Details for: A1BG

Gene ID: 1

Symbol: A1BG

Ensembl ID: ENSG00000121410

Description: alpha-1-B glycoprotein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 11.82
    Marker Score: 12382
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.58
    Marker Score: 13876
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 2.48
    Marker Score: 1078.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.22
    Marker Score: 5754
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.92
    Marker Score: 8271
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.86
    Marker Score: 18799
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.81
    Marker Score: 11614
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.7
    Marker Score: 2115
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.55
    Marker Score: 1123
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.5
    Marker Score: 337
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.33
    Marker Score: 5733
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.28
    Marker Score: 1538
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.27
    Marker Score: 14253
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.24
    Marker Score: 2160
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.19
    Marker Score: 1277
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.18
    Marker Score: 747.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.17
    Marker Score: 2090
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.14
    Marker Score: 1149
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.14
    Marker Score: 1614
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4735
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.12
    Marker Score: 4324
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.11
    Marker Score: 4545
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.09
    Marker Score: 412
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.09
    Marker Score: 245.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.06
    Marker Score: 429
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.06
    Marker Score: 376
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.03
    Marker Score: 2174
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.02
    Marker Score: 1209
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.02
    Marker Score: 697
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.01
    Marker Score: 1098
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71726.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47950
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.99
    Marker Score: 887
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.99
    Marker Score: 55277
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.96
    Marker Score: 5857
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.94
    Marker Score: 351
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.92
    Marker Score: 623
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.91
    Marker Score: 30975
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5133
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 358
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.89
    Marker Score: 596
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.86
    Marker Score: 1615
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1599.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.83
    Marker Score: 285
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.81
    Marker Score: 2198
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12589
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.8
    Marker Score: 348
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.79
    Marker Score: 539
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.78
    Marker Score: 7740
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.78
    Marker Score: 205
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.78
    Marker Score: 325
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.76
    Marker Score: 315
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.75
    Marker Score: 374
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1212
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379.5
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.73
    Marker Score: 348
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.73
    Marker Score: 1390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 663
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.72
    Marker Score: 821
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.71
    Marker Score: 428
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.71
    Marker Score: 709
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.71
    Marker Score: 787
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.71
    Marker Score: 448.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.7
    Marker Score: 376
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.7
    Marker Score: 192
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7
    Marker Score: 319.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.68
    Marker Score: 4375.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.68
    Marker Score: 1908
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.67
    Marker Score: 488
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.67
    Marker Score: 190
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.67
    Marker Score: 2872
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.67
    Marker Score: 386
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.66
    Marker Score: 440
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.65
    Marker Score: 231
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.65
    Marker Score: 1136
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.64
    Marker Score: 616.5
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.64
    Marker Score: 198
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.63
    Marker Score: 369
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.63
    Marker Score: 16071
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.63
    Marker Score: 360
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.63
    Marker Score: 160
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.62
    Marker Score: 610
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.62
    Marker Score: 356
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.62
    Marker Score: 1204
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.61
    Marker Score: 6144
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.61
    Marker Score: 1477
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.61
    Marker Score: 295.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.6
    Marker Score: 411
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 381
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1209
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.59
    Marker Score: 1612.5

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Other Information

**Key characteristics:** - A1BG is a type I glycoprotein, which are characterized by the presence of a single extracellular domain. - It is expressed in high levels in hematopoietic cells, where it is involved in cell adhesion and signaling. - A1BG is also expressed in various tissues, including the skin, lungs, and brain. - It is a key component of the platelet alpha granule lumen, a specialized structure involved in platelet aggregation. **Pathways and functions:** - A1BG is involved in several biological processes, including cell adhesion, signaling, and aggregation. - It is a key regulator of platelet aggregation, a process that is essential for blood clotting. - A1BG also plays a role in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in the A1BG gene have been linked to several human diseases, including platelet disorders such as von Willebrand disease and thrombocytopenia. - A1BG is a potential therapeutic target for these disorders, as it can inhibit platelet aggregation and improve blood clotting.

Genular Protein ID: 778135372

Symbol: A1BG_HUMAN

Name: Alpha-1B-glycoprotein

UniProtKB Accession Codes:

P04217 A8K052 Q68CK0 Q8IYJ6 Q96P39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 3 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15221005

Title: Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.

PubMed ID: 15221005

DOI: 10.1038/sj.onc.1207782

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3458201

Title: Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family.

PubMed ID: 3458201

DOI: 10.1073/pnas.83.8.2363

PubMed ID: 15461460

Title: Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma.

PubMed ID: 15461460

DOI: 10.1021/bi048823e

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 495
  • Mass: 54254
  • Checksum: 8E611BDC3BC824C8
  • Sequence:
    • MSMLVVFLLL WGVTWGPVTE AAIFYETQPS LWAESESLLK PLANVTLTCQ AHLETPDFQL 
FKNGVAQEPV HLDSPAIKHQ FLLTGDTQGR YRCRSGLSTG WTQLSKLLEL TGPKSLPAPW 
LSMAPVSWIT PGLKTTAVCR GVLRGVTFLL RREGDHEFLE VPEAQEDVEA TFPVHQPGNY 
SCSYRTDGEG ALSEPSATVT IEELAAPPPP VLMHHGESSQ VLHPGNKVTL TCVAPLSGVD 
FQLRRGEKEL LVPRSSTSPD RIFFHLNAVA LGDGGHYTCR YRLHDNQNGW SGDSAPVELI 
LSDETLPAPE FSPEPESGRA LRLRCLAPLE GARFALVRED RGGRRVHRFQ SPAGTEALFE 
LHNISVADSA NYSCVYVDLK PPFGGSAPSE RLELHVDGPP PRPQLRATWS GAVLAGRDAV 
LRCEGPIPDV TFELLREGET KAVKTVRTPG AAANLELIFV GPQHAGNYRC RYRSWVPHTF 
ESELSDPVEL LVAES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.