Details for: CL2000006

Cell ID: CL2000006

Cell Name: tonsil germinal center B cell

Marker Score Threshold: 2967
(Derived using integrated single-cell and genomic data)

Description: Any germinal center B cell that is part of a tonsil.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.21
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.21
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.16
    Ensembl ID: ENSG00000111348
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.16
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.12
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.1
    Ensembl ID: ENSG00000124172
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 3.03
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.98
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.96
    Ensembl ID: ENSG00000169100
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.95
    Ensembl ID: ENSG00000067560
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 2.86
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.79
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.68
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.59
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.55
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.55
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.52
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.5
    Ensembl ID: ENSG00000198668
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.48
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.48
    Ensembl ID: ENSG00000110955
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 2.44
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.42
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.36
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.32
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.3
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.29
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 2.23
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.19
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.15
    Ensembl ID: ENSG00000143761
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.12
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.11
    Ensembl ID: ENSG00000179218
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 2.04
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 2.01
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.99
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.97
    Ensembl ID: ENSG00000132965
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.94
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.89
    Ensembl ID: ENSG00000159199
  • Gene Symbol: BIK (ENSG00000100290)
    Fold Change: 1.87
    Ensembl ID: ENSG00000100290
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 1.85
    Ensembl ID: ENSG00000110987
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.82
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.8
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.79
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 1.77
    Ensembl ID: ENSG00000074370
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.74
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BLK (ENSG00000136573)
    Fold Change: 1.72
    Ensembl ID: ENSG00000136573
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.69
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.66
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.61
    Ensembl ID: ENSG00000177556
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.6
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.6
    Ensembl ID: ENSG00000128272
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.58
    Ensembl ID: ENSG00000004455
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.58
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.57
    Ensembl ID: ENSG00000117054
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.57
    Ensembl ID: ENSG00000023445
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.54
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.53
    Ensembl ID: ENSG00000122359
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.52
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.51
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.47
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.43
    Ensembl ID: ENSG00000015475
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.4
    Ensembl ID: ENSG00000113916
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.37
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.36
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.36
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BIRC5 (ENSG00000089685)
    Fold Change: 1.35
    Ensembl ID: ENSG00000089685
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.35
    Ensembl ID: ENSG00000172270
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.33
    Ensembl ID: ENSG00000101444
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.32
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.32
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.31
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADA (ENSG00000196839)
    Fold Change: 1.3
    Ensembl ID: ENSG00000196839
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.3
    Ensembl ID: ENSG00000010671
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.29
    Ensembl ID: ENSG00000165527
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.28
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.27
    Ensembl ID: ENSG00000100412
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.26
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.23
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.21
    Ensembl ID: ENSG00000140299
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 1.21
    Ensembl ID: ENSG00000140379
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.2
    Ensembl ID: ENSG00000130402
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.2
    Ensembl ID: ENSG00000198356
  • Gene Symbol: CCNA2 (ENSG00000145386)
    Fold Change: 1.15
    Ensembl ID: ENSG00000145386
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.14
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.13
    Ensembl ID: ENSG00000148700
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.13
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.12
    Ensembl ID: ENSG00000197894
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.12
    Ensembl ID: ENSG00000173020
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.12
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.11
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CAPN1 (ENSG00000014216)
    Fold Change: 1.11
    Ensembl ID: ENSG00000014216
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.11
    Ensembl ID: ENSG00000089820
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.11
    Ensembl ID: ENSG00000012779
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160683
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.09
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.09
    Ensembl ID: ENSG00000197043
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.07
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.06
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.05
    Ensembl ID: ENSG00000111275
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104765
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cellular location**: The cell is located in the tonsil, a part of the immune system responsible for filtering and processing antigens. 2. **B cell type**: The cell is a type of B cell, which is a type of immune cell responsible for producing antibodies. 3. **Germinal center**: The cell is part of a germinal center, a specialized area within the lymph node where B cells undergo clonal expansion and differentiation. 4. **Actin filament and adherens junctions interactions**: The cell expresses genes involved in actin filament and adherens junctions interactions, which are essential for cell adhesion, migration, and signaling. 5. **Angiogenesis**: The cell expresses genes involved in angiogenesis, the process of new blood vessel formation, which is essential for immune cell migration and tissue development. 6. **Apoptosis**: The cell expresses genes involved in apoptosis, the process of programmed cell death, which is essential for maintaining immune homeostasis. **Clinical Significance** 1. **Immune response development**: The cell plays a crucial role in the development of immune responses, particularly in the context of infections such as Leishmania. 2. **Autoimmune diseases**: Abnormalities in the cell's function and signaling pathways have been implicated in autoimmune diseases, such as autoimmune hemolytic anemia. 3. **Cancer**: The cell's role in the development of immune responses has also been implicated in cancer, particularly in the context of tumor immune evasion. 4. **Infectious diseases**: The cell's ability to recognize and respond to pathogens has been implicated in the development of infectious diseases, such as Leishmania. 5. **Immunotherapy**: The cell's function and signaling pathways have been targeted in immunotherapies, such as checkpoint inhibitors, to enhance immune responses against cancer and other diseases. In conclusion, the cell CL2000006 is a specialized type of B cell that plays a crucial role in the development of immune responses, particularly in the context of infections. Its key characteristics, including its cellular location, B cell type, and expression of genes involved in actin filament and adherens junctions interactions, angiogenesis, and apoptosis, make it an important component of the immune system. Its clinical significance lies in its role in the development of immune responses, autoimmune diseases, cancer, infectious diseases, and immunotherapy.