Details for: CL4023011

Cell ID: CL4023011

Cell Name: lamp5 GABAergic cortical interneuron

Marker Score Threshold: 14,952
(Derived using integrated single-cell and genomic data)

Description: A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Lamp5.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 2.87
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.86
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.85
    Ensembl ID: ENSG00000145362
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.81
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 2.79
    Ensembl ID: ENSG00000171094
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 2.79
    Ensembl ID: ENSG00000100077
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.72
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.7
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.62
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.62
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.61
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.56
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.5
    Ensembl ID: ENSG00000278540
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.5
    Ensembl ID: ENSG00000134982
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 2.48
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 2.45
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.44
    Ensembl ID: ENSG00000157087
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.42
    Ensembl ID: ENSG00000143153
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.41
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 2.35
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 2.31
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.24
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 2.21
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.21
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.19
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.17
    Ensembl ID: ENSG00000170634
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.14
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 2.13
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 2.12
    Ensembl ID: ENSG00000183044
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 2.03
    Ensembl ID: ENSG00000006125
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 2.02
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.99
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.98
    Ensembl ID: ENSG00000029534
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.97
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.96
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.96
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.94
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.93
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 1.87
    Ensembl ID: ENSG00000078549
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.84
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.82
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 1.76
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.75
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.73
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.73
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.72
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.67
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.66
    Ensembl ID: ENSG00000072110
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.63
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.57
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.55
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.54
    Ensembl ID: ENSG00000133794
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.54
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.52
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.51
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.5
    Ensembl ID: ENSG00000143437
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.5
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.5
    Ensembl ID: ENSG00000113273
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.45
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.43
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 1.42
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.39
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.39
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.37
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.37
    Ensembl ID: ENSG00000138031
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.37
    Ensembl ID: ENSG00000090861
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.37
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.34
    Ensembl ID: ENSG00000197381
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.33
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ATP1B2 (ENSG00000129244)
    Fold Change: 1.33
    Ensembl ID: ENSG00000129244
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.33
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.32
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.31
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ATP6V1C1 (ENSG00000155097)
    Fold Change: 1.3
    Ensembl ID: ENSG00000155097
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.26
    Ensembl ID: ENSG00000069849
  • Gene Symbol: TRIM23 (ENSG00000113595)
    Fold Change: 1.26
    Ensembl ID: ENSG00000113595
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.23
    Ensembl ID: ENSG00000123268
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.22
    Ensembl ID: ENSG00000075239
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.21
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 1.2
    Ensembl ID: ENSG00000115170
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.16
    Ensembl ID: ENSG00000197043
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.16
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.14
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.13
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.12
    Ensembl ID: ENSG00000152234
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.12
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.12
    Ensembl ID: ENSG00000135390
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.11
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.1
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.09
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.09
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.06
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.05
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.05
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ARG2 (ENSG00000081181)
    Fold Change: 1.03
    Ensembl ID: ENSG00000081181
  • Gene Symbol: ATP7B (ENSG00000123191)
    Fold Change: 1.03
    Ensembl ID: ENSG00000123191
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.03
    Ensembl ID: ENSG00000067842

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in lamp5 GABAergic cortical interneuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in lamp5 GABAergic cortical interneuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The CL4023011 cell line is characterized by the following key features: * **Transcriptomic distinctness**: The CL4023011 cell line is a transcriptomically distinct GABAergic neuron that expresses Lamp5, which is a unique marker for this cell type. * **Gene expression profile**: The CL4023011 cell line has a distinct gene expression profile that includes genes involved in adenosine deaminase activity, adenosine to inosine editing, and metal ion binding. * **Axon guidance and axonogenesis**: The CL4023011 cell line is associated with genes involved in axon guidance and axonogenesis, which are critical for the development and maintenance of neuronal connections. * **Neuronal development**: The CL4023011 cell line is also associated with genes involved in neuronal development, including genes involved in the development of the cerebral cortex and the maturation of GABAergic neurons. * **GABAergic neurotransmission**: The CL4023011 cell line is a GABAergic neuron, which means that it uses GABA (gamma-aminobutyric acid) as a neurotransmitter to regulate neuronal activity. **Clinical Significance** The clinical significance of the CL4023011 cell line is not yet fully understood, but it may play a role in the regulation of GABAergic neurotransmission and the development of neurological disorders. Some potential clinical implications of this cell type include: * **Neurological disorders**: The CL4023011 cell line may contribute to the development of neurological disorders such as epilepsy, anxiety, and depression, which are characterized by abnormal GABAergic neurotransmission. * **Neurodevelopmental disorders**: The CL4023011 cell line may also contribute to the development of neurodevelopmental disorders such as autism spectrum disorder and schizophrenia, which are characterized by abnormalities in neuronal development and connectivity. * **Cancer**: The CL4023011 cell line may also play a role in the development of cancer, particularly in the context of receptor tyrosine kinase signaling pathways. **Future Research Directions** Future research directions for the CL4023011 cell line include: * **Characterization of gene expression**: Further characterization of the gene expression profile of the CL4023011 cell line is needed to understand its role in GABAergic neurotransmission and neuronal development. * **Investigation of clinical implications**: Further investigation of the clinical implications of the CL4023011 cell line is needed to understand its role in neurological disorders and cancer. * **Development of therapeutic strategies**: Development of therapeutic strategies that target the CL4023011 cell line may provide new treatments for neurological disorders and cancer.