Details for: CL4023013

Cell ID: CL4023013

Cell Name: corticothalamic-projecting glutamatergic cortical neuron

Marker Score Threshold: 9,501
(Derived using integrated single-cell and genomic data)

Description: A glutamatergic neuron located in the cerebral cortex that projects to the thalamus.

Synonyms: CT projecting neuron

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.93
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.93
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.92
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.91
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.9
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.9
    Ensembl ID: ENSG00000152092
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.9
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.89
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.89
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.89
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.89
    Ensembl ID: ENSG00000278540
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.88
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.88
    Ensembl ID: ENSG00000156110
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.87
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.87
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.87
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.85
    Ensembl ID: ENSG00000162104
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 1.85
    Ensembl ID: ENSG00000034053
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.84
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.84
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.84
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.82
    Ensembl ID: ENSG00000137845
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.82
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.81
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.81
    Ensembl ID: ENSG00000072110
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.8
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.78
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.77
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.75
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.74
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.73
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.72
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.72
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.72
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.72
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.69
    Ensembl ID: ENSG00000149311
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.67
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.67
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.66
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 1.64
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.63
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.63
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.6
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.6
    Ensembl ID: ENSG00000035687
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.59
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.57
    Ensembl ID: ENSG00000173175
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.57
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.56
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.56
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.55
    Ensembl ID: ENSG00000133794
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.55
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 1.54
    Ensembl ID: ENSG00000077522
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.53
    Ensembl ID: ENSG00000197043
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.51
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.51
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.51
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.5
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.5
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 1.5
    Ensembl ID: ENSG00000240038
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.49
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.48
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.48
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.47
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.46
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.43
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.43
    Ensembl ID: ENSG00000135503
  • Gene Symbol: TRIM23 (ENSG00000113595)
    Fold Change: 1.43
    Ensembl ID: ENSG00000113595
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.42
    Ensembl ID: ENSG00000104763
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.42
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.42
    Ensembl ID: ENSG00000047648
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.41
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.37
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.35
    Ensembl ID: ENSG00000123268
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.35
    Ensembl ID: ENSG00000138175
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.35
    Ensembl ID: ENSG00000136717
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.35
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: 1.34
    Ensembl ID: ENSG00000175164
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.31
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.3
    Ensembl ID: ENSG00000134287
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.29
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.29
    Ensembl ID: ENSG00000143761
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.26
    Ensembl ID: ENSG00000090861
  • Gene Symbol: ADORA1 (ENSG00000163485)
    Fold Change: 1.23
    Ensembl ID: ENSG00000163485
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.22
    Ensembl ID: ENSG00000100280
  • Gene Symbol: STS (ENSG00000101846)
    Fold Change: 1.2
    Ensembl ID: ENSG00000101846
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.2
    Ensembl ID: ENSG00000131269
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.19
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 1.18
    Ensembl ID: ENSG00000170214
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.18
    Ensembl ID: ENSG00000159461
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.18
    Ensembl ID: ENSG00000113273
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 1.16
    Ensembl ID: ENSG00000078549
  • Gene Symbol: ABCA2 (ENSG00000107331)
    Fold Change: 1.15
    Ensembl ID: ENSG00000107331
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.15
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ADCY6 (ENSG00000174233)
    Fold Change: 1.15
    Ensembl ID: ENSG00000174233
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.13
    Ensembl ID: ENSG00000110330
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.13
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.12
    Ensembl ID: ENSG00000072778
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APAF1 (ENSG00000120868)
    Fold Change: 1.02
    Ensembl ID: ENSG00000120868
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 1.01
    Ensembl ID: ENSG00000173208

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in corticothalamic-projecting glutamatergic cortical neuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in corticothalamic-projecting glutamatergic cortical neuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The CL4023013 neuron exhibits the following key characteristics: 1. **Glutamatergic projection**: The neuron projects to the thalamus, a structure involved in the relaying of sensory information to the cerebral cortex. 2. **ANK2 gene expression**: The neuron expresses the ANK2 gene, which is involved in protein localization, cell surface organization, and intracellular calcium ion homeostasis. 3. **Cytoskeletal organization**: The neuron has a complex cytoskeletal organization, with a band, apical plasma membrane, and T-tubules, which are involved in the regulation of cardiac muscle contraction and sensory perception. 4. **Ion channel activity**: The neuron exhibits ion channel activity, including sodium and potassium ion transmembrane transport, which is involved in the regulation of membrane potential and sensory perception. 5. **Protein localization**: The neuron has a complex protein localization system, with proteins localized to the plasma membrane, endoplasmic reticulum, and Golgi apparatus, which is involved in the regulation of protein targeting to the cell surface and intracellular signaling. **Clinical Significance** The CL4023013 neuron plays a crucial role in various physiological processes, including: 1. **Cardiac muscle contraction**: The neuron is involved in the regulation of cardiac muscle contraction, heart rate, and blood pressure, and is a potential target for the treatment of cardiac diseases such as hypertension and heart failure. 2. **Sensory perception**: The neuron is involved in the processing of sensory information, particularly sound and sour taste, and is a potential target for the treatment of sensory disorders such as hearing loss and taste disorders. 3. **Neuroinflammatory response**: The neuron is involved in the regulation of neuroinflammatory responses, and is a potential target for the treatment of neuroinflammatory disorders such as multiple sclerosis and Alzheimer's disease. In conclusion, the CL4023013 neuron is a complex and multifunctional neuron that plays a crucial role in various physiological processes, including cardiac muscle contraction, sensory perception, and neuroinflammatory response. Further research is needed to fully understand the function and regulation of this neuron, and to identify potential therapeutic targets for the treatment of various diseases associated with this neuron.