Details for: CL4023018

Cell ID: CL4023018

Cell Name: pvalb GABAergic cortical interneuron

Marker Score Threshold: 36,890
(Derived using integrated single-cell and genomic data)

Description: A transcriptomically distinct GABAergic interneuron with a soma located in a cerebral cortex and it expresses Parvalbumin. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Pvalb.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 2.46
    Ensembl ID: ENSG00000135298
  • Gene Symbol: FGF12 (ENSG00000114279)
    Fold Change: 2.46
    Ensembl ID: ENSG00000114279
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 2.46
    Ensembl ID: ENSG00000150672
  • Gene Symbol: FGF14 (ENSG00000102466)
    Fold Change: 2.46
    Ensembl ID: ENSG00000102466
  • Gene Symbol: ERBB4 (ENSG00000178568)
    Fold Change: 2.46
    Ensembl ID: ENSG00000178568
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 2.46
    Ensembl ID: ENSG00000169862
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 2.46
    Ensembl ID: ENSG00000088538
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.45
    Ensembl ID: ENSG00000145362
  • Gene Symbol: GRM5 (ENSG00000168959)
    Fold Change: 2.45
    Ensembl ID: ENSG00000168959
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 2.45
    Ensembl ID: ENSG00000141837
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 2.45
    Ensembl ID: ENSG00000151067
  • Gene Symbol: GRIN2B (ENSG00000273079)
    Fold Change: 2.45
    Ensembl ID: ENSG00000273079
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.45
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 2.45
    Ensembl ID: ENSG00000182389
  • Gene Symbol: GRIA4 (ENSG00000152578)
    Fold Change: 2.45
    Ensembl ID: ENSG00000152578
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 2.45
    Ensembl ID: ENSG00000134769
  • Gene Symbol: GRIA1 (ENSG00000155511)
    Fold Change: 2.44
    Ensembl ID: ENSG00000155511
  • Gene Symbol: GABRB2 (ENSG00000145864)
    Fold Change: 2.44
    Ensembl ID: ENSG00000145864
  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 2.44
    Ensembl ID: ENSG00000173406
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.44
    Ensembl ID: ENSG00000108684
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.44
    Ensembl ID: ENSG00000151914
  • Gene Symbol: GRIK2 (ENSG00000164418)
    Fold Change: 2.44
    Ensembl ID: ENSG00000164418
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 2.44
    Ensembl ID: ENSG00000018236
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.43
    Ensembl ID: ENSG00000142599
  • Gene Symbol: GABRG3 (ENSG00000182256)
    Fold Change: 2.43
    Ensembl ID: ENSG00000182256
  • Gene Symbol: GRIA2 (ENSG00000120251)
    Fold Change: 2.43
    Ensembl ID: ENSG00000120251
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.43
    Ensembl ID: ENSG00000157087
  • Gene Symbol: GABRB1 (ENSG00000163288)
    Fold Change: 2.42
    Ensembl ID: ENSG00000163288
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 2.42
    Ensembl ID: ENSG00000130226
  • Gene Symbol: GPM6A (ENSG00000150625)
    Fold Change: 2.42
    Ensembl ID: ENSG00000150625
  • Gene Symbol: GRIA3 (ENSG00000125675)
    Fold Change: 2.41
    Ensembl ID: ENSG00000125675
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 2.4
    Ensembl ID: ENSG00000157388
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 2.4
    Ensembl ID: ENSG00000148408
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.4
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CTNNA2 (ENSG00000066032)
    Fold Change: 2.39
    Ensembl ID: ENSG00000066032
  • Gene Symbol: FHIT (ENSG00000189283)
    Fold Change: 2.39
    Ensembl ID: ENSG00000189283
  • Gene Symbol: GRID1 (ENSG00000182771)
    Fold Change: 2.39
    Ensembl ID: ENSG00000182771
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.38
    Ensembl ID: ENSG00000152092
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 2.37
    Ensembl ID: ENSG00000257923
  • Gene Symbol: DTNB (ENSG00000138101)
    Fold Change: 2.37
    Ensembl ID: ENSG00000138101
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 2.36
    Ensembl ID: ENSG00000100077
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.36
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 2.35
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ELAVL3 (ENSG00000196361)
    Fold Change: 2.35
    Ensembl ID: ENSG00000196361
  • Gene Symbol: FER (ENSG00000151422)
    Fold Change: 2.35
    Ensembl ID: ENSG00000151422
  • Gene Symbol: DNM1 (ENSG00000106976)
    Fold Change: 2.35
    Ensembl ID: ENSG00000106976
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.34
    Ensembl ID: ENSG00000156110
  • Gene Symbol: GAD2 (ENSG00000136750)
    Fold Change: 2.33
