Details for: CL4028006

Cell ID: CL4028006

Cell Name: alveolar type 2 fibroblast cell

Marker Score Threshold: 556
(Derived using integrated single-cell and genomic data)

Description: A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia.

Synonyms: adventitial fibroblast, alveolar fibroblast, matrix fibroblast 2, mesenchymal alveolar niche cell, type-2 associated stromal cell, alveolar type 2 fibroblast cell, AF2, AdvF, MANC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 6.77
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 6.61
    Ensembl ID: ENSG00000151067
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 5.58
    Ensembl ID: ENSG00000047648
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 5.58
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 5.29
    Ensembl ID: ENSG00000135298
  • Gene Symbol: CDH11 (ENSG00000140937)
    Fold Change: 4.94
    Ensembl ID: ENSG00000140937
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 4.85
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 4.66
    Ensembl ID: ENSG00000197381
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 4.45
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 4.43
    Ensembl ID: ENSG00000157388
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 4.4
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 4.29
    Ensembl ID: ENSG00000122786
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 4.05
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 3.71
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 3.52
    Ensembl ID: ENSG00000154188
  • Gene Symbol: C7 (ENSG00000112936)
    Fold Change: 3.41
    Ensembl ID: ENSG00000112936
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 3.1
    Ensembl ID: ENSG00000140836
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 2.86
    Ensembl ID: ENSG00000079102
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.82
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 2.73
    Ensembl ID: ENSG00000140945
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.68
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BMP5 (ENSG00000112175)
    Fold Change: 2.61
    Ensembl ID: ENSG00000112175
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 2.6
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 2.58
    Ensembl ID: ENSG00000196616
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.53
    Ensembl ID: ENSG00000204217
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 2.43
    Ensembl ID: ENSG00000113916
  • Gene Symbol: RUNX1 (ENSG00000159216)
    Fold Change: 2.37
    Ensembl ID: ENSG00000159216
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.31
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.29
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 2.21
    Ensembl ID: ENSG00000165029
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.21
    Ensembl ID: ENSG00000198589
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.12
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.09
    Ensembl ID: ENSG00000157764
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 2.05
    Ensembl ID: ENSG00000171791
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.99
    Ensembl ID: ENSG00000153956
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.99
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.94
    Ensembl ID: ENSG00000134480
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 1.92
    Ensembl ID: ENSG00000182326
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.89
    Ensembl ID: ENSG00000138760
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.79
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.78
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.77
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 1.77
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.69
    Ensembl ID: ENSG00000097007
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.65
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.58
    Ensembl ID: ENSG00000072110
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.58
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.56
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.54
    Ensembl ID: ENSG00000145362
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.54
    Ensembl ID: ENSG00000119138
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.52
    Ensembl ID: ENSG00000159403
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.48
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.48
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.47
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.46
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.46
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.45
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.4
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.39
    Ensembl ID: ENSG00000076555
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.37
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.36
    Ensembl ID: ENSG00000162104
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.35
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.34
    Ensembl ID: ENSG00000143437
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.32
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.29
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.26
    Ensembl ID: ENSG00000149311
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.25
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.24
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.22
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.2
    Ensembl ID: ENSG00000004897
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.19
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.17
    Ensembl ID: ENSG00000149257
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.17
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 1.15
    Ensembl ID: ENSG00000140743
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.14
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.14
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.13
    Ensembl ID: ENSG00000156273
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.13
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.12
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.11
    Ensembl ID: ENSG00000070831
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.11
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.1
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.09
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.08
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.07
    Ensembl ID: ENSG00000110955
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.07
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.06
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.05
    Ensembl ID: ENSG00000164111
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.05
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.04
    Ensembl ID: ENSG00000159842
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.04
    Ensembl ID: ENSG00000134982
  • Gene Symbol: CDK8 (ENSG00000132964)
    Fold Change: 1.04
    Ensembl ID: ENSG00000132964
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.04
    Ensembl ID: ENSG00000083123
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.04
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.04
    Ensembl ID: ENSG00000019582
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.03
    Ensembl ID: ENSG00000106624
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.02
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1
    Ensembl ID: ENSG00000122359

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in alveolar type 2 fibroblast cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in alveolar type 2 fibroblast cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The alveolar type 2 fibroblast (AF2) is characterized by the following key features: 1. **Location**: The AF2 cell is localized to the vascular adventitia of the alveolus, where it interacts with the extracellular matrix and other cells. 2. **Gene Expression**: The AF2 cell expresses specific genes involved in cell adhesion, migration, and extracellular matrix organization, including DST, CACNA1C, and ARHGAP6. 3. **Cellular Function**: The AF2 cell is involved in various physiological processes, including wound healing, inflammation, and immune response. 4. **Pathways**: The AF2 cell is involved in several signaling pathways, including actin cytoskeleton organization, focal adhesion assembly, and Rho GTPase cycle. 5. **Cell-Cell Interaction**: The AF2 cell interacts with other cells, including endothelial cells, smooth muscle cells, and immune cells, to maintain the integrity of the alveolar structure and function. **Clinical Significance** The alveolar type 2 fibroblast (AF2) plays a crucial role in maintaining the integrity of the alveolar structure and function, and abnormalities in AF2 function have been implicated in various pulmonary diseases. Some of the clinical significance of the AF2 cell includes: 1. **Pulmonary Fibrosis**: Abnormalities in AF2 function have been implicated in pulmonary fibrosis, a condition characterized by the scarring of lung tissue. 2. **Asthma**: The AF2 cell is involved in the pathogenesis of asthma, a condition characterized by airway inflammation and hyperresponsiveness. 3. **Wound Healing**: The AF2 cell is involved in wound healing, and abnormalities in AF2 function can lead to impaired wound healing. 4. **Inflammation**: The AF2 cell is involved in the regulation of inflammation, and abnormalities in AF2 function can lead to excessive or inadequate inflammation. In summary, the alveolar type 2 fibroblast (AF2) is a critical cell type involved in maintaining the integrity of the alveolar structure and function, and abnormalities in AF2 function have been implicated in various pulmonary diseases. Further research is needed to fully understand the role of the AF2 cell in pulmonary disease and to develop effective therapeutic strategies to target this cell type.