Details for: CL2000047

Cell ID: CL2000047

Cell Name: brainstem motor neuron

Marker Score Threshold: 581
(Derived using integrated single-cell and genomic data)

Description: Any motor neuron that is part of a brainstem.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 3.96
    Ensembl ID: ENSG00000153956
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 3.8
    Ensembl ID: ENSG00000145362
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.57
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 3.41
    Ensembl ID: ENSG00000151150
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.33
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CACNA1E (ENSG00000198216)
    Fold Change: 3.29
    Ensembl ID: ENSG00000198216
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 3.27
    Ensembl ID: ENSG00000079102
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 3.13
    Ensembl ID: ENSG00000168675
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.11
    Ensembl ID: ENSG00000142599
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.95
    Ensembl ID: ENSG00000198589
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.92
    Ensembl ID: ENSG00000134982
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 2.82
    Ensembl ID: ENSG00000151067
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 2.71
    Ensembl ID: ENSG00000018236
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 2.52
    Ensembl ID: ENSG00000170558
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 2.46
    Ensembl ID: ENSG00000148408
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.45
    Ensembl ID: ENSG00000034053
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.43
    Ensembl ID: ENSG00000204217
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.33
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.22
    Ensembl ID: ENSG00000152092
  • Gene Symbol: CHRM3 (ENSG00000133019)
    Fold Change: 2.22
    Ensembl ID: ENSG00000133019
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.21
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 2.19
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 2.15
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.09
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.06
    Ensembl ID: ENSG00000278540
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 2.05
    Ensembl ID: ENSG00000152495
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 2.03
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.97
    Ensembl ID: ENSG00000058668
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.92
    Ensembl ID: ENSG00000166710
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.9
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CRMP1 (ENSG00000072832)
    Fold Change: 1.88
    Ensembl ID: ENSG00000072832
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.86
    Ensembl ID: ENSG00000157764
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.84
    Ensembl ID: ENSG00000130294
  • Gene Symbol: CHRM2 (ENSG00000181072)
    Fold Change: 1.76
    Ensembl ID: ENSG00000181072
  • Gene Symbol: CPE (ENSG00000109472)
    Fold Change: 1.75
    Ensembl ID: ENSG00000109472
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.71
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.69
    Ensembl ID: ENSG00000075340
  • Gene Symbol: CDH8 (ENSG00000150394)
    Fold Change: 1.68
    Ensembl ID: ENSG00000150394
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.65
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.61
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 1.6
    Ensembl ID: ENSG00000141837
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.59
    Ensembl ID: ENSG00000075624
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.57
    Ensembl ID: ENSG00000131143
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.56
    Ensembl ID: ENSG00000127184
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 1.49
    Ensembl ID: ENSG00000066382
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 1.49
    Ensembl ID: ENSG00000182389
  • Gene Symbol: CHN1 (ENSG00000128656)
    Fold Change: 1.47
    Ensembl ID: ENSG00000128656
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.45
    Ensembl ID: ENSG00000156110
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.42
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.42
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CDK8 (ENSG00000132964)
    Fold Change: 1.41
    Ensembl ID: ENSG00000132964
  • Gene Symbol: CREBBP (ENSG00000005339)
    Fold Change: 1.4
    Ensembl ID: ENSG00000005339
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.37
    Ensembl ID: ENSG00000172757
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.34
    Ensembl ID: ENSG00000078053
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.31
    Ensembl ID: ENSG00000107779
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.3
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CDH12 (ENSG00000154162)
    Fold Change: 1.3
    Ensembl ID: ENSG00000154162
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.3
    Ensembl ID: ENSG00000173175
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.3
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 1.28
    Ensembl ID: ENSG00000157087
  • Gene Symbol: CNR1 (ENSG00000118432)
    Fold Change: 1.28
    Ensembl ID: ENSG00000118432
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.28
    Ensembl ID: ENSG00000138760
