Cell ID: CL4023036

Cell Name: chandelier pvalb GABAergic cortical interneuron

CSI Thresholds:

Select	Context	Threshold
	Overall	20.8709
	Neocortex	251.2206
	Neocortex + Healthy	250.8508
	Middle temporal gyrus	248.7567
	Middle temporal gyrus + Dementia	175.2213
	Middle temporal gyrus + Healthy	99.0273
	Dorsolateral prefrontal cortex + Dementia	98.6856
	Dementia	92.7049
	Primary visual cortex	43.6758
	Dorsolateral prefrontal cortex	36.9946
	Dorsolateral prefrontal cortex + Healthy	23.1492
	Healthy	20.9038
	Primary visual cortex + Healthy	13.6581
	Primary somatosensory cortex	10.9259
	Primary somatosensory cortex + Healthy	10.8839
	Primary auditory cortex	10.8399
	Primary auditory cortex + Healthy	10.8107
	Anterior cingulate cortex + Healthy	6.5470
	Angular gyrus	6.5249
	Angular gyrus + Healthy	6.5207
	Anterior cingulate cortex	6.4898

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(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A transcriptomically distinct pvalb GABAergic cortical interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Chandelier.

Synonyms: Chandelier PV