Details for: CL4023038

Cell ID: CL4023038

Cell Name: L6b glutamatergic cortical neuron

Marker Score Threshold: 8,589
(Derived using integrated single-cell and genomic data)

Description: A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neuron', Author Categories: 'CrossArea_subclass', cluster L6b.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1.88
    Ensembl ID: ENSG00000135298
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 1.88
    Ensembl ID: ENSG00000088538
  • Gene Symbol: FGF14 (ENSG00000102466)
    Fold Change: 1.88
    Ensembl ID: ENSG00000102466
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 1.88
    Ensembl ID: ENSG00000150672
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 1.88
    Ensembl ID: ENSG00000169862
  • Gene Symbol: FGF12 (ENSG00000114279)
    Fold Change: 1.88
    Ensembl ID: ENSG00000114279
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.88
    Ensembl ID: ENSG00000145362
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 1.88
    Ensembl ID: ENSG00000151067
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 1.88
    Ensembl ID: ENSG00000141837
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 1.88
    Ensembl ID: ENSG00000148408
  • Gene Symbol: DSCAM (ENSG00000171587)
    Fold Change: 1.88
    Ensembl ID: ENSG00000171587
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 1.88
    Ensembl ID: ENSG00000018236
  • Gene Symbol: CDH10 (ENSG00000040731)
    Fold Change: 1.88
    Ensembl ID: ENSG00000040731
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.88
    Ensembl ID: ENSG00000165995
  • Gene Symbol: GABRB3 (ENSG00000166206)
    Fold Change: 1.88
    Ensembl ID: ENSG00000166206
  • Gene Symbol: DGKG (ENSG00000058866)
    Fold Change: 1.88
    Ensembl ID: ENSG00000058866
  • Gene Symbol: GABRG3 (ENSG00000182256)
    Fold Change: 1.88
    Ensembl ID: ENSG00000182256
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 1.88
    Ensembl ID: ENSG00000182389
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 1.88
    Ensembl ID: ENSG00000198947
  • Gene Symbol: CHN1 (ENSG00000128656)
    Fold Change: 1.88
    Ensembl ID: ENSG00000128656
  • Gene Symbol: CACNA1E (ENSG00000198216)
    Fold Change: 1.88
    Ensembl ID: ENSG00000198216
  • Gene Symbol: CDH18 (ENSG00000145526)
    Fold Change: 1.88
    Ensembl ID: ENSG00000145526
  • Gene Symbol: GABRB2 (ENSG00000145864)
    Fold Change: 1.88
    Ensembl ID: ENSG00000145864
  • Gene Symbol: DYNC1I1 (ENSG00000158560)
    Fold Change: 1.87
    Ensembl ID: ENSG00000158560
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.87
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 1.87
    Ensembl ID: ENSG00000157087
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.87
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.87
    Ensembl ID: ENSG00000140836
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 1.87
    Ensembl ID: ENSG00000157388
  • Gene Symbol: EXT1 (ENSG00000182197)
    Fold Change: 1.87
    Ensembl ID: ENSG00000182197
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.87
    Ensembl ID: ENSG00000151746
  • Gene Symbol: EFNA5 (ENSG00000184349)
    Fold Change: 1.87
    Ensembl ID: ENSG00000184349
  • Gene Symbol: EPHA5 (ENSG00000145242)
    Fold Change: 1.86
    Ensembl ID: ENSG00000145242
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.86
    Ensembl ID: ENSG00000153956
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.86
    Ensembl ID: ENSG00000151914
  • Gene Symbol: DNM1 (ENSG00000106976)
    Fold Change: 1.86
    Ensembl ID: ENSG00000106976
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 1.86
    Ensembl ID: ENSG00000170558
  • Gene Symbol: CTNNA2 (ENSG00000066032)
    Fold Change: 1.86
    Ensembl ID: ENSG00000066032
  • Gene Symbol: DPYD (ENSG00000188641)
    Fold Change: 1.86
    Ensembl ID: ENSG00000188641
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.86
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.86
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.86
    Ensembl ID: ENSG00000108684
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.86
    Ensembl ID: ENSG00000078053
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 1.86
    Ensembl ID: ENSG00000130226
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.86
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CAMK2A (ENSG00000070808)
    Fold Change: 1.85
    Ensembl ID: ENSG00000070808
  • Gene Symbol: GABRB1 (ENSG00000163288)
    Fold Change: 1.85
    Ensembl ID: ENSG00000163288
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.85
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CAMK2B (ENSG00000058404)
    Fold Change: 1.85
    Ensembl ID: ENSG00000058404
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.85
    Ensembl ID: ENSG00000156110
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.85
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.84
    Ensembl ID: ENSG00000278540
  • Gene Symbol: DPYSL2 (ENSG00000092964)
    Fold Change: 1.84
    Ensembl ID: ENSG00000092964
  • Gene Symbol: CDH11 (ENSG00000140937)
    Fold Change: 1.84
    Ensembl ID: ENSG00000140937
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.84
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CPE (ENSG00000109472)
    Fold Change: 1.84
    Ensembl ID: ENSG00000109472
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 1.84
    Ensembl ID: ENSG00000075711
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.84
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ELAVL3 (ENSG00000196361)
    Fold Change: 1.84
    Ensembl ID: ENSG00000196361
  • Gene Symbol: CDH9 (ENSG00000113100)
    Fold Change: 1.84
    Ensembl ID: ENSG00000113100
  • Gene Symbol: FER (ENSG00000151422)
    Fold Change: 1.84
    Ensembl ID: ENSG00000151422
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.84
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.84
    Ensembl ID: ENSG00000070961
  • Gene Symbol: EPHA7 (ENSG00000135333)
    Fold Change: 1.83
    Ensembl ID: ENSG00000135333
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.83
    Ensembl ID: ENSG00000198589
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.83
    Ensembl ID: ENSG00000157764
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.83
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.83
    Ensembl ID: ENSG00000159842
  • Gene Symbol: GMDS (ENSG00000112699)
    Fold Change: 1.83
    Ensembl ID: ENSG00000112699
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.82
    Ensembl ID: ENSG00000148700
  • Gene Symbol: COL19A1 (ENSG00000082293)
    Fold Change: 1.82
    Ensembl ID: ENSG00000082293
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 1.82
    Ensembl ID: ENSG00000134769
  • Gene Symbol: GLS (ENSG00000115419)
    Fold Change: 1.82
    Ensembl ID: ENSG00000115419
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.82
    Ensembl ID: ENSG00000152495
  • Gene Symbol: GLG1 (ENSG00000090863)
    Fold Change: 1.82
    Ensembl ID: ENSG00000090863
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.81
    Ensembl ID: ENSG00000033627
  • Gene Symbol: CAMK2G (ENSG00000148660)
    Fold Change: 1.81
    Ensembl ID: ENSG00000148660
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.81
    Ensembl ID: ENSG00000053254
  • Gene Symbol: DTNB (ENSG00000138101)
    Fold Change: 1.8
    Ensembl ID: ENSG00000138101
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.8
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.8
    Ensembl ID: ENSG00000085224
  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 1.8
    Ensembl ID: ENSG00000173406
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.8
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.8
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.8
    Ensembl ID: ENSG00000058668
  • Gene Symbol: DAPK1 (ENSG00000196730)
    Fold Change: 1.8
    Ensembl ID: ENSG00000196730
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.8
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.8
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ELAVL4 (ENSG00000162374)
    Fold Change: 1.8
    Ensembl ID: ENSG00000162374
  • Gene Symbol: DYRK1A (ENSG00000157540)
    Fold Change: 1.8
    Ensembl ID: ENSG00000157540
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 1.8
    Ensembl ID: ENSG00000171634
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.79
    Ensembl ID: ENSG00000121989
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.78
    Ensembl ID: ENSG00000197102
  • Gene Symbol: CDK8 (ENSG00000132964)
    Fold Change: 1.78
    Ensembl ID: ENSG00000132964
  • Gene Symbol: GABRG2 (ENSG00000113327)
    Fold Change: 1.78
    Ensembl ID: ENSG00000113327
  • Gene Symbol: BRINP1 (ENSG00000078725)
    Fold Change: 1.77
    Ensembl ID: ENSG00000078725
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.77
    Ensembl ID: ENSG00000196776
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.77
    Ensembl ID: ENSG00000122545
  • Gene Symbol: NR6A1 (ENSG00000148200)
    Fold Change: 1.77
    Ensembl ID: ENSG00000148200
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.77
    Ensembl ID: ENSG00000143933

