Cell ID: CL4030063

Cell Name: L4 intratelencephalic projecting glutamatergic neuron

CSI Thresholds:

Select	Context	Threshold
	Overall	10.9607
	Brodmann (1909) area 17 + Healthy	93.6896
	Neocortex + Healthy	91.3976
	Neocortex	91.2874
	Prefrontal cortex + Healthy	67.8671
	Prefrontal cortex	50.9606
	Telencephalon + Healthy	49.4197
	Chronic obstructive pulmonary disease	48.7714
	Medial orbital frontal cortex + Chronic obstructive pulmonary disease	48.7714
	COVID-19	46.4597
	Medial orbital frontal cortex + COVID-19	46.4597
	Breast cancer	40.1194
	Medial orbital frontal cortex + Breast cancer	40.1194
	Brodmann (1909) area 17	38.0825
	Forebrain	36.9566
	Brodmann (1909) area 9	31.0878
	Heart disorder	30.4352
	Medial orbital frontal cortex + Heart disorder	30.4352
	Brodmann (1909) area 9 + Healthy	25.4408
	Myocardial infarction	23.3812
	Medial orbital frontal cortex + Myocardial infarction	23.3812
	Telencephalon	21.2446
	Forebrain + Healthy	17.9731
	Brodmann (1909) area 10 + Healthy	16.7268
	Brodmann (1909) area 10	16.7195
	Medial orbital frontal cortex	12.6210
	Small cell lung carcinoma	11.2689
	Medial orbital frontal cortex + Small cell lung carcinoma	11.2689
	Tongue cancer	10.1258
	Medial orbital frontal cortex + Tongue cancer	10.1258
	Healthy	8.9825
	Influenza	8.7949
	Medial orbital frontal cortex + Influenza	8.7949
	Cardiomyopathy	7.9982
	Medial orbital frontal cortex + Cardiomyopathy	7.9982
	Visual cortex + Healthy	6.2488
	Visual cortex	6.2217

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(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L4 IT.

Synonyms: L4 IT