Details for: CL4023033

Cell ID: CL4023033

Cell Name: OFF retinal ganglion cell

Marker Score Threshold: 419
(Derived using integrated single-cell and genomic data)

Description: A retinal ganglion cell that is depolarized by decreased illumination of their receptive field center.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.61
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.55
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 2.46
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.43
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.42
    Ensembl ID: ENSG00000156110
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.41
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.4
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.38
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 2.35
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 2.32
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.31
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.27
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 2.2
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.2
    Ensembl ID: ENSG00000157087
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 2.18
    Ensembl ID: ENSG00000135298
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.16
    Ensembl ID: ENSG00000134982
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.13
    Ensembl ID: ENSG00000107282
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.12
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.04
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.02
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 2.01
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.93
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.92
    Ensembl ID: ENSG00000143153
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.91
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.84
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.83
    Ensembl ID: ENSG00000087274
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.82
    Ensembl ID: ENSG00000084234
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 1.81
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.8
    Ensembl ID: ENSG00000149311
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.75
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.74
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.71
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.7
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.69
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.68
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.68
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.67
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.66
    Ensembl ID: ENSG00000162104
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.64
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.64
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.62
    Ensembl ID: ENSG00000164742
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.61
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.61
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.59
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.59
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.59
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.53
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.52
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.52
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ANGPT2 (ENSG00000091879)
    Fold Change: 1.51
    Ensembl ID: ENSG00000091879
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.5
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.5
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.49
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.48
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.47
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.44
    Ensembl ID: ENSG00000184009
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.42
    Ensembl ID: ENSG00000166747
  • Gene Symbol: BDH1 (ENSG00000161267)
    Fold Change: 1.42
    Ensembl ID: ENSG00000161267
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.4
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.38
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.38
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.35
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 1.35
    Ensembl ID: ENSG00000171094
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.31
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.31
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.29
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143322
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.27
    Ensembl ID: ENSG00000113916
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.27
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.26
    Ensembl ID: ENSG00000130402
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.25
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.19
    Ensembl ID: ENSG00000174437
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.19
    Ensembl ID: ENSG00000183020
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.18
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.16
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.16
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.15
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.15
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ALDOC (ENSG00000109107)
    Fold Change: 1.13
    Ensembl ID: ENSG00000109107
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.09
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 1.09
    Ensembl ID: ENSG00000173208
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.09
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.07
    Ensembl ID: ENSG00000120437
  • Gene Symbol: BCAT2 (ENSG00000105552)
    Fold Change: 1.06
    Ensembl ID: ENSG00000105552
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.05
    Ensembl ID: ENSG00000137486
  • Gene Symbol: HCN2 (ENSG00000099822)
    Fold Change: 1.05
    Ensembl ID: ENSG00000099822
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.04
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.04
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165629
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.03
    Ensembl ID: ENSG00000151729
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.03
    Ensembl ID: ENSG00000133794
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.03
    Ensembl ID: ENSG00000111348
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.03
    Ensembl ID: ENSG00000090861
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.02
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.01
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: N/A
    Ensembl ID: ENSG00000131269
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: N/A
    Ensembl ID: ENSG00000198931

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in OFF retinal ganglion cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in OFF retinal ganglion cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The OFF retinal ganglion cell (CL4023033) exhibits the following key characteristics: 1. **Depolarization response**: The cell is depolarized by decreased illumination of its receptive field center. 2. **ANK2 gene**: The cell expresses the ANK2 gene, which is involved in maintaining the structural integrity of the cell membrane and regulating membrane trafficking. 3. **ANK3 gene**: The cell expresses the ANK3 gene, which is involved in regulating axon guidance and cell adhesion. 4. **ZFHX3 gene**: The cell expresses the ZFHX3 gene, which is involved in regulating transcriptional activity and cell differentiation. 5. **Protein localization**: The cell exhibits specific patterns of protein localization, including the targeting of proteins to the plasma membrane, endoplasmic reticulum, and Golgi apparatus. 6. **Protein trafficking**: The cell involves various forms of protein trafficking, including endocytosis, exocytosis, and vesicle-mediated transport. 7. **Cell adhesion**: The cell exhibits strong adhesion properties, including homotypic cell-cell adhesion and interactions with L1CAM and NRCAM. **Clinical Significance** The OFF retinal ganglion cell (CL4023033) has significant clinical implications, particularly in the context of retinal degeneration and visual impairments. Understanding the molecular mechanisms underlying the function and dysfunction of this cell type can provide valuable insights into the development of novel therapeutic strategies for the treatment of retinal diseases. 1. **Retinal degeneration**: The OFF retinal ganglion cell is a key component of the retina, and its dysfunction can contribute to retinal degeneration and visual impairments. 2. **Visual impairments**: The cell's response to decreased illumination can be affected by various factors, including age-related macular degeneration and diabetic retinopathy. 3. **Neurological disorders**: The cell's axon guidance and cell adhesion properties can be affected by various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Therapeutic targeting**: The cell's unique characteristics can be targeted for the development of novel therapeutic strategies, including gene therapy and small molecule therapies. In conclusion, the OFF retinal ganglion cell (CL4023033) is a complex cell type that exhibits unique characteristics, including protein localization, trafficking, and modification. Understanding these characteristics can provide valuable insights into the development of novel therapeutic strategies for the treatment of retinal diseases and visual impairments.