Details for: CL4023038

Cell ID: CL4023038

Cell Name: L6b glutamatergic cortical neuron

Marker Score Threshold: 8589
(Derived using integrated single-cell and genomic data)

Description: A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neuron', Author Categories: 'CrossArea_subclass', cluster L6b.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.88
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.87
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.87
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.87
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.86
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.86
    Ensembl ID: ENSG00000108684
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.86
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.85
    Ensembl ID: ENSG00000156110
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.85
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.84
    Ensembl ID: ENSG00000278540
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.84
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.84
    Ensembl ID: ENSG00000164742
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.84
    Ensembl ID: ENSG00000100077
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.83
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.83
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.82
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.8
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.8
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.8
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.79
    Ensembl ID: ENSG00000121989
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.76
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.76
    Ensembl ID: ENSG00000170634
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 1.75
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.74
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.74
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.74
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.73
    Ensembl ID: ENSG00000143322
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.7
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.69
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.68
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.67
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.67
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.66
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.65
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.65
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.64
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.63
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.58
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.58
    Ensembl ID: ENSG00000135503
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.58
    Ensembl ID: ENSG00000084234
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.56
    Ensembl ID: ENSG00000163697
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.55
    Ensembl ID: ENSG00000166747
  • Gene Symbol: APBB1 (ENSG00000166313)
    Fold Change: 1.54
    Ensembl ID: ENSG00000166313
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.54
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.53
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 1.51
    Ensembl ID: ENSG00000077522
  • Gene Symbol: TRIM23 (ENSG00000113595)
    Fold Change: 1.5
    Ensembl ID: ENSG00000113595
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.5
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 1.48
    Ensembl ID: ENSG00000078549
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.48
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.47
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.47
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.47
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.46
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 1.45
    Ensembl ID: ENSG00000196177
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.45
    Ensembl ID: ENSG00000105221
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.44
    Ensembl ID: ENSG00000105290
  • Gene Symbol: AMY2B (ENSG00000240038)
    Fold Change: 1.44
    Ensembl ID: ENSG00000240038
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.43
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.43
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 1.43
    Ensembl ID: ENSG00000155897
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.42
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.4
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.39
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.39
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.38
    Ensembl ID: ENSG00000143761
  • Gene Symbol: STS (ENSG00000101846)
    Fold Change: 1.38
    Ensembl ID: ENSG00000101846
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.38
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.36
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.36
    Ensembl ID: ENSG00000170017
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100280
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.34
    Ensembl ID: ENSG00000162688
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.33
    Ensembl ID: ENSG00000133794
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.33
    Ensembl ID: ENSG00000123268
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.32
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.31
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.29
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.27
    Ensembl ID: ENSG00000131269
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: 1.27
    Ensembl ID: ENSG00000090861
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.27
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.27
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.27
    Ensembl ID: ENSG00000047648
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.24
    Ensembl ID: ENSG00000196961
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.24
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ADORA1 (ENSG00000163485)
    Fold Change: 1.22
    Ensembl ID: ENSG00000163485
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.2
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ADCY6 (ENSG00000174233)
    Fold Change: 1.19
    Ensembl ID: ENSG00000174233
  • Gene Symbol: ABCA2 (ENSG00000107331)
    Fold Change: 1.18
    Ensembl ID: ENSG00000107331
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.18
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.17
    Ensembl ID: ENSG00000110330
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.15
    Ensembl ID: ENSG00000159461
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.13
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.13
    Ensembl ID: ENSG00000113273
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 1.11
    Ensembl ID: ENSG00000170214
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.08
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ARHGDIG (ENSG00000242173)
    Fold Change: 1.06
    Ensembl ID: ENSG00000242173
  • Gene Symbol: APAF1 (ENSG00000120868)
    Fold Change: 1.05
    Ensembl ID: ENSG00000120868
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.02
    Ensembl ID: ENSG00000161533
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.02
    Ensembl ID: ENSG00000138363
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 1.01
    Ensembl ID: ENSG00000173208
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cortical Layer 6b Location**: The cell is specifically found in the cortical layer 6b, which is a distinct layer within the neocortex. 2. **Glutamatergic Neuron**: The cell is a glutamatergic neuron, meaning it uses glutamate as its primary neurotransmitter. 3. **Transcriptomically Related to Corticothalamic-Projecting Neurons**: The cell is transcriptomically related to corticothalamic-projecting neurons, which suggests a shared genetic background. 4. **Differential Projections**: The cell exhibits differential projections to the thalamus or anterior cingulate, indicating a unique connection pattern. 5. **ANK2, ANK3, and ADCY2 Genes**: The associated genes reveal various cellular processes, including axon guidance, cytoskeletal organization, and signal transduction. **Clinical Significance** 1. **Neocortical Organization**: The cell's transcriptomic profile provides insights into the organization of the neocortex, specifically the layer 6b. 2. **Neurological Disorders**: The cell's unique connection pattern and gene expression profile may be relevant to neurological disorders, such as Alzheimer's disease or Parkinson's disease, which affect the neocortex. 3. **Neuroplasticity**: The cell's ability to exhibit differential projections suggests a role in neuroplasticity, which is essential for learning and memory. 4. **Thalamic and Anterior Cingulate Connections**: The cell's projections to the thalamus or anterior cingulate may be involved in regulating consciousness, attention, or emotional processing. **Conclusion** The cell CL4023038 is a glutamatergic cortical neuron specifically found in the cortical layer 6b. Its transcriptomic profile reveals various cellular processes, including axon guidance, cytoskeletal organization, and signal transduction. The cell's unique connection pattern and gene expression profile may be relevant to neurological disorders and neuroplasticity, highlighting the importance of further research into the functions and organization of this cell type within the neocortex.