Details for: CL4023040

Cell ID: CL4023040

Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron

Marker Score Threshold: 61,499
(Derived using integrated single-cell and genomic data)

Description: An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layers L2/3-6.

Synonyms: L2/3-6 IT projecting neuron

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 2.08
    Ensembl ID: ENSG00000135298
  • Gene Symbol: FGF14 (ENSG00000102466)
    Fold Change: 2.08
    Ensembl ID: ENSG00000102466
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 2.08
    Ensembl ID: ENSG00000150672
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.08
    Ensembl ID: ENSG00000145362
  • Gene Symbol: FGF12 (ENSG00000114279)
    Fold Change: 2.08
    Ensembl ID: ENSG00000114279
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 2.08
    Ensembl ID: ENSG00000169862
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 2.08
    Ensembl ID: ENSG00000088538
  • Gene Symbol: CTNNA2 (ENSG00000066032)
    Fold Change: 2.08
    Ensembl ID: ENSG00000066032
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 2.08
    Ensembl ID: ENSG00000151067
  • Gene Symbol: DSCAM (ENSG00000171587)
    Fold Change: 2.08
    Ensembl ID: ENSG00000171587
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 2.08
    Ensembl ID: ENSG00000018236
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.08
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 2.08
    Ensembl ID: ENSG00000141837
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 2.08
    Ensembl ID: ENSG00000198947
  • Gene Symbol: GABRB3 (ENSG00000166206)
    Fold Change: 2.08
    Ensembl ID: ENSG00000166206
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.08
    Ensembl ID: ENSG00000151914
  • Gene Symbol: GABRB2 (ENSG00000145864)
    Fold Change: 2.07
    Ensembl ID: ENSG00000145864
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 2.07
    Ensembl ID: ENSG00000148408
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 2.07
    Ensembl ID: ENSG00000182389
  • Gene Symbol: GABRG3 (ENSG00000182256)
    Fold Change: 2.07
    Ensembl ID: ENSG00000182256
  • Gene Symbol: DYNC1I1 (ENSG00000158560)
    Fold Change: 2.07
    Ensembl ID: ENSG00000158560
  • Gene Symbol: CDH18 (ENSG00000145526)
    Fold Change: 2.07
    Ensembl ID: ENSG00000145526
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 2.07
    Ensembl ID: ENSG00000130226
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.07
    Ensembl ID: ENSG00000157087
  • Gene Symbol: CDH10 (ENSG00000040731)
    Fold Change: 2.07
    Ensembl ID: ENSG00000040731
  • Gene Symbol: CHN1 (ENSG00000128656)
    Fold Change: 2.07
    Ensembl ID: ENSG00000128656
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.07
    Ensembl ID: ENSG00000142599
  • Gene Symbol: GABRB1 (ENSG00000163288)
    Fold Change: 2.07
    Ensembl ID: ENSG00000163288
  • Gene Symbol: EFNA5 (ENSG00000184349)
    Fold Change: 2.06
    Ensembl ID: ENSG00000184349
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 2.06
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CHRM3 (ENSG00000133019)
    Fold Change: 2.06
    Ensembl ID: ENSG00000133019
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.06
    Ensembl ID: ENSG00000142192
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 2.06
    Ensembl ID: ENSG00000075711
  • Gene Symbol: DNM1 (ENSG00000106976)
    Fold Change: 2.06
    Ensembl ID: ENSG00000106976
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.06
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.06
    Ensembl ID: ENSG00000151746
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 2.05
    Ensembl ID: ENSG00000157388
  • Gene Symbol: EXT1 (ENSG00000182197)
    Fold Change: 2.05
    Ensembl ID: ENSG00000182197
  • Gene Symbol: GLS (ENSG00000115419)
    Fold Change: 2.05
    Ensembl ID: ENSG00000115419
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.05
    Ensembl ID: ENSG00000108684
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 2.05
    Ensembl ID: ENSG00000165995
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.04
    Ensembl ID: ENSG00000204217
  • Gene Symbol: DPYD (ENSG00000188641)
    Fold Change: 2.04
    Ensembl ID: ENSG00000188641
  • Gene Symbol: EPHA4 (ENSG00000116106)
    Fold Change: 2.04
    Ensembl ID: ENSG00000116106
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 2.04
    Ensembl ID: ENSG00000078053
  • Gene Symbol: FER (ENSG00000151422)
    Fold Change: 2.04
    Ensembl ID: ENSG00000151422
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 2.04
    Ensembl ID: ENSG00000079102
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 2.04
    Ensembl ID: ENSG00000134769
  • Gene Symbol: CAMK2A (ENSG00000070808)
    Fold Change: 2.04
    Ensembl ID: ENSG00000070808
  • Gene Symbol: DPYSL2 (ENSG00000092964)
    Fold Change: 2.03
    Ensembl ID: ENSG00000092964
  • Gene Symbol: DGKB (ENSG00000136267)
    Fold Change: 2.03
    Ensembl ID: ENSG00000136267
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.03
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.03
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 2.03
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.03
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.03
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.03
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.03
    Ensembl ID: ENSG00000157764
  • Gene Symbol: EPHA5 (ENSG00000145242)
    Fold Change: 2.03
    Ensembl ID: ENSG00000145242
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.03
    Ensembl ID: ENSG00000198668
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.03
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ELAVL4 (ENSG00000162374)
    Fold Change: 2.02
    Ensembl ID: ENSG00000162374
  • Gene Symbol: CDH8 (ENSG00000150394)
    Fold Change: 2.02
    Ensembl ID: ENSG00000150394
  • Gene Symbol: DTNB (ENSG00000138101)
    Fold Change: 2.02
    Ensembl ID: ENSG00000138101
  • Gene Symbol: BRINP1 (ENSG00000078725)
    Fold Change: 2.02
    Ensembl ID: ENSG00000078725
  • Gene Symbol: FHIT (ENSG00000189283)
    Fold Change: 2.02
    Ensembl ID: ENSG00000189283
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.01
    Ensembl ID: ENSG00000198589
  • Gene Symbol: ELAVL3 (ENSG00000196361)
    Fold Change: 2.01
    Ensembl ID: ENSG00000196361
  • Gene Symbol: GABRG2 (ENSG00000113327)
    Fold Change: 2.01
    Ensembl ID: ENSG00000113327
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 2.01
    Ensembl ID: ENSG00000170558
  • Gene Symbol: DNAH6 (ENSG00000115423)
    Fold Change: 2.01
    Ensembl ID: ENSG00000115423
  • Gene Symbol: CAMK2B (ENSG00000058404)
    Fold Change: 2.01
    Ensembl ID: ENSG00000058404
  • Gene Symbol: GLG1 (ENSG00000090863)
    Fold Change: 2
    Ensembl ID: ENSG00000090863
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.99
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CPE (ENSG00000109472)
    Fold Change: 1.99
    Ensembl ID: ENSG00000109472
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 1.99
    Ensembl ID: ENSG00000171634
  • Gene Symbol: FUT8 (ENSG00000033170)
    Fold Change: 1.99
    Ensembl ID: ENSG00000033170
  • Gene Symbol: DYRK1A (ENSG00000157540)
    Fold Change: 1.98
    Ensembl ID: ENSG00000157540
  • Gene Symbol: EPHA3 (ENSG00000044524)
    Fold Change: 1.98
    Ensembl ID: ENSG00000044524
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.97
    Ensembl ID: ENSG00000033627
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.97
    Ensembl ID: ENSG00000197102
  • Gene Symbol: CACNA1E (ENSG00000198216)
    Fold Change: 1.97
    Ensembl ID: ENSG00000198216
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 1.97
    Ensembl ID: ENSG00000143669
  • Gene Symbol: GMDS (ENSG00000112699)
    Fold Change: 1.97
    Ensembl ID: ENSG00000112699
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.97
    Ensembl ID: ENSG00000159842
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.97
    Ensembl ID: ENSG00000107282
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.96
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ESRRG (ENSG00000196482)
    Fold Change: 1.96
    Ensembl ID: ENSG00000196482
  • Gene Symbol: EPB41L2 (ENSG00000079819)
    Fold Change: 1.96
    Ensembl ID: ENSG00000079819
  • Gene Symbol: CAMK2G (ENSG00000148660)
    Fold Change: 1.96
    Ensembl ID: ENSG00000148660
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.96
    Ensembl ID: ENSG00000134982
  • Gene Symbol: FYN (ENSG00000010810)
    Fold Change: 1.95
    Ensembl ID: ENSG00000010810
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.95
    Ensembl ID: ENSG00000143933
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.95
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.95
    Ensembl ID: ENSG00000058668
  • Gene Symbol: DMXL1 (ENSG00000172869)
    Fold Change: 1.94
    Ensembl ID: ENSG00000172869
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.94
    Ensembl ID: ENSG00000134480
  • Gene Symbol: GLRB (ENSG00000109738)
    Fold Change: 1.94
    Ensembl ID: ENSG00000109738
  • Gene Symbol: ELAVL2 (ENSG00000107105)
    Fold Change: 1.94
    Ensembl ID: ENSG00000107105

