Details for: CL4023017

Cell ID: CL4023017

Cell Name: sst GABAergic cortical interneuron

Marker Score Threshold: 19892
(Derived using integrated single-cell and genomic data)

Description: A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst). The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Sst.

Synonyms: SOM+ inhibitory interneuron, SST+ IN, somatostatin-expressing inhibitory interneuron

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.91
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.91
    Ensembl ID: ENSG00000145362
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.83
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.77
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.75
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.63
    Ensembl ID: ENSG00000157087
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.62
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 2.59
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.58
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.55
    Ensembl ID: ENSG00000278540
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.53
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 2.49
    Ensembl ID: ENSG00000159842
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 2.49
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.48
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 2.44
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.43
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 2.39
    Ensembl ID: ENSG00000029534
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.32
    Ensembl ID: ENSG00000107282
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.32
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 2.27
    Ensembl ID: ENSG00000183044
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.27
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.26
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 2.24
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.22
    Ensembl ID: ENSG00000108684
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 2.19
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.19
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.12
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 2.1
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 2.08
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.98
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 1.97
    Ensembl ID: ENSG00000078549
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 1.95
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.91
    Ensembl ID: ENSG00000149311
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.9
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.85
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.82
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.82
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.82
    Ensembl ID: ENSG00000162104
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.8
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.78
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.75
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.72
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.71
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.71
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.69
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.62
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.62
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.6
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.58
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.58
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.56
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.55
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.54
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.54
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP6V1C1 (ENSG00000155097)
    Fold Change: 1.52
    Ensembl ID: ENSG00000155097
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 1.51
    Ensembl ID: ENSG00000171094
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.5
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.46
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.45
    Ensembl ID: ENSG00000117054
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.43
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.42
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.41
    Ensembl ID: ENSG00000136717
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.4
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.4
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.38
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.37
    Ensembl ID: ENSG00000197043
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.37
    Ensembl ID: ENSG00000104964
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.35
    Ensembl ID: ENSG00000101966
  • Gene Symbol: TRIM23 (ENSG00000113595)
    Fold Change: 1.35
    Ensembl ID: ENSG00000113595
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.34
    Ensembl ID: ENSG00000138175
  • Gene Symbol: STS (ENSG00000101846)
    Fold Change: 1.31
    Ensembl ID: ENSG00000101846
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.31
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.3
    Ensembl ID: ENSG00000138031
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.3
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.3
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.29
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.23
    Ensembl ID: ENSG00000035687
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.23
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.22
    Ensembl ID: ENSG00000123268
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.21
    Ensembl ID: ENSG00000090861
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 1.2
    Ensembl ID: ENSG00000240038
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.2
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.18
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.18
    Ensembl ID: ENSG00000113273
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.16
    Ensembl ID: ENSG00000164904
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.16
    Ensembl ID: ENSG00000133794
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.14
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.13
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.12
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP1B2 (ENSG00000129244)
    Fold Change: 1.11
    Ensembl ID: ENSG00000129244
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.1
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.09
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.08
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.05
    Ensembl ID: ENSG00000067842
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.04
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.03
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.02
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.01
    Ensembl ID: ENSG00000111275
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.01
    Ensembl ID: ENSG00000067560
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Transcriptomic Profile**: The cell expresses somatostatin (sst), which is a key marker for this cell type. The transcriptomic profile of this cell is distinct from other cortical interneurons, as it is defined by the expression of sst and other specific genes. 2. **GABAergic Neuron**: The cell is a GABAergic neuron, which means it uses gamma-aminobutyric acid (GABA) as its primary neurotransmitter. GABA is an inhibitory neurotransmitter that helps to regulate neural excitability and synaptic transmission. 3. **Cortical Interneuron**: The cell is a cortical interneuron, which is a type of neuron found in the cerebral cortex. Cortical interneurons play a crucial role in regulating neural circuitry and modulating excitatory neurotransmission. 4. **Inhibitory Interneuron**: The cell is an inhibitory interneuron, which means it uses GABA to inhibit the activity of other neurons. Inhibitory interneurons help to regulate neural excitability and prevent excessive neuronal activity. 5. **Expressing Specific Genes**: The cell expresses a range of specific genes, including ANK3, ANK2, and RERE. These genes are involved in various cellular processes, including cell signaling, protein localization, and transcription regulation. **Clinical Significance** 1. **Neurological Disorders**: The sst GABAergic cortical interneuron is involved in regulating neural circuitry and modulating excitatory neurotransmission. Alterations in this cell type have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Cognitive Impairment**: The sst GABAergic cortical interneuron plays a crucial role in regulating cognitive processes, including attention, memory, and learning. Alterations in this cell type have been implicated in cognitive impairment and dementia. 3. **Neurodevelopmental Disorders**: The sst GABAergic cortical interneuron is involved in regulating neural development and maturation. Alterations in this cell type have been implicated in neurodevelopmental disorders, including autism spectrum disorder and intellectual disability. 4. **Therapeutic Targets**: The sst GABAergic cortical interneuron is a potential therapeutic target for the treatment of various neurological disorders. Modulating the activity of this cell type may help to regulate neural circuitry and improve cognitive function. In conclusion, the sst GABAergic cortical interneuron is a unique cell type that plays a crucial role in regulating neural circuitry and modulating excitatory neurotransmission. Alterations in this cell type have been implicated in various neurological disorders, and modulating its activity may provide a potential therapeutic target for the treatment of these conditions.