Details for: CL4023012

Cell ID: CL4023012

Cell Name: near-projecting glutamatergic cortical neuron

Marker Score Threshold: 9406
(Derived using integrated single-cell and genomic data)

Description: A glutamatergic neuron located in the cerebral cortex that projects axons locally rather than distantly.

Synonyms: NP neuron

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.2
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.2
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.2
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.19
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.17
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.16
    Ensembl ID: ENSG00000157087
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.15
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.14
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.14
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.13
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.13
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.09
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 2.06
    Ensembl ID: ENSG00000075340
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.05
    Ensembl ID: ENSG00000034053
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 2.04
    Ensembl ID: ENSG00000078053
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.04
    Ensembl ID: ENSG00000134982
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.03
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.02
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 2.02
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.99
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.96
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.93
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.92
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.91
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.91
    Ensembl ID: ENSG00000167972
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.9
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.89
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 1.87
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.87
    Ensembl ID: ENSG00000087274
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.87
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.81
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.8
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.8
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.79
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.78
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.77
    Ensembl ID: ENSG00000149311
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.76
    Ensembl ID: ENSG00000183020
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.7
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.7
    Ensembl ID: ENSG00000121989
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.65
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.64
    Ensembl ID: ENSG00000197381
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.59
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.59
    Ensembl ID: ENSG00000160710
  • Gene Symbol: STS (ENSG00000101846)
    Fold Change: 1.56
    Ensembl ID: ENSG00000101846
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 1.55
    Ensembl ID: ENSG00000240038
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.53
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.53
    Ensembl ID: ENSG00000117054
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.52
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.52
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.51
    Ensembl ID: ENSG00000113273
  • Gene Symbol: ADORA1 (ENSG00000163485)
    Fold Change: 1.49
    Ensembl ID: ENSG00000163485
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.46
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.46
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.45
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.44
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.44
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.43
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.42
    Ensembl ID: ENSG00000104763
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.4
    Ensembl ID: ENSG00000101966
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.4
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.39
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.39
    Ensembl ID: ENSG00000090861
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.39
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.38
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.38
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.37
    Ensembl ID: ENSG00000196177
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.35
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.34
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.33
    Ensembl ID: ENSG00000140836
  • Gene Symbol: TRIM23 (ENSG00000113595)
    Fold Change: 1.32
    Ensembl ID: ENSG00000113595
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.29
    Ensembl ID: ENSG00000133794
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.29
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.27
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.27
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.25
    Ensembl ID: ENSG00000135503
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.2
    Ensembl ID: ENSG00000123268
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.19
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.18
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ADCY6 (ENSG00000174233)
    Fold Change: 1.17
    Ensembl ID: ENSG00000174233
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.16
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.13
    Ensembl ID: ENSG00000067842
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.13
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.13
    Ensembl ID: ENSG00000134287
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ABCA2 (ENSG00000107331)
    Fold Change: 1.1
    Ensembl ID: ENSG00000107331
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.08
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.08
    Ensembl ID: ENSG00000196961
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.07
    Ensembl ID: ENSG00000105290
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.06
    Ensembl ID: ENSG00000067560
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.06
    Ensembl ID: ENSG00000159461
  • Gene Symbol: ATP1B2 (ENSG00000129244)
    Fold Change: 1.06
    Ensembl ID: ENSG00000129244
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.04
    Ensembl ID: ENSG00000138363
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.03
    Ensembl ID: ENSG00000100280
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.02
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.01
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.01
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1
    Ensembl ID: ENSG00000173175
Hovered Details

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Hovered Details

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**Key Characteristics** The near-projecting glutamatergic cortical neuron has several key characteristics: 1. **Local axon projection**: The axon of this neuron projects locally, meaning that it does not extend far from the neuron body. 2. **Glutamatergic**: This neuron uses glutamate as its primary neurotransmitter. 3. **Cortical location**: The neuron is located in the cerebral cortex, which is the outer layer of the brain responsible for processing sensory information and controlling movement. 4. **Ankyrin binding**: The neuron's cytoskeleton is anchored to the plasma membrane by ankyrin proteins. 5. **Axon guidance**: The neuron's axon is involved in axon guidance, which is the process by which axons navigate to their target locations during development. 6. **Cardiac muscle regulation**: The neuron's axon is also involved in regulating cardiac muscle contraction. **Clinical Significance** The near-projecting glutamatergic cortical neuron has several clinical significance: 1. **Neurological disorders**: Abnormalities in this neuron's function have been implicated in various neurological disorders, including epilepsy, Parkinson's disease, and Alzheimer's disease. 2. **Cardiac arrhythmias**: Abnormalities in the neuron's regulation of cardiac muscle contraction have been implicated in cardiac arrhythmias, such as atrial fibrillation. 3. **Neuromuscular junction dysfunction**: Abnormalities in the neuron's axon guidance and regulation of muscle contraction have been implicated in neuromuscular junction dysfunction, such as myasthenia gravis. 4. **Developmental disorders**: Abnormalities in the neuron's development and maintenance have been implicated in developmental disorders, such as autism spectrum disorder. **Genetic Basis** The near-projecting glutamatergic cortical neuron is encoded by the ANK2 gene, which is involved in various cellular processes, including axon guidance, cell adhesion, and regulation of cardiac muscle contraction. Mutations in the ANK2 gene have been implicated in various neurological and cardiac disorders. **Pathways/Ontology** The near-projecting glutamatergic cortical neuron is involved in various signaling pathways, including: 1. **Adenylate cyclase signaling pathway**: This pathway is involved in regulating cardiac muscle contraction and relaxation. 2. **GABA_B receptor signaling pathway**: This pathway is involved in regulating neuronal excitability and synaptic transmission. 3. **Calcium-dependent events**: This pathway is involved in regulating cardiac muscle contraction and relaxation. 4. **Cytoskeleton organization**: This pathway is involved in regulating axon guidance and cell adhesion. Overall, the near-projecting glutamatergic cortical neuron is a complex cell type that plays a critical role in various cellular processes, including synaptic transmission, cell adhesion, and regulation of cardiac muscle contraction.