Cell ID: CL4033058

Cell Name: luminal hormone-sensing cell of mammary gland

CSI Thresholds:

Select	Context	Threshold
	Overall	6.1542
	Upper outer quadrant of breast + Healthy	74.1504
	Upper outer quadrant of breast	73.9819
	Breast	17.5876
	Breast + Healthy	15.3838
	Healthy	6.4423

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(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A luminal epithelial cell of the mammary gland that transduces endocrine cues to orchestrate proliferation, architectural remodeling, and differentiation of other cells in the mammary gland via paracrine signaling. This cell expresses high levels of estrogen receptors. In humans, a luminal hormone-sensing cell can be identified by high levels of EpCAM and low levels of CD49f, and in mice it can be identified by low levels of CD29 and high levels of Foxa1, CD133, and Sca1 (Ly6a).

Synonyms: hormone sensing cell, hormone-sensing mammary epithelial cell, luminal hormone-responsive cell, luminal mature cell, ER-positive luminal hormone-sensor cell, HS, HS-MEC, LHS, LumHR