Details for: CL4023036

Cell ID: CL4023036

Cell Name: chandelier pvalb GABAergic cortical interneuron

Marker Score Threshold: 4,146
(Derived using integrated single-cell and genomic data)

Description: A transcriptomically distinct pvalb GABAergic cortical interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Chandelier.

Synonyms: Chandelier PV

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 2.62
    Ensembl ID: ENSG00000135298
  • Gene Symbol: GRIA1 (ENSG00000155511)
    Fold Change: 2.62
    Ensembl ID: ENSG00000155511
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 2.62
    Ensembl ID: ENSG00000150672
  • Gene Symbol: FGF14 (ENSG00000102466)
    Fold Change: 2.62
    Ensembl ID: ENSG00000102466
  • Gene Symbol: GRIA4 (ENSG00000152578)
    Fold Change: 2.62
    Ensembl ID: ENSG00000152578
  • Gene Symbol: FGF12 (ENSG00000114279)
    Fold Change: 2.62
    Ensembl ID: ENSG00000114279
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 2.62
    Ensembl ID: ENSG00000088538
  • Gene Symbol: GABRG3 (ENSG00000182256)
    Fold Change: 2.62
    Ensembl ID: ENSG00000182256
  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 2.62
    Ensembl ID: ENSG00000173406
  • Gene Symbol: ERBB4 (ENSG00000178568)
    Fold Change: 2.62
    Ensembl ID: ENSG00000178568
  • Gene Symbol: GRIK2 (ENSG00000164418)
    Fold Change: 2.62
    Ensembl ID: ENSG00000164418
  • Gene Symbol: GRIN2B (ENSG00000273079)
    Fold Change: 2.62
    Ensembl ID: ENSG00000273079
  • Gene Symbol: GRM5 (ENSG00000168959)
    Fold Change: 2.62
    Ensembl ID: ENSG00000168959
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 2.62
    Ensembl ID: ENSG00000141837
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 2.61
    Ensembl ID: ENSG00000130226
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 2.61
    Ensembl ID: ENSG00000169862
  • Gene Symbol: GRID1 (ENSG00000182771)
    Fold Change: 2.61
    Ensembl ID: ENSG00000182771
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.61
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 2.6
    Ensembl ID: ENSG00000171094
  • Gene Symbol: GPM6A (ENSG00000150625)
    Fold Change: 2.6
    Ensembl ID: ENSG00000150625
  • Gene Symbol: DGKB (ENSG00000136267)
    Fold Change: 2.6
    Ensembl ID: ENSG00000136267
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 2.6
    Ensembl ID: ENSG00000018236
  • Gene Symbol: CTNNA2 (ENSG00000066032)
    Fold Change: 2.6
    Ensembl ID: ENSG00000066032
  • Gene Symbol: GABRB2 (ENSG00000145864)
    Fold Change: 2.6
    Ensembl ID: ENSG00000145864
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.6
    Ensembl ID: ENSG00000151150
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 2.59
    Ensembl ID: ENSG00000134769
  • Gene Symbol: GRIA2 (ENSG00000120251)
    Fold Change: 2.59
    Ensembl ID: ENSG00000120251
  • Gene Symbol: GRIA3 (ENSG00000125675)
    Fold Change: 2.59
    Ensembl ID: ENSG00000125675
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 2.58
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.58
    Ensembl ID: ENSG00000157087
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.57
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 2.57
    Ensembl ID: ENSG00000155897
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 2.56
    Ensembl ID: ENSG00000157388
  • Gene Symbol: GRID2 (ENSG00000152208)
    Fold Change: 2.56
    Ensembl ID: ENSG00000152208
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 2.56
    Ensembl ID: ENSG00000182389
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 2.56
    Ensembl ID: ENSG00000148408
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 2.54
    Ensembl ID: ENSG00000100077
  • Gene Symbol: CDH12 (ENSG00000154162)
    Fold Change: 2.52
    Ensembl ID: ENSG00000154162
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.52
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.51
    Ensembl ID: ENSG00000152092
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.51
    Ensembl ID: ENSG00000142192
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.51
    Ensembl ID: ENSG00000142599
  • Gene Symbol: DAPK1 (ENSG00000196730)
    Fold Change: 2.51
    Ensembl ID: ENSG00000196730
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 2.5
    Ensembl ID: ENSG00000198947
  • Gene Symbol: CA8 (ENSG00000178538)
    Fold Change: 2.5
    Ensembl ID: ENSG00000178538
  • Gene Symbol: FGF13 (ENSG00000129682)
    Fold Change: 2.5
    Ensembl ID: ENSG00000129682
  • Gene Symbol: FER (ENSG00000151422)
    Fold Change: 2.49
    Ensembl ID: ENSG00000151422
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.47