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in L2/3-6 intratelencephalic projecting glutamatergic neuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in L2/3-6 intratelencephalic projecting glutamatergic neuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Location**: The neuron is found in cortical layers L2/3-6 of the intratelencephalic region, suggesting a role in regulating synaptic transmission and plasticity within these layers. 2. **Neurotransmitter**: The neuron is a glutamatergic neuron, releasing glutamate as its primary neurotransmitter. 3. **Gene Symbol**: ADGRB3 (also known as FGF14) is the gene symbol for this neuron, indicating its involvement in various cellular and molecular pathways. 4. **Genetic Relationships**: The neuron interacts with other genes, including DLG2 (PSD-95), FGF12, CTNND2, DOCK3, and CACNA1C, which are involved in cell-cell signaling, synaptic transmission, and neuronal development. **Clinical Significance** 1. **Neurological Disorders**: Abnormalities in glutamatergic neurotransmission, such as those affecting ADGRB3, have been implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and Parkinson's disease. 2. **Synaptic Plasticity**: The regulation of synaptic transmission and plasticity by ADGRB3 is crucial for learning and memory, making it a potential target for therapeutic interventions in conditions characterized by impaired synaptic function. 3. **Neurodevelopmental Disorders**: Alterations in the expression or function of ADGRB3 have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 4. **Cognitive Function**: The interaction between ADGRB3 and other genes involved in synaptic transmission and neuronal development may influence cognitive function, making it a potential target for therapeutic interventions in cognitive impairments. In conclusion, the intratelencephalic-projecting glutamatergic neuron with gene symbol ADGRB3 plays a critical role in regulating synaptic transmission and plasticity, particularly in the context of glutamate binding and activation. Its interactions with other genes and its involvement in various cellular and molecular pathways make it a valuable target for therapeutic interventions in neurological and neurodevelopmental disorders.