Cell ID: CL4023041

Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron

CSI Thresholds:

Select	Context	Threshold
	Overall	35.0319
	Middle temporal gyrus + Dementia	333.2362
	Neocortex	327.2848
	Neocortex + Healthy	326.9852
	Middle temporal gyrus	264.5348
	Dementia	256.3533
	Middle temporal gyrus + Healthy	148.1298
	Prefrontal cortex	58.8694
	Prefrontal cortex + Healthy	49.7217
	Primary visual cortex	41.7975
	Healthy	34.2888
	Forebrain	31.3185
	Primary auditory cortex + Healthy	28.5566
	Primary auditory cortex	28.4649
	Brodmann (1909) area 9	25.5785
	Primary visual cortex + Healthy	22.3791
	Brodmann (1909) area 17	21.8879
	Anterior cingulate cortex + Healthy	18.2332
	Anterior cingulate cortex	18.2302
	Dorsolateral prefrontal cortex + Healthy	16.9746
	Dorsolateral prefrontal cortex	16.6669
	Brodmann (1909) area 10 + Healthy	16.5550
	Brodmann (1909) area 10	16.5524
	Forebrain + Healthy	16.2049
	Brodmann (1909) area 17 + Healthy	13.1465
	Brodmann (1909) area 9 + Healthy	10.6266
	Visual cortex	5.6924
	Visual cortex + Healthy	5.6879
	Primary somatosensory cortex + Healthy	3.6538
	Primary somatosensory cortex	3.6506
	Dorsolateral prefrontal cortex + Dementia	1.3355
	Angular gyrus + Healthy	0.2556
	Angular gyrus	0.2544

Select

(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons ', Author Categories: 'CrossArea_subclass', clusters L5 ET.

Synonyms: subcerebral projection (SCPN) neuron, Pyramidal tract-like (PT-l), burst-firing layer 5 neuron, thick-tufted layer 5 (TTL5) pyramidal neuron, pyramidal tract (PT) neuron, L5b neuron