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ELAVL3 (ENSG00000196361)
    Fold Change: 2.47
    Ensembl ID: ENSG00000196361
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 2.47
    Ensembl ID: ENSG00000151067
  • Gene Symbol: GABRB3 (ENSG00000166206)
    Fold Change: 2.46
    Ensembl ID: ENSG00000166206
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 2.43
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.43
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.43
    Ensembl ID: ENSG00000156110
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.43
    Ensembl ID: ENSG00000134982
  • Gene Symbol: GNAQ (ENSG00000156052)
    Fold Change: 2.42
    Ensembl ID: ENSG00000156052
  • Gene Symbol: GNAL (ENSG00000141404)
    Fold Change: 2.42
    Ensembl ID: ENSG00000141404
  • Gene Symbol: EXT1 (ENSG00000182197)
    Fold Change: 2.42
    Ensembl ID: ENSG00000182197
  • Gene Symbol: DTNB (ENSG00000138101)
    Fold Change: 2.41
    Ensembl ID: ENSG00000138101
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 2.41
    Ensembl ID: ENSG00000152495
  • Gene Symbol: INPP4A (ENSG00000040933)
    Fold Change: 2.41
    Ensembl ID: ENSG00000040933
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.41
    Ensembl ID: ENSG00000143153
  • Gene Symbol: EPHA5 (ENSG00000145242)
    Fold Change: 2.4
    Ensembl ID: ENSG00000145242
  • Gene Symbol: GTF2I (ENSG00000263001)
    Fold Change: 2.4
    Ensembl ID: ENSG00000263001
  • Gene Symbol: DNM1 (ENSG00000106976)
    Fold Change: 2.4
    Ensembl ID: ENSG00000106976
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.39
    Ensembl ID: ENSG00000278540
  • Gene Symbol: CDH18 (ENSG00000145526)
    Fold Change: 2.39
    Ensembl ID: ENSG00000145526
  • Gene Symbol: CAMK2B (ENSG00000058404)
    Fold Change: 2.39
    Ensembl ID: ENSG00000058404
  • Gene Symbol: RUNX2 (ENSG00000124813)
    Fold Change: 2.38
    Ensembl ID: ENSG00000124813
  • Gene Symbol: DYNC1I1 (ENSG00000158560)
    Fold Change: 2.38
    Ensembl ID: ENSG00000158560
  • Gene Symbol: GNAO1 (ENSG00000087258)
    Fold Change: 2.38
    Ensembl ID: ENSG00000087258
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.37
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.37
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.37
    Ensembl ID: ENSG00000170017
  • Gene Symbol: FYN (ENSG00000010810)
    Fold Change: 2.35
    Ensembl ID: ENSG00000010810
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 2.34
    Ensembl ID: ENSG00000134480
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.34
    Ensembl ID: ENSG00000157764
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.34
    Ensembl ID: ENSG00000198589
  • Gene Symbol: GRIK1 (ENSG00000171189)
    Fold Change: 2.33
    Ensembl ID: ENSG00000171189
  • Gene Symbol: CDH9 (ENSG00000113100)
    Fold Change: 2.33
    Ensembl ID: ENSG00000113100
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2.33
    Ensembl ID: ENSG00000087460
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.32
    Ensembl ID: ENSG00000204217
  • Gene Symbol: GSK3B (ENSG00000082701)
    Fold Change: 2.3
    Ensembl ID: ENSG00000082701
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.3
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 2.3
    Ensembl ID: ENSG00000257923
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.29
    Ensembl ID: ENSG00000034053
  • Gene Symbol: GLS (ENSG00000115419)
    Fold Change: 2.29
    Ensembl ID: ENSG00000115419
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 2.28
    Ensembl ID: ENSG00000134871
  • Gene Symbol: HIVEP2 (ENSG00000010818)
    Fold Change: 2.27
    Ensembl ID: ENSG00000010818
  • Gene Symbol: IGF1R (ENSG00000140443)
    Fold Change: 2.27
    Ensembl ID: ENSG00000140443
  • Gene Symbol: ARHGAP35 (ENSG00000160007)
    Fold Change: 2.26
    Ensembl ID: ENSG00000160007
  • Gene Symbol: FHIT (ENSG00000189283)
    Fold Change: 2.26
    Ensembl ID: ENSG00000189283
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.25
    Ensembl ID: ENSG00000170634
  • Gene Symbol: BRINP1 (ENSG00000078725)
    Fold Change: 2.25
    Ensembl ID: ENSG00000078725
  • Gene Symbol: GUCY1A2 (ENSG00000152402)
    Fold Change: 2.25
    Ensembl ID: ENSG00000152402
  • Gene Symbol: ENSA (ENSG00000143420)
    Fold Change: 2.24
    Ensembl ID: ENSG00000143420
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 2.24
    Ensembl ID: ENSG00000140743
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 2.24
    Ensembl ID: ENSG00000159842
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 2.24
    Ensembl ID: ENSG00000171634
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.24
    Ensembl ID: ENSG00000070961

