Details for: CL4023012

Cell ID: CL4023012

Cell Name: near-projecting glutamatergic cortical neuron

Marker Score Threshold: 9,406
(Derived using integrated single-cell and genomic data)

Description: A glutamatergic neuron located in the cerebral cortex that projects axons locally rather than distantly.

Synonyms: NP neuron

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 2.2
    Ensembl ID: ENSG00000135298
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 2.2
    Ensembl ID: ENSG00000088538
  • Gene Symbol: FGF14 (ENSG00000102466)
    Fold Change: 2.2
    Ensembl ID: ENSG00000102466
  • Gene Symbol: GRM5 (ENSG00000168959)
    Fold Change: 2.2
    Ensembl ID: ENSG00000168959
  • Gene Symbol: FGF12 (ENSG00000114279)
    Fold Change: 2.2
    Ensembl ID: ENSG00000114279
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 2.2
    Ensembl ID: ENSG00000150672
  • Gene Symbol: GPM6A (ENSG00000150625)
    Fold Change: 2.2
    Ensembl ID: ENSG00000150625
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.2
    Ensembl ID: ENSG00000145362
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 2.2
    Ensembl ID: ENSG00000169862
  • Gene Symbol: GRIN2A (ENSG00000183454)
    Fold Change: 2.2
    Ensembl ID: ENSG00000183454
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.2
    Ensembl ID: ENSG00000108684
  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 2.2
    Ensembl ID: ENSG00000173406
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.2
    Ensembl ID: ENSG00000078295
  • Gene Symbol: DSCAM (ENSG00000171587)
    Fold Change: 2.2
    Ensembl ID: ENSG00000171587
  • Gene Symbol: CDH18 (ENSG00000145526)
    Fold Change: 2.2
    Ensembl ID: ENSG00000145526
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 2.2
    Ensembl ID: ENSG00000141837
  • Gene Symbol: GRIA4 (ENSG00000152578)
    Fold Change: 2.2
    Ensembl ID: ENSG00000152578
  • Gene Symbol: GRIA2 (ENSG00000120251)
    Fold Change: 2.19
    Ensembl ID: ENSG00000120251
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 2.19
    Ensembl ID: ENSG00000018236
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 2.19
    Ensembl ID: ENSG00000130226
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 2.19
    Ensembl ID: ENSG00000151067
  • Gene Symbol: GRIN2B (ENSG00000273079)
    Fold Change: 2.19
    Ensembl ID: ENSG00000273079
  • Gene Symbol: GABRB1 (ENSG00000163288)
    Fold Change: 2.19
    Ensembl ID: ENSG00000163288
  • Gene Symbol: CDH8 (ENSG00000150394)
    Fold Change: 2.19
    Ensembl ID: ENSG00000150394
  • Gene Symbol: GRM3 (ENSG00000198822)
    Fold Change: 2.19
    Ensembl ID: ENSG00000198822
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.19
    Ensembl ID: ENSG00000151150
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 2.19
    Ensembl ID: ENSG00000198947
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 2.19
    Ensembl ID: ENSG00000182389
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 2.19
    Ensembl ID: ENSG00000148408
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 2.19
    Ensembl ID: ENSG00000134769
  • Gene Symbol: GRM8 (ENSG00000179603)
    Fold Change: 2.19
    Ensembl ID: ENSG00000179603
  • Gene Symbol: GRID1 (ENSG00000182771)
    Fold Change: 2.19
    Ensembl ID: ENSG00000182771
  • Gene Symbol: GABRG3 (ENSG00000182256)
    Fold Change: 2.19
    Ensembl ID: ENSG00000182256
  • Gene Symbol: DGKB (ENSG00000136267)
    Fold Change: 2.18
    Ensembl ID: ENSG00000136267
  • Gene Symbol: CHN1 (ENSG00000128656)
    Fold Change: 2.18
    Ensembl ID: ENSG00000128656
  • Gene Symbol: GABRB3 (ENSG00000166206)
    Fold Change: 2.18
    Ensembl ID: ENSG00000166206
  • Gene Symbol: GABRB2 (ENSG00000145864)
    Fold Change: 2.18
    Ensembl ID: ENSG00000145864
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.18
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CTNNA2 (ENSG00000066032)
    Fold Change: 2.18
    Ensembl ID: ENSG00000066032
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.17
    Ensembl ID: ENSG00000170017
  • Gene Symbol: DYNC1I1 (ENSG00000158560)
    Fold Change: 2.17
    Ensembl ID: ENSG00000158560
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.16
    Ensembl ID: ENSG00000157087
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.16
    Ensembl ID: ENSG00000145349
  • Gene Symbol: EFNA5 (ENSG00000184349)
    Fold Change: 2.16
    Ensembl ID: ENSG00000184349
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 2.15
    Ensembl ID: ENSG00000075711
  • Gene Symbol: GNAQ (ENSG00000156052)
    Fold Change: 2.15
    Ensembl ID: ENSG00000156052
  • Gene Symbol: GNAO1 (ENSG00000087258)
    Fold Change: 2.15
    Ensembl ID: ENSG00000087258
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.15
