Details for: CL4023032

Cell ID: CL4023032

Cell Name: ON retinal ganglion cell

Marker Score Threshold: 273
(Derived using integrated single-cell and genomic data)

Description: A retinal ganglion cell that is depolarized by illumination of its receptive field center.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 3.97
    Ensembl ID: ENSG00000156508
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.65
    Ensembl ID: ENSG00000166710
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 3.38
    Ensembl ID: ENSG00000149806
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 3.24
    Ensembl ID: ENSG00000087086
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.13
    Ensembl ID: ENSG00000172757
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 3.12
    Ensembl ID: ENSG00000132475
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 3.11
    Ensembl ID: ENSG00000168028
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.01
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.98
    Ensembl ID: ENSG00000075624
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.97
    Ensembl ID: ENSG00000104529
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.95
    Ensembl ID: ENSG00000127184
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.87
    Ensembl ID: ENSG00000167996
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.86
    Ensembl ID: ENSG00000114942
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 2.76
    Ensembl ID: ENSG00000206503
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.72
    Ensembl ID: ENSG00000124172
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 2.69
    Ensembl ID: ENSG00000163041
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.68
    Ensembl ID: ENSG00000131143
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 2.62
    Ensembl ID: ENSG00000234745
  • Gene Symbol: JUNB (ENSG00000171223)
    Fold Change: 2.62
    Ensembl ID: ENSG00000171223
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.57
    Ensembl ID: ENSG00000111775
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 2.57
    Ensembl ID: ENSG00000135486
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.55
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.54
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.53
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.53
    Ensembl ID: ENSG00000164919
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 2.53
    Ensembl ID: ENSG00000204525
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 2.53
    Ensembl ID: ENSG00000120129
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 2.53
    Ensembl ID: ENSG00000170345
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.51
    Ensembl ID: ENSG00000167658
  • Gene Symbol: JUN (ENSG00000177606)
    Fold Change: 2.51
    Ensembl ID: ENSG00000177606
  • Gene Symbol: HLA E (ENSG00000204592)
    Fold Change: 2.48
    Ensembl ID: ENSG00000204592
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.47
    Ensembl ID: ENSG00000111640
  • Gene Symbol: HSPA8 (ENSG00000109971)
    Fold Change: 2.46
    Ensembl ID: ENSG00000109971
  • Gene Symbol: HSPA5 (ENSG00000044574)
    Fold Change: 2.37
    Ensembl ID: ENSG00000044574
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.36
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.32
    Ensembl ID: ENSG00000185650
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.32
    Ensembl ID: ENSG00000122566
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 2.31
    Ensembl ID: ENSG00000165119
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 2.28
    Ensembl ID: ENSG00000096384
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.27
    Ensembl ID: ENSG00000179218
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.27
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.26
    Ensembl ID: ENSG00000126267
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 2.26
    Ensembl ID: ENSG00000205581
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 2.22
    Ensembl ID: ENSG00000051523
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 2.21
    Ensembl ID: ENSG00000110321
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 2.19
    Ensembl ID: ENSG00000080824
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 2.18
    Ensembl ID: ENSG00000169567
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 2.18
    Ensembl ID: ENSG00000176340
  • Gene Symbol: HMGN2 (ENSG00000198830)
    Fold Change: 2.16
    Ensembl ID: ENSG00000198830
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 2.14
    Ensembl ID: ENSG00000156976
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.14
    Ensembl ID: ENSG00000133639
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 2.13
    Ensembl ID: ENSG00000084207
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 2.12
    Ensembl ID: ENSG00000155368
  • Gene Symbol: HSPB1 (ENSG00000106211)
    Fold Change: 2.12
    Ensembl ID: ENSG00000106211
  • Gene Symbol: EIF3E (ENSG00000104408)
    Fold Change: 2.05
    Ensembl ID: ENSG00000104408
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.04
    Ensembl ID: ENSG00000134825
  • Gene Symbol: H2AZ1 (ENSG00000164032)
    Fold Change: 2
    Ensembl ID: ENSG00000164032
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.98
    Ensembl ID: ENSG00000129562
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.97
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.95
    Ensembl ID: ENSG00000198668
  • Gene Symbol: DSCAM (ENSG00000171587)
    Fold Change: 1.95
    Ensembl ID: ENSG00000171587
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 1.95
    Ensembl ID: ENSG00000167468
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 1.95
    Ensembl ID: ENSG00000153187
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.94
    Ensembl ID: ENSG00000145362
  • Gene Symbol: CTNNA2 (ENSG00000066032)
    Fold Change: 1.94
    Ensembl ID: ENSG00000066032
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 1.94
    Ensembl ID: ENSG00000108654
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 1.94
    Ensembl ID: ENSG00000130226
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 1.94
    Ensembl ID: ENSG00000189403
  • Gene Symbol: KCNC2 (ENSG00000166006)
    Fold Change: 1.94
    Ensembl ID: ENSG00000166006
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.93
    Ensembl ID: ENSG00000143761
  • Gene Symbol: GNG5 (ENSG00000174021)
    Fold Change: 1.93
    Ensembl ID: ENSG00000174021
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 1.93
    Ensembl ID: ENSG00000169862
  • Gene Symbol: FGF12 (ENSG00000114279)
    Fold Change: 1.93
    Ensembl ID: ENSG00000114279
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 1.92
    Ensembl ID: ENSG00000148408
  • Gene Symbol: DNM1 (ENSG00000106976)
    Fold Change: 1.91
    Ensembl ID: ENSG00000106976
  • Gene Symbol: EBF1 (ENSG00000164330)
    Fold Change: 1.91
    Ensembl ID: ENSG00000164330
  • Gene Symbol: GRIA4 (ENSG00000152578)
    Fold Change: 1.91
    Ensembl ID: ENSG00000152578
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.91
    Ensembl ID: ENSG00000005022
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.91
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 1.91
    Ensembl ID: ENSG00000141837
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 1.91
    Ensembl ID: ENSG00000088538
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.9
    Ensembl ID: ENSG00000151150
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 1.9
    Ensembl ID: ENSG00000150672
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 1.89
    Ensembl ID: ENSG00000134769
  • Gene Symbol: LSAMP (ENSG00000185565)
    Fold Change: 1.89
    Ensembl ID: ENSG00000185565
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.88
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1.88
    Ensembl ID: ENSG00000135298
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 1.88
    Ensembl ID: ENSG00000018236
  • Gene Symbol: ESRRG (ENSG00000196482)
    Fold Change: 1.88
    Ensembl ID: ENSG00000196482
  • Gene Symbol: GRIA2 (ENSG00000120251)
    Fold Change: 1.87
    Ensembl ID: ENSG00000120251
  • Gene Symbol: KCNMA1 (ENSG00000156113)
    Fold Change: 1.87
    Ensembl ID: ENSG00000156113
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.87
    Ensembl ID: ENSG00000067560
  • Gene Symbol: NRG1 (ENSG00000157168)
    Fold Change: 1.86
    Ensembl ID: ENSG00000157168
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.86
    Ensembl ID: ENSG00000029534
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.86
    Ensembl ID: ENSG00000099622
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.85
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.84
    Ensembl ID: ENSG00000165995
  • Gene Symbol: DYNC1I1 (ENSG00000158560)
    Fold Change: 1.84
    Ensembl ID: ENSG00000158560
  • Gene Symbol: PDIA3 (ENSG00000167004)
    Fold Change: 1.84
    Ensembl ID: ENSG00000167004
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.84
    Ensembl ID: ENSG00000156110

