Details for: A1BG

Gene ID: 1

Symbol: A1BG

Ensembl ID: ENSG00000121410

Description: alpha-1-B glycoprotein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 80.4268
    Cell Significance Index: -12.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.8020
    Cell Significance Index: -8.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 31.5619
    Cell Significance Index: -16.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.9120
    Cell Significance Index: -13.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 20.4911
    Cell Significance Index: -13.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.0896
    Cell Significance Index: -12.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4016
    Cell Significance Index: -14.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.1322
    Cell Significance Index: 34.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.4674
    Cell Significance Index: -10.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2856
    Cell Significance Index: -12.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0339
    Cell Significance Index: -6.6400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.6578
    Cell Significance Index: 44.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3478
    Cell Significance Index: 151.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.2745
    Cell Significance Index: 72.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1691
    Cell Significance Index: 430.4600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.1656
    Cell Significance Index: 13.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.9232
    Cell Significance Index: 366.0000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.6382
    Cell Significance Index: 6.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8968
    Cell Significance Index: 66.8400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.8509
    Cell Significance Index: 4.9000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7046
    Cell Significance Index: 10.4000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.6850
    Cell Significance Index: 1.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6673
    Cell Significance Index: 19.1300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.5913
    Cell Significance Index: 2.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4993
    Cell Significance Index: 14.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4832
    Cell Significance Index: 47.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4648
    Cell Significance Index: 205.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4402
    Cell Significance Index: 397.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4388
    Cell Significance Index: 8.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4086
    Cell Significance Index: 10.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3495
    Cell Significance Index: 24.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3165
    Cell Significance Index: 36.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3072
    Cell Significance Index: 14.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2577
    Cell Significance Index: 41.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2552
    Cell Significance Index: 32.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2119
    Cell Significance Index: 24.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1975
    Cell Significance Index: 21.4900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1852
    Cell Significance Index: 1.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1622
    Cell Significance Index: 20.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1592
    Cell Significance Index: 4.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1514
    Cell Significance Index: 30.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0762
    Cell Significance Index: 10.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0524
    Cell Significance Index: 18.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0494
    Cell Significance Index: 1.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0416
    Cell Significance Index: 2.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0346
    Cell Significance Index: 2.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0333
    Cell Significance Index: 18.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0273
    Cell Significance Index: 0.3100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0143
    Cell Significance Index: 0.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0056
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0064
    Cell Significance Index: -12.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0073
    Cell Significance Index: -13.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0087
    Cell Significance Index: -13.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0101
    Cell Significance Index: -13.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0102
    Cell Significance Index: -0.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0116
    Cell Significance Index: -8.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0160
    Cell Significance Index: -0.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0161
    Cell Significance Index: -9.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0192
    Cell Significance Index: -3.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0197
    Cell Significance Index: -14.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0219
    Cell Significance Index: -13.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0242
    Cell Significance Index: -15.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0251
    Cell Significance Index: -1.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0257
    Cell Significance Index: -1.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0323
    Cell Significance Index: -14.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0365
    Cell Significance Index: -0.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0390
    Cell Significance Index: -2.0500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0428
    Cell Significance Index: -0.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0440
    Cell Significance Index: -12.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0491
    Cell Significance Index: -3.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0510
    Cell Significance Index: -10.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0579
    Cell Significance Index: -1.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0659
    Cell Significance Index: -11.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0684
    Cell Significance Index: -6.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0712
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0894
    Cell Significance Index: -10.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1003
    Cell Significance Index: -14.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1003
    Cell Significance Index: -6.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1047
    Cell Significance Index: -12.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1056
    Cell Significance Index: -2.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1164
    Cell Significance Index: -7.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1203
    Cell Significance Index: -7.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1231
    Cell Significance Index: -12.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1533
    Cell Significance Index: -3.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1553
    Cell Significance Index: -3.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1589
    Cell Significance Index: -7.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1730
    Cell Significance Index: -2.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1789
    Cell Significance Index: -13.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1806
    Cell Significance Index: -7.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1982
    Cell Significance Index: -15.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2050
    Cell Significance Index: -5.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2103
    Cell Significance Index: -11.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2231
    Cell Significance Index: -8.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2566
    Cell Significance Index: -13.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2661
    Cell Significance Index: -4.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2739
    Cell Significance Index: -7.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2832
    Cell Significance Index: -14.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2863
    Cell Significance Index: -10.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2906
    Cell Significance Index: -9.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** A1BG is a glycoprotein composed of two heavy chains and two light chains, with a molecular weight of approximately 180 kDa. It has multiple binding sites for various ligands, including complement proteins, lipids, and carbohydrates. 2. **Cellular Expression:** A1BG is expressed in various cell types, including thymocytes, hepatocytes, pancreatic D cells, and myeloid dendritic cells. Its expression is tissue-specific and regulated by various transcription factors. 3. **Biological Process:** A1BG is involved in multiple biological processes, including immune response, hemostasis, and cellular regulation. It plays a role in regulating the activity of various immune cells, including neutrophils and T cells. **Pathways and Functions:** 1. **Immune Response:** A1BG is involved in regulating the activity of immune cells, including neutrophils and T cells. It modulates the production of cytokines and chemokines, influencing the recruitment of immune cells to sites of inflammation. 2. **Hemostasis:** A1BG plays a role in regulating platelet activation and aggregation. It binds to platelet surface receptors, modulating the release of granular contents and influencing platelet function. 3. **Cellular Regulation:** A1BG is involved in regulating cellular processes, including cell adhesion, migration, and proliferation. It interacts with various cell surface receptors, influencing cell behavior and tissue homeostasis. 4. **Neutrophil Degranulation:** A1BG is involved in regulating neutrophil degranulation, a process that involves the release of granular contents, including antimicrobial peptides and enzymes. **Clinical Significance:** 1. **Autoimmune Disorders:** A1BG has been implicated in various autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. Its dysregulation is associated with disease progression and tissue damage. 2. **Cardiovascular Diseases:** A1BG has been linked to cardiovascular diseases, including atherosclerosis and thrombosis. Its dysregulation is associated with increased risk of cardiovascular events. 3. **Cancer:** A1BG has been implicated in cancer development and progression, including breast, lung, and colon cancers. Its dysregulation is associated with tumor growth, invasion, and metastasis. 4. **Neurological Disorders:** A1BG has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. Its dysregulation is associated with neuroinflammation and neuronal damage. In conclusion, alpha-1B-glycoprotein is a multifunctional protein involved in various biological processes, including immune response, hemostasis, and cellular regulation. Its dysregulation is associated with various diseases, including autoimmune disorders, cardiovascular diseases, and cancer. Further research is needed to fully elucidate the role of A1BG in human health and disease.

