
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.66
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.65
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.65
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.64
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.63
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.61
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.58
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 1.57
    Ensembl ID: ENSG00000184254
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: 1.49
    Ensembl ID: ENSG00000175906
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.47
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.44
    Ensembl ID: ENSG00000107262
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.43
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.42
    Ensembl ID: ENSG00000196975
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.35
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.33
    Ensembl ID: ENSG00000164904
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.33
    Ensembl ID: ENSG00000121410
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.33
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.32
    Ensembl ID: ENSG00000060971
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.32
    Ensembl ID: ENSG00000175899
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.31
    Ensembl ID: ENSG00000177105
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.29
    Ensembl ID: ENSG00000196961
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.25
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.2
    Ensembl ID: ENSG00000134287
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.18
    Ensembl ID: ENSG00000138363
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.17
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.15
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.14
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.14
    Ensembl ID: ENSG00000100412
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.12
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.08
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.06
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.06
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.04
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.03
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: 1.02
    Ensembl ID: ENSG00000136518
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Enlarged nucleus**: The nucleus of decidual cells is larger and more prominent than that of normal endometrial stromal cells. 2. **Dense membrane-bound secretory granules**: Decidual cells contain dense, membrane-bound secretory granules that are rich in proteins and lipids. 3. **Cytoplasmic accumulation of glycogen and lipid droplets**: Decidual cells have a high level of glycogen and lipid droplets in their cytoplasm, which are involved in energy storage and lipid metabolism. 4. **Transformed endometrial stromal cells**: Decidual cells are derived from the transformation of endometrial stromal cells during decidualization. **Clinical Significance** 1. **Pregnancy maintenance**: Decidual cells play a crucial role in maintaining the implantation of the fertilized egg and supporting the growth of the placenta. 2. **Immune regulation**: Decidual cells regulate the immune response during pregnancy, preventing rejection of the fetus by the maternal immune system. 3. **Endometrial function**: Decidual cells are involved in the regulation of endometrial function, including menstruation, ovulation, and implantation. 4. **Endometrial cancer**: Abnormal decidual cells have been implicated in the development of endometrial cancer. 5. **Reproductive disorders**: Decidual cell dysfunction has been linked to reproductive disorders such as recurrent miscarriage, infertility, and preterm labor. **Genes and Pathways** Decidual cells are regulated by a complex network of genes and pathways, including: 1. **APOD**: Decidual cells express the APOD gene, which is involved in lipid metabolism and immune regulation. 2. **ACTG1**: Decidual cells express the ACTG1 gene, which is involved in actin dynamics and cell motility. 3. **APOE**: Decidual cells express the APOE gene, which is involved in cholesterol metabolism and lipid transport. 4. **Nr1h2 and Nr1h3**: Decidual cells express the Nr1h2 and Nr1h3 genes, which are involved in cholesterol transport and efflux. These genes and pathways are involved in various cellular processes, including lipid metabolism, immune regulation, and cell motility, which are critical for maintaining pregnancy and reproductive health.