    Ensembl ID: ENSG00000204217
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.15
    Ensembl ID: ENSG00000142599
  • Gene Symbol: FER (ENSG00000151422)
    Fold Change: 2.15
    Ensembl ID: ENSG00000151422
  • Gene Symbol: GRIA1 (ENSG00000155511)
    Fold Change: 2.15
    Ensembl ID: ENSG00000155511
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 2.15
    Ensembl ID: ENSG00000152495
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 2.14
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 2.14
    Ensembl ID: ENSG00000157388
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 2.14
    Ensembl ID: ENSG00000079102
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.14
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.14
    Ensembl ID: ENSG00000278540
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.14
    Ensembl ID: ENSG00000151746
  • Gene Symbol: DNM1 (ENSG00000106976)
    Fold Change: 2.14
    Ensembl ID: ENSG00000106976
  • Gene Symbol: GRIK2 (ENSG00000164418)
    Fold Change: 2.13
    Ensembl ID: ENSG00000164418
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.13
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ELAVL3 (ENSG00000196361)
    Fold Change: 2.13
    Ensembl ID: ENSG00000196361
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.13
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ELAVL4 (ENSG00000162374)
    Fold Change: 2.13
    Ensembl ID: ENSG00000162374
  • Gene Symbol: DPYSL2 (ENSG00000092964)
    Fold Change: 2.13
    Ensembl ID: ENSG00000092964
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.12
    Ensembl ID: ENSG00000157764
  • Gene Symbol: EPHA5 (ENSG00000145242)
    Fold Change: 2.12
    Ensembl ID: ENSG00000145242
  • Gene Symbol: GHR (ENSG00000112964)
    Fold Change: 2.12
    Ensembl ID: ENSG00000112964
  • Gene Symbol: CDH11 (ENSG00000140937)
    Fold Change: 2.12
    Ensembl ID: ENSG00000140937
  • Gene Symbol: DAPK1 (ENSG00000196730)
    Fold Change: 2.11
    Ensembl ID: ENSG00000196730
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 2.11
    Ensembl ID: ENSG00000140945
  • Gene Symbol: DCC (ENSG00000187323)
    Fold Change: 2.11
    Ensembl ID: ENSG00000187323
  • Gene Symbol: CPE (ENSG00000109472)
    Fold Change: 2.11
    Ensembl ID: ENSG00000109472
  • Gene Symbol: EPHA7 (ENSG00000135333)
    Fold Change: 2.1
    Ensembl ID: ENSG00000135333
  • Gene Symbol: FHIT (ENSG00000189283)
    Fold Change: 2.1
    Ensembl ID: ENSG00000189283
  • Gene Symbol: BRINP1 (ENSG00000078725)
    Fold Change: 2.1
    Ensembl ID: ENSG00000078725
  • Gene Symbol: CDH10 (ENSG00000040731)
    Fold Change: 2.1
    Ensembl ID: ENSG00000040731
  • Gene Symbol: GRIN1 (ENSG00000176884)
    Fold Change: 2.1
    Ensembl ID: ENSG00000176884
  • Gene Symbol: CRYM (ENSG00000103316)
    Fold Change: 2.1
    Ensembl ID: ENSG00000103316
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.09
    Ensembl ID: ENSG00000156110
  • Gene Symbol: GLS (ENSG00000115419)
    Fold Change: 2.09
    Ensembl ID: ENSG00000115419
  • Gene Symbol: CDH6 (ENSG00000113361)
    Fold Change: 2.09
    Ensembl ID: ENSG00000113361
  • Gene Symbol: DTNB (ENSG00000138101)
    Fold Change: 2.09
    Ensembl ID: ENSG00000138101
  • Gene Symbol: CHRM2 (ENSG00000181072)
    Fold Change: 2.09
    Ensembl ID: ENSG00000181072
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.09
    Ensembl ID: ENSG00000085224
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.08
    Ensembl ID: ENSG00000198589
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 2.07
    Ensembl ID: ENSG00000140743
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 2.07
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 2.06
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ESRRG (ENSG00000196482)
    Fold Change: 2.06
    Ensembl ID: ENSG00000196482
  • Gene Symbol: GLG1 (ENSG00000090863)
    Fold Change: 2.05
    Ensembl ID: ENSG00000090863
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.05
    Ensembl ID: ENSG00000034053
  • Gene Symbol: FUT8 (ENSG00000033170)
    Fold Change: 2.05
    Ensembl ID: ENSG00000033170
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 2.05
    Ensembl ID: ENSG00000171634
  • Gene Symbol: CAMK2A (ENSG00000070808)
    Fold Change: 2.05
    Ensembl ID: ENSG00000070808
  • Gene Symbol: GRIA3 (ENSG00000125675)
    Fold Change: 2.04
    Ensembl ID: ENSG00000125675
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 2.04
    Ensembl ID: ENSG00000078053
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.04
    Ensembl ID: ENSG00000134982
  • Gene Symbol: GSK3B (ENSG00000082701)
    Fold Change: 2.04
    Ensembl ID: ENSG00000082701
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.03
    Ensembl ID: ENSG00000163697