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in ON retinal ganglion cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in ON retinal ganglion cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * **Retinal Ganglion Cells (RGCs)**: RGCs are specialized neurons that transmit visual information from the eye to the brain. They are depolarized by illumination of their receptive field center, which triggers a signaling cascade that ultimately leads to the transmission of visual information. * **EEF1A1**: EEF1A1 is a gene that plays a crucial role in autophagy, a process by which cells recycle damaged or dysfunctional components. EEF1A1 is also involved in the regulation of protein synthesis and translation. * **B2M**: B2M is a gene that plays a critical role in the adaptive immune system. It is involved in the processing and presentation of antigens to T-cells, which is essential for the activation of the immune response. * **FAU**: FAU is a gene that is involved in the regulation of translation initiation. It is a component of the eukaryotic translation initiation complex and plays a crucial role in the initiation of protein synthesis. **Clinical Significance** * **Retinal Ganglion Cell Loss**: RGC loss is a hallmark of various retinal diseases, including glaucoma and age-related macular degeneration. Understanding the mechanisms of RGC function and dysfunction is critical for the development of novel therapeutic strategies. * **Autophagy Dysregulation**: Dysregulation of autophagy has been implicated in various diseases, including cancer, neurodegenerative disorders, and infectious diseases. EEF1A1 plays a critical role in regulating autophagy, and its dysregulation may contribute to disease pathogenesis. * **Antigen Presentation**: B2M plays a critical role in the processing and presentation of antigens to T-cells, which is essential for the activation of the immune response. Dysregulation of B2M expression or function may contribute to immune-related disorders. * **Translation Initiation**: FAU is a critical component of the eukaryotic translation initiation complex, and its dysregulation may contribute to various diseases, including cancer and infectious diseases. **Disease Associations** * **Glaucoma**: RGC loss is a hallmark of glaucoma, a group of eye disorders that can lead to irreversible vision loss. * **Age-related Macular Degeneration**: RGC loss is also associated with age-related macular degeneration, a leading cause of vision loss in older adults. * **Cancer**: Dysregulation of autophagy has been implicated in various cancers, including breast, lung, and colon cancer. * **Neurodegenerative Disorders**: Dysregulation of autophagy has also been implicated in various neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. **Future Directions** * **Understanding RGC Function and Dysfunction**: Further research is needed to understand the mechanisms of RGC function and dysfunction, which will inform the development of novel therapeutic strategies for retinal diseases. * **Regulation of Autophagy**: Understanding the regulation of autophagy will provide insights into the development of novel therapeutic strategies for various diseases, including cancer and neurodegenerative disorders. * **Antigen Presentation**: Further research is needed to understand the mechanisms of antigen presentation and the role of B2M in the adaptive immune response. * **Translation Initiation**: Understanding the regulation of translation initiation will provide insights into the development of novel therapeutic strategies for various diseases, including cancer and infectious diseases.