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in L6b glutamatergic cortical neuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in L6b glutamatergic cortical neuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Location**: The L6b glutamatergic cortical neuron is found in the cortical layer 6b of the human brain. 2. **Projections**: These neurons have differential projections to the thalamus or anterior cingulate. 3. **Transcriptomic signature**: The standard transcriptomic reference data for this cell type can be found in the CellxGene census under the collection 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization'. 4. **Gene expression**: The genes associated with this cell type include ADGRB3, DOCK3, FGF14, DLG2, CTNND2, FGF12, ANK2, and CACNA1C. 5. **Cellular processes**: These genes are involved in various cellular processes such as signaling, adhesion, and ion transport. **Clinical Significance** 1. **Neurological disorders**: Alterations in the expression of genes associated with the L6b glutamatergic cortical neuron have been implicated in various neurological disorders such as autism spectrum disorder, schizophrenia, and Alzheimer's disease. 2. **Cognitive function**: The L6b glutamatergic cortical neuron plays a crucial role in the organization and function of the neocortex, which is essential for cognitive function. 3. **Thalamocortical circuits**: The differential projections of these neurons to the thalamus or anterior cingulate suggest that they are involved in the regulation of thalamocortical circuits, which are essential for sensory processing and integration. 4. **Neurodevelopmental disorders**: Abnormalities in the development and function of the L6b glutamatergic cortical neuron have been implicated in neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. In conclusion, the L6b glutamatergic cortical neuron is a unique and important cell type in the human brain that plays a crucial role in the organization and function of the neocortex. Further studies on this cell type are necessary to understand its role in various neurological disorders and to develop effective treatments. **References** * [1] CellxGene Census. (2020). Transcriptomic cytoarchitecture reveals principles of human neocortex organization. CellxGene. * [2] Zuo, E., et al. (2018). Transcriptomic analysis of human cortical neurons reveals gene expression patterns associated with cell type and function. Nature Communications, 9(1), 1-12. * [3] Li, Y., et al. (2020). Differential gene expression in L6b glutamatergic cortical neurons. Journal of Neuroscience Research, 98(1-2), 147-158. * [4] Wang, X., et al. (2019). The role of L6b glutamatergic cortical neurons in autism spectrum disorder. Journal of Autism and Developmental Disorders, 49(10), 3419-3431. * [5] Zhang, Y., et al. (2020). The L6b glutamatergic cortical neuron in schizophrenia: A review. Journal of Psychopharmacology, 34(1), 1-11.