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in near-projecting glutamatergic cortical neuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in near-projecting glutamatergic cortical neuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Neuron Type**: Near-projecting glutamatergic cortical neuron 2. **Axon Projection**: Local axon projection, not distantly projecting axons 3. **Glutamatergic Synapse**: Involved in glutamate release and neurotransmission 4. **Genes**: * ADGRB3 (Adenylate cyclase-activating g protein-coupled receptor) * DOCK3 (GTPase activator activity) * FGF14 (Growth factor activity) * GRM5 (Adenylate cyclase-inhibiting g protein-coupled glutamate receptor) * FGF12 (Growth factor activity) 5. **Pathways/Ontology**: * Adenylate cyclase-activating g protein-coupled receptor signaling pathway * Cell surface receptor signaling pathway * Cerebellar climbing fiber to purkinje cell synapse * G protein-coupled receptor activity * G protein-coupled receptor signaling pathway * Gtpase activator activity * Maintenance of synapse structure * Membrane * Motor learning * Myoblast fusion * Negative regulation of angiogenesis * Neuron remodeling * Plasma membrane * Positive regulation of synapse assembly * Postsynapse * Postsynaptic density membrane * Protein binding * Regulation of dendrite morphogenesis * Regulation of synapse maturation * Regulation of synapse pruning * Synaptic cleft **Clinical Significance** 1. **Neurological Disorders**: Impaired glutamatergic neurotransmission has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Learning and Memory**: Glutamatergic neurons, like the one in question, play a crucial role in learning and memory. Dysregulation of glutamatergic neurotransmission has been linked to cognitive impairments. 3. **Neurodegenerative Diseases**: The near-projecting glutamatergic cortical neuron's involvement in synaptic transmission and plasticity makes it a potential target for therapeutic interventions in neurodegenerative diseases. 4. **Neurodevelopmental Disorders**: Abnormalities in glutamatergic neurotransmission have been implicated in neurodevelopmental disorders, such as autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD). 5. **Neuropharmacology**: Understanding the function and regulation of near-projecting glutamatergic cortical neurons can inform the development of novel therapeutic strategies for neurological disorders. In conclusion, the near-projecting glutamatergic cortical neuron is a complex cell type involved in various cellular processes, including glutamatergic neurotransmission and synaptic plasticity. Its dysfunction has been implicated in various neurological disorders, making it a promising target for therapeutic interventions.