Details for: CL4023032

Cell ID: CL4023032

Cell Name: ON retinal ganglion cell

Marker Score Threshold: 273
(Derived using integrated single-cell and genomic data)

Description: A retinal ganglion cell that is depolarized by illumination of its receptive field center.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.65
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.98
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.72
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.55
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.54
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.53
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.94
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.93
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.91
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.9
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.88
    Ensembl ID: ENSG00000128272
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.87
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.86
    Ensembl ID: ENSG00000029534
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.85
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.84
    Ensembl ID: ENSG00000156110
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.83
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.82
    Ensembl ID: ENSG00000140836
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.8
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 1.79
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.78
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.77
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.77
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.76
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.74
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 1.71
    Ensembl ID: ENSG00000157087
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.71
    Ensembl ID: ENSG00000134982
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.7
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 1.68
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.66
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.65
    Ensembl ID: ENSG00000033627
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.62
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.61
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.6
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.6
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.59
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.58
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.54
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.54
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.54
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.51
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.5
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.48
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 1.47
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.42
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.42
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.41
    Ensembl ID: ENSG00000087274
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.4
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.38
    Ensembl ID: ENSG00000162104
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.34
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.34
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.34
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.33
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.33
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.32
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.32
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.32
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.31
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.29
    Ensembl ID: ENSG00000175054
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.28
    Ensembl ID: ENSG00000148090
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.27
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.27
    Ensembl ID: ENSG00000114573
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.27
    Ensembl ID: ENSG00000107262
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.25
    Ensembl ID: ENSG00000167972
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.25
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.24
    Ensembl ID: ENSG00000198363
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.24
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.24
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.23
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.23
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.23
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.23
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.21
    Ensembl ID: ENSG00000159199
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.21
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.19
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.19
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.17
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.17
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ANGPT2 (ENSG00000091879)
    Fold Change: 1.15
    Ensembl ID: ENSG00000091879
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.15
    Ensembl ID: ENSG00000130402
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.15
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.14
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.14
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.13
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.12
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.11
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.11
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143727
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.1
    Ensembl ID: ENSG00000105221
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.1
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.09
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.08
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.06
    Ensembl ID: ENSG00000120437
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100823
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.03
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.03
    Ensembl ID: ENSG00000182718
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Retinal Ganglion Cell**: The cell is a type of RGC that is responsible for transmitting visual information from the retina to the brain. 2. **Depolarized by Illumination**: The cell is depolarized by illumination of its receptive field center, which is a critical step in visual processing. 3. **Genetic Profile**: The cell's genetic profile includes genes involved in adaptive immune responses, amyloid fiber formation, and antigen presentation. 4. **Pathways and Ontology**: The cell's pathways and ontology include adaptive immune system, amyloid fiber formation, and antigen processing and presentation. 5. **Adaptive Immune System**: The cell is involved in adaptive immune responses, which are critical for protecting the body against infection and disease. 6. **Amyloid Fiber Formation**: The cell is involved in the formation of amyloid fibers, which are abnormal protein structures that can contribute to neurodegenerative diseases. 7. **Antigen Presentation**: The cell is involved in antigen presentation, which is the process by which the cell presents antigens to the immune system to trigger an immune response. **Clinical Significance** 1. **Visual Impairment**: The cell's dysfunction can contribute to visual impairment and blindness. 2. **Neurodegenerative Diseases**: The cell's involvement in amyloid fiber formation can contribute to neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 3. **Immune System Disorders**: The cell's involvement in adaptive immune responses can contribute to immune system disorders such as autoimmune diseases and immunodeficiency disorders. 4. **Infectious Diseases**: The cell's involvement in antigen presentation can contribute to infectious diseases such as HIV and tuberculosis. 5. **Retinal Diseases**: The cell's dysfunction can contribute to retinal diseases such as glaucoma and age-related macular degeneration. In conclusion, the cell ID CL4023032 is a unique retinal ganglion cell that plays a critical role in visual processing and immune system function. Its dysfunction can contribute to a range of clinical disorders, including visual impairment, neurodegenerative diseases, immune system disorders, infectious diseases, and retinal diseases. Further research is needed to understand the mechanisms underlying this cell's function and dysfunction, and to develop effective treatments for these disorders.