Details for: CL4023036

Cell ID: CL4023036

Cell Name: chandelier pvalb GABAergic cortical interneuron

Marker Score Threshold: 4146
(Derived using integrated single-cell and genomic data)

Description: A transcriptomically distinct pvalb GABAergic cortical interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Chandelier.

Synonyms: Chandelier PV

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.61
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 2.6
    Ensembl ID: ENSG00000171094
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.6
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 2.58
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.58
    Ensembl ID: ENSG00000157087
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 2.57
    Ensembl ID: ENSG00000155897
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 2.54
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.51
    Ensembl ID: ENSG00000152092
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.51
    Ensembl ID: ENSG00000142192
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.51
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 2.43
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.43
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.43
    Ensembl ID: ENSG00000156110
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.43
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.41
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.39
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.37
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.37
    Ensembl ID: ENSG00000170017
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.3
    Ensembl ID: ENSG00000163697
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.29
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.25
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 2.24
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.24
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 2.19
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 2.18
    Ensembl ID: ENSG00000075340
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.16
    Ensembl ID: ENSG00000107282
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 2.08
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 2.06
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 2.04
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 2.04
    Ensembl ID: ENSG00000197381
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 2.02
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.01
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 2.01
    Ensembl ID: ENSG00000078549
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.98
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.96
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.96
    Ensembl ID: ENSG00000163399
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.95
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.89
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.88
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.84
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.84
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.77
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.77
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.77
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.76
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.69
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.69
    Ensembl ID: ENSG00000167972
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.67
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.65
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.61
    Ensembl ID: ENSG00000097007
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.61
    Ensembl ID: ENSG00000133794
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.6
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.57
    Ensembl ID: ENSG00000100412
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.57
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.56
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.55
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.53
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.53
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.52
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.51
    Ensembl ID: ENSG00000165029
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.5
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.47
    Ensembl ID: ENSG00000138175
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.44
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.4
    Ensembl ID: ENSG00000069849
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.39
    Ensembl ID: ENSG00000101966
  • Gene Symbol: STS (ENSG00000101846)
    Fold Change: 1.38
    Ensembl ID: ENSG00000101846
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.37
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.36
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.34
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.32
    Ensembl ID: ENSG00000185883
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 1.31
    Ensembl ID: ENSG00000240038
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.31
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.3
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.28
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.28
    Ensembl ID: ENSG00000152234
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.28
    Ensembl ID: ENSG00000090861
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.27
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.27
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.26
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP1B2 (ENSG00000129244)
    Fold Change: 1.24
    Ensembl ID: ENSG00000129244
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.23
    Ensembl ID: ENSG00000113273
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.2
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.2
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ATP6V1C1 (ENSG00000155097)
    Fold Change: 1.2
    Ensembl ID: ENSG00000155097
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.19
    Ensembl ID: ENSG00000123505
  • Gene Symbol: TRIM23 (ENSG00000113595)
    Fold Change: 1.18
    Ensembl ID: ENSG00000113595
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.17
    Ensembl ID: ENSG00000067842
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.16
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.13
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.12
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.07
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.07
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.05
    Ensembl ID: ENSG00000123268
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.03
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.02
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.02
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 1.01
    Ensembl ID: ENSG00000173208
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Morphology**: Chandelier PV cells have a distinct morphology, characterized by straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. 2. **Synaptic targeting**: Chandelier PV cells primarily target the axon initial segment (AIS) of pyramidal neurons, with a single cell innervating hundreds of pyramidal cells in a clustered manner. 3. **Gene expression**: Chandelier PV cells are recognizable by the expression of specific genes, including ANK2, ANK3, and ANK1. 4. **Transcriptomic profile**: Chandelier PV cells have a distinct transcriptomic profile, which can be identified using transcriptomic analysis. **Clinical Significance** Chandelier PV cells play a crucial role in regulating the activity of pyramidal neurons and maintaining the integrity of neural circuits. Dysregulation of Chandelier PV cells has been implicated in various neurological disorders, including epilepsy, schizophrenia, and Alzheimer's disease. Understanding the function and dysfunction of Chandelier PV cells is essential for the development of novel therapeutic strategies for these disorders. **Implications for Neurological Disorders** 1. **Epilepsy**: Dysregulation of Chandelier PV cells has been implicated in the pathophysiology of epilepsy. Targeting Chandelier PV cells may provide a novel therapeutic approach for treating epilepsy. 2. **Schizophrenia**: Abnormalities in Chandelier PV cells have been observed in individuals with schizophrenia. Understanding the function of Chandelier PV cells in schizophrenia may provide insights into the development of novel therapeutic strategies. 3. **Alzheimer's disease**: Chandelier PV cells have been shown to be affected in Alzheimer's disease. Targeting Chandelier PV cells may provide a novel therapeutic approach for treating Alzheimer's disease. **Future Directions** 1. **Transcriptomic analysis**: Further transcriptomic analysis is needed to understand the gene expression profile of Chandelier PV cells and their role in regulating neural circuits. 2. **Functional studies**: Functional studies are needed to understand the function of Chandelier PV cells and their role in regulating pyramidal neuron activity. 3. **Therapeutic strategies**: Novel therapeutic strategies targeting Chandelier PV cells are needed to treat neurological disorders, including epilepsy, schizophrenia, and Alzheimer's disease.