Details for: CL4028006

Cell ID: CL4028006

Cell Name: alveolar type 2 fibroblast cell

Marker Score Threshold: 556
(Derived using integrated single-cell and genomic data)

Description: A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia.

Synonyms: adventitial fibroblast, alveolar fibroblast, matrix fibroblast 2, mesenchymal alveolar niche cell, type-2 associated stromal cell, alveolar type 2 fibroblast cell, AF2, AdvF, MANC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 6.77
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 6.61
    Ensembl ID: ENSG00000151067
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 5.58
    Ensembl ID: ENSG00000047648
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 5.58
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 5.29
    Ensembl ID: ENSG00000135298
  • Gene Symbol: CDH11 (ENSG00000140937)
    Fold Change: 4.94
    Ensembl ID: ENSG00000140937
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 4.85
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 4.66
    Ensembl ID: ENSG00000197381
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 4.45
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 4.43
    Ensembl ID: ENSG00000157388
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 4.4
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 4.29
    Ensembl ID: ENSG00000122786
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 4.05
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 3.71
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 3.52
    Ensembl ID: ENSG00000154188
  • Gene Symbol: C7 (ENSG00000112936)
    Fold Change: 3.41
    Ensembl ID: ENSG00000112936
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 3.1
    Ensembl ID: ENSG00000140836
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 2.86
    Ensembl ID: ENSG00000079102
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.82
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 2.73
    Ensembl ID: ENSG00000140945
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.68
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BMP5 (ENSG00000112175)
    Fold Change: 2.61
    Ensembl ID: ENSG00000112175
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 2.6
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 2.58
    Ensembl ID: ENSG00000196616
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.53
    Ensembl ID: ENSG00000204217
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 2.43
    Ensembl ID: ENSG00000113916
  • Gene Symbol: RUNX1 (ENSG00000159216)
    Fold Change: 2.37
    Ensembl ID: ENSG00000159216
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.31
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.29
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 2.21
    Ensembl ID: ENSG00000165029
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.21
    Ensembl ID: ENSG00000198589
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.12
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.09
    Ensembl ID: ENSG00000157764
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 2.05
    Ensembl ID: ENSG00000171791
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.99
    Ensembl ID: ENSG00000153956
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.99
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.94
    Ensembl ID: ENSG00000134480
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 1.92
    Ensembl ID: ENSG00000182326
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.89
    Ensembl ID: ENSG00000138760
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.79
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.78
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.77
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 1.77
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.69
    Ensembl ID: ENSG00000097007
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.65
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.58
    Ensembl ID: ENSG00000072110
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.58
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.56
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.54
    Ensembl ID: ENSG00000145362
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.54
    Ensembl ID: ENSG00000119138
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.52
    Ensembl ID: ENSG00000159403
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.48
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.48
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.47
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.46
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.46
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.45
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.4
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.39
    Ensembl ID: ENSG00000076555
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.37
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.36
    Ensembl ID: ENSG00000162104
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.35
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.34
    Ensembl ID: ENSG00000143437
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.32
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.29
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.26
    Ensembl ID: ENSG00000149311
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.25
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.24
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.22
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.2
    Ensembl ID: ENSG00000004897
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.19
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.17
    Ensembl ID: ENSG00000149257
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.17
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 1.15
    Ensembl ID: ENSG00000140743
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.14
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.14
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.13
    Ensembl ID: ENSG00000156273
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.13
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.12
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.11
    Ensembl ID: ENSG00000070831
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.11
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.1
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.09
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.08
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.07
    Ensembl ID: ENSG00000110955
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.07
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.06
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.05
    Ensembl ID: ENSG00000164111
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.05
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.04
    Ensembl ID: ENSG00000159842
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.04
    Ensembl ID: ENSG00000134982
  • Gene Symbol: CDK8 (ENSG00000132964)
    Fold Change: 1.04
    Ensembl ID: ENSG00000132964
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.04
    Ensembl ID: ENSG00000083123
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.04
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.04
    Ensembl ID: ENSG00000019582
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.03
    Ensembl ID: ENSG00000106624
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.02
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1
    Ensembl ID: ENSG00000122359
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cellular Location**: The alveolar type 2 fibroblast is located in the alveolus and vascular adventitia, where it plays a crucial role in maintaining the structure and function of the lungs. 2. **Cellular Function**: The cell is involved in various biological processes, including wound healing, extracellular matrix organization, and cell communication. It produces and secretes various extracellular matrix components, such as collagen and elastin, which are essential for maintaining the integrity of the lung tissue. 3. **Gene Expression**: The cell expresses a range of genes involved in cellular processes, including DST, CACNA1C, ARHGAP6, A2M, ADGRB3, and CDH11. These genes are involved in various cellular processes, including cell signaling, cell adhesion, and cell migration. 4. **Protein Expression**: The cell expresses a range of proteins involved in cellular processes, including actin, integrins, and cadherins. These proteins are involved in cell adhesion, cell migration, and cell signaling. **Clinical Significance** 1. **Pulmonary Fibrosis**: Alveolar type 2 fibroblasts are involved in the pathogenesis of pulmonary fibrosis, a disease characterized by the scarring of lung tissue. The cell's ability to produce and secrete extracellular matrix components can lead to the accumulation of scar tissue and the destruction of lung function. 2. **Respiratory Diseases**: Alveolar type 2 fibroblasts are involved in the pathogenesis of various respiratory diseases, including chronic obstructive pulmonary disease (COPD) and asthma. The cell's ability to produce and secrete extracellular matrix components can lead to the inflammation and scarring of lung tissue. 3. **Cancer**: Alveolar type 2 fibroblasts are involved in the pathogenesis of lung cancer, particularly small cell lung cancer. The cell's ability to produce and secrete extracellular matrix components can lead to the invasion and metastasis of cancer cells. 4. **Therapeutic Applications**: Understanding the role of alveolar type 2 fibroblasts in various diseases has led to the development of therapeutic strategies aimed at modulating the cell's function and behavior. For example, inhibitors of the cell's ability to produce and secrete extracellular matrix components have been developed as potential treatments for pulmonary fibrosis and other respiratory diseases. In conclusion, the alveolar type 2 fibroblast is a complex cell that plays a crucial role in maintaining the structure and function of the lungs. Its ability to produce and secrete extracellular matrix components, as well as its involvement in various cellular processes, make it an important target for therapeutic interventions in various diseases.