Details for: CL2000060

Cell ID: CL2000060

Cell Name: placental villous trophoblast

Marker Score Threshold: 3930
(Derived using integrated single-cell and genomic data)

Description: A trophoblast of placental villi. These cells fuse to form synctial trophoplast - the placental side of the interface between the placenta and maternal blood sinusoids in the decidua.

Synonyms: vCTB, villous cytotrophoblast

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.32
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.31
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.3
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.29
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.29
    Ensembl ID: ENSG00000084234
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.27
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.27
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.27
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2.27
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.26
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.26
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.26
    Ensembl ID: ENSG00000154518
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 2.25
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.25
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.25
    Ensembl ID: ENSG00000165629
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.24
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.24
    Ensembl ID: ENSG00000135390
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 2.24
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 2.24
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.22
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.21
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.19
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.18
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.17
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.17
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 2.16
    Ensembl ID: ENSG00000197894
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.15
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.15
    Ensembl ID: ENSG00000159199
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.13
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.11
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 2.1
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.1
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.1
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 2.06
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 2.05
    Ensembl ID: ENSG00000138279
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.05
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 2.01
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.98
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.97
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.96
    Ensembl ID: ENSG00000213465
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.96
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.94
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.93
    Ensembl ID: ENSG00000138363
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.93
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.89
    Ensembl ID: ENSG00000004059
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.88
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.87
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP6V1B1 (ENSG00000116039)
    Fold Change: 1.86
    Ensembl ID: ENSG00000116039
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.86
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.83
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.8
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.8
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.79
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.79
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.77
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.74
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.71
    Ensembl ID: ENSG00000147416
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.71
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.71
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.7
    Ensembl ID: ENSG00000162688
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.68
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.68
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.66
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.64
    Ensembl ID: ENSG00000204574
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.62
    Ensembl ID: ENSG00000177105
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.58
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.57
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.57
    Ensembl ID: ENSG00000060971
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.53
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.52
    Ensembl ID: ENSG00000239900
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1.52
    Ensembl ID: ENSG00000164062
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.48
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ACADS (ENSG00000122971)
    Fold Change: 1.47
    Ensembl ID: ENSG00000122971
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.44
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ALAS1 (ENSG00000023330)
    Fold Change: 1.42
    Ensembl ID: ENSG00000023330
  • Gene Symbol: ADRB1 (ENSG00000043591)
    Fold Change: 1.4
    Ensembl ID: ENSG00000043591
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.39
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.39
    Ensembl ID: ENSG00000196975
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.35
    Ensembl ID: ENSG00000151729
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.31
    Ensembl ID: ENSG00000090861
  • Gene Symbol: ARG2 (ENSG00000081181)
    Fold Change: 1.31
    Ensembl ID: ENSG00000081181
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.22
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.19
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.19
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.18
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: 1.16
    Ensembl ID: ENSG00000136518
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.15
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.12
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.11
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.09
    Ensembl ID: ENSG00000140836
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.07
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ALAD (ENSG00000148218)
    Fold Change: 1.07
    Ensembl ID: ENSG00000148218
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.06
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.05
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ACP2 (ENSG00000134575)
    Fold Change: 1.02
    Ensembl ID: ENSG00000134575
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.02
    Ensembl ID: ENSG00000137486
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.01
    Ensembl ID: ENSG00000183020
Hovered Details

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Hovered Details

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**Key Characteristics** * **Gene Symbol:** ANXA1 * **Ensembl ID:** ENSG00000135046 * **Cell Type:** Placental villous trophoblast (VCTB) cells * **Function:** Forms a synctial trophoplast, facilitating nutrient and waste exchange between the placenta and maternal blood * **Protein Characteristics:** Small, cysteine-rich protein that binds calcium ions * **Pathways/Ontology:** Actin cytoskeleton organization, Actin filament, Adaptive immune response, Adherens junction, Alpha-beta T cell differentiation, Apical plasma membrane, Basolateral plasma membrane, Cadherin binding involved in cell-cell adhesion, Calcium-dependent phospholipid binding, Calcium-dependent protein binding, Calcium ion binding, Cell-cell adhesion, Cell surface, Cellular response to glucocorticoid stimulus, Cellular response to vascular endothelial growth factor stimulus, Class a/1 (rhodopsin-like receptors), Collagen-containing extracellular matrix, Cornified envelope, Cytokine signaling in immune system, Cytoplasm, Cytosol, Early endosome membrane, Endosome, Extracellular exosome, Extracellular region, Extracellular space, Focal adhesion, Formyl peptide receptors bind formyl peptides and many other ligands, G alpha (i) signalling events, G alpha (q) signalling events, Gpcr downstream signalling, Gpcr ligand binding, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, Granulocyte chemotaxis, Immune system, Inflammatory response, Innate immune response, Interleukin-4 and interleukin-13 signaling, Keratinocyte differentiation, Lateral plasma membrane, Lipid binding, Localization, Monocyte chemotaxis, Motile cilium, Muscle contraction, Negative regulation of apoptotic process, Negative regulation of exocytosis, Negative regulation of interleukin-8 production, Negative regulation of T-helper 2 cell differentiation, Neutrophil activation, Neutrophil clearance, Neutrophil homeostasis, Nucleoplasm, Nucleus, Peptide cross-linking, Peptide ligand-binding receptors, Phagocytic cup, Phagocytosis, Phosphatidylserine binding, Phospholipase a2 inhibitor activity, Phospholipid binding, Plasma membrane, Positive regulation of cell migration involved in sprouting angiogenesis, Positive regulation of interleukin-2 production, Positive regulation of T-helper 1 cell differentiation, Positive regulation of T cell proliferation, Positive regulation of vesicle fusion, Positive regulation of wound healing, Protein binding, Regulation of cell shape, Regulation of hormone secretion, Regulation of inflammatory response, Regulation of interleukin-1 production, Regulation of leukocyte migration, Sarcolemma, Signaling by gpcr, Signaling by interleukins, Signaling receptor binding, Signal transduction, Smooth muscle contraction, Vesicle **Clinical Significance** The ANXA1 protein plays a crucial role in the formation of the synctial trophoplast, which is essential for the exchange of nutrients and waste products between the placenta and maternal blood. Dysregulation of ANXA1 expression or function has been implicated in various pregnancy-related disorders, including preeclampsia, placental insufficiency, and fetal growth restriction. Additionally, ANXA1 has been implicated in the regulation of the immune response, angiogenesis, and wound healing, making it a potential target for the treatment of various diseases, including cancer, inflammatory disorders, and cardiovascular disease. In conclusion, the ANXA1 protein is a key regulator of cellular processes in placental villous trophoblast cells, and its dysregulation has been implicated in various pregnancy-related disorders and diseases. Further research is needed to fully understand the function and clinical significance of ANXA1 in human health and disease.