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.27
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CDH7 (ENSG00000081138)
    Fold Change: 1.25
    Ensembl ID: ENSG00000081138
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.24
    Ensembl ID: ENSG00000135940
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.24
    Ensembl ID: ENSG00000164919
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.23
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.2
    Ensembl ID: ENSG00000099622
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.19
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.19
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.17
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.15
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.15
    Ensembl ID: ENSG00000164742
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.15
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.14
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.12
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CDH10 (ENSG00000040731)
    Fold Change: 1.12
    Ensembl ID: ENSG00000040731
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.12
    Ensembl ID: ENSG00000198668
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.11
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.1
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.09
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.08
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.08
    Ensembl ID: ENSG00000156273
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.07
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.06
    Ensembl ID: ENSG00000060982
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.06
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CDH11 (ENSG00000140937)
    Fold Change: 1.06
    Ensembl ID: ENSG00000140937
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.05
    Ensembl ID: ENSG00000148090
  • Gene Symbol: CHM (ENSG00000188419)
    Fold Change: 1.05
    Ensembl ID: ENSG00000188419
  • Gene Symbol: CHD3 (ENSG00000170004)
    Fold Change: 1.05
    Ensembl ID: ENSG00000170004
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 1.04
    Ensembl ID: ENSG00000157388
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.04
    Ensembl ID: ENSG00000122218
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.03
    Ensembl ID: ENSG00000162433
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.02
    Ensembl ID: ENSG00000179218
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.02
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143322
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.02
    Ensembl ID: ENSG00000134825
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.01
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.01
    Ensembl ID: ENSG00000097007
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1
    Ensembl ID: ENSG00000070831
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cell Type**: Brainstem motor neuron 2. **Location**: Brainstem 3. **Function**: Controls voluntary movements 4. **Gene Expression**: CACNA2D1, ANK2, DST 5. **Pathways/Ontologies**: * Calcium ion import across plasma membrane * Calcium ion transmembrane transport via high voltage-gated calcium channel * Calcium ion transport, Calcium ion transport into cytosol * Cardiac muscle cell action potential involved in contraction * Cellular response to amyloid-beta * Extracellular exosome * L-type voltage-gated calcium channel complex * Membrane depolarization during bundle of his cell action potential * Metal ion binding * Neuronal dense core vesicle * Plasma membrane * Positive regulation of high voltage-gated calcium channel activity * Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel * Regulation of calcium ion transport * Regulation of heart rate by cardiac conduction * Regulation of membrane repolarization during action potential * Regulation of ventricular cardiac muscle cell membrane repolarization * Sarcoplasmic reticulum * Voltage-gated calcium channel activity * Voltage-gated calcium channel activity involved in bundle of his cell action potential * Voltage-gated calcium channel activity involved in cardiac muscle cell action potential * Voltage-gated calcium channel complex 6. **Protein Localization**: ANK2, DST **Clinical Significance** 1. **Motor Neuron Disease**: The cell's dysfunction can lead to motor neuron disease, such as amyotrophic lateral sclerosis (ALS), which affects voluntary movements. 2. **Cardiac Conduction**: The cell's regulation of cardiac muscle contraction and heart rate by cardiac conduction is crucial for maintaining normal cardiac function. 3. **Neurological Disorders**: The cell's response to amyloid-beta and its role in neuronal dense core vesicle formation may be relevant to neurological disorders such as Alzheimer's disease. 4. **Cancer**: The cell's involvement in protein localization and cell signaling may be relevant to cancer development and progression. 5. **Neurological Disorders**: The cell's regulation of calcium ion transport and membrane depolarization may be relevant to neurological disorders such as epilepsy and Parkinson's disease. In conclusion, the cell CL2000047 is a brainstem motor neuron with complex functions and regulatory mechanisms. Its dysfunction can lead to various neurological and cardiac disorders, highlighting the importance of understanding its biology and pathology.