Details for: CL4028003

Cell ID: CL4028003

Cell Name: alveolar capillary type 2 endothelial cell

Marker Score Threshold: 1448
(Derived using integrated single-cell and genomic data)

Description: An alveolar capillary endothelial cell that is located proximally to alveolar capillary type 1 endothelial cells and in close apposition to alveolar type 1 epithelial cells (also known as type I pneumocytes).

Synonyms: CD34hi endothelial cells, Car4+ capillary endothelial cell, aerocyte, alveolar capillary cell, capillary 2 cell, aCAP

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 4.7
    Ensembl ID: ENSG00000240583
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 4.57
    Ensembl ID: ENSG00000105974
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.56
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.5
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CA4 (ENSG00000167434)
    Fold Change: 4.43
    Ensembl ID: ENSG00000167434
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 4.36
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.05
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 3.94
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.93
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 3.93
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 3.88
    Ensembl ID: ENSG00000105971
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.85
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: 3.65
    Ensembl ID: ENSG00000139567
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.59
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.56
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 3.41
    Ensembl ID: ENSG00000198898
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 3.3
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.2
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 3.18
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 3.13
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.13
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.04
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.99
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.95
    Ensembl ID: ENSG00000122786
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 2.94
    Ensembl ID: ENSG00000149131
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 2.86
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.69
    Ensembl ID: ENSG00000164111
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 2.69
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.69
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.61
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.59
    Ensembl ID: ENSG00000182718
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.56
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 2.46
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.42
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.38
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.34
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.23
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.22
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.21
    Ensembl ID: ENSG00000104964
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 2.06
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.05
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.04
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 2.04
    Ensembl ID: ENSG00000213465
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.02
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.96
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.96
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.93
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.91
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.89
    Ensembl ID: ENSG00000077549
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.83
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.82
    Ensembl ID: ENSG00000128272
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.81
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.79
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.77
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.77
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.75
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.73
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.71
    Ensembl ID: ENSG00000071553
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.7
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.7
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.68
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ADRB1 (ENSG00000043591)
    Fold Change: 1.67
    Ensembl ID: ENSG00000043591
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.66
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.65
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.64
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.62
    Ensembl ID: ENSG00000110092
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.58
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.56
    Ensembl ID: ENSG00000176171
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.56
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.54
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.52
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.52
    Ensembl ID: ENSG00000142188
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.51
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.5
    Ensembl ID: ENSG00000104763
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.49
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.47
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.46
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.46
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.44
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.39
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.36
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.34
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.34
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.29
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.28
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104267
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.27
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.26
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.18
    Ensembl ID: ENSG00000085224
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.17
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.16
    Ensembl ID: ENSG00000137486
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.14
    Ensembl ID: ENSG00000108561
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.11
    Ensembl ID: ENSG00000106992
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.1
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.09
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.06
    Ensembl ID: ENSG00000047648
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.04
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.02
    Ensembl ID: ENSG00000075239
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.01
    Ensembl ID: ENSG00000198931
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: AC2E are found in the alveolar capillaries of the lungs, proximal to alveolar capillary type 1 endothelial cells and in close apposition to alveolar type 1 epithelial cells (type I pneumocytes). 2. **Gene Expression**: AC2E express specific genes, including AQP1, which is involved in water transport and ion transport. 3. **Function**: AC2E play a crucial role in maintaining the integrity of the alveolar-capillary barrier, regulating gas exchange, and modulating inflammation in response to various stimuli. 4. **Cell Signaling**: AC2E are involved in various cellular processes, including cell signaling, through the regulation of ion channels and transporters. 5. **Water Transport**: AC2E are involved in water transport across the alveolar-capillary membrane, which is essential for maintaining lung homeostasis. **Clinical Significance** 1. **Respiratory Diseases**: Understanding the function and regulation of AC2E is essential for understanding the pathophysiology of respiratory diseases, such as acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and pulmonary hypertension. 2. **Gas Exchange**: AC2E play a crucial role in regulating gas exchange in the lungs, which is essential for maintaining lung homeostasis and preventing respiratory complications. 3. **Inflammation**: AC2E are involved in modulating inflammation in response to various stimuli, which is essential for preventing respiratory complications and promoting lung repair. 4. **Therapeutic Targeting**: AC2E are potential therapeutic targets for the treatment of respiratory diseases, such as ARDS and COPD, where modulating inflammation and regulating gas exchange are critical for improving patient outcomes. 5. **Basic Research**: Understanding the function and regulation of AC2E is essential for advancing our knowledge of lung physiology and pathophysiology, which is critical for developing new treatments and therapies for respiratory diseases.