    Ensembl ID: ENSG00000136750
  • Gene Symbol: EXT1 (ENSG00000182197)
    Fold Change: 2.33
    Ensembl ID: ENSG00000182197
  • Gene Symbol: GRIK3 (ENSG00000163873)
    Fold Change: 2.33
    Ensembl ID: ENSG00000163873
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.33
    Ensembl ID: ENSG00000204217
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.33
    Ensembl ID: ENSG00000134982
  • Gene Symbol: GTF2I (ENSG00000263001)
    Fold Change: 2.32
    Ensembl ID: ENSG00000263001
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.32
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ESRRG (ENSG00000196482)
    Fold Change: 2.32
    Ensembl ID: ENSG00000196482
  • Gene Symbol: GAD1 (ENSG00000128683)
    Fold Change: 2.32
    Ensembl ID: ENSG00000128683
  • Gene Symbol: ELAVL2 (ENSG00000107105)
    Fold Change: 2.32
    Ensembl ID: ENSG00000107105
  • Gene Symbol: GABRB3 (ENSG00000166206)
    Fold Change: 2.32
    Ensembl ID: ENSG00000166206
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.32
    Ensembl ID: ENSG00000085224
  • Gene Symbol: DYNC1I1 (ENSG00000158560)
    Fold Change: 2.32
    Ensembl ID: ENSG00000158560
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 2.32
    Ensembl ID: ENSG00000164742
  • Gene Symbol: CDH18 (ENSG00000145526)
    Fold Change: 2.31
    Ensembl ID: ENSG00000145526
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.3
    Ensembl ID: ENSG00000278540
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2.3
    Ensembl ID: ENSG00000087460
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 2.29
    Ensembl ID: ENSG00000198947
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.29
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 2.29
    Ensembl ID: ENSG00000155897
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.28
    Ensembl ID: ENSG00000157764
  • Gene Symbol: GLS (ENSG00000115419)
    Fold Change: 2.28
    Ensembl ID: ENSG00000115419
  • Gene Symbol: GNAQ (ENSG00000156052)
    Fold Change: 2.28
    Ensembl ID: ENSG00000156052
  • Gene Symbol: DAPK1 (ENSG00000196730)
    Fold Change: 2.28
    Ensembl ID: ENSG00000196730
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.27
    Ensembl ID: ENSG00000145349
  • Gene Symbol: GRIN1 (ENSG00000176884)
    Fold Change: 2.27
    Ensembl ID: ENSG00000176884
  • Gene Symbol: RUNX2 (ENSG00000124813)
    Fold Change: 2.27
    Ensembl ID: ENSG00000124813
  • Gene Symbol: GNAL (ENSG00000141404)
    Fold Change: 2.26
    Ensembl ID: ENSG00000141404
  • Gene Symbol: GRIN2A (ENSG00000183454)
    Fold Change: 2.26
    Ensembl ID: ENSG00000183454
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.26
    Ensembl ID: ENSG00000070961
  • Gene Symbol: GLG1 (ENSG00000090863)
    Fold Change: 2.25
    Ensembl ID: ENSG00000090863
  • Gene Symbol: GSK3B (ENSG00000082701)
    Fold Change: 2.25
    Ensembl ID: ENSG00000082701
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 2.25
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.24
    Ensembl ID: ENSG00000170634
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.24
    Ensembl ID: ENSG00000198589
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 2.24
    Ensembl ID: ENSG00000144674
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.24
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ARHGAP35 (ENSG00000160007)
    Fold Change: 2.24
    Ensembl ID: ENSG00000160007
  • Gene Symbol: DPYSL2 (ENSG00000092964)
    Fold Change: 2.23
    Ensembl ID: ENSG00000092964
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 2.23
    Ensembl ID: ENSG00000079102
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 2.23
    Ensembl ID: ENSG00000075711
  • Gene Symbol: CAMK2B (ENSG00000058404)
    Fold Change: 2.22
    Ensembl ID: ENSG00000058404
  • Gene Symbol: ETV6 (ENSG00000139083)
    Fold Change: 2.22
    Ensembl ID: ENSG00000139083
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 2.22
    Ensembl ID: ENSG00000171634
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.21
    Ensembl ID: ENSG00000163697
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.2
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 2.2
    Ensembl ID: ENSG00000183044
  • Gene Symbol: EFNA5 (ENSG00000184349)
    Fold Change: 2.19
    Ensembl ID: ENSG00000184349
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.18
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ENSA (ENSG00000143420)
    Fold Change: 2.18
    Ensembl ID: ENSG00000143420
  • Gene Symbol: FBN1 (ENSG00000166147)
    Fold Change: 2.18
    Ensembl ID: ENSG00000166147
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.18
    Ensembl ID: ENSG00000198668
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 2.18
    Ensembl ID: ENSG00000143669

