Cell ID: CL4030059

Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron

CSI Thresholds:

Select	Context	Threshold
	Overall	13.3299
	Neocortex	91.1265
	Neocortex + Healthy	91.0397
	Medial orbital frontal cortex + Breast cancer	79.5754
	Breast cancer	79.5492
	Prefrontal cortex + Healthy	63.9032
	Dorsolateral prefrontal cortex	54.8593
	Medial orbital frontal cortex + Heart disorder	52.5016
	Heart disorder	52.4531
	Prefrontal cortex	48.3346
	Myocardial infarction	36.4554
	Medial orbital frontal cortex + Myocardial infarction	36.4477
	Small cell lung carcinoma	34.5844
	Medial orbital frontal cortex + Small cell lung carcinoma	34.5725
	Telencephalon + Healthy	33.2294
	Forebrain	29.9177
	Brodmann (1909) area 17	26.3593
	Medial orbital frontal cortex + Chronic obstructive pulmonary disease	25.7851
	Chronic obstructive pulmonary disease	25.7818
	Medial orbital frontal cortex + COVID-19	25.4110
	COVID-19	25.4003
	Influenza	20.8379
	Medial orbital frontal cortex + Influenza	20.8339
	Brodmann (1909) area 9	19.4622
	Forebrain + Healthy	18.8283
	Brodmann (1909) area 17 + Healthy	14.1636
	Healthy	13.1687
	Medial orbital frontal cortex + Tongue cancer	12.3036
	Tongue cancer	12.2921
	Brodmann (1909) area 9 + Healthy	11.3559
	Temporal lobe	10.4332
	Medial orbital frontal cortex	9.5008
	Telencephalon	9.2959
	Brodmann (1909) area 10 + Healthy	8.4835
	Brodmann (1909) area 10	8.4801
	Isolated focal cortical dysplasia type II	6.0871
	Visual cortex + Healthy	5.9782
	Visual cortex	5.9538
	Dorsolateral prefrontal cortex + Healthy	2.0267
	Medial orbital frontal cortex + Cardiomyopathy	1.7014
	Cardiomyopathy	1.7012

Select

(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found between cortical layer 2-4. This intratelencephalic-projecting glutamatergic neuron has thin-tufted apical dendrites and extends its axonal projection into L5 in the neocortex. This neuronal type has a hyperpolarised resting membrane potential. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L2/3 IT.

Synonyms: L2/3 IT