Details for: CL4023033

Cell ID: CL4023033

Cell Name: OFF retinal ganglion cell

Marker Score Threshold: 419
(Derived using integrated single-cell and genomic data)

Description: A retinal ganglion cell that is depolarized by decreased illumination of their receptive field center.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.61
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.55
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 2.46
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.43
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.42
    Ensembl ID: ENSG00000156110
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.41
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.4
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.38
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 2.35
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 2.32
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.31
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.27
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 2.2
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.2
    Ensembl ID: ENSG00000157087
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 2.18
    Ensembl ID: ENSG00000135298
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.16
    Ensembl ID: ENSG00000134982
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.13
    Ensembl ID: ENSG00000107282
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.12
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.04
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.02
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 2.01
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.93
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.92
    Ensembl ID: ENSG00000143153
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.91
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.84
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.83
    Ensembl ID: ENSG00000087274
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.82
    Ensembl ID: ENSG00000084234
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 1.81
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.8
    Ensembl ID: ENSG00000149311
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.75
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.74
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.71
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.7
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.69
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.68
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.68
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.67
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.66
    Ensembl ID: ENSG00000162104
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.64
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.64
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.62
    Ensembl ID: ENSG00000164742
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.61
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.61
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.59
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.59
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.59
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.53
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.52
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.52
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ANGPT2 (ENSG00000091879)
    Fold Change: 1.51
    Ensembl ID: ENSG00000091879
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.5
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.5
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.49
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.48
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.47
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.44
    Ensembl ID: ENSG00000184009
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.42
    Ensembl ID: ENSG00000166747
  • Gene Symbol: BDH1 (ENSG00000161267)
    Fold Change: 1.42
    Ensembl ID: ENSG00000161267
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.4
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.38
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.38
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.35
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 1.35
    Ensembl ID: ENSG00000171094
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.31
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.31
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.29
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143322
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.27
    Ensembl ID: ENSG00000113916
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.27
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.26
    Ensembl ID: ENSG00000130402
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.25
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.19
    Ensembl ID: ENSG00000174437
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.19
    Ensembl ID: ENSG00000183020
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.18
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.16
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.16
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.15
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.15
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ALDOC (ENSG00000109107)
    Fold Change: 1.13
    Ensembl ID: ENSG00000109107
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.09
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 1.09
    Ensembl ID: ENSG00000173208
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.09
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.07
    Ensembl ID: ENSG00000120437
  • Gene Symbol: BCAT2 (ENSG00000105552)
    Fold Change: 1.06
    Ensembl ID: ENSG00000105552
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.05
    Ensembl ID: ENSG00000137486
  • Gene Symbol: HCN2 (ENSG00000099822)
    Fold Change: 1.05
    Ensembl ID: ENSG00000099822
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.04
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.04
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165629
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.03
    Ensembl ID: ENSG00000151729
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.03
    Ensembl ID: ENSG00000133794
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.03
    Ensembl ID: ENSG00000111348
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.03
    Ensembl ID: ENSG00000090861
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.02
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.01
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: N/A
    Ensembl ID: ENSG00000131269
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: N/A
    Ensembl ID: ENSG00000198931
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Depolarization by decreased illumination**: The OFF retinal ganglion cell is depolarized by decreased illumination of its receptive field center, which is a unique characteristic of this cell type. 2. **ANK2 gene**: The ANK2 gene is involved in the regulation of membrane trafficking and protein localization, which are essential for maintaining proper cellular function. 3. **ANK3 gene**: The ANK3 gene is involved in the regulation of membrane depolarization during cardiac muscle cell action potential and is also involved in the regulation of potassium ion transport. 4. **ZFHX3 gene**: The ZFHX3 gene is involved in the regulation of transcriptional regulation and is also involved in the regulation of muscle organ development. 5. **Apical plasma membrane**: The OFF retinal ganglion cell has an apical plasma membrane, which is involved in the regulation of membrane trafficking and protein localization. 6. **Basolateral plasma membrane**: The OFF retinal ganglion cell also has a basolateral plasma membrane, which is involved in the regulation of membrane trafficking and protein localization. 7. **Cytoskeletal anchor activity**: The OFF retinal ganglion cell has cytoskeletal anchor activity, which is involved in the regulation of cytoskeleton organization and protein localization. 8. **Axon guidance**: The OFF retinal ganglion cell is involved in axon guidance, which is essential for maintaining proper neural connections. **Clinical Significance** 1. **Visual processing**: The OFF retinal ganglion cell plays a crucial role in visual processing and is essential for maintaining proper visual function. 2. **Retinal degeneration**: The OFF retinal ganglion cell is affected in retinal degeneration diseases such as glaucoma and age-related macular degeneration. 3. **Cardiac function**: The ANK3 gene is also involved in the regulation of cardiac muscle cell contraction and is essential for maintaining proper cardiac function. 4. **Neurological disorders**: The ZFHX3 gene is involved in the regulation of transcriptional regulation and is also involved in the regulation of muscle organ development, which is essential for maintaining proper neurological function. In conclusion, the OFF retinal ganglion cell is a unique cell type that plays a crucial role in visual processing and is essential for maintaining proper visual function. Its genes, including ANK2, ANK3, and ZFHX3, are involved in various cellular processes such as membrane trafficking, protein localization, and transcriptional regulation. The clinical significance of this cell type is significant, as it is affected in retinal degeneration diseases and is also involved in cardiac function and neurological disorders.