Genular Protein ID: 778135372

Symbol: A1BG_HUMAN

Name: Alpha-1B-glycoprotein

UniProtKB Accession Codes:

P04217 A8K052 Q68CK0 Q8IYJ6 Q96P39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DisGeNET 1 DrugBank 3 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15221005

Title: Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.

PubMed ID: 15221005

DOI: 10.1038/sj.onc.1207782

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3458201

Title: Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family.

PubMed ID: 3458201

DOI: 10.1073/pnas.83.8.2363

PubMed ID: 15461460

Title: Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma.

PubMed ID: 15461460

DOI: 10.1021/bi048823e

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 495
  • Mass: 54254
  • Checksum: 8E611BDC3BC824C8
  • Sequence:
    • MSMLVVFLLL WGVTWGPVTE AAIFYETQPS LWAESESLLK PLANVTLTCQ AHLETPDFQL 
FKNGVAQEPV HLDSPAIKHQ FLLTGDTQGR YRCRSGLSTG WTQLSKLLEL TGPKSLPAPW 
LSMAPVSWIT PGLKTTAVCR GVLRGVTFLL RREGDHEFLE VPEAQEDVEA TFPVHQPGNY 
SCSYRTDGEG ALSEPSATVT IEELAAPPPP VLMHHGESSQ VLHPGNKVTL TCVAPLSGVD 
FQLRRGEKEL LVPRSSTSPD RIFFHLNAVA LGDGGHYTCR YRLHDNQNGW SGDSAPVELI 
LSDETLPAPE FSPEPESGRA LRLRCLAPLE GARFALVRED RGGRRVHRFQ SPAGTEALFE 
LHNISVADSA NYSCVYVDLK PPFGGSAPSE RLELHVDGPP PRPQLRATWS GAVLAGRDAV 
LRCEGPIPDV TFELLREGET KAVKTVRTPG AAANLELIFV GPQHAGNYRC RYRSWVPHTF 
ESELSDPVEL LVAES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.