Details for: CL4023013

Cell ID: CL4023013

Cell Name: corticothalamic-projecting glutamatergic cortical neuron

Marker Score Threshold: 9501
(Derived using integrated single-cell and genomic data)

Description: A glutamatergic neuron located in the cerebral cortex that projects to the thalamus.

Synonyms: CT projecting neuron

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.93
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.93
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.92
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.91
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.9
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.9
    Ensembl ID: ENSG00000152092
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.9
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.89
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.89
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.89
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.89
    Ensembl ID: ENSG00000278540
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.88
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.88
    Ensembl ID: ENSG00000156110
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.87
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.87
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.87
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.85
    Ensembl ID: ENSG00000162104
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 1.85
    Ensembl ID: ENSG00000034053
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.84
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.84
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.84
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.82
    Ensembl ID: ENSG00000137845
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.82
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.81
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.81
    Ensembl ID: ENSG00000072110
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.8
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.78
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.77
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.75
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.74
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.73
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.72
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.72
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.72
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.72
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.69
    Ensembl ID: ENSG00000149311
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.67
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.67
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.66
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 1.64
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.63
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.63
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.6
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.6
    Ensembl ID: ENSG00000035687
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.59
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.57
    Ensembl ID: ENSG00000173175
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.57
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.56
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.56
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.55
    Ensembl ID: ENSG00000133794
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.55
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 1.54
    Ensembl ID: ENSG00000077522
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.53
    Ensembl ID: ENSG00000197043
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.51
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.51
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.51
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.5
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.5
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 1.5
    Ensembl ID: ENSG00000240038
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.49
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.48
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.48
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.47
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.46
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.43
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.43
    Ensembl ID: ENSG00000135503
  • Gene Symbol: TRIM23 (ENSG00000113595)
    Fold Change: 1.43
    Ensembl ID: ENSG00000113595
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.42
    Ensembl ID: ENSG00000104763
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.42
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.42
    Ensembl ID: ENSG00000047648
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.41
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.37
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.35
    Ensembl ID: ENSG00000123268
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.35
    Ensembl ID: ENSG00000138175
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.35
    Ensembl ID: ENSG00000136717
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.35
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: 1.34
    Ensembl ID: ENSG00000175164
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.31
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.3
    Ensembl ID: ENSG00000134287
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.29
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.29
    Ensembl ID: ENSG00000143761
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.26
    Ensembl ID: ENSG00000090861
  • Gene Symbol: ADORA1 (ENSG00000163485)
    Fold Change: 1.23
    Ensembl ID: ENSG00000163485
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.22
    Ensembl ID: ENSG00000100280
  • Gene Symbol: STS (ENSG00000101846)
    Fold Change: 1.2
    Ensembl ID: ENSG00000101846
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.2
    Ensembl ID: ENSG00000131269
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.19
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 1.18
    Ensembl ID: ENSG00000170214
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.18
    Ensembl ID: ENSG00000159461
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.18
    Ensembl ID: ENSG00000113273
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 1.16
    Ensembl ID: ENSG00000078549
  • Gene Symbol: ABCA2 (ENSG00000107331)
    Fold Change: 1.15
    Ensembl ID: ENSG00000107331
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.15
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ADCY6 (ENSG00000174233)
    Fold Change: 1.15
    Ensembl ID: ENSG00000174233
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.13
    Ensembl ID: ENSG00000110330
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.13
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.12
    Ensembl ID: ENSG00000072778
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APAF1 (ENSG00000120868)
    Fold Change: 1.02
    Ensembl ID: ENSG00000120868
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 1.01
    Ensembl ID: ENSG00000173208
Hovered Details

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Hovered Details

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**Key Characteristics** The corticothalamic-projecting glutamatergic cortical neuron (CL4023013) has several distinct characteristics that set it apart from other neurons: 1. **Projection to the thalamus**: The CL4023013 neuron projects to the thalamus, a structure that relays sensory and motor signals to the cerebral cortex. 2. **Glutamatergic neurotransmission**: The CL4023013 neuron uses glutamate as its neurotransmitter, which is the primary excitatory neurotransmitter in the central nervous system. 3. **Expression of specific genes**: The CL4023013 neuron expresses genes such as ANK2, ASIC2, and ADCY1, which are involved in various cellular processes. 4. **Involvement in cardiac muscle contraction and regulation**: The CL4023013 neuron plays a crucial role in regulating cardiac muscle contraction, heart rate, and blood pressure. **Clinical Significance** The corticothalamic-projecting glutamatergic cortical neuron (CL4023013) has significant implications for various cardiovascular disorders, including: 1. **Cardiac arrhythmias**: Abnormalities in the CL4023013 neuron can lead to cardiac arrhythmias, such as atrial fibrillation and ventricular tachycardia. 2. **Hypertension**: Dysregulation of the CL4023013 neuron can contribute to hypertension, a condition characterized by elevated blood pressure. 3. **Heart failure**: Impaired function of the CL4023013 neuron can lead to heart failure, a condition characterized by reduced cardiac function and decreased ability to pump blood effectively. 4. **Neurological disorders**: The CL4023013 neuron is also involved in various neurological disorders, including epilepsy, Alzheimer's disease, and Parkinson's disease. In conclusion, the corticothalamic-projecting glutamatergic cortical neuron (CL4023013) is a specialized type of neuron that plays a crucial role in regulating cardiac muscle contraction, heart rate, and blood pressure. Its dysfunction can contribute to various cardiovascular disorders, highlighting the importance of understanding the mechanisms underlying this neuron's function.