Details for: CL4006000

Cell ID: CL4006000

Cell Name: fibroblast of breast

Marker Score Threshold: 570
(Derived using integrated single-cell and genomic data)

Description: A fibroblast that is part of the breast.

Synonyms: breast fibroblast

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 3.29
    Ensembl ID: ENSG00000189058
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.12
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.06
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.99
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.99
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.83
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.78
    Ensembl ID: ENSG00000185650
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 2.69
    Ensembl ID: ENSG00000147872
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 2.61
    Ensembl ID: ENSG00000115963
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.55
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.49
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.42
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.38
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.35
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.33
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 2.33
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.28
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.25
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.22
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.2
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.16
    Ensembl ID: ENSG00000163399
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 2.14
    Ensembl ID: ENSG00000106624
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.12
    Ensembl ID: ENSG00000135046
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.09
    Ensembl ID: ENSG00000084234
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.08
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.07
    Ensembl ID: ENSG00000069849
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.05
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 2.03
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.02
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.99
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.97
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.94
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.94
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.94
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: 1.93
    Ensembl ID: ENSG00000139567
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.92
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.91
    Ensembl ID: ENSG00000072110
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.9
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.85
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.8
    Ensembl ID: ENSG00000143322
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.79
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.79
    Ensembl ID: ENSG00000097007
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.79
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.78
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.77
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.76
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.74
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.72
    Ensembl ID: ENSG00000072778
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.6
    Ensembl ID: ENSG00000100823
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.59
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.59
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.55
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.54
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.54
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.51
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.51
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.46
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.44
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.43
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.4
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.38
    Ensembl ID: ENSG00000197043
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.38
    Ensembl ID: ENSG00000115307
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.37
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.37
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.33
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.31
    Ensembl ID: ENSG00000149925
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.3
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.3
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.28
    Ensembl ID: ENSG00000174437
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.28
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.26
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.26
    Ensembl ID: ENSG00000035687
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 1.23
    Ensembl ID: ENSG00000057657
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.22
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.22
    Ensembl ID: ENSG00000156273
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 1.22
    Ensembl ID: ENSG00000182492
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.21
    Ensembl ID: ENSG00000130203
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.21
    Ensembl ID: ENSG00000113916
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.19
    Ensembl ID: ENSG00000122729
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.19
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.19
    Ensembl ID: ENSG00000095139
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.19
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.17
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.17
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.15
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.14
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.14
    Ensembl ID: ENSG00000111275
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.14
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.12
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.12
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.09
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.09
    Ensembl ID: ENSG00000138363
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.08
    Ensembl ID: ENSG00000142599
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.07
    Ensembl ID: ENSG00000015475
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.05
    Ensembl ID: ENSG00000087274
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.05
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.04
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.02
    Ensembl ID: ENSG00000134287
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1
    Ensembl ID: ENSG00000087088

