Cell ID: CL4033016

Cell Name: secondary crest myofibroblast

CSI Thresholds:

Select	Context	Threshold
	Overall	6.0238
	Lung	7.0328
	Healthy	3.4976
	Lung + Healthy	2.9509

Select

(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A myofibroblast that is part of an alveoli during alveolarization. The contractile force of this cell elongates the secondary crest, while producing a framework of elastin and tenascin. During the maturation of the septa, secondary crest myofibroblasts, together with matrix fibroblasts, secrete metalloproteinases and other ECM‐remodeling proteins to thin the septal tip ECM. The secondary crest myofibroblast continues producing elastin, eventually undergoing apoptosis during adulthood.

Synonyms: secondary-crest myofibroblast, SCMF, SCMFs, alveolar myofibroblast