Details for: CL4023018

Cell ID: CL4023018

Cell Name: pvalb GABAergic cortical interneuron

Marker Score Threshold: 36890
(Derived using integrated single-cell and genomic data)

Description: A transcriptomically distinct GABAergic interneuron with a soma located in a cerebral cortex and it expresses Parvalbumin. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Pvalb.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.45
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.45
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.44
    Ensembl ID: ENSG00000108684
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.43
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.43
    Ensembl ID: ENSG00000157087
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.4
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.38
    Ensembl ID: ENSG00000152092
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 2.36
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 2.35
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.34
    Ensembl ID: ENSG00000156110
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.33
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 2.32
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.3
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.29
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 2.29
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.26
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 2.25
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.24
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.24
    Ensembl ID: ENSG00000078295
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.21
    Ensembl ID: ENSG00000163697
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.2
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 2.2
    Ensembl ID: ENSG00000183044
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.18
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 2.17
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 2.12
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 2.11
    Ensembl ID: ENSG00000171094
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 2.1
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.1
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 2.07
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.07
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 2.06
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 2.02
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 2.01
    Ensembl ID: ENSG00000078549
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 2.01
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 2
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.98
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.92
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.92
    Ensembl ID: ENSG00000149311
  • Gene Symbol: STS (ENSG00000101846)
    Fold Change: 1.9
    Ensembl ID: ENSG00000101846
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.87
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.85
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.83
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.81
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.8
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.77
    Ensembl ID: ENSG00000100412
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.76
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.72
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.71
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.68
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.68
    Ensembl ID: ENSG00000143322
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.64
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.62
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.62
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.6
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.54
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.53
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.53
    Ensembl ID: ENSG00000143437
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.52
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.52
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.5
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.48
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.47
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.47
    Ensembl ID: ENSG00000138175
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.47
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.43
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.43
    Ensembl ID: ENSG00000075624
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.42
    Ensembl ID: ENSG00000101966
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.41
    Ensembl ID: ENSG00000133794
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.41
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.4
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.39
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.38
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.38
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 1.37
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.36
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.36
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.36
    Ensembl ID: ENSG00000123268
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.36
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 1.35
    Ensembl ID: ENSG00000240038
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.35
    Ensembl ID: ENSG00000165029
  • Gene Symbol: TRIM23 (ENSG00000113595)
    Fold Change: 1.33
    Ensembl ID: ENSG00000113595
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.33
    Ensembl ID: ENSG00000090861
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.32
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.3
    Ensembl ID: ENSG00000067842
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.28
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.27
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.26
    Ensembl ID: ENSG00000113273
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.19
    Ensembl ID: ENSG00000115361
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.18
    Ensembl ID: ENSG00000130707
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.17
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.16
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.16
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ARG2 (ENSG00000081181)
    Fold Change: 1.14
    Ensembl ID: ENSG00000081181
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.12
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 1.1
    Ensembl ID: ENSG00000115170
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.08
    Ensembl ID: ENSG00000159461
  • Gene Symbol: ACVR2B (ENSG00000114739)
    Fold Change: 1.01
    Ensembl ID: ENSG00000114739
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1
    Ensembl ID: ENSG00000134287
Hovered Details

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Hovered Details

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**Key Characteristics** The pvalb interneuron is a GABAergic interneuron that is characterized by the following key features: 1. **Parvalbumin expression**: The pvalb interneuron expresses parvalbumin, a calcium-binding protein that is specifically associated with parvalbumin-positive interneurons. 2. **Cerebral cortex localization**: The pvalb interneuron is found in the cerebral cortex, specifically in the layer II/III region. 3. **Unique transcriptomic profile**: The pvalb interneuron has a distinct transcriptomic profile that is characterized by the expression of specific genes, including ANK2, ASIC2, and RERE. 4. **Ion channel expression**: The pvalb interneuron expresses a range of ion channels, including ASIC2, which is involved in regulating synaptic transmission and plasticity. 5. **Calcium homeostasis**: The pvalb interneuron plays a critical role in regulating calcium homeostasis in the cerebral cortex, particularly in the context of synaptic transmission and plasticity. **Clinical Significance** The pvalb interneuron plays a critical role in regulating neural circuit function, particularly in the context of synaptic transmission and plasticity. Dysregulation of the pvalb interneuron has been implicated in a range of neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. 1. **Epilepsy**: The pvalb interneuron has been implicated in the pathophysiology of epilepsy, particularly in the context of seizure generation and propagation. 2. **Schizophrenia**: The pvalb interneuron has been implicated in the pathophysiology of schizophrenia, particularly in the context of cognitive dysfunction and synaptic plasticity. 3. **Autism spectrum disorder**: The pvalb interneuron has been implicated in the pathophysiology of autism spectrum disorder, particularly in the context of social cognition and synaptic plasticity. **Implications for Neural Function and Disease** The pvalb interneuron plays a critical role in regulating neural circuit function, particularly in the context of synaptic transmission and plasticity. Dysregulation of the pvalb interneuron has been implicated in a range of neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. 1. **Synaptic transmission and plasticity**: The pvalb interneuron plays a critical role in regulating synaptic transmission and plasticity, particularly in the context of learning and memory. 2. **Neural circuit function**: The pvalb interneuron is involved in regulating neural circuit function, particularly in the context of sensory processing and cognitive function. 3. **Neurodevelopmental disorders**: The pvalb interneuron has been implicated in the pathophysiology of neurodevelopmental disorders, particularly in the context of autism spectrum disorder and schizophrenia. In conclusion, the pvalb interneuron is a critical component of the cerebral cortex, playing a key role in regulating neural circuit function, particularly in the context of synaptic transmission and plasticity. Dysregulation of the pvalb interneuron has been implicated in a range of neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. Further research is needed to fully understand the role of the pvalb interneuron in neural function and disease.