Details for: CL4023016

Cell ID: CL4023016

Cell Name: vip GABAergic cortical interneuron

Marker Score Threshold: 37976
(Derived using integrated single-cell and genomic data)

Description: A transcriptomically distinct cortical GABAergic neuron that expresses the vasocactive intestinal polypeptide and that has its soma located in the cerebral cortex. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Vip.

Synonyms: VIP interneuron, VIP neuron, VIP-Expressing GABAergic Neuron, Vip GABAergic neuron, VIP type, VIP-IN, Vip, cortical VIP neuron

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 2.75
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.74
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.74
    Ensembl ID: ENSG00000145362
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.68
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.66
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.58
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.58
    Ensembl ID: ENSG00000157087
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.58
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.57
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.56
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.49
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.48
    Ensembl ID: ENSG00000156110
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.44
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.43
    Ensembl ID: ENSG00000143153
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.42
    Ensembl ID: ENSG00000107282
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 2.41
    Ensembl ID: ENSG00000100077
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.28
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.28
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.27
    Ensembl ID: ENSG00000170634
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 2.21
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 2.2
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.19
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 2.14
    Ensembl ID: ENSG00000143322
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 2.13
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 2.1
    Ensembl ID: ENSG00000159842
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.08
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 2.08
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 2.07
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 2.04
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 2.03
    Ensembl ID: ENSG00000170214
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 2.02
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.98
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 1.96
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.96
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 1.9
    Ensembl ID: ENSG00000078549
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.89
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.86
    Ensembl ID: ENSG00000162104
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.85
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.84
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.84
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.83
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.83
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.8
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.75
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.72
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.69
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.69
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.69
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.69
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.68
    Ensembl ID: ENSG00000072110
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.63
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.61
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.58
    Ensembl ID: ENSG00000140836
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.57
    Ensembl ID: ENSG00000166747
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.54
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.54
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.52
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 1.52
    Ensembl ID: ENSG00000155897
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.52
    Ensembl ID: ENSG00000162688
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.51
    Ensembl ID: ENSG00000101966
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.5
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.44
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.44
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.4
    Ensembl ID: ENSG00000113273
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.4
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.4
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.39
    Ensembl ID: ENSG00000117054
  • Gene Symbol: TRIM23 (ENSG00000113595)
    Fold Change: 1.39
    Ensembl ID: ENSG00000113595
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.39
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.38
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.38
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.35
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ASIC1 (ENSG00000110881)
    Fold Change: 1.34
    Ensembl ID: ENSG00000110881
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.34
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATP1B2 (ENSG00000129244)
    Fold Change: 1.34
    Ensembl ID: ENSG00000129244
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.33
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.33
    Ensembl ID: ENSG00000100412
  • Gene Symbol: STS (ENSG00000101846)
    Fold Change: 1.32
    Ensembl ID: ENSG00000101846
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.31
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.3
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.27
    Ensembl ID: ENSG00000152234
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 1.27
    Ensembl ID: ENSG00000240038
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.24
    Ensembl ID: ENSG00000123268
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.23
    Ensembl ID: ENSG00000090861
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.23
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.21
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.2
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143761
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.17
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.17
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.12
    Ensembl ID: ENSG00000133794
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.1
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.07
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.06
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACVR2B (ENSG00000114739)
    Fold Change: 1.06
    Ensembl ID: ENSG00000114739
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.05
    Ensembl ID: ENSG00000067842
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.04
    Ensembl ID: ENSG00000134287
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.03
    Ensembl ID: ENSG00000100280
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.02
    Ensembl ID: ENSG00000159461
  • Gene Symbol: AMPD2 (ENSG00000116337)
    Fold Change: 1.01
    Ensembl ID: ENSG00000116337
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Transcriptomic Profile**: The cell's transcriptomic profile is distinct from other cortical neurons, with a unique set of genes that are involved in various cellular processes. 2. **Expression of VIP**: The cell expresses vasocactive intestinal polypeptide (VIP), which is a neurotransmitter that modulates neural activity. 3. **Location in Cerebral Cortex**: The cell's soma is located in the cerebral cortex, which is the outer layer of the brain responsible for processing sensory information. 4. **GABAergic Neuron**: The cell is a GABAergic neuron, which is a type of neuron that uses the neurotransmitter GABA to modulate neural activity. 5. **ANK Genes**: The cell expresses a set of genes that are involved in axon guidance and cell surface protein binding, including ANK3, ANK2, and RERE. **Clinical Significance** 1. **Modulation of Neural Activity**: The cell's expression of VIP and its involvement in axon guidance and cell surface protein binding suggest that it plays a role in modulating neural activity. 2. **Involvement in Neurological Disorders**: The cell's transcriptomic profile and expression of VIP suggest that it may be involved in the pathogenesis of neurological disorders such as Alzheimer's disease and Parkinson's disease. 3. **Potential Therapeutic Target**: The cell's unique transcriptomic profile and expression of VIP make it a potential therapeutic target for the treatment of neurological disorders. 4. **Role in Neurodevelopment**: The cell's involvement in axon guidance and cell surface protein binding suggests that it plays a role in neurodevelopment and may be involved in the formation of neural circuits. **Comparison with Other Cells** 1. **Comparison with Cortical Neurons**: The cell's transcriptomic profile and expression of VIP are distinct from those of other cortical neurons, which suggests that it has a unique role in the cerebral cortex. 2. **Comparison with GABAergic Neurons**: The cell's expression of VIP and its involvement in axon guidance and cell surface protein binding make it similar to other GABAergic neurons, but its unique transcriptomic profile and expression of VIP set it apart from other GABAergic neurons. 3. **Comparison with Neuronal Cells**: The cell's transcriptomic profile and expression of VIP are distinct from those of other neuronal cells, which suggests that it has a unique role in the nervous system. **Future Research Directions** 1. **Investigation of VIP's Role in Neural Activity**: Further research is needed to investigate the role of VIP in modulating neural activity and its involvement in neurological disorders. 2. **Investigation of the Cell's Transcriptomic Profile**: Further research is needed to investigate the cell's transcriptomic profile and its involvement in neurodevelopment and neurological disorders. 3. **Development of Therapeutic Strategies**: Further research is needed to develop therapeutic strategies that target the cell's unique transcriptomic profile and expression of VIP. In conclusion, the cell CL4023016 is a vip GABAergic cortical interneuron that has a unique transcriptomic profile and expression of VIP. Its clinical significance lies in its potential role in modulating neural activity and its involvement in neurological disorders. Further research is needed to investigate the cell's transcriptomic profile, expression of VIP, and role in neurodevelopment and neurological disorders.