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in pvalb GABAergic cortical interneuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in pvalb GABAergic cortical interneuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The pvalb GABAergic cortical interneuron is a GABAergic interneuron that is specifically identified by its expression of Parvalbumin. This cell type is characterized by several key features, including: * **Soma location**: The pvalb interneuron has a soma located in the cerebral cortex. * **GABAergic function**: The pvalb interneuron is a GABAergic interneuron, meaning it releases GABA, an inhibitory neurotransmitter, to regulate neuronal activity. * **Parvalbumin expression**: The pvalb interneuron expresses Parvalbumin, a calcium-binding protein that is specific to this cell type. * **Unique gene expression profile**: The pvalb interneuron has a distinct gene expression profile that is characterized by the expression of specific genes involved in synaptic transmission and neuronal activity. **Clinical Significance** The pvalb GABAergic cortical interneuron plays a crucial role in regulating synaptic transmission and neuronal activity in the cerebral cortex. Dysregulation of this cell type has been implicated in various neurological and psychiatric disorders, including: * **Epilepsy**: Abnormalities in the pvalb interneuron have been linked to the development of epilepsy. * **Schizophrenia**: Alterations in the pvalb interneuron have been observed in individuals with schizophrenia. * **Autism spectrum disorder**: Abnormalities in the pvalb interneuron have been linked to the development of autism spectrum disorder. **Pathways and Genes Involved** The pvalb GABAergic cortical interneuron is involved in several key pathways and genes, including: * **Adenylate cyclase-activating g protein-coupled receptor signaling pathway**: This pathway is involved in regulating GABAergic transmission and neuronal activity. * **Cell surface receptor signaling pathway**: This pathway is involved in regulating synaptic transmission and neuronal activity. * **FGF12**: This gene is involved in regulating neuronal development and synaptic transmission. * **DLG2**: This gene is involved in regulating synaptic transmission and neuronal activity. * **FGF14**: This gene is involved in regulating neuronal development and synaptic transmission. * **ERBB4**: This gene is involved in regulating neuronal development and synaptic transmission. * **CTNND2**: This gene is involved in regulating synaptic transmission and neuronal activity. * **DOCK3**: This gene is involved in regulating neuronal development and synaptic transmission. In conclusion, the pvalb GABAergic cortical interneuron is a unique cell type that plays a crucial role in regulating synaptic transmission and neuronal activity in the cerebral cortex. Dysregulation of this cell type has been implicated in various neurological and psychiatric disorders, and further research is needed to understand the complex mechanisms underlying its function.