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in chandelier pvalb GABAergic cortical interneuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in chandelier pvalb GABAergic cortical interneuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * Morphology: Chandelier PV cells have a distinctive morphology, with vertically oriented strings of synaptic boutons and straight terminal axonal 'cartridges' that target exclusively the AIS of pyramidal cells. * Targeting: Chandelier PV cells target the AIS of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner. * Synaptic transmission: Chandelier PV cells are involved in regulating the activity of pyramidal neurons through the release of GABA, which modulates the excitability of pyramidal cells. * Gene expression: Chandelier PV cells express a unique set of genes, including ADGRB3, GRIA1, DLG2, FGF14, and FGF12, which are involved in various cellular processes, including synaptic transmission, cell signaling, and growth factor activity. * Transcriptional profile: Chandelier PV cells have a distinct transcriptional profile, which is characterized by the expression of genes involved in synaptic transmission, cell signaling, and growth factor activity. **Clinical Significance** Chandelier PV cells play a critical role in regulating the activity of pyramidal neurons and are involved in various cognitive and behavioral processes, including learning, memory, and motor control. Dysregulation of chandelier PV cells has been implicated in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Further research on the function and dysfunction of chandelier PV cells is needed to understand their role in human brain function and disease. **Pathways and Ontology** Chandelier PV cells are involved in various signaling pathways, including: * Adenylate cyclase-activating g protein-coupled receptor signaling pathway * Cell surface receptor signaling pathway * Cerebellar climbing fiber to purkinje cell synapse * G protein-coupled receptor activity * G protein-coupled receptor signaling pathway * Gtpase activator activity * Maintenance of synapse structure * Membrane * Motor learning * Myoblast fusion * Negative regulation of angiogenesis * Neuron remodeling * Plasma membrane * Positive regulation of synapse assembly * Postsynapse * Postsynaptic density membrane * Protein binding * Regulation of dendrite morphogenesis * Regulation of synapse maturation * Regulation of synapse pruning * Synaptic cleft * Gene Symbol: ADGRB3 * Gene Symbol: GRIA1 * Gene Symbol: DLG2 * Gene Symbol: FGF14 * Gene Symbol: FGF12 These pathways are involved in various cellular processes, including synaptic transmission, cell signaling, and growth factor activity.