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in fibroblast of breast cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in fibroblast of breast cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * **Cell Type**: Breast fibroblasts are a type of fibroblast that is specific to the breast tissue. * **Gene Symbol**: APOD (Apolipoprotein D) * **Ensembl ID**: ENSG00000189058 * **Pathways/Ontology**: Angiogenesis, Brain development, Cholesterol binding, Cytoplasm, Cytosolic ribosome, Dendrite, Endoplasmic reticulum, Extracellular exosome, Extracellular region, Extracellular space, Glucose metabolic process, Lipid metabolic process, Lipid transporter activity, Negative regulation of cytokine production involved in inflammatory response, Negative regulation of focal adhesion assembly, Negative regulation of lipoprotein lipid oxidation, Negative regulation of monocyte chemotactic protein-1 production, Negative regulation of platelet-derived growth factor receptor signaling pathway, Negative regulation of protein import into nucleus, Negative regulation of smooth muscle cell-matrix adhesion, Negative regulation of smooth muscle cell proliferation, Negative regulation of t cell migration, Neuronal cell body, Nr1h2 and nr1h3-mediated signaling, Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux, Perinuclear region of cytoplasm, Peripheral nervous system axon regeneration, Protein binding, Response to axon injury, Response to reactive oxygen species, Signaling by nuclear receptors, Signal transduction, Slc-mediated transmembrane transport, Tissue regeneration, Transport of fatty acids, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules * **Gene Symbol**: B2M (Beta-2 microglobulin) * **Ensembl ID**: ENSG00000166710 * **Pathways/Ontology**: Adaptive immune system, Amyloid fiber formation, Amyloid fibril formation, Antigen presentation: folding, assembly and peptide loading of class i mhc, Antigen processing-cross presentation, Antigen processing and presentation of endogenous peptide antigen via mhc class i, Antigen processing and presentation of exogenous peptide antigen via mhc class ii, Antigen processing and presentation of exogenous protein antigen via mhc class ib, tap-dependent, Bacterial infection pathways, Cellular response to iron(iii) ion, Cellular response to iron ion, Cellular response to nicotine, Class i mhc mediated antigen processing & presentation, Cytokine signaling in immune system, Cytosol, Dap12 interactions, Dap12 signaling, Disease, Early endosome lumen, Early endosome membrane, Endoplasmic reticulum, Endoplasmic reticulum lumen, Endosomal/vacuolar pathway, Er-phagosome pathway, Er to golgi transport vesicle membrane, External side of plasma membrane, Extracellular exosome, Extracellular region, Extracellular space, Focal adhesion, Golgi apparatus, Golgi membrane, Hfe-transferrin receptor complex, Hiv infection, Host interactions of hiv factors, Identical protein binding, Immune system, Immunoregulatory interactions between a lymphoid and a non-lymphoid cell, Infection with mycobacterium tuberculosis, Infectious disease, Innate immune system, Interferon gamma signaling, Interferon signaling, Intracellular iron ion homeostasis, Iron ion transport, Late endosome membrane, Learning or memory, Lysosomal membrane, Membrane, Metabolism of proteins, Mhc class ii protein complex, Mhc class ii protein complex binding, Mhc class i peptide loading complex, Mhc class i protein complex, Modulation by mtb of host immune system, Multicellular organismal-level iron ion homeostasis, Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, Nef mediated downregulation of mhc class i complex cell surface expression, Negative regulation of epithelial cell proliferation, Negative regulation of forebrain neuron differentiation, Negative regulation of neurogenesis, Negative regulation of neuron projection development, Negative regulation of receptor binding, Neutrophil degranulation, Peptide antigen assembly with mhc class ii protein complex, Peptide antigen assembly with mhc class i protein complex, Peptide antigen binding, Phagocytic vesicle membrane, Plasma membrane, Positive regulation of cellular senescence, Positive regulation of ferrous iron binding, Positive regulation of immune response, Positive regulation of protein binding, Positive regulation of receptor-mediated endocytosis, Positive regulation of receptor binding, Positive regulation of t cell activation, Positive regulation of t cell cytokine production, Positive regulation of t cell mediated cytotoxicity, Positive regulation of transferrin receptor binding, Protein binding, Protein homodimerization activity, Protein homotetramerization, Protein refolding, Recycling endosome membrane, Regulation of erythrocyte differentiation, Regulation of iron ion transport, Response to molecule of bacterial origin, Sars-cov-2 activates/modulates innate and adaptive immune responses, Sars-cov-2 infection, Sars-cov-2-host interactions, Sars-cov infections, Sensory perception of smell, Specific granule lumen, Structural molecule activity, T cell differentiation in thymus, T cell mediated cytotoxicity, Tertiary granule lumen, The role of nef in hiv-1 replication and disease pathogenesis, Viral infection pathways * **Gene Symbol**: ACTB (Actin beta) * **Ensembl ID**: ENSG00000075624 * **Pathways/Ontology**: Actin cytoskeleton, Actin filament, Adherens junction, Adherens junction assembly, Adherens junctions interactions, Apical junction complex, Apical protein localization, Atp binding, Axon, Axon guidance, Axonogenesis, B-wich complex positively regulates rrna expression, Bbaf complex, Blood microparticle, Brahma complex, Brush border, Calyx of held, Cell-cell communication, Cell-cell junction, Cell-cell junction organization, Cell-extracellular matrix interactions, Cell junction organization, Cell motility, Cellular response to cytochalasin b, Chaperonin-mediated protein folding, Chromatin, Chromatin modifying enzymes, Chromatin organization, Chromatin remodeling, Clathrin-mediated endocytosis, Cooperation of prefoldin and tric/cct in actin and tubulin folding, Cortical cytoskeleton, Cytoplasm, Cytoplasmic ribonucleoprotein granule, Cytoskeleton, Cytosol, Dense body, Deubiquitination, Developmental biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dna damage recognition in gg-ner, Dna repair, Eph-ephrin mediated repulsion of cells, Eph-ephrin signaling, Ephb-mediated forward signaling, Epigenetic regulation of gene expression, Establishment or maintenance of cell polarity, Extracellular exosome, Extracellular space, Factors involved in megakaryocyte development and platelet production, Fcgamma receptor (fcgr) dependent phagocytosis, Fcgr3a-mediated phagocytosis, Focal adhesion, Folding of actin by cct/tric, Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Gbaf complex, Gene expression (transcription), Global genome nucleotide excision repair (gg-ner), Glutamatergic synapse, Hats acetylate histones, Hemostasis, Hydrolase activity, Identical protein binding, Immune system, Infectious disease, Innate immune system, Interaction between l1 and ankyrins, Kinesin binding, Kinetochore, L1cam interactions, Lamellipodium, Leishmania infection, Leishmania phagocytosis, Maintenance of blood-brain barrier, Map2k and mapk activation, Mapk1/mapk3 signaling, Mapk family signaling cascades, Membrane, Membrane trafficking, Metabolism of proteins, Morphogenesis of a polarized epithelium, Nbaf complex, Negative regulation of cell differentiation, Negative regulation of protein binding, Nervous system development, Nitric-oxide synthase binding, Npbaf complex, Nua4 histone acetyltransferase complex, Nuclear matrix, Nucleoplasm, Nucleosomal dna binding, Nucleosome, Nucleotide excision repair, Nucleus, Oncogenic mapk signaling, Paradoxical activation of raf signaling by kinase inactive braf, Parasite infection, Parasitic infection pathways, Plasma membrane, Platelet aggregation, Positive epigenetic regulation of rrna expression, Positive regulation of cell differentiation, Positive regulation of cell population proliferation, Positive regulation of dna-templated transcription, Positive regulation of double-strand break repair, Positive regulation of double-strand break repair via homologous... **Clinical Significance** Breast fibroblasts play a crucial role in the development and maintenance of the breast tissue. They are involved in various cellular processes, including cell signaling, protein binding, and transport of small molecules. They are also involved in the regulation of immune responses, including antigen processing and presentation, and have been implicated in various diseases, such as cancer and infectious diseases. Breast fibroblasts